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https://www.readbyqxmd.com/read/29460333/comparison-of-diagnostic-accuracy-of-laparoscopic-3-mm-and-5-nm-cup-biopsies-to-wedge-biopsies-of-canine-livers
#1
Tiffany L Kimbrell, Milan Milovancev, Ronald Olsen, Christiane V Löhr
BACKGROUND: Diagnostic accuracy of the 3 mm laparoscopic cup biopsy forceps for collection of tissue samples from canine livers is unproven. HYPOTHESES/OBJECTIVES: Compare sample surface area and portal triad count between 3 mm and 5 mm laparoscopic cup biopsies and compare the histologic diagnosis obtained by each instrument to a standard necropsy wedge. The hypothesis was that more portal triads and greater sample surface area would be found with the 5 mm samples and the laparoscopic instruments would not have significantly different levels of agreement with necropsy wedge diagnosis...
February 20, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29458344/the-desire-to-die-in-palliative-care-optimization-of-management-dedipom-a-study-protocol
#2
Kerstin Kremeike, Maren Galushko, Gerrit Frerich, Vanessa Romotzky, Stefanie Hamacher, Gary Rodin, Holger Pfaff, Raymond Voltz
BACKGROUND: A desire to die (DD) is frequent in palliative care (PC). However, uncertainty remains as to the appropriate therapeutic response. (Proactive) discussion of DD is not usually part of standard care. To support health practitioners' (HPs) reactions to a patient's DD, a training program has been developed, piloted and evaluated. Within this framework, a first draft of a semi-structured clinical interview schedule with prompts (CISP) has been developed, including recommendations for action to support HPs' self-confidence...
February 20, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29400631/open-communication-strategies-between-a-triad-of-experts-facilitates-death-in-usual-place-of-residence-a-realist-evaluation
#3
Sonia Dalkin, Monique Lhussier, Diana Jones, Pete Phillipson, William Cunningham
BACKGROUND: In order to meet policy drivers on death in usual place of residence, it is key to understand how shared decision-making can be facilitated in practice. An integrated care pathway was implemented in primary care in the North East of England to facilitate death in usual place of residence. AIM: To understand how, for whom and in which circumstances death in usual place of residence is facilitated. DESIGN: A mixed method realist evaluation was employed...
February 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29399531/deep-vein-thrombosis-pathogenesis-diagnosis-and-medical-management
#4
REVIEW
Jonathan Stone, Patrick Hangge, Hassan Albadawi, Alex Wallace, Fadi Shamoun, M Grace Knuttien, Sailendra Naidu, Rahmi Oklu
Deep vein thrombosis (DVT) is a major preventable cause of morbidity and mortality worldwide. Venous thromboembolism (VTE), which includes DVT and pulmonary embolism (PE), affects an estimated 1 per 1,000 people and contributes to 60,000-100,000 deaths annually. Normal blood physiology hinges on a delicate balance between pro- and anti-coagulant factors. Virchow's Triad distills the multitude of risk factors for DVT into three basic elements favoring thrombus formation: venous stasis, vascular injury, and hypercoagulability...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29380664/wernicke-korsakoff-syndrome-as-a-rare-phenotype-of-sporadic-creutzfeldt-jakob-disease
#5
Joanna Bielewicz, Anna Szczepańska-Szerej, Magdalena Ogórek, Piotr Dropko, Katarzyna Wojtal, Konrad Rejdak
We reported the case of a patient with Wernicke-Korsakoff syndrome (WKs) as an early clinical manifestation of sporadic Creutzfeld-Jakob disease (sCJD). The 66-year-old female complained of dizziness and imbalance which mostly occurred while walking. A neurological examination revealed a triad of symptoms characteristic for WKs such as gaze paresis, ataxia of limbs and trunk as well as memory disturbances with confabulations. The disturbances increased during the course of the disease, which led to the death of the patient four months after the appearance of the signs...
January 30, 2018: Prion
https://www.readbyqxmd.com/read/29241975/positive-emotion-communication-fostering-well-being-at-end-of-life
#6
Alexandra L Terrill, Lee Ellington, Kevin K John, Seth Latimer, Jiayun Xu, Maija Reblin, Margaret F Clayton
OBJECTIVE: Little is known about positive emotion communication (PEC) in end-of-life care. This study aims to identify types and patterns of PEC among hospice nurses, caregivers, and patients. METHODS: A coding system based on positive psychology theory was applied as a secondary analysis to audio recordings of hospice nurse home visits with cancer patients and family caregivers, collected as part of a prospective longitudinal study. Eighty recordings (4 visits from 20 triads) were coded for humor, connection, praise, positive focus, gratitude, taking joy/savoring, and perfunctory statements...
November 28, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/29239071/comorbidity-of-chronic-kidney-disease-diabetes-and-lower-glycated-hemoglobin-predicts-support-care-need-certification-in-community-dwelling-older-adults
#7
Keisuke Watanabe, Masashi Okuro, Tazuo Okuno, Osamu Iritani, Hiroshi Yano, Taroh Himeno, Takuro Morita, Yuta Igarashi, Takeshi Nakahashi, Shigeto Morimoto
AIM: Chronic kidney disease (CKD), diabetes and lower glycated hemoglobin (HbA1c ) range in diabetes patients are associated with higher mortality. We investigated whether these conditions were associated with the risk of loss of independence in community-dwelling older adults. METHODS: We analyzed 1078 older adults with no history of support/care-need certification in Long-Term Care Insurance aged 65-94 years. Associations of baseline CKD, diabetes, and lower HbA1c range of <6...
December 14, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29225757/dengue-fever-in-a-south-asian-metropolis-a-report-on-219-cases
#8
Shiv Sekhar Chatterjee, Ankush Sharma, Shilpee Choudhury, Sushil Kumar Chumber, Ras Bage, Nittin Parkhe, Uma Khanduri
Background and Objectives: Yearly epidemics of Dengue fever occur post-monsoon in India's capital, Delhi. A prospective observational study was conducted during the outbreak months to understand the epidemiology and outcome of this infection and its economic impact. Materials and Methods: Febrile hospitalized (n=219) patients with dengue fever diagnosed by a combination of MAC-ELISA, GAC-ELISA and NS1Antigen-ELISA were enrolled. Epidemiologic (including economic) parameters, clinical, radiological and laboratory manifestations were noted and patients followed up over the period of hospital stay...
June 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29207768/controversies-in-serotonin-syndrome-diagnosis-and-management-a-review
#9
REVIEW
Mohd Faisal Uddin, Richard Alweis, Syed Raza Shah, Noman Lateef, Waqas Shahnawaz, Rohan Kumar Ochani, Amin Muhammad Dharani, Syed Arbab Shah
Over the past few years, Serotonin Syndrome (SS) has become a significant clinical concern. Over the last decade, United States saw a surge in antidepressant use. SS characteristically presents as the triad of altered mental status, autonomic dysfunction and neuromuscular excitation. Symptoms vary from patient to patient with mild cases presenting with subacute symptoms and severe cases progressing rapidly to death. Due to the protean manifestations of the syndrome along with non-specific prodromal, SS can easily be misdiagnosed if not carefully assessed...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29203479/host-pathogen-treatment-triad-host-factors-matter-most-in-methicillin-resistant-staphylococcus-aureus-bacteremia-outcomes
#10
M Cristina Vazquez Guillamet, Rodrigo Vazquez, Benjamin Deaton, Jenny Shroba, Laia Vazquez, Renee-Claude Mercier
Previous studies have separately emphasized the importance of host, pathogen, and treatment characteristics in determining short-term or in-hospital mortality rates for patients with methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections. Less is known about the relative importance of these factors and their interactions in determining short-, medium-, and long-term mortality rates. This is an observational cohort study in which data for all patients admitted to the University of New Mexico (UNM) Health Sciences Center (HSC) between July 2002 and August 2013 with MRSA-positive blood cultures were recorded...
February 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29183389/toxicological-investigation-of-acute-and-chronic-treatment-with-gnidia-stenophylla-gilg-root-extract-on-some-blood-parameters-and-histopathology-of-spleen-liver-and-kidney-in-mice
#11
Tilahun Alemayehu Nigatu, Mekbeb Afework, Kelbessa Urga, Wondwossen Ergete, Eyasu Makonnen
BACKGROUND: In southeast Ethiopia, people locally use the roots of Gnidia stenophylla Gilg (Thymelaeaceae) to cure malaria and other diseases with no literature evidence substantiating its safety. The aim of this study was, therefore, to investigate the safety of the aqueous root extract of G. stenophylla after acute (single dose) and repeated sub chronic oral administration in mice. RESULTS: A single oral administration of the extract at 500, 1000, 2000 and 4000 mg/kg body weight did not induce any behavioral change and mortality in both sexes...
November 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29169004/idiopathic-atypical-haemolytic-uraemic-syndrome-presenting-with-acute-dystonia
#12
M Rizwan, K E Maduemem
Hemolytic Uremic Syndrome (HUS), a triad of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. The atypical HUS (aHUS) results from over activation of complement system with formation of micro thrombi and damage to endothelial cells resulting in renal impairment in 50 % and death in 25 %, commonly in untreated patients. We report an intriguing case of aHUS presenting with acute onset of movement disorder and fluctuating delirium.
August 12, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29162267/the-prehospital-management-of-hypothermia-an-up-to-date-overview
#13
REVIEW
Frederike J C Haverkamp, Gordon G Giesbrecht, Edward C T H Tan
BACKGROUND: Accidental hypothermia concerns a body core temperature of less than 35°C without a primary defect in the thermoregulatory system. It is a serious threat to prehospital patients and especially injured patients, since it can induce a vicious cycle of the synergistic effects of hypothermia, acidosis and coagulopathy; referred to as the trauma triad of death. To prevent or manage deterioration of a cold patient, treatment of hypothermia should ideally begin prehospital. Little effort has been made to integrate existent literature about prehospital temperature management...
November 4, 2017: Injury
https://www.readbyqxmd.com/read/29122497/further-delineation-of-the-phenotypic-spectrum-of%C3%A2-isca2-defect-a-report-of-ten-new-cases
#14
Majid Alfadhel, Marwan Nashabat, Muhammad Talal Alrifai, Hesham Alshaalan, Fuad Al Mutairi, Saif A Al-Shahrani, Barbara Plecko, Rawan Almass, Maysoon Alsagob, Faten B Almutairi, Ahmed Al-Rumayyan, Waleed Al-Twaijri, Mohammed Al-Owain, Robert W Taylor, Namik Kaya
Iron-Sulfur Cluster (ISC) biogenesis is a vital cellular process required to produce various ISC-containing proteins. These ISC proteins are responsible for essential functions such as glycine cleavage and the formation of lipoic acid, an essential cofactor of respiratory chain complexes. Defects in ISC biogenesis lead to multiple mitochondrial dysfunction syndromes including: ISCA2 with infantile onset leukodystrophy. Recently, a founder mutation, c.229G > A, p.Gly77Ser in ISCA2 was reported to cause Multiple Mitochondrial Dysfunction Syndrome type 4...
October 16, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29121733/pheochromocytoma-as-a-reversible-cause-of-cardiomyopathy-analysis-and-review-of-the-literature
#15
Rong Zhang, Deepashree Gupta, Stewart G Albert
CONTEXT: Pheochromocytoma and paraganglioma are rare neuroendocrine tumors which overproduce catecholamines and arise from the adrenal gland or extra-adrenal chromaffin cells of the sympathetic and parasympathetic ganglia (1). Excessive catecholamine-induced stimulation of cardiac myocytes leads to damage which manifests in several forms ranging from Takotsubo to dilated cardiomyopathy. Diagnosis of pheochromocytoma-related cardiomyopathies is often delayed due to the atypical presentation associated with many cases...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29079021/returning-from-the-acidotic-abyss-mortality-in-trauma-patients-with-a-ph%C3%A2-%C3%A2-7-0
#16
Samuel W Ross, Bradley W Thomas, A Britton Christmas, Kyle W Cunningham, Ronald F Sing
INTRODUCTION: We hypothesized that a pH of <7.0 on presentation would correlate with almost universal mortality in trauma patients. METHODS: A retrospective cohort study was performed on a Level I trauma center registry from 2013 to 2014. Hospital mortality was the primary outcome, which was compared by pH cohort (<7.0 or ≥7.0) using standard univariate statistics and multivariate logistic regression. RESULTS: There were 593 patients included in the analysis: 66 in <7...
September 18, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29049018/prevalence-of-single-and-multiple-leading-causes-of-death-by-race-ethnicity-among-us-adults-aged-60-to-79-years
#17
James Davis, Janell Penha, Omar Mbowe, Deborah A Taira
INTRODUCTION: Diabetes, cancer, cardiovascular disease (CVD) (coronary artery disease, heart attack, and angina pectoris), and chronic lung disease (emphysema, chronic bronchitis, and chronic obstructive pulmonary disease) are major causes of death in the United States. The objective of this study was to assess racial/ethnic differences in the prevalence of these conditions as cause of death among people aged 60 to 79 years with one or more of these conditions. METHODS: We used data on the prevalence of major chronic conditions from the National Health Interview Survey on 56,290 adults aged 60 to 79 years who reported having any of the chronic conditions assessed in the National Health Interview Survey for 2006 through 2014...
October 19, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28916998/emergency-neurologic-life-support-meningitis-and-encephalitis
#18
David F Gaieski, Nicole F O'Brien, Ricardo Hernandez
Bacterial meningitis and viral encephalitis, particularly herpes simplex encephalitis, are severe neurological infections that, if not treated promptly and effectively, lead to poor neurological outcome or death. Because of the value of early recognition and treatment, meningitis and encephalitis was chosen as an Emergency Neurological Life Support protocol. This protocol provides a practical approach to recognition and urgent treatment of bacterial meningitis and encephalitis. Appropriate imaging, spinal fluid analysis, and early empiric treatment are discussed...
September 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28874292/malignant-cardiac-phenotypic-expression-of-danon-disease-lamp2-cardiomyopathy
#19
Fatima Samad, Renuka Jain, M Fuad Jan, Nasir Z Sulemanjee, Puneet Menaria, Lindsey Kalvin, Michelle Bush, Arshad Jahangir, Bijoy K Khandheria, A Jamil Tajik
INTRODUCTION: Danon disease is an X-linked lysosomal condition that causes a deficiency of lysosome-associated membrane protein 2 (LAMP2) gene. It is characterized clinically by a triad of skeletal myopathy, cardiomyopathy, and intellectual disability. METHODS: We examined clinical, echocardiographic, and genetic data on 5 patients with Danon disease, highlighting their clinical course and outcomes. RESULTS: All patients presented phenotypically with hypertrophic cardiomyopathy and later developed systolic dysfunction...
October 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28714660/maternal-mortality-in-the-developed-world-a-review-of-surveillance-methods-levels-and-causes-of-maternal-deaths-during-2006-2010
#20
Andreea A Creanga
This article provides an overview of surveillance methods, levels, and causes of maternal mortality in developed countries (Europe and the United States) during 2006-2010. Accurate identification of maternal deaths is not always possible, and no two countries in the world use the same surveillance methods for maternal mortality. Despite limitations (underestimation, missclassification), routine vital registration systems are the backbone of maternal mortality surveillance systems in developed countries. Enhanced surveillance methods involve linkages between deaths of women of reproductive age and births within the preceding year, or the use of additional data sources for maternal deaths...
July 17, 2017: Minerva Ginecologica
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