keyword
MENU ▼
Read by QxMD icon Read
search

Candida esophagitis in childrens

keyword
https://www.readbyqxmd.com/read/28913339/ulcerative-gastritis-and-esophagitis-in-two-children-with-sarcina-ventriculi-infection
#1
Tim G J de Meij, Michiel P van Wijk, Aart Mookhoek, Andries E Budding
Sarcina ventriculi is a Gram-positive, obligate anaerobic coccus, with a characteristic morphology. Only 22 cases of human infections by this microorganism, including 7 in children, have been reported in literature so far. Affected subjects usually present with abdominal pain, nausea, vomiting, and delayed gastric emptying. However, life-threatening complications, like emphysematous gastritis and gastric perforation have also been described. Gastroparesis and gastric outlet obstruction have been considered as a potential etiologic factor...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28791666/clinical-pharmacokinetics-and-pharmacodynamics-of-micafungin
#2
REVIEW
Roeland E Wasmann, Eline W Muilwijk, David M Burger, Paul E Verweij, Catherijne A Knibbe, Roger J Brüggemann
Micafungin is a selective inhibitor of the synthesis of fungal 1,3-β-D-glucan, an essential component of the fungal cell wall. It is available as a powder for infusion only and is registered for the treatment of invasive and esophageal candidiasis in addition to prophylaxis of Candida infections in both adults and children. Average exposure after a single intravenous 100 mg dose in healthy adults is 133 mg h/L. Both exposure and maximum plasma concentration show linear dose proportional pharmacokinetics (PK) over a 0...
March 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/25421470/population-pharmacokinetics-of-micafungin-and-its-metabolites-m1-and-m5-in-children-and-adolescents
#3
RANDOMIZED CONTROLLED TRIAL
William W Hope, Atsunori Kaibara, Michael Roy, Antonio Arrieta, Nkechi Azie, Laura L Kovanda, Daniel K Benjamin
The aim of this analysis was to identify therapeutic micafungin regimens for children that produce the same micafungin exposures known to be effective for the prevention and treatment of Candida infections in adults. Pediatric pharmacokinetic data from 229 patients between the ages of 4 months and <17 years were obtained from four phase I and two phase III clinical trials. Population pharmacokinetic models were used to simulate the proportion of children who had a steady-state area under the concentration-time curve at 24 hours (AUC24) of micafungin within the 10th to 90th percentile range observed in a population of adults receiving a dose of micafungin with established efficacy for invasive candidiasis (100 mg/day), i...
February 2015: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/24703644/-the-challenge-for-dermatologists-of-early-apeced-diagnosis
#4
E Puzenat, G Bellaud, P Saugier-Veber, C Crémillieux, B Mignot, P Humbert, F Aubin
BACKGROUND: Polyglandular auto-immune syndrome type 1 (PAS-1) or auto-immune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare autosomal recessive disorder linked to auto-immune regulator (AIRE) gene mutations. Herein, we report the case of a 3-year-old boy with APECED emphasizing the wide phenotypic variability and the extent of skin lesions. PATIENTS AND METHODS: A 3-year-old boy with a history of auto-immune hepatitis was referred for a generalized pruriginous urticaria-like eruption present for one month...
April 2014: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/24031107/clinical-characteristics-of-pediatric-esophagitis-in-southern-iran-a-single-center-experience
#5
Mozhgan Zahmatkeshan, Khadijesadat Najib, Bita Geramizadeh, Ebrahim Fallahzadeh, Mahmood Haghighat, Mohammad Hadi Imanieh
BACKGROUND: We sought to determine the clinical characteristics of pediatric esophagitis in southern Iran. METHODS: This cross-sectional study was conducted over a 4-year period, from 2005 to 2009, in Nemazee Hospital, a tertiary healthcare center in Shiraz, southern Iran. We consecutively included all pediatric patients (<18 years) who underwent endoscopy in our center and had pathology-confirmed diagnosis of esophagitis. Data regarding the patients' demographic characteristics, comorbidities, and clinical findings were recorded using a questionnaire...
June 2013: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/23692846/esophageal-stricture-due-to-recurrent-mucositis-in-a-patient-with-acute-lymphoblastic-leukemia
#6
Eda Karadağ-Öncel, Senay Kenç, Selin Aytaç, Yusuf Aydemir, Gülin Hızal, Aysel Yüce, Ateş Kara
An esophageal stricture is one of the complications that may develop during cancer treatment in children. Although more commonly associated with radiotherapy, recurrent mucositis has also been implicated. Presented herein is a case of a patient with acute lymphoblastic leukemia who suffered recurrent attacks of severe mucositis. Initial management of ensuing dysphagia included antifungal treatment for candida esophagitis. A subsequent upper endoscopy due to persistence of dysphagia revealed the presence of an esophageal stricture...
January 2013: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/22612259/diagnostic-and-therapeutic-endoscopy-in-children-and-adolescents-with-cancer
#7
Stephan Buderus, Hannah Sonderkötter, Gudrun Fleischhack, Michael J Lentze
UNLABELLED: Chemotherapy regimes in children with cancer often cause gastrointestinal side effects. Only limited data exist on the use of endoscopy in this group of patients. METHODS: Retrospective review over a time period of 8.5 years identified 57 endoscopies (49 upper endoscopies, four colonoscopies, three sigmoidoscopies, one rectoscopy) in 38 patients (mean age 12.8 years). Seventeen children (45%) had hematological malignancies and 21 (55%) had solid tumors...
August 2012: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/21596284/-fungal-infections-in-children-with-malignant-disease
#8
G Michel
Intensified chemotherapy and hematopoietic stem cell transplantation result in severe and prolonged granulocytopenia with an increased risk of invasive fungal infections. The major fungal species that cause serious infections in cancer patients are Candida species and Aspergillus species. The main features of Candida infection in this context are oropharyngeal candidiasis and Candida esophagitis, chronic disseminated candidiasis, also known as hepatosplenic candidiasis, and candidemia. Aspergillus can cause severe lung infection but also sinusal or CNS infection...
May 2011: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/21420572/-scientific-evidence-supporting-the-use-of-micafungin-in-the-treatment-of-invasive-candidiasis
#9
REVIEW
Miguel Montejo, Guillermo Quindós
Micafungin is a semisynthetic lipopeptide developed from Coleophoma empetri, which blocks the synthesis of β-1,3-D-glucan, an essential component of the fungal wall, though non-competitive inhibition of β-1,3-D-glucan synthetase. Micafungin is a dose-dependent candidacidal agent with excellent in vitro efficacy against most Candida spp. including species resistant to amphotericin B, such as Candida lusitaniae, several azoles, such as C. glabrata or C. krusei, and isolates not susceptible to other echinocandins...
March 2011: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/19718541/esophageal-candidiasis-in-an-immunocompetent-girl
#10
Mohammed Yahya Hasosah, Mahmmod Showail, Ashraf Al-Sahafi, Mohammed Satti, Kevan Jacobson
BACKGROUND: Infections of the esophagus are rare and most commonly seen in children with immune suppression resulting from malignancy, chronic metabolic or infectious disease, or immunosuppressive drug therapy. METHODS: An 18-month-old girl on inhaled corticosteroid for bronchial asthma presented with coffee-ground emesis and melena. Upper endoscopy revealed yellow-white plaques scattered over the mucosa of the distal esophagus. Biopsy results showed chronic esophagitis with features of reflux disease...
May 2009: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/19463282/-micafungin-in-invasive-candidiasis-among-oncohematological-patients
#11
REVIEW
Isidro Jarque, Miguel Angel Sanz
BACKGROUND: Invasive candidiasis is a severe infection among onco-hematological patients, with an attributable mortality around 40%. Micafungin has shown efficacy in antifungal prophylaxis among hematopoietic stem cell transplant recipients and in the treatment of esophageal candidiasis. AIMS: To assess the role of micafungin in the treatment of invasive candidiasis among onco-hematological patients. METHODS: Literature review. RESULTS: In a study on 126 patients with candidemia treated with micafungin, an overall response rate of 83% was reported...
March 31, 2009: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/19255017/a-prospective-multicenter-study-of-caspofungin-for-the-treatment-of-documented-candida-or-aspergillus-infections-in-pediatric-patients
#12
MULTICENTER STUDY
Theoklis E Zaoutis, Hasan S Jafri, Li-Min Huang, Franco Locatelli, Asher Barzilai, Wolfram Ebell, William J Steinbach, John Bradley, Jay M Lieberman, Chih-Cheng Hsiao, Nita Seibel, Hans-Juergen Laws, Melinda Gamba, Maria Petrecz, Arlene F Taylor, Kim M Strohmaier, Joseph W Chow, Nicholas A Kartsonis, Angela L Ngai
OBJECTIVE: We evaluated the safety, tolerability, and efficacy of caspofungin in pediatric patients with invasive aspergillosis, invasive candidiasis, or esophageal candidiasis. METHODS: This was a multicenter, prospective, open-label study in children 3 months to 17 years of age with proven or probable invasive aspergillosis, proven invasive candidiasis, or proven esophageal candidiasis. All of the patients received caspofungin 70 mg/m(2) on day 1, followed by 50 mg/m(2) per day (maximum: 70 mg/day), as primary or salvage monotherapy...
March 2009: Pediatrics
https://www.readbyqxmd.com/read/18043034/gastrointestinal-tract-pathology-in-patients-with-common-variable-immunodeficiency-cvid-a-clinicopathologic-study-and-review
#13
Jason A Daniels, Howard M Lederman, Anirban Maitra, Elizabeth A Montgomery
BACKGROUND: Common variable immunodeficiency (CVID) is characterized by a host of gastrointestinal (GI) lesions that can mimic other conditions. METHODS: We reviewed clinical documentation and samples from 132 separate GI biopsy or resection sites on 20 CVID patients obtained over a 26-year period, including biopsies from the colon (34), esophagus (19), small intestine (38), and stomach (35), a partial gastrectomy, small bowel resection, colectomy, 2 cholecystectomies, and 1 appendectomy...
December 2007: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/17545784/nongastroesophageal-reflux-disease-related-infectious-inflammatory-and-injurious-disorders-of-the-esophagus
#14
REVIEW
Fabio Pace, Stefano Pallotta, Spinello Antinori
PURPOSE OF REVIEW: To review recently published studies presenting novel and relevant information on some esophageal infectious, inflammatory and injurious diseases. RECENT FINDINGS: In the treatment of Candida esophagitis, fluconazole remains the treatment of choice, but clinical failures indicate new therapeutic opportunities, like two new echinocandins, micafungin and anidulafungin. Eosinophilic esophagitis is an increasingly recognized entity. New therapeutic insights come from a six-food elimination diet in children and from fluticasone propionate in adults; humanized monoclonal IgG antibody anti-interlukin-5, mepolizumab, has been shown to decrease eosinophilia and ameliorate symptoms...
July 2007: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/17352110/-esophageal-replacement-12-years-experience
#15
COMPARATIVE STUDY
L F Avila, A L Luis, J L Encinas, A M Andrés, O Suárez, L Martínez, A Fernández, A Queizán, J Murcia, P Olivares, L Lassaletta, J A Tovar
UNLABELLED: Esophageal replacement is a surgical procedure rarely indicated in children. It is used in esophageal atresia type I and long-gap atresia when anastomosis is not possible, corrosive strictures and other unusual causes. Type and location of the graft depend on etiology and surgeon preferences. We analyse our results of a large series of esophageal replacement. METHODS: . We reviewed esophageal replacements carried out in our department between January-1992 and December-2004...
October 2006: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/16865941/-the-role-of-candida-sp-in-etiopathogenesis-of-esophageal-gastric-and-duodenal-mucosa-inflammation-in-children
#16
Beata Fortak, Izabela Płaneta-Małecka, Jadwiga Trojanowska-Lipczyk, Elzbieta Czkwianianc, Eleonora Dyńiska, Beata Kozieł
UNLABELLED: The aim of the study was to demonstrate morphological traits of Candida-induced upper alimentary tract mucosa inflammation. The material for the study comprised 18 children aged 4 to 18 years treated at the I Department of Paediatrics and Gastroenterology, Institute Polish Mother Health Centre. In these children positive mycologic cultures were obtained from alimentary tract inflammed mucosa sections. Upper alimentary tract endoscopy was performed and macroscopic and microscopic evaluation was made...
2004: Wiadomości Parazytologiczne
https://www.readbyqxmd.com/read/16707972/dilated-intercellular-spaces-a-major-morphological-feature-of-esophagitis
#17
Alberto M Ravelli, Vincenzo Villanacci, Nella Ruzzenenti, Piergiovanni Grigolato, Pamela Tobanelli, Catherine Klersy, Guido Rindi
OBJECTIVES: Dilated intercellular spaces (DIS) in the esophageal epithelium have been identified by electron microscopy as marker of acid reflux damage in experimental animals and adults with gastroesophageal reflux disease (GERD). We aimed to identify and quantify DIS by light microscopy in pediatric GERD and esophagitis. METHODS: We prospectively took esophageal biopsies in 70 consecutive pediatric patients, 48 of whom had GERD symptoms. On hematoxylin and eosin-stained sections esophagitis was scored histologically, and DIS were graded as 0 (absent), + (small and focal), ++ (moderate) or +++ (large and diffuse)...
May 2006: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/16516623/the-management-of-treatment-related-esophageal-complications-in-children-and-adolescents-with-cancer
#18
Dave R Lal, Hamid R Foroutan, Wendy T Su, Suzanne L Wolden, Farid Boulad, Michael P La Quaglia
BACKGROUND AND PURPOSE: Serious treatment-induced esophageal strictures and tracheoesophageal fistulae are rare in the pediatric oncology population. This report details our experience with their management. METHODS: We retrospectively reviewed our experience with pediatric oncology patients treated for esophageal complications over a 23-year period. Serious complications were defined as development of strictures requiring dilatation or an esophageal fistula. Fifteen patients were identified, 5 of which had been previously reported...
March 2006: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/16436720/safety-and-pharmacokinetics-of-intravenous-anidulafungin-in-children-with-neutropenia-at-high-risk-for-invasive-fungal-infections
#19
MULTICENTER STUDY
Daniel K Benjamin, Timothy Driscoll, Nita L Seibel, Corina E Gonzalez, Maureen M Roden, Rahki Kilaru, Kay Clark, James A Dowell, Jennifer Schranz, Thomas J Walsh
Anidulafungin is an echinocandin with activity against Candida species and Aspergillus species. Adult dosages under study are 50 mg/day for esophageal candidiasis and 100 mg/day for invasive candidiasis and aspergillosis. Little is known, however, about the safety and pharmacokinetics of anidulafungin in children. A multicenter, ascending-dosage study of neutropenic pediatric patients was therefore conducted. Patients were divided into two age cohorts (2 to 11 years and 12 to 17 years) and were enrolled into sequential groups to receive 0...
February 2006: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/16075235/gastroesophageal-reflux-strictures-in-children-management-and-outcome
#20
A Numanoglu, A J W Millar, R A Brown, H Rode
UNLABELLED: Esophageal reflux (GER) strictures are frequently diagnosed late and require a prolonged management programme depending on the severity of the stricture. Management protocols include medical therapy, bouginage, fundoplication, stricture resection and even interposition grafting. Our preferred method is to delay the anti-reflux surgery until the esophagitis is medically controlled, adequate enteral intake with weight gain is achieved and the oesophageal narrowing adequately dilated...
August 2005: Pediatric Surgery International
keyword
keyword
170501
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"