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https://www.readbyqxmd.com/read/30534868/-management-of-non-alcoholic-fatty-liver-disease
#1
Fabian Lanuza, Jorge Sapunar, Edmundo Hofmann
Non-alcoholic fatty liver disease (NAFDL) includes fatty liver or simple steatosis, characterized by lipid deposits in hepatocytes and more advanced stages such as steatohepatitis (NASH) and non-alcoholic cirrhosis. Physical inactivity, hypercaloric and unbalanced diet together with aging play a key role in the pathogenesis of NAFLD and are strongly associated with metabolic and physical activity continue to be major components in prevention and first-line treatment to attenuate or reverse NAFLD. Dietary patterns, their composition and weight reduction would be the most relevant nutritional aspects in NAFDL treatment...
August 2018: Revista Médica de Chile
https://www.readbyqxmd.com/read/30487501/role-of-liver-biopsy-in-the-diagnosis-of-neonatal-cholestasis-due-to-biliary-atresia
#2
M S Hasan, A B Karim, M Rukunuzzaman, A Haque, M A Akhter, U K Shoma, F Yasmin, M A Rahman
Biliary atresia is the commonest cause of cholestatic jaundice. Early diagnosis & surgical correction helps long time survival & prevent development of cirrhosis. This study was conducted to find out the role of liver biopsy in the diagnosis of biliary atresia having positive hepatobiliary scintigraphy as there is chance of false positivity. This cross sectional study was carried out in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh at Paediatric Gastroenterology & Nutrition Department from January 2014 to June 2015...
October 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/30450976/association-between-serum-c-reactive-protein-concentration-and-nutritional-status-of-malignant-tumor-patients
#3
Jia Mi Yu, Mei Yang, Hong Xia Xu, Wei Li, Zhen Ming Fu, Yuan Lin, Ying Ying Shi, Chun Hua Song, Han Ping Shi, Zeng Qing Guo
BACKGROUND: The level of the systemic inflammatory marker C-reactive protein (CRP) is elevated in many patients with malignant disease and may be related to nutritional status. OBJECTIVE: To analyze the association between serum CRP levels in patients with malignant tumors and their nutritional status. METHOD: A total of 3,692 cases were analyzed and the serum CRP levels were determined using an immunometric assay. Nutritional status was assessed by using patient-generated subjective global assessment (PG-SGA)...
November 17, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/30431619/evaluation-of-prognostic-values-of-inflammation-based-makers-in-patients-with-hbv-related-acute-on-chronic-liver-failure
#4
Junjun Cai, Kai Wang, Tao Han, Huiqing Jiang
Systemic inflammatory responses are associated with the development and progression of liver failure. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), red cell distribution width (RDW), RDW-to platelet ratio (RPR), mean platelet volume (MPV), and MPV-to platelet ratio (MPR) are markers of systemic inflammation. This study aimed to evaluate the prognostic values of these inflammatory markers in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF)...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30425765/relationship-between-sarcopenia-and-both-physical-activity-and-lifestyle-in-patients-with-chronic-liver-disease
#5
Kazuki Ohashi, Toru Ishikawa, Asami Hoshi, Mitsuyuki Suzuki, Yuta Mitobe, Etsuko Yamada, Hansani Madushika Abeywickrama, Nao Seki, Chikayo Koyama, Hagiko Aoki, Yu Koyama
Background: Sarcopenia can affect the prognosis of patients with cirrhosis or hepatocellular carcinoma. Exercise therapy and nutritional therapy are carried out to prevent processing sarcopenia. In addition, changing lifestyle is also important. However, there are only few reports on the physical activities (PAs) and lifestyle of chronic liver disease patients and their association with sarcopenia. The aim of this study is to examine the relationship between sarcopenia in patients with chronic liver disease and both PA and lifestyle...
December 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/30398915/the-effect-of-the-branched-chain-amino-acids-on-the-i-in-vitro-i-activity-of-bovine-intestinal-alkaline-phosphatase
#6
Gary William Boyd, Marion Drew, Shannon Ward, Marianne Baird, Christopher Connaboy, Scott Murray Graham
Branched-chain amino acids (BCAA) are used as nutritional support for patients with a range of conditions including liver cirrhosis and in-born errors of amino acid metabolism, and are commonly used "sports"/exercise supplements. The effects of the BCAA on the <i>in-vitro</i> activity of calf intestinal alkaline phosphatase (EC. 3.1.3.1) were studied. All three BCAA were found to be uncompetitive inhibitors of the enzyme with L-leucine being the most potent (Ki' = 24.9mM) and L-valine, the least potent (Ki' = 37mM)...
November 6, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/30398038/projection-of-diabetes-prevalence-in-korean-adults-for-the-year-2030-using-risk-factors-identified-from-national-data
#7
Inkyung Baik
BACKGROUND: A number of studies have reported future prevalence estimates for diabetes mellitus (DM), but these studies have been limited for the Korean population. The present study aimed to construct a forecasting model that includes risk factors for type 2 DM using individual- and national-level data for Korean adults to produce prevalence estimates for the year 2030. METHODS: Time series data from the Korea National Health and Nutrition Examination Survey and national statistics from 2005 to 2013 were used...
October 31, 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/30397876/outcomes-of-bariatric-surgery-in-patients-with-cirrhosis
#8
Inka Miñambres, Miguel Angel Rubio, Ana de Hollanda, Irene Breton, Nuria Vilarrasa, Silvia Pellitero, Marta Bueno, Albert Lecube, Clara Marcuello, Albert Goday, Maria D Ballesteros, German Soriano, Assumpta Caixàs
CONTEXT: Information concerning the risk-benefit profile of bariatric surgery in subjects with liver cirrhosis is scarce. Our aim was to describe the long-term outcomes of bariatric surgery in a cohort of patients with liver cirrhosis submitted to bariatric surgery. METHODS: This was a multicenter, retrospective observational study performed by the Obesity Group of the Spanish Society of Endocrinology and Nutrition (GOSEEN), with a review of patients with cirrhosis who had undergone bariatric surgery during the period from April 2004 to March 2017 in ten public reference hospitals in Spain...
November 5, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/30367658/jaundice-revisited-recent-advances-in-the-diagnosis-and-treatment-of-inherited-cholestatic-liver-diseases
#9
REVIEW
Huey-Ling Chen, Shang-Hsin Wu, Shu-Hao Hsu, Bang-Yu Liou, Hui-Ling Chen, Mei-Hwei Chang
BACKGROUND: Jaundice is a common symptom of inherited or acquired liver diseases or a manifestation of diseases involving red blood cell metabolism. Recent progress has elucidated the molecular mechanisms of bile metabolism, hepatocellular transport, bile ductular development, intestinal bile salt reabsorption, and the regulation of bile acids homeostasis. MAIN BODY: The major genetic diseases causing jaundice involve disturbances of bile flow. The insufficiency of bile salts in the intestines leads to fat malabsorption and fat-soluble vitamin deficiencies...
October 26, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/30362139/comorbidities-concomitant-medications-and-potential-drug-drug-interactions-with-interferon-free-direct-acting-antiviral-agents-in-hepatitis-c-patients-in-taiwan
#10
Chen-Hua Liu, Ming-Lung Yu, Cheng-Yuan Peng, Tsai-Yuan Hsieh, Yi-Hsiang Huang, Wei-Wen Su, Pin-Nan Cheng, Chih-Lin Lin, Ching-Chu Lo, Chi-Yi Chen, Jyh-Jou Chen, Qian Ma, Craig Brooks-Rooney, Jia-Horng Kao
BACKGROUND: While direct-acting antivirals have been approved for treating hepatitis C, the guidelines highlight the importance of considering potential drug-drug interactions between DAAs and concomitant medications. AIM: To assess comorbidity prevalence, concomitant medication use and potential drug-drug interactions between DAAs and concomitant medications for hepatitis C patients in Taiwan. METHODS: This cross-sectional study enrolled 822 patients from May to August 2016 in Taiwan...
October 25, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/30340810/a-review-of-the-pathogenic-and-therapeutic-role-of-nutrition-in-pediatric-nonalcoholic-fatty-liver-disease
#11
REVIEW
Nadia Panera, Barbara Barbaro, Claudia Della Corte, Antonella Mosca, Valerio Nobili, Anna Alisi
Nonalcoholic fatty liver disease (NAFLD) is a multifaceted disorder that ranges from simple fatty liver to nonalcoholic steatohepatitis (NASH) with or without fibrosis, which may evolve toward cirrhosis and hepatocellular carcinoma. It is currently considered a "global" and "epidemic" disease, whose prevalence is progressively increasing even in pediatric age. The incidence of NAFLD is very high in overweight/obese children, and a greater risk of disease progression is associated with severe obesity, highlighting the role of nutrition...
October 2018: Nutrition Research
https://www.readbyqxmd.com/read/30312295/the-prognostic-value-of-prognostic-nutritional-index-in-hepatocellular-carcinoma-patients-a-meta-analysis-of-observational-studies
#12
Zhiling Wang, Jie Wang, Peijun Wang
BACKGROUND AND AIMS: The clinical value of the prognostic nutritional index (PNI) in hepatocellular carcinoma (HCC) has been investigated in previous studies, but the results remain controversial. Here we present a meta-analysis to systematically review the association between PNI and HCC prognosis. METHOD: PubMed, EMBASE, Web of Science databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. A meta-analysis was performed to determine the prognostic and clinic-pathological values of PNI in HCC patients...
2018: PloS One
https://www.readbyqxmd.com/read/30292583/dietary-management-and-supplementation-with-branched-chain-amino-acids-in-cirrhosis-of-the-liver
#13
A Ruiz-Margáin, O Méndez-Guerrero, B M Román-Calleja, S González-Rodríguez, G Fernández-Del-Rivero, P A Rodríguez-Córdova, A Torre, R U Macías-Rodríguez
One of the most important characteristics of malnutrition is the loss of muscle mass and the severe depletion of the protein reserve, secondarily affecting energy metabolism. That impacts nutritional status and the progression of disease-related complications. Nutritional treatment is one of the main factors in the comprehensive management of those patients. Achieving adequate energy intake that provides the macronutrients and micronutrients necessary to prevent or correct malnutrition is attempted through dietary measures...
October 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/30288329/racial-ethnic-and-county-specific-prevalence-of-chronic-hepatitis-b-and-its-burden-in-california
#14
Mehlika Toy, Bin Wei, Tejpal S Virdi, An Le, Huy Trinh, Jiayi Li, Jian Zhang, Ann W Hsing, Samuel K So, Mindie H Nguyen
Background: In the United States, the highest burden of chronic hepatitis B (CHB) and CHB-related liver cancer is in the state of California, primarily in the San Francisco (SF) Bay and Los Angeles (LA) areas. The aim of this study was to estimate county-specific hepatitis B surface antigen (HBsAg) prevalence and quantify CHB cases by age, race/ethnicity, nativity, and disease activity status. Methods: Twelve counties in SF Bay Area and three large counties in LA area were included for this analysis...
2018: Hepatology, Medicine and Policy
https://www.readbyqxmd.com/read/30272092/usefulness-of-simplified-nutritional-appetite-questionnaire-snaq-in-appetite-assessment-in-elder-patients-with-liver-cirrhosis
#15
T Wang, J Shen
BACKGROUND: Appetite has received little attention in health care and researches in liver cirrhosis. The Simplified Nutritional Appetite Questionnaire (SNAQ), a self-assessment nutritional screening tool, could be used to screen the risk of malnutrition and weight loss. Our objective was to assess the usefulness of SNAQ in appetite assessment in patients with liver cirrhosis. METHODS: Seventy patients were enrolled. Appetite assessment was applied in the enrolled patients by completing SNAQ...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/30259203/should-sarcopenia-increase-priority-for-transplant-or-is-it-a-contraindication
#16
REVIEW
Guido Stirnimann, Maryam Ebadi, Puneeta Tandon, Aldo J Montano-Loza
PURPOSE OF REVIEW: The purpose of this review is to discuss the current evidence regarding the impact of sarcopenia on patients with cirrhosis awaiting liver transplantation and to determine if its presence should be considered a criterion for expedited transplantation or a contraindication for transplantation. RECENT FINDINGS: Sarcopenia is a negative predictor of survival in patients on a waiting list and after liver transplant. The gut-liver axis and the liver-muscle axis have been explored to understand the complex pathophysiology of sarcopenia...
September 26, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/30244656/the-benefit-of-supplemental-nutrition-education-for-severely-malnourished-patients-awaiting-liver-transplant
#17
Amanda J Chaney, Michael G Heckman
INTRODUCTION: Nutritional interventions improve patient outcomes and reduce mortality in patients with cirrhosis by reducing infection risk, ascites, length of stay in hospital and intensive care unit, and mortality. Follow-up phone calls have been found to be useful in improving patient adherence to therapy. PROBLEM: The purpose of this quality improvement project was to determine whether supplemental nutrition education would improve nutrition and outcomes among patients with cirrhosis who are undergoing a liver transplant evaluation...
September 24, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/30180152/pretransplant-sarcopenia-in-patients-with-nash-cirrhosis-does-not-impact-rehospitalization-or-mortality
#18
Elizabeth S Aby, Edward Lee, Satvir S Saggi, Matthew R Viramontes, Jonathan F Grotts, Vatche G Agopian, Ronald W Busuttil, Sammy Saab
BACKGROUND: Malnutrition and muscle wasting are common in patients with end-stage liver disease (ESLD), yet go underdiagnosed. Frequently used indices of nutritional status, such as body mass index, are inflated in patients with ESLD due to a fluid overloaded state. Previous work has demonstrated a strong association between psoas muscle area, a surrogate for sarcopenia, and worse survival following liver transplantation; however, the impact of sarcopenia on post liver transplant outcomes in patients with nonalcoholic steatohepatitis (NASH) cirrhosis has not been evaluated...
September 1, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30158477/the-relationship-between-controlling-nutritional-conut-score-and-clinical-markers-among-adults-with-hepatitis-c-virus-related-liver-cirrhosis
#19
Hiroki Nishikawa, Kazunori Yoh, Hirayuki Enomoto, Noriko Ishii, Yoshinori Iwata, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Kunihiro Hasegawa, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
AIMS: To identify the relationship between the Controlling Nutrition Status (CONUT) score and clinical parameters among adults with hepatitis C virus (HCV)-related liver cirrhosis (LC) ( n = 264, 141 males and 123 females). METHODS: The relationship between the CONUT score and clinical variables such as Child-Pugh classification were investigated. We also examined factors linked to poor nutritional state as determined by CONUT score. RESULTS: According to the CONUT score, normal nutritional state was found in 57 patients, mild malnutrition state in 132, moderate malnutrition state in 68 and severe malnutrition state in 7...
August 29, 2018: Nutrients
https://www.readbyqxmd.com/read/30153225/international-liver-transplantation-consensus-statement-on-end-stage-liver-disease-due-to-nonalcoholic-steatohepatitis-and-liver-transplantation
#20
Emmanuel Tsochatzis, Audrey Coilly, Silvio Nadalin, Josh Levistky, Yaman Tokat, Mark Ghobrial, John Klinck, Marina Berenguer
Nonalcoholic steatohepatitis (NASH)-related cirrhosis has become one of the most common indications for liver transplantation (LT), particularly in candidates over the age of 65 years. Typically, NASH candidates have concurrent obesity, metabolic and cardiovascular risks, which directly impact patient evaluation and selection, waitlist morbidity and mortality and eventually posttransplant outcomes. The purpose of these guidelines is to highlight specific features commonly observed in NASH candidates and strategies to optimize pretransplant evaluation and waitlist survival...
August 27, 2018: Transplantation
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