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JOURNAL ARTICLE
Tuohua Mao, Chenxuan Zhang, Shuang Yang, Yingying Bi, Man Li, Jia Yu
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease associated with type 2 diabetes mellitus (T2D). NAFLD can progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and even cancer, all of which have a very poor prognosis. Semaglutide, a novel glucagon-like peptide-1 (GLP-1) receptor agonist, has been recognized as a specific drug for the treatment of diabetes. In this study, we used a gene mutation mouse model (db/db mice) to investigate the potential liver-improving effects of semaglutide...
April 3, 2024: Biochemical and Biophysical Research Communications
#22
JOURNAL ARTICLE
X R Zheng, J X Peng, X Song, B Liu, C Zhong, X Y Chen, B X Zhang, L Peng, K S Zhu, C Xie
Objective: To study the effect of hepatitis B virus (HBV) infection on the occurrence of liver damage, HBV reactivation (HBVr) and the influence of HBVr on the prognosis of patients with advanced hepatocellular carcinoma (HCC) receiving systemic therapy. Methods: The clinical data of 403 patients with HBV-related HCC at the Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University et al, from July 2018 to December 2020 were collected. The incidence of liver damage and HBVr during systematic therapy, and the influence of HBVr on survival prognosis were analyzed...
April 9, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
#23
JOURNAL ARTICLE
Carina Boros, Olivier Sutter, François Cauchy, Nathalie Ganne-Carrié, Pierre Nahon, Gisele N'kontchou, Marianne Ziol, Véronique Grando, Alix Demory, Lorraine Blaise, Fédérica Dondero, François Durand, Olivier Soubrane, Mickael Lesurtel, Alexis Laurent, Oliver Seror, Jean Charles Nault
INTRODUCTION: We aim to assess the long-term outcomes of percutaneous multi-bipolar radiofrequency (mbpRFA) as the first treatment for hepatocellular carcinoma (HCC) in transplant-eligible cirrhotic patients, followed by salvage transplantation for intrahepatic distant tumour recurrence or liver failure. MATERIALS AND METHODS: We included transplant-eligible patients with cirrhosis and a first diagnosis of HCC within Milan criteria treated by upfront mbp RFA. Transplantability was defined by age <70 years, social support, absence of significant comorbidities, no active alcohol use and no recent extrahepatic cancer...
April 6, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
#24
JOURNAL ARTICLE
Qian Zhang, Yuhui Liu, Liangliang Ren, Junqing Li, Weiran Lin, Lijuan Lou, Minghan Wang, Chaoying Li, Ying Jiang
Hepatocellular carcinoma (HCC) seriously threatens human health, mostly developed from liver fibrosis or cirrhosis. Since diethylnitrosamine (DEN) and carbon tetrachloride (CCl4 )-induced HCC mouse model almost recapitulates the characteristic of HCC with fibrosis and inflammation, it is taken as an essential tool to investigate the pathogenesis of HCC. However, a comprehensive understanding of the protein expression profile of this model is little. In this study, we performed proteomic analysis of this model to elucidate its proteomic characteristics...
April 5, 2024: Scientific Reports
#25
JOURNAL ARTICLE
Xiang-Hao Cai, Yun-Ming Tang, Shu-Ru Chen, Jia-Hui Pang, Yu-Tian Chong, Hong Cao, Xin-Hua Li
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) is commonly utilized as a prognostic indicator in end-stage liver disease (ESLD), encompassing conditions like liver failure and decompensated cirrhosis. Nevertheless, some studies have contested the prognostic value of NLR in ESLD. AIM: To investigate the ability of NLR to predict ESLD. METHODS: Databases, such as Embase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Weipu, and Wanfang, were comprehensively searched to identify studies published before October 2022 assessing the prognostic ability of NLR to predict mortality in patients with ESLD...
March 27, 2024: World Journal of Hepatology
#26
MULTICENTER STUDY
Song-Man Yu, Hai Li, Guo-Hong Deng, Xian-Bo Wang, Xin Zheng, Jin-Jun Chen, Zhong-Ji Meng, Yu-Bao Zheng, Yan-Hang Gao, Zhi-Ping Qian, Feng Liu, Xiao-Bo Lu, Yu Shi, Jia Shang, Ruo-Chan Chen, Yan Huang
BACKGROUND: Acute decompensation (AD) of cirrhosis is associated with high short-term mortality, mainly due to the development of acute-on-chronic liver failure (ACLF). Thus, there is a need for biomarkers for early and accurate identification of AD patients with high risk of development of ACLF and mortality. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is released from activated innate immune cells and correlated with various inflammatory processes. AIM: To explore the prognostic value of sTREM-1 in patients with AD of cirrhosis...
March 7, 2024: World Journal of Gastroenterology: WJG
#27
EDITORIAL
Shi-Xue Xu, Fan Yang, Nan Ge, Jin-Tao Guo, Si-Yu Sun
The albumin-bilirubin (ALBI) score, which was proposed to assess the prognosis of patients with hepatocellular carcinoma, has gradually been extended to other liver diseases in recent years, including primary biliary cholangitis, liver cirrhosis, hepatitis, liver transplantation, and liver injury. The ALBI score is often compared with classical scores such as the Child-Pugh and model for end-stage liver disease scores or other noninvasive prediction models. It is widely employed because of its immunity to subjective evaluation indicators and ease of obtaining detection indicators...
March 7, 2024: World Journal of Gastroenterology: WJG
#28
JOURNAL ARTICLE
Xuan-Ji Li, Hui-Hui Meng
BACKGROUND: Cirrhosis is a common liver disease, and ascites is one of the common clinical conditions. However, the clinical manifestations of ascites combined with hyponatremia as a high-risk condition and its relationship to patient prognosis have not been fully studied. AIM: To explore the clinical manifestations, prognostic factors, and relationships of ascites with hyponatremia in patients with cirrhosis to provide better diagnostic and treatment strategies...
March 27, 2024: World Journal of Gastrointestinal Surgery
#29
JOURNAL ARTICLE
Huimin Liu, Hai Li, Guohong Deng, Xin Zheng, Yan Huang, Jinjun Chen, Zhongji Meng, Yanhang Gao, Zhiping Qian, Feng Liu, Xiaobo Lu, Yu Shi, Jia Shang, Huadong Yan, Yubao Zheng, Zixuan Shen, Liang Qiao, Weituo Zhang, Xianbo Wang
BACKGROUND AND AIM: A high aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio is associated with liver injury in liver disease; however, no data exist regarding its relationship with 90-day prognosis in patients with acute exacerbation of chronic liver disease. METHODS: In this study, 3,758 participants (955 with advanced fibrosis and 2,803 with cirrhosis) from the CATCH-LIFE cohort in China were included. The relationships between different AST/ALT ratios and the risk of adverse 90-day outcomes (death or liver transplantation) were determined in patients with cirrhosis or hepatitis B virus (HBV)-associated advanced fibrosis, respectively...
2024: Frontiers in Medicine
#30
REVIEW
Francisco Capinha, Carlos Noronha Ferreira
Nonmalignant portal vein thrombosis (PVT) is a common complication of cirrhosis especially at the stage of decompensations. The diagnosis of PVT in cirrhosis is often incidental and it may be detected during routine semestral abdominal ultrasound with Doppler during screening for hepatocellular carcinoma or during hospitalization for decompensated cirrhosis. After detection of PVT on abdominal ultrasound, it is important to evaluate patients with cross-sectional imaging to determine the age of thrombus, whether acute or chronic, the extent and degree of luminal occlusion of the portal vein, and to rule out hepatocellular carcinoma or other underlying malignancy...
April 2024: GE Portuguese Journal of Gastroenterology
#31
JOURNAL ARTICLE
Arun Jose, Natalia Rahman, Alexander R Opotowsky, Thomas J Glorioso, Stephen W Waldo, Katarina Zeder, Arnold Seto, Jean M Elwing, Francis X McCormack, Bradley A Maron
BACKGROUND: Portopulmonary hypertension (PoPH), associated with increased mortality, can limit treatment options for liver diseases. Data on the continuum of clinical risk related to cardiopulmonary hemodynamics in PoPH are lacking. METHODS AND RESULTS: As part of the United States national Veterans Affairs Clinical Assessment, Reporting, and Tracking database, we performed a retrospective cohort study of adults with cirrhosis undergoing right heart catheterization between October 1, 2017, and September 30, 2022...
April 3, 2024: Journal of the American Heart Association
#32
JOURNAL ARTICLE
Eun Sun Jang, Hwa Young Choi, Moran Ki, Bo Hyun Kim, Kyung-Ah Kim, Sook-Hyang Jeong
BACKGROUND: Wilson's disease (WD) is an autosomal recessive disorder in which copper (Cu) accumulates in organs, particularly in the liver and central nervous system. This study aimed to investigate the prevalence, incidence, and treatment patterns of WD patients in Korea. METHODS: National Health Insurance System (NHIS) claims data from 2010 to 2020 were analyzed. patients with WD as a primary or additional diagnosis at least once were identified using the International Classification of Diseases (ICD)-10 disease code E83...
April 1, 2024: Journal of Korean Medical Science
#33
JOURNAL ARTICLE
Yingyun Guo, Shan Tian, Na Zhan, Chuan Liu, Jiao Li, Jiaming Hu, Meiqi Qiu, Binglu Huang, Weiguo Dong
Portal vein tumor thrombosis (PVTT) frequently leads to malignant ascites (MA) in individuals with hepatocellular carcinoma (HCC), remaining a bottleneck in the treatment. This study aimed to explore the differences in microbes in paired groups and provide novel insights into PVTT and MA-related treatments. Formalin-fixed paraffin embedding ascite samples were collected from MA secondary to HCC and benign ascites (BA) secondary to liver cirrhosis (LC). Ascitic microbiota profiles were determined in the HCC and LC groups by 16S rRNA sequencing...
April 2, 2024: MBio
#34
Aizaz A Shah, Vemparala Priyatha, Yamna Ali, Abdul Wahab, Mahejehan A Salarzai, Junaid Ahmad, Noman Salih
We present a rare case of a 25-year-old woman who developed idiopathic portal hypertension and ascites four days after delivering a stillborn child at term. She had no previous liver illness or risk factors for portal vein thrombosis. Investigations revealed a dilated portal vein, esophageal varices, and high serum-albumin gradient ascites, all of which point to a presinusoidal etiology of portal hypertension. There was no indication of cirrhosis, hepatic or portal vein thrombosis, metabolic or autoimmune liver diseases, or persistent infections...
March 2024: Curēus
#35
JOURNAL ARTICLE
Tomoko Tadokoro, Takako Nomura, Koji Fujita, Takushi Manabe, Kei Takuma, Mai Nakahara, Kyoko Oura, Shima Mimura, Joji Tani, Asahiro Morishita, Hideki Kobara, Masafumi Ono, Tsutomu Masaki
BACKGROUND: Hepatocellular carcinoma (HCC) in autoimmune hepatitis (AIH) was considered rare but is increasing with prolonged prognosis. Its impact on the overall prognosis of AIH is unknown, and treatment has not been established. AIM: To investigate the risk factors and prognosis of HCC in patients with AIH and identify appropriate management strategies. METHODS: We studied patients with AIH including background liver disease, sex, age, complications, treatment, response to treatment, liver fibrosis, prognosis, and treatment...
April 1, 2024: BMC Gastroenterology
#36
JOURNAL ARTICLE
Hannes Hegmar, Axel Wester, Soo Aleman, Jens Backman, Erik Degerman, Håkan Ekvall, Katarina Lund, Åsa Lundgren, Patrik Nasr, Afshin Shahnavaz, Johan Vessby, Johan Westin, Kristina Önnerhag, Hannes Hagström
BACKGROUND & AIMS: Liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) is a non-invasive diagnostic biomarker of liver fibrosis. It is uncertain if LSM can predict risk for future liver-related outcomes in large, heterogenous populations. METHODS: This Swedish multi-centre cohort study included patients (n = 14 414) from 16 sites who underwent LSM by VCTE between 2008 and 2020. Outcomes were ascertained from national registers...
April 1, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
#37
JOURNAL ARTICLE
Xingping Zhou, Jinjin Luo, Xi Liang, Peng Li, Keke Ren, Dongyan Shi, Jiaojiao Xin, Jing Jiang, Jiaxian Chen, Lulu He, Hui Yang, Shiwen Ma, Bingqi Li, Jun Li
BACKGROUND AND AIM: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a complicated syndrome with high short-term mortality. Effective biomarkers are required for its early diagnosis and prognosis. This study aimed to determine the diagnostic and prognostic value of thrombomodulin (TM) in patients with HBV-ACLF. METHODS: The expression of TM during disease progression was evaluated through transcriptomics analysis. The plasma TM concentrations of 393 subjects with HBV-ACLF (n=213), acute-on-chronic hepatic dysfunction (ACHD, n=50), liver cirrhosis (LC, n=50) or chronic hepatitis B (CHB, n=50), and normal controls (NC, n=30) from a prospective multicenter cohort, were measured to verify the diagnostic and prognostic significance of plasma TM for HBV-ACLF patients by enzyme-linked immunosorbent assay (ELISA)...
2024: Infection and Drug Resistance
#38
JOURNAL ARTICLE
Jungang Ma, Zhuo Chen, Shuixia Liu, Chuan Chen, Wei Guan, Mingying Geng, He Xiao, Bijing Mao, Bin Wang
BACKGROUND: This study aims to develop a prognostic model for overall survival based on potential methylation sites within B-cell translocation gene 2 ( BTG2 ) in Chinese patients with hepatocellular carcinoma (HCC). METHODS: This is a retrospective study. The beta values of nine CpG sites and RSEM normalized count values of BTG2 gene were extracted from the Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) (TCGA-LIHC) dataset, with the beta value representing the methylation level by indicating the ratio of the intensity of the methylated bead type to the combined locus intensity...
April 15, 2024: Heliyon
#39
Emily Krier, Ursulina Tomczak, Thomas Checketts, Saurabh Chandan
Pneumocystis jirovecii is an opportunistic fungus typically causing pulmonary infection in immunocompromised persons. We present a case of Pneumocystis jirovecii pneumonia (PJP) in a patient with alcoholic hepatitis and underlying cirrhosis. PJP in patients with alcoholic hepatitis or cirrhosis is sparsely reported in literature. This condition carries a poor prognosis and high mortality. Clinicians need to recognize alcohol use resulting in liver damage as a significant etiological risk factor for PJP.
April 2024: ACG Case Reports Journal
#40
JOURNAL ARTICLE
Julien Rossignol, Danielle Canioni, Achille Aouba, Cristina Bulai-Livideanu, Stéphane Barete, Charles Lancesseur, Laura Polivka, Marine Madrange, Thomas Ballul, Antoine Neuraz, Celine Greco, Julie Agopian, Fabienne Brenet, Patrice Dubreuil, Richard Lemal, Olivier Tournilhac, Louis Terriou, David Launay, Laurence Bouillet, Clément Gourguechon, Laurent Frenzel, Cécile Meni, Caroline Gaudy-Marqueste, Marie Gousseff, Edwige Le Mouel, Mohamed Hamidou, Antoine Neel, Dana Ranta, Roland Jaussaud, Philippe Guilpain, Thierry J Molina, Julie Bruneau, Ludovic Lhermitte, Nicolas Garcelon, Rose-Marie Javier, Fabien Pelletier, Florence Castelain, Frederique Retornaz, Quentin Cabrera, Patricia Zunic, Marie Pierre Gourin, Ewa Wierzbicka-Hainaut, Jean François Viallard, Christian Lavigne, Cyrille Hoarau, Isabelle Durieu, Maël Heiblig, Sophie Dimicoli-Salazar, Jose M Torregrosa-Diaz, Angèle Soria, Michel Arock, Olivier Lortholary, Christine Bodemer, Stanislas Pol, Vincent Mallet, Olivier Hermine, Ghandi Damaj
BACKGROUND AND AIMS: Systemic mastocytosis (SM) is characterized by the accumulation of atypical mast cells (MCs) in organs. Liver histology of SM has been marginally described and accurate histological classification is critical, given the consequences of aggressive SM diagnosis. We aimed to describe the histological features associated with liver SM using updated tools. METHODS: Using the database of the French Reference Centre for Mastocytosis, we retrospectively identified patients with a liver biopsy (LB) and a diagnosis of SM...
March 30, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
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