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(Angiogenesis OR microvessel OR neovascularization OR neovessel) AND plaque

Yu V Belov, G V Sinyavin, A I Bredikhina, E V Guseva, E V Barinov, E A Lukyanova, P Yu Luzan
Previously, atherosclerosis was considered a disease accompanied exclusively by lipids accumulation. At present time success of fundamental and experimental science confirmed that atherosclerotic process is also associated with neovascularization and prolonged inflammatory response at all stages of atherogenesis from initial manifestations to thrombotic complications. The cause of atherosclerotic plaque instability is neovascularization, which is accompanied by intra-plaque hemorrhage and damage. Complications of carotid arteries atherosclerosis are strokes and transient ischemic attacks...
2018: Khirurgiia
Margreet R de Vries, Laura Parma, Erna A B Peters, Abbey Schepers, Jaap F Hamming, J Wouter Jukema, Marie-José Goumans, Liang Guo, Aloke V Finn, Renu Virmani, C Keith Ozaki, Paul H A Quax
BACKGROUND: Plaque angiogenesis is associated with atherosclerotic lesion growth, plaque instability and negative clinical outcome. Plaque angiogenesis is a natural occurring process to fulfill the increasing demand of oxygen and nourishment of the vessel wall. However, inadequate formed, immature plaque neovessels are leaky and cause intraplaque hemorrhage. OBJECTIVE: Blockade of VEGFR2 normalizes the unbridled process of plaque neovessel formation and induces maturation of nascent vessels resulting in prevention of intraplaque hemorrhage and influx of inflammatory cells into the plaque and subsequently increases plaque stability...
August 13, 2018: Journal of Internal Medicine
Manolis Vavuranakis, Theodore G Papaioannou, Dimitrios Vrachatis, Michael Katsimboulas, Elias A Sanidas, Sophia Vaina, George Agrogiannis, Efstratios Patsouris, Ioannis Kakadiaris, Christodoulos Stefanadis, Dimitrios Tousoulis
OBJECTIVE: Neoangiogenesis is pathophysiologically related to atherosclerotic plaque growth and vulnerability. We examined the in vivo performance of a computational method using contrast-enhanced intravascular ultrasound (CE-IVUS) to detect and quantify aortic wall neovascularization in rabbits. We also compared these findings with histological data. METHODS: Nine rabbits were fed with a hyperlipidemic diet. IVUS image sequences were continuously recorded before and after the injection of a contrast agent...
August 2018: Anatolian Journal of Cardiology
Daina Kashiwazaki, Shusuke Yamamoto, Naoki Akioka, Naoya Kuwayama, Kyo Noguchi, Satoshi Kuroda
BACKGROUND AND PURPOSE: This study was aimed to assess the hypothesis that unstable plaque formation in the carotid artery is one of phenotypes of chronic and systemic inflammation. METHODS: This study included 8 symptomatic patients with internal carotid stenosis (ICS) and 7 healthy controls. All subjects underwent 18 F-fluorodeoxyglucos positron emission tomography (18 F-FDG PET) of whole body. Plaque vulnerability was evaluated on magnetic resonance imaging (MRI)...
August 4, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
T Mücke, C Wolff, A M Fichter, M von Düring, A Kanatas, L M Ritschl
Atherosclerosis is a systemic condition that is responsible for many diseases, and becomes a problem in cases where plaques form at several sites. The formation of a thrombotic embolus may jeopardise vascular operations, including microvascular anastomoses in replantation procedures or free tissue transfers. A mobile imaging tool for the detection of thrombosis preoperatively or intraoperatively would be valuable. An intimal injury, simulating removal of atherosclerotic plaques, was made microsurgically in 60 rat aortas, and results were analysed macroscopically, histologically, and with intraoperative indocyanine green (ICG) videoangiography immediately postoperatively...
July 30, 2018: British Journal of Oral & Maxillofacial Surgery
Paula Fratini, Nathia Nathaly Rigoglio, Gustavo de Sá Schiavo Matias, Ana Claudia O Carreira, Rose Eli Grassi Rici, Maria Angelica Miglino
Regenerative medicine has been growing because of the emergent need for tissues/organs for transplants and restorative surgeries. Biological scaffolds are important tools to try to solve this problem. The one used in this reserach was developed by an acellular biological scaffold from canine placenta with a rich source of cellular matrix. After decellularization, the cellular matrix demonstrated structural preservation with the presence of important functional proteins such as collagen, fibronectin, and laminin...
2018: BioResearch Open Access
Yingfeng Tu, Yao Sun, Yuhua Fan, Zhen Cheng, Bo Yu
Recently, multimodality molecular imaging has evolved into a fast-growing research field with goals of detecting and measuring biological processes in vivo non-invasively. Researchers have come to realize that the complementary abilities of different imaging modalities over single modality could provide more precisely information for the diagnosis of diseases. At present, nanoparticles-based multimodal imaging probes have received significant attention because of their ease of preparation and straightforward integration of each modality into one entity...
July 31, 2018: Cellular Physiology and Biochemistry
Seidu A Richard
Chlamydia pneumoniae(C.Pn) is an obligatory intracellular bacterium that is associated with respiratory tract infections like pneumonia, pharyngitis and bronchitis. It has also been implicated in cerebrovascular (stroke) as well as cardiovascular diseases. The most possible pathway via which C.Pn elicits its pathogenesis could be via activation of human vascular smooth muscle cells (VSMCs) proliferation resulting in the stimulation of toll like receptor-4 (TLR-4) and/or phospho-44/42(p44/p42) mitogen-activated protein kinases (MAPK)...
July 17, 2018: Current Neurovascular Research
Masatomo Miura, Kiyofumi Yamada, Seigo Shindo, Kazuma Matsumoto, Kazutaka Uchida, Manabu Shirakawa, Youji Kuramoto, Shinichi Yoshimura
BACKGROUND: Neovascularization (NV) plays an important role in plaque progression and plaque vulnerability. However, visualization of NV is difficult using by standard imaging tools. Recently, optical frequency domain imaging (OFDI) has provided intra-plaque microstructure that could not be visualized by previous imaging modalities. Here, we report a rare case that NV in the carotid plaque was detected both prior to carotid artery stenting (CAS) and in-stent restenotic lesion using OFDI...
July 11, 2018: World Neurosurgery
Andrea Caporali, Magnus Bäck, Mat J Daemen, Imo E Hoefer, Elizabeth A Jones, Esther Lutgens, Christian M Matter, Marie-Luce Bochaton-Piallat, Arndt F Siekmann, Judith C Sluimer, Sabine Steffens, José Tuñón, Cecile Vindis, Jolanda J Wentzel, Seppo Ylä-Herttuala, Paul C Evans
Modulation of vessel growth holds great promise for treatment of cardiovascular disease. Strategies to promote vascularization can potentially restore function in ischaemic tissues. On the other hand, plaque neovascularization has been shown to associate with vulnerable plaque phenotypes and adverse events. The current lack of clinical success in regulating vascularization illustrates the complexity of the vascularization process, which involves a delicate balance between pro- and anti-angiogenic regulators and effectors...
July 17, 2018: Cardiovascular Research
Marie-Helene Roy-Cardinal, Francois Destrempes, Gilles Soulez, Guy Cloutier
Quantitative ultrasound (QUS) imaging methods including elastography, echogenicity analysis and speckle statistical modeling are available from a single ultrasound radiofrequency data acquisition. Since these ultrasound imaging methods provide complementary quantitative tissue information, characterization of carotid artery plaques may gain from their combination. Sixty-six patients with symptomatic (n=26) and asymptomatic (n=40) carotid atherosclerotic plaques were included in the study. Of these, 31 underwent magnetic resonance imaging (MRI) to characterize plaque vulnerability and quantify plaque components...
June 29, 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
T Pereira, A Betriu, R Alves
Carotid adventitia vasa vasorum neovascularization (VVn) is associated with the initial stages of arteriosclerosis and with the formation of unstable plaque. However, techniques to accurately quantify that neovascularization in a standard, fast, non-invasive, and efficient way are still lacking. The development of such techniques holds the promise of enabling wide, inexpensive, and safe screening programs that could stratify patients and help in personalized preventive cardiovascular medicine. In this paper, we review the recent scientific literature pertaining to imaging techniques that could set the stage for the development of standard methods for quantitative assessment of atherosclerotic plaque and carotid VVn...
June 21, 2018: Trends in Cardiovascular Medicine
Tatsuya Tanaka, Atsushi Ogata, Jun Masuoka, Taichiro Mizokami, Tomihiro Wakamiya, Yukiko Nakahara, Kohei Inoue, Shoko Shimokawa, Fumitaka Yoshioka, Nobuaki Momozaki, Shuji Sakata, Tatsuya Abe
OBJECTIVE Intraplaque hemorrhage (IPH) is most often caused by the rupture of neovessels; however, the factors of intraplaque neovessel vulnerability remain unclear. In this study, the authors focused on pericytes and aimed to investigate the relationship between IPH and pericytes. METHODS The authors retrospectively analyzed the medical records of all patients with carotid artery stenoses who had undergone carotid endarterectomy at their hospitals between August 2008 and March 2016. Patients with carotid plaques that could be evaluated histopathologically were eligible for study inclusion...
June 29, 2018: Journal of Neurosurgery
F Simon, A Oberhuber, N Floros, P Düppers, H Schelzig, M Duran
Chronic ischemia of the lower extremities is an everyday problem in vascular surgery clinics. In Germany, approximately 3% of all hospitalizations are due to peripheral artery disease (PAD), with critical limb ischemia (CLI) in particular showing a rapid increase. The consequences of chronic undersupply range from reduced walking distance to loss of limbs. At the beginning there are stress factors, such as hyperlipidemia (LDL), free radicals, arterial hypertension, infections or subclinical inflammation that interfere with endothelial homeostasis and cause endothelial dysfunction with increased permeability...
2018: Gefässchirurgie: Zeitschrift Für Vaskuläre und Endovaskuläre Chirurgie
Paola Perrotta, Besa Emini Veseli, Bieke Van der Veken, Lynn Roth, Wim Martinet, Guido R Y De Meyer
Atherosclerosis is a complex multifactorial disease that affects large and medium-sized arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular complications remain a leading cause of death and morbidity in the Western world. There is a considerable difference in safety profile between a stable and a vulnerable, rupture-prone lesion. The need for plaque-stabilizing therapies is high, and for a long time the lack of a suitable animal model mimicking advanced human atherosclerotic plaques made it very difficult to make progress in this area...
June 19, 2018: Vascular Pharmacology
Yu-Li Chen, Feng-Qiu Liu, Yuan Guo, Juan Cheng, Lu Yang, Min Lu, Pan Li, Jie Xu, Tao Yu, Zhi-Gang Wang, Yang Cao, Hai-Tao Ran
Angiogenesis is a common pathological characteristic of many solid tumors and vulnerable atherosclerotic plaques. Photothermal therapy (PTT) is a promising method to reduce neovascularization. To increase the targeting ability and efficiency of PTT, a novel polymeric nanosystem that encapsulates phthalocyanine zinc (ZnPc) and perfluorohexane (PFH) was developed to target the new blood vessels of breast tumors. After being conjugated to the anti-VEGFR-2 antibody, the polymeric nanoparticles (NPs) targeted vascular endothelial cells efficiently...
July 24, 2018: Biomaterials Science
Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea Estefania Vasconez, James A Oo, Adelheid Kratzer, Sandeep Kumar, Flávia Rezende, Ivana Josipovic, Dominique Thomas, Hector Giral, Yannick Schreiber, Gerd Geisslinger, Christian Fork, Xia Yang, Fragiska Sigala, Casey E Romanoski, Jens Kroll, Hanjoong Jo, Ulf Landmesser, Aldons J Lusis, Dmitry Namgaladze, Ingrid Fleming, Matthias S Leisegang, Jun Zhu, Ralf P Brandes
Oxidized phospholipids (oxPAPC) induce endothelial dysfunction and atherosclerosis. Here we show that oxPAPC induce a gene network regulating serine-glycine metabolism with the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) as a causal regulator using integrative network modeling and Bayesian network analysis in human aortic endothelial cells. The cluster is activated in human plaque material and by atherogenic lipoproteins isolated from plasma of patients with coronary artery disease (CAD)...
June 12, 2018: Nature Communications
Zhaojun Li, Yun Bai, Wanbin Li, Feng Gao, Yi Kuang, Lianfang Du, Xianghong Luo
Inflammatory activity plays a central role in the development of carotid rupture-vulnerable atherosclerotic plaques, which is one of the major contributors to acute ischemic stroke. Our objective was to characterize carotid intraplaque neovascularizations (INP) using contrast-enhanced ultrasound (CEUS) and evaluate plaque burden through exploring the relationship between INP and cell count of peripheral leukocytes. Sixty-two patients with large artery atherosclerosis (LAA) were enrolled in this study. CEUS was performed to characterize the carotid artery plaques...
June 11, 2018: Scientific Reports
Niki Katsiki, Dimitri P Mikhailidis, Maciej Banach
Leptin, an adipokine that is implicated in the control of food intake via appetite suppression, may also stimulate oxidative stress, inflammation, thrombosis, arterial stiffness, angiogenesis and atherogenesis. These leptin-induced effects may predispose to the development of cardiovascular diseases. In the present review we discuss the evidence linking leptin levels with the presence, severity and/or prognosis of both coronary artery disease and non-cardiac vascular diseases such as stroke, carotid artery disease, peripheral artery disease (PAD) and abdominal aortic aneurysms (AAA) as well as with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM)...
July 2018: Acta Pharmacologica Sinica
Aiko Shimokado, Yoshiki Matsuo, Takashi Kubo, Tsuyoshi Nishiguchi, Akira Taruya, Ikuko Teraguchi, Yasutsugu Shiono, Makoto Orii, Takashi Tanimoto, Takashi Yamano, Yasushi Ino, Takeshi Hozumi, Atsushi Tanaka, Yasuteru Muragaki, Takashi Akasaka
BACKGROUND AND AIMS: The aim of this study was to assess agreement between optical coherence tomography (OCT) and histopathology for healed coronary plaques (HCPs) in human coronary arteries ex vivo, and to evaluate the prevalence and characteristics of HCPs in vivo. METHODS: Ex vivo OCT images were co-registered with histopathology in 144 cross-sections with ≥50% stenosis. Of these, 30 randomly selected pairs were employed to define morphological features of OCT for HCPs (OCT-derived HCPs); the remaining 114 pairs were used to evaluate the accuracy of OCT in detecting histologically-defined HCPs...
May 21, 2018: Atherosclerosis
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