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Prognosis cirrhosis

Sijie Cheng, Tieling Li, Cheng Wang, Keyu Wang, Chengcai Lai, Jin Yan, Hongxia Fan, Fang Sun, Zhaohai Wang, Peirui Zhang, Linxiang Yu, Zhixian Hong, Guanglin Lei, Baijun Sun, Yuan Gao, Zhaohui Xiao, Xu Ji, Ruilan Wang, Jianzhong Wu, Xiliang Wang, Shaogeng Zhang, Penghui Yang
Hepatocellular carcinoma (HCC) is the most common neoplasm and is a leading cause of cancer-related death. Despite advances in the diagnosis and management of HCC, its prognosis remain unfavorable. Accumulating evidence has shown that long intergenic noncoding RNAs (lincRNAs) play central roles in the development of HCC. In this study, we identified a long intergenic noncoding RNA referred to as lincRNA P7 in HCC and explored its clinical significance and biological functions in HCC. The expression level of lincRNA P7 was significantly aberrantly deceased in HCC cancer tissues and cells lines...
November 16, 2018: Oncotarget
Xiaotao Jiang, Linling Xie, Cihui Huang, Yishen Liu, Haining Liu, Binqian Liu, Liang Zheng
BACKGROUND: Characterized by diffuse hepatic fibrosis and nodule formation, hepatitis B cirrhosis (HBC), an important result of chronic hepatitis B development, mainly contains compensated and decompensated stage. Compensated cirrhosis can further develop into decompensated stage and hepatocellular carcinoma with serious complications and high mortality. Antiviral therapy using interferon (IFN) or nucleos(t)ide analogs (NUCs) is essential for improving the prognosis of the disease but IFN has large side effects while NUCs often develop drug resistance...
December 2018: Medicine (Baltimore)
Abuduaiheti Maimaitiming, Xing Zhou, Xianxiong Ma, Yongming Huang, Qingbo Wang, Rui Deng, Yahui Ren, Xinqun Chai, Pei Zhang
PURPOSE: CD24 is overexpressed in hepatocellular carcinoma (HCC) tumor tissues and in the highly metastatic HCC cell lines. However, plasma CD24 level in HCC patients and the correlation of plasma CD24 level with clinicopathological factors and prognosis of HCC patients still remain unclear. MATERIALS AND METHODS: Enzyme-linked immunosorbent assay was used to detect plasma CD24 level in 86 HCC patients, 35 healthy subjects, 26 patients with liver cirrhosis and 23 patients with chronic hepatitis...
December 13, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Wenjie Zheng, Junling Yang, Zhizhen Dong, Li Wang, Miao Fang, Wei Wu, Dengfu Yao, Min Yao
Purpose: High mobility group box 3 (HMGB3) is associated with hepatocytes malignant transformation by our previous work. We continued to investigate the diagnostic and prognostic values of HMGB3 for hepatocellular carcinoma (HCC). Patients and methods: Circulating HMGB3 levels were quantitatively detected in a cohort of 225 patients with chronic liver diseases by ELISA and compared with alpha-fetoprotein by the receiver operating characteristic curve. HMGB3 expression in tissues of 170 HCC was detected by tissue microarray and immunohistochemistry...
2018: Cancer Management and Research
Jae Yoon Jeong, Sanghyeok Lim, Joo Hyun Sohn, Jae Gon Lee, Dae Won Jun, Yongsoo Kim
Background: Sarcopenia is associated with a poor prognosis in patients with liver cirrhosis. However, it is not known whether the rate of skeletal muscle depletion is also associated with a poor prognosis. We investigated the prognostic impact of the rate of skeletal muscle depletion in patients with liver cirrhosis. Methods: We included retrospectively all patients with liver cirrhosis who underwent both multiple computed tomography scans and hepatic venous pressure gradient (HVPG) measurements...
December 10, 2018: Journal of Korean Medical Science
Fai-Meng Sou, Cheng-Kun Wu, Kuo-Chin Chang, Sheng-Nan Lu, Jing-Houng Wang, Chao-Hung Hung, Chien-Hung Chen, Kwong-Ming Kee, Yi-Hao Yen, Ming-Tsung Lin, Ming-Chao Tsai, Tsung-Hui Hu
BACKGROUND: Hepatitis C virus (HCV)-infected patients who achieved sustained virologic response (SVR) may still develop hepatocellular carcinoma (HCC). The characteristic of HCC and the prognosis between SVR and non-SVR patients were not well known. METHODS: Among 1884 HCV-infected patients who were treated with pegylated IFN plus ribavirin therapies, 122 patients developed HCC during follow-up were enrolled in this study. Laboratory data were collected before and at least 1 year after IFN-based therapy, as well as the latest follow-up...
December 4, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Eman A Toraih, Hani G Alrefai, Mohammad H Hussein, Ghada M Helal, Moataz S Khashana, Manal S Fawzy
OBJECTIVE: Identification of new molecular markers to enhance early diagnosis, prognosis and/or treatment of hepatocellular carcinoma (HCC) is a need. TOM34 (34 kDa-translocase of the outer mitochondrial membrane) protein expression deregulation has demonstrated to be involved in the growth of many cancers. Here, we aimed at evaluating serum TOM34 and some heat shock proteins (HSPA4, HSPA1B, and HSP90AA1) expressions in hepatitis C virus (HCV)-related cirrhosis and HCV-induced HCC relative to controls and correlating these expressions to the clinicopathological data...
December 3, 2018: Clinical Biochemistry
Jan Klimas, Christopher Fairgrieve, Helen Tobin, Catherine-Anne Field, Clodagh Sm O'Gorman, Liam G Glynn, Eamon Keenan, Jean Saunders, Gerard Bury, Colum Dunne, Walter Cullen
BACKGROUND: Problem alcohol use is common among people who use illicit drugs (PWID) and is associated with adverse health outcomes. It is also an important factor contributing to a poor prognosis among drug users with hepatitis C virus (HCV) as it impacts on progression to hepatic cirrhosis or opioid overdose in PWID. OBJECTIVES: To assess the effectiveness of psychosocial interventions to reduce alcohol consumption in PWID (users of opioids and stimulants). SEARCH METHODS: We searched the Cochrane Drugs and Alcohol Group trials register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, and PsycINFO, from inception up to August 2017, and the reference lists of eligible articles...
December 5, 2018: Cochrane Database of Systematic Reviews
Lichen Xu, Shuangwei Ying, Jianhua Hu, Yunyun Wang, Meifang Yang, Tiantian Ge, Chunhong Huang, Qiaomai Xu, Haihong Zhu, Zhi Chen, Weihang Ma
BACKGROUND: Cirrhosis always goes with profound immunity compromise, and makes those patients easily be the target of pneumonia. Cirrhotic patients with pneumonia have a dramatically increased mortality. To recognize the risk factors of mortality and to optimize stratification are critical for improving survival rate. METHODS: Two hundred and three cirrhotic patients with pneumonia at a tertiary care hospital were included in this retrospective study. Demographical, clinical and laboratory parameters, severity models and prognosis were recorded...
December 4, 2018: Respiratory Research
Guillermo Ontanilla-Clavijo, Javier Ampuero, Samuel Borreguero, Javier Rosell, Manuel Romero-Gómez
BACKGROUND: bioelectrical impedance analysis is a technique for the determination of the hydropic component. The hydropic component, determined by blood volume, could be a reflection of the hemodynamic situation. This study aimed to evaluate the usefulness of peripheral bioelectrical impedance analysis (BIA) for the prediction of hemodynamic changes in large-volume paracentesis and prognosis. METHODS: this was a proof-of-concept prospective study of 14 patients with liver cirrhosis and refractory ascites...
December 4, 2018: Revista Española de Enfermedades Digestivas
Fangyuan Gao, Xiaoshu Li, Gang Wan, Yuxin Li, Qun Zhang, Yao Liu, Huimin Liu, Hai Li, Xianbo Wang
BACKGROUND: Acute decompensation (AD) has been shown to be associated with a high mortality rate for cirrhosis patients. This study aimed to develop a prognostic nomogram to evaluating the individual prognosis for AD of cirrhosis in chronic hepatitis B (CHB). METHODS: The nomogram was developed using data from a retrospective study on 509 patients hospitalized for AD of CHB cirrhosis from October 2008 to February 2014 at the Beijing Ditan Hospital, Capital Medical University...
December 3, 2018: BMC Gastroenterology
Li-Kun Wang, Xiao-Fei An, Xue-Liang Wu, Su-Mei Zhang, Rui-Min Yang, Chao Han, Jie-Lin Yang, Yi-Cheng Wang
BACKGROUND: In chronic liver diseases, cirrhosis ranks as the 14th highest death cause worldwide, developing into decompensated cirrhosis. A potential and feasible technique in assessing cardiac function is urgent. This study explores if the Doppler myocardial performance (Tei) index combined with the plasma B-type natriuretic peptide (BNP) levels can assess cardiac function in patients with decompensated cirrhosis. METHODS: A total of 140 individuals were selected in the study and were classified into 3 groups: control group (n = 40, healthy individuals), compensated cirrhosis group (n = 50), and decompensated cirrhosis group (n = 50)...
November 2018: Medicine (Baltimore)
Yan Song, Weizhi Li, Hui Xue, Litao Ruan
BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS) is the method of choice for the treatment of portal hypertension. The Tei index is the most sensitive indicator of myocardial function. DESIGN: This study enrolled 31 patients with cirrhosis who underwent TIPS and were followed up over a median period of 34 months (range 2-60 months). Baseline Meld score and the changes in the Tei index within 1 month after TIPS and their potential relationship with prognosis were evaluated...
December 1, 2018: Echocardiography
Vladimir Valakh, Steven Gresswell, Alexander Kirichenko
BACKGROUND/AIM: Our study reviewed the results of patients with hepatocellular carcinoma and Child-Pugh score 8-11 cirrhosis treated with stereotactic body radiotherapy when liver transplant was not an option. PATIENTS AND METHODS: A retrospective review was performed on 15 patients with Child-Pugh class B and C cirrhosis treated with stereotactic body radiotherapy. The median total dose was 35 Gy in 4-5 fractions. None were listed for a liver transplant due to either being outside of the Milan criteria or to medical contraindications...
December 2018: Anticancer Research
Xiumei Wang, Youde Liu, Jing Sun, Wenjing Gong, Ping Sun, Xiangshuo Kong, Miaomiao Yang, Weiwei Zhang
Objective: To investigate the expression of Mitofusin-2 (MFN2) in HCC tissues and its role in the development of HCC. Methods: A total of 107 HCC specimens were collected for tissue microarray analysis and immunohistochemistry (IHC) analysis. The relationship between MFN2 expression and clinical features of patients with HCC was analyzed. Results: Expression level of MFN2 in HCC tissues was 0.92 ± 0.78, significantly lower than that of matched paracancerous liver tissues (1...
2018: Infectious Agents and Cancer
J Wu, L Jia, Y Y Li, J Li, H W Yu, Y K Zhu, Z J Hu, Q H Meng, F S Wang
Objective: To evaluate the incidence, and the characteristics of organ failure in relationship to prognosis in hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) patients using chronic liver failure-sequential organ failure assessment (CLIF-SOFA) score for judgments of clinical treatment and prognosis. Methods: Clinical data of 316 patients who were diagnosed as HBV-ACLF during hospitalization from February 2015 to February 2016 were retrospectively analyzed. Intrahepatic and extrahepatic organ failures were assessed according to CLIF-SOFA score, and the relationship between clinical characteristics and prognosis was analyzed...
October 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
(no author information available yet)
Current guideline developed by the Chinese Society of Hepatology on the management of hepatic encephalopathy in cirrhosis is grounded on the published evidences and panelists' consensus. This guideline presents recommendations for diagnosis and management of covert and overt hepatic encephalopathy, and underline the importance of screening minimal hepatic encephalopathy in patients with end-stage liver diseases. In addition, it also stresses that early identification and timely treatments are the means to know the prognosis...
October 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Fei Gao, Jun-Chi Xu, Li Zhu, Hui Chen, Xiao-Yan Zhu, Xin-Ran You, Shu-Xiang Li, Chen-Lu Zhu, Chen Yang, Chuan-Wu Zhu, Ping Xu
B7-H3, one of the costimulatory members participating in checkpoint pathway, has been shown to be upregulated after hepatitis B virus (HBV) infection. To further explore the clinical significance of dynamic B7-H3 expression during the progression of HBV infection, we systematically investigated the expression pattern of B7-H3 and the correlation of B7-H3 expression with the ratio of T lymphocyte subsets and clinical parameters at different stages in the course of the disease. Flow cytometry and enzyme-linked immunosorbent assay data showed that soluble form of B7-H3 (sB7-H3) was positively correlated with the frequency of Treg cells in acute hepatitis B (AHB), chronic hepatitis B (CHB), and hepatocellular carcinoma patients with HBV infection (HBV-HCC)...
November 27, 2018: Viral Immunology
Gitte Dam, Hendrik Vilstrup, Per Kragh Andersen, Lars Bossen, Hugh Watson, Peter Jepsen
BACKGROUND & AIMS: Many patients with cirrhosis use proton pump inhibitors (PPI). We aimed to determine their effects on the risk and prognosis of infections in patients with cirrhosis and ascites. METHODS: We used data from three 1-year trials of satavaptan treatment of ascites (N=1198) to compare incidence and 90-day mortality of first-time infections between users and nonusers of PPI. With standard and marginal structural Cox models we adjusted for differences in gender, age, cirrhosis etiology, MELD score, serum albumin, lactulose use, severity of ascites, and history of spontaneous bacterial peritonitis or variceal bleeding...
November 25, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Maryam Ebadi, Aldo J Montano-Loza
Sarcopenia and frailty are among the most common features of cirrhosis that contribute significantly to morbidity and mortality; however, sarcopenia is not identical to frailty. Sarcopenia is a critical reduction in skeletal muscle mass associated with poor outcomes. The main components of frailty are sarcopenia and physical impairment, which result in a cumulative decline in physiologic reserve (1, 2). This article is protected by copyright. All rights reserved.
November 25, 2018: Liver Transplantation
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