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Culture dissociative disorder

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https://www.readbyqxmd.com/read/30116185/consciousness-and-personhood-in-medical-care
#1
Stefanie Blain-Moraes, Eric Racine, George A Mashour
Current paradigms in Western medicine often fail to differentiate clearly between consciousness, responsiveness and personhood. The growing number of individuals who exist with sustainable cardiopulmonary systems but who are behaviorally unresponsive has prompted a cultural reconsideration of the relationship between the presence of consciousness and what it means to be a person. This article presents relevant clinical situations that exemplify the different modes in which personhood and consciousness can be associated and dissociated: disorders of consciousness, emergence from anesthesia, and neocortical death...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/30058948/differential-diagnosis-between-anomalous-experiences-and-dissociation-disorder-using-the-dissociative-disorders-interview-schedule-ddis
#2
Sérgio Vencio, Rafael Caiado-Vencio, Leonardo Caixeta
BACKGROUND: It is important to understand the most diverse cultural aspects related to religiosity. Scientifically, it is important to understand religious manifestations and their relation to health, and to differentiate them from psychopathological manifestations. OBJECTIVE: To evaluate the mental health of a group of mediums and compare it with that of a control group from the same religious context who do not manifest mediumship, using the Dissociative Disorders Interview Schedule (DDIS)...
July 30, 2018: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/30006706/neuron-oligodendrocyte-myelination-coculture
#3
Yi Pang, Kimberly Simpson, José Javier Miguel-Hidalgo, Renate Savich
Myelination cell culture systems are useful tools for studying myelin biology and myelin-related disorders. Compared to a number of established protocols for dissociated pure oligodendrocyte (OL) culture, methods for myelination culture are limited. We recently developed a mixed neuron-glia coculture system that generates robust and efficient myelination. By optimizing cell culture conditions, dissociated neural progenitor cells from embryonic rat spinal cords develop into neurons and glial cells including profiles of oligodendrocyte (OL) lineage...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29926835/amyloid-beta-dependent-phosphorylation-of-collapsin-response-mediator-protein-2-dissociates-kinesin-in-alzheimer-s-disease
#4
Sara H Mokhtar, Min Joung Kim, Kylie A Magee, Pei Mun Aui, Speros Thomas, Maha M Bakhuraysah, Amani A Alrehaili, Jae Young Lee, David L Steer, Rachel Kenny, Catriona McLean, Michael F Azari, Antonis Birpanagos, Ewlina Lipiec, Philip Heraud, Bayden Wood, Steven Petratos
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles. Prior to the development of these characteristic pathological hallmarks of AD, anterograde axonal transport is impaired. However, the key proteins that initiate these intracellular impairments remain elusive. The collapsin response mediator protein-2 (CRMP-2) plays an integral role in kinesin-1-dependent axonal transport and there is evidence that phosphorylation of CRMP-2 releases kinesin-1...
June 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29859877/free-floating-adult-human-brain-derived-slice-cultures-as-a-model-to-study-the-neuronal-impact-of-alzheimer-s-disease-associated-a%C3%AE-oligomers
#5
Niele D Mendes, Artur Fernandes, Glaucia M Almeida, Luis E Santos, Maria Clara Selles, N M Lyra E Silva, Carla M Machado, José A C Horta-Júnior, Paulo R Louzada, Fernanda G De Felice, Soniza Alves-Leon, Jorge Marcondes, João Alberto Assirati, Caio M Matias, William L Klein, Norberto Garcia-Cairasco, Sergio T Ferreira, Luciano Neder, Adriano Sebollela
BACKGROUND: Slice cultures have been prepared from several organs. With respect to the brain, advantages of slice cultures over dissociated cell cultures include maintenance of the cytoarchitecture and neuronal connectivity. Slice cultures from adult human brain have been reported and constitute a promising method to study neurological diseases. Despite this potential, few studies have characterized in detail cell survival and function along time in short-term, free-floating cultures...
September 1, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29742812/binding-of-free-and-immune-complex-associated-hepatitis-c-virus-to-erythrocytes-is-mediated-by-the-complement-system
#6
Kazi Abdus Salam, Richard Y Wang, Teresa Grandinetti, Valeria De Giorgi, Harvey J Alter, Robert D Allison
Erythrocytes bind circulating immune complexes (IC) and facilitate IC clearance from the circulation. Chronic hepatitis C virus (HCV) infection is associated with IC-related disorders. In this study we investigated the kinetics and mechanism of HCV and HCV-IC binding to and dissociation from erythrocytes. Cell culture-produced HCV was mixed with erythrocytes from healthy blood donors and erythrocyte-associated virus particles were quantified. Purified complement proteins, complement-depleted serum, and complement receptor antibodies were used to investigate complement-mediated HCV-erythrocyte binding...
May 9, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29595074/alleviation-of-hippocampal-endoplasmic-reticulum-stress-by-allomyrina-dichotoma-larvae-extract
#7
Jongwan Kim, Md Nazmul Haque, Tae-Won Goo, Il Soo Moon
In the brain, endoplasmic reticulum (ER) stress results in synaptic dysfunction and eventually leads to neurodegeneration. Allomyrina dichotoma larvae are a Chinese ethnomedicine and are widely used in East Asia. In the present study, we investigated the ability of ethanol extract of A. dichotoma larvae (ADE) to improve synaptic structure and function by activating unfolded protein response (UPR) under ER stress in animal and neuron culture models. ER stress was induced in obese mice fed a high fat diet (HFD) or by treating dissociated cultures of rat embryonic (E19) hippocampal neurons with tunicamycin (TM)...
2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29589801/psychometric-properties-of-the-pathological-dissociation-measures-among-chinese-a-pilot-study-using-online-methods
#8
Hong Wang Fung, Tat Ming Choi, Chitat Chan, Colin A Ross
PURPOSE: Pathological dissociation (PD) is an easily overlooked phenomenon in the mental health field. Standardized assessment is important for identifying dissociative symptoms and disorders. However, the use of PD measures in Chinese cultures needs investigation. This pilot study investigated the psychometric properties of three PD measures among Hong Kong Chinese. METHODS: The psychometric properties of the Dissociative Experiences Scale-Taxon, the 5-item Somatoform Dissociation Questionnaire, and the Self-Report Version of the Dissociative Disorders Interview Schedule (SR-DDIS) were evaluated using online methods in Hong Kong...
July 2018: Journal of Evidence-informed Social Work
https://www.readbyqxmd.com/read/29529266/varieties-of-self-disorder-a-bio-pheno-social-model-of-schizophrenia
#9
Louis Sass, Juan P Borda, Luis Madeira, Elizabeth Pienkos, Barnaby Nelson
The self-disorder model offers a unifying way of conceptualizing schizophrenia's highly diverse symptoms (positive, negative, disorganized), of capturing their distinctive bizarreness, and of conceiving their longitudinal development. These symptoms are viewed as differing manifestations of an underlying disorder of ipseity or core-self: hyper-reflexivity/diminished-self-presence with accompanying disturbances of "grip" or "hold" on reality. Recent revision to this phenomenological theory, in particular distinguishing primary-vs-secondary factors, offers a bio-pheno-social model that is consistent with recent empirical findings and offers several advantages: (1) It helps account for the temporal variations of the symptoms or syndrome, including longitudinal progression, but also the shorter-term, situationally reactive, and sometimes defensive or quasi-intentional variability of symptom-expression that can occur in schizophrenia (consistent with understanding some aspects of ipseity-disturbance as dynamic and mutable, involving shifting attitudes or experiential orientations)...
June 6, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29525830/ptsd-of-rape-after-is-islamic-state-captivity
#10
Jan Ilhan Kizilhan
Research into the psychological consequences of rape on women in war and warlike situations is limited. The aims of this study were (a) to describe the prevalence and the nature of PTSD symptoms among Yazidi women reporting rape during IS captivity, (b) to describe comorbidity of other psychological disorders, and (c) to examine the risk factors associated with posttraumatic stress disorder.The study included 296 Yazidi women survivors of rape and has been conducted in Germany since January 2016 as part of a special-quota project in the German region of Baden-Wuerttemberg, designed to support the women and children who have escaped after being held hostage by IS...
March 10, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29476060/quantitative-3-d-morphometric-analysis-of-individual-dendritic-spines
#11
Subhadip Basu, Punam Kumar Saha, Matylda Roszkowska, Marta Magnowska, Ewa Baczynska, Nirmal Das, Dariusz Plewczynski, Jakub Wlodarczyk
The observation and analysis of dendritic spines morphological changes poses a major challenge in neuroscience studies. The alterations of their density and/or morphology are indicators of the cellular processes involved in neural plasticity underlying learning and memory, and are symptomatic in neuropsychiatric disorders. Despite ongoing intense investigations in imaging approaches, the relationship between changes in spine morphology and synaptic function is still unknown. The existing quantitative analyses are difficult to perform and require extensive user intervention...
February 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29371591/mif-inhibits-the-formation-and-toxicity-of-misfolded-sod1-amyloid-aggregates-implications-for-familial-als
#12
Neta Shvil, Victor Banerjee, Guy Zoltsman, Tom Shani, Joy Kahn, Salah Abu-Hamad, Niv Papo, Stanislav Engel, Jurgen Bernhagen, Adrian Israelson
Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease caused by the progressive loss of motor neurons in the brain and spinal cord. It has been suggested that toxicity of mutant SOD1 results from its misfolding, however, it is yet unclear why misfolded SOD1 accumulates specifically within motor neurons. We recently demonstrated that macrophage migration inhibitory factor (MIF)-a multifunctional protein with cytokine/chemokine activity and cytosolic chaperone-like properties-inhibits the accumulation of misfolded SOD1...
January 25, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29353299/creation-of-the-txp-parenting-questionnaire-and-study-of-its-psychometric-properties
#13
Ana Benito, Gema Calvo, Matías Real-López, María José Gallego, Sonia Francés, Ángel Turbi, Gonzalo Haro
Parenting is linked to conduct disorders (CD) and substance related disorders (SRD) in adolescents, but with differences according to cultural context. A questionnaire with two versions (parenting questionnaire TXP-A for adolescents and TXP-C  for primary caregivers) was designed using the Delphi method to evaluate parenting practices related to CD and SRD in a Spanish population. It was validated in a community sample of 631 adolescents aged between 14 and 16 and their caregivers. Results suggest a 29-item TXP-A questionnaire with bifactorial structure: affection-communication and control-structure, with high internal (Cronbach’s alpha=0...
January 15, 2018: Adicciones
https://www.readbyqxmd.com/read/29283036/from-distress-to-disease-a-critique-of-the-medicalisation-of-possession-in-dsm-5
#14
Divya Padmanabhan
This paper critiques the category of possession-form dissociative identity disorder as defined in the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) published in 2013 by the American Psychiatric Association (APA). The DSM as an index of psychiatry pathologises possession by categorising it as a form of dissociative identity disorder. Drawing upon ethnographic fieldwork, this paper argues that such a pathologisation medicalises possession, which is understood as a non-pathological condition in other contexts such as by those individuals who manifest possession at a temple in Kerala, South India...
December 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/29178947/dangguijakyak-san-ameliorates-memory-deficits-in-ovariectomized-mice-by-upregulating-hippocampal-estrogen-synthesis
#15
Deok-Sang Hwang, Namkwon Kim, Jin Gyu Choi, Hyo Geun Kim, Hocheol Kim, Myung Sook Oh
BACKGROUND: Dangguijakyak-san (DJS) is an herbal formulation that has been clinically applicable for treating postmenopausal symptoms and neurological disorders. It is reported that hippocampal estrogen attenuates memory impairment via neuroprotection and synaptogenesis. However, the effect of DJS on hippocampal estrogen synthesis remains unknown. In this study, we explored the effect of DJS and its neuroprotective mechanism against memory impairment in ovariectomized (OVX) mice, with respect to hippocampal estrogen stimulation...
November 25, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29145065/gestational-differences-in-murine-placenta-glycolytic-metabolism-and-pregnancy-parameters
#16
Renee E Albers, Christopher A Waker, Chanel Keoni, Melissa R Kaufman, Michael A Bottomley, Sarah Min, David R Natale, Thomas L Brown
The placenta is a complex and essential organ composed largely of fetal-derived cells, including several different trophoblast subtypes that work in unison to support nutrient transport to the fetus during pregnancy. Abnormal placental development can lead to pregnancy-associated disorders that often involve metabolic dysfunction. The scope of dysregulated metabolism during placental development may not be fully representative of the in vivo state in defined culture systems, such as cell lines or isolated primary cells...
February 2018: Theriogenology
https://www.readbyqxmd.com/read/29076084/dissecting-regulatory-mechanisms-using-mouse-fetal-liver-derived-erythroid-cells
#17
Skye C McIver, Kyle J Hewitt, Xin Gao, Charu Mehta, Jing Zhang, Emery H Bresnick
Multipotent hematopoietic stem cells differentiate into an ensemble of committed progenitor cells that produce the diverse blood cells essential for life. Physiological mechanisms governing hematopoiesis, and mechanistic aberrations underlying non-malignant and malignant hematologic disorders, are often very similar in mouse and man. Thus, mouse models provide powerful systems for unraveling mechanisms that control hematopoietic stem/progenitor cell (HSPC) function in their resident microenvironments in vivo...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29044469/co-differentiation-of-human-pluripotent-stem-cells-derived-cardiomyocytes-and-endothelial-cells-from-cardiac-mesoderm-provides-a-three-dimensional-model-of-cardiac-microtissue
#18
Elisa Giacomelli, Milena Bellin, Valeria V Orlova, Christine L Mummery
The formation of cardiac mesodermal subtypes is highly regulated in time and space during heart development. In vitro models based on human pluripotent stem cells (hPS cells) provide opportunities to study mechanisms underlying fate choices governing lineage specification from common cardiovascular progenitors in human embryos. The generation of cardiac endothelial cells in particular allows the creation of complex models of cardiovascular disorders in which either cardiomyocytes or endothelial cells are affected...
October 18, 2017: Current Protocols in Human Genetics
https://www.readbyqxmd.com/read/28812237/pharmacological-effects-on-ceroid-lipofuscin-and-neuronal-structure-in-cln3-%C3%A2-ex7-8-mouse-brain-cultures
#19
Douglas E Brenneman, David A Pearce, Attila Kovacs, Shawn DeFrees
Juvenile Batten disease (JBD) is an inherited disorder that is characterized by the development of blindness, seizures, and progressive motor, psychiatric, and cognitive impairment. A model of JBD expressing the predominant human mutation (Cln3 ∆ex7/8 ) has been explored. Dissociated brain cultures from Cln3 ∆ex7/8 knock-in mice were compared to wild type (WT) for effects on granules of ceroid lipofuscin (CL) and neuronal structure. Utilizing high content image analysis of CL granules identified with antibodies to mitochondrial ATP synthase subunit c or tripeptidyl peptidase-1, significant increases in the areas for both immunoreactive granules were observed in Cln3 ∆ex7/8 cultures in comparison to WT...
September 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28664138/naringenin-inhibits-pacemaking-activity-in-interstitial-cells-of-cajal-from-murine-small-intestine
#20
Hyun Jung Kim, Byung Joo Kim
BACKGROUND: Naringenin (NRG) is a common dietary polyphenolic constituent of fruits. NRG has diverse pharmacological activities, and is used in traditional medicine to treat various diseases including gastrointestinal (GI) disorders. Interstitial cells of Cajal (ICCs) are pacemaker cells of the GI tract. In this study, the authors investigated the effects of NRG on ICCs and on GI motility in vitro and in vivo. METHODS: ICCs were dissociated from mouse small intestines by enzymatic digestion...
June 2017: Integrative Medicine Research
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