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(Angiogenesis OR microvessel OR neovascularization OR neovessel) AND plaque

R E Kalinin, I A Suchkov, N D Mzhavanadze, É A Klimentova, A F Ncheĭe
Prevalence of atherosclerotic peripheral artery disease (PAD) has steadily been increasing all over the world, affecting approximately 10% of the population. PAD dramatically decreases the patients' quality of life and is accompanied by high risks of limb amputation and death. Reconstructive and restorative interventions make it possible to achieve the highest success in treatment of PAD. Their results largely depend on the state of the patient's peripheral bed. Currently, the periphery is objectively assessed by means of ultrasonographic duplex examination, digital subtraction angiography, roentgen computed tomographic angiography (CTA), and in a series of cases magnetic resonance tomographic angiography (MRA)...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Giuseppe Amato, Giorgio Romano, Roberto Puleio, Antonino Agrusa, Thorsten Goetze, Eliana Gulotta, Luca Gordini, Enrico Erdas, Piergiorgio Calò
Despite undisputed improvements, prosthetics hernia repair continues to be affected by unacceptable rates of complications. Postoperative adverse events such as discomfort and chronic pain represent a subject of increasing concern among the surgical community. Poor quality biologic response, stiff scar plates, and mesh shrinkage, a typical effect of conventional static meshes and plugs, are all indicated as the main reasons for many of the complications related to inguinal hernia repair. Even the conventional concept of treatment based upon a supposed reinforcement of the groin consequent to the fibrotic incorporation of meshes, would appear to be inadequate in the light of the latest scientific evidence concerning the degenerative genesis of inguinal hernia...
October 14, 2018: Artificial Organs
Yu V Belov, G V Sinyavin, E V Barinov, A M Grabuzdov
Problem of internal carotid artery disease diagnosis appears to be crucial today. Complications of this pathology are strokes and transient ischemic attacks. There is no technology for their prediction or at least stratifying risks. Some recent researches are devoted to a new diagnostic method. This new technology is called Contrast Enhanced Ultrasonography (CEUS) and followed by outstanding results in studying the morphological peculiarities of internal carotid artery plaques and predicting the probability of complications...
2018: Khirurgiia
Sang-Woong Choi, Hyungseop Kim, In-Cheol Kim, Cheol-Hyun Lee, Jongmin Hwang, Hyoung-Seob Park, Yun-Kyeong Cho, Hyuck-Jun Yoon, Chang-Wook Nam, Seongwook Han, Seung-Ho Hur
PURPOSE: Ultrasonographic contrast enhancement of carotid plaque (CECP) has been used to detect neovascularization of vasa vasorum and plaque. However, it is uncertain whether CECP can provide risk stratification of coronary artery disease (CAD). This study aimed to evaluate the relationship between CECP and manifestations of acute coronary syndrome (ACS) in established CAD patients and to explore the prognostic implication of CECP for cardiovascular (CV) clinical outcomes. METHODS: A medical record review revealed that contrast-enhanced ultrasonography was performed to evaluate carotid atherosclerosis in 209 coronary artery-stented and 105 non-stented patients...
September 2018: Journal of Clinical Ultrasound: JCU
Pauline Mury, Erica N Chirico, Mathilde Mura, Antoine Millon, Emmanuelle Canet-Soulas, Vincent Pialoux
Atherosclerosis, a complex cardiovascular disease, is a leading cause of mortality and morbidity worldwide. Oxidative stress and inflammation are both involved in the development of atherosclerotic plaque as they increase the biological processes associated with this pathology, such as endothelial dysfunction and macrophage recruitment and adhesion. Atherosclerotic plaque rupture leading to major ischemic events is the result of vulnerable plaque progression, which is a result of the detrimental effect of oxidative stress and inflammation on risk factors for atherosclerotic plaque rupture, such as intraplaque hemorrhage, neovascularization, and fibrous cap thickness...
October 9, 2018: Sports Medicine
Philip Dusart, Linn Fagerberg, Ljubica Perisic, Mete Civelek, Eike Struck, Ulf Hedin, Mathias Uhlén, David-Alexandre Trégouët, Thomas Renné, Jacob Odeberg, Lynn M Butler
The intermediate filament protein nestin is expressed during embryonic development, but considered largely restricted to areas of regeneration in the adult. Here, we perform a body-wide transcriptome and protein-profiling analysis to reveal that nestin is constitutively, and highly-selectively, expressed in adult human endothelial cells (EC), independent of proliferative status. Correspondingly, we demonstrate that it is not a marker for tumour EC in multiple malignancy types. Imaging of EC from different vascular beds reveals nestin subcellular distribution is shear-modulated...
October 2, 2018: Scientific Reports
Z Cai, Y He, Y Chen
The mammalian target of rapamycin (mTOR) regulates multiple pathophysiological processes, such as cell development, angiogenesis, autophagy, as well as innate-adaptive immune responses. Numerous studies have demonstrated that mTOR signaling plays an important role in the process of atherosclerosis (AS) itself or AS-related diseases. The activation of mTOR signaling contributes to the endothelium dysfunction and the formation of foam cells via enhancing the process from monocyte to macrophage in the initial stage of atherosclerosis...
September 26, 2018: Current Molecular Medicine
Scott M Eskildsen, David J Berkoff, Stephen A Kallianos, Paul S Weinhold
Interleukin-1 (IL1) is a cytokine that plays a role in inflammation and is a potential contributor to the inflammation present in tendinopathy. Its inhibition may be of use in the treatment of tendinopathy and has been a target for treatment. To evaluate how an IL1-receptor antagonist (IL1-RA) reverses pathologic changes associated with established patellar tendinopathy, we randomized 48 Sprague-Dawley retired breeder rats into three groups having weekly bilateral patellar tendon injections for 6 weeks. The control group received 0...
September 26, 2018: Scandinavian Journal of Medicine & Science in Sports
Jonathan Vigne, James Thackeray, Jeroen Essers, Marcus Makowski, Zoreh Varasteh, Adelina Curaj, Angelos Karlas, Emmanuel Canet-Soulas, Willem Mulder, Fabian Kiessling, Michael Schäfers, René Botnar, Moritz Wildgruber, Fabien Hyafil
Atherosclerotic plaques can remain quiescent for years, but become life threatening upon rupture or disruption, initiating clot formation in the vessel lumen and causing acute myocardial infarction and ischemic stroke. Whether and how a plaque ruptures is determined by its macroscopic structure and microscopic composition. Rupture-prone plaques usually consist of a thin fibrous cap with few smooth muscle cells, a large lipid core, a dense infiltrate of inflammatory cells, and neovessels. Such lesions, termed high-risk plaques, can remain asymptomatic until the thrombotic event...
September 24, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Daina Kashiwazaki, Shiraishi Keitaro, Shusuke Yamamoto, Tetsuhiro Kamo, Haruto Uchino, Hisayasu Saito, Naoki Akioka, Naoya Kuwayama, Kyo Noguchi, Satoshi Kuroda
OBJECTIVE: Carotid endarterectomy (CEA) is known to reduce stroke risk in patients with symptomatic, moderate to severe carotid stenosis, but have no apparent impact in patients with symptomatic, mild (<50%) carotid stenosis. However, recent development of non-invasive imaging modalities has shown that a certain subgroup of them are at high risk for further ischemic events in spite of antiplatelet therapy. This study, therefore, was aimed to clarify their clinical features and to explore the impact of CEA for them...
September 20, 2018: World Neurosurgery
David Miguel, Jesús María de Frutos-Baraja, Francisco López-Lara, María Antonia Saornil, Ciro García-Álvarez, Pilar Alonso, Patricia Diezhandino
Purpose: To assess the influence of the radiobiological doses, tumor, and treatment features on retinopathy, cataracts, retinal detachment, optic neuropathy, vitreous hemorrhage, and neovascular glaucoma at the authors' institution after brachytherapy for posterior uveal melanoma. Material and methods: Medical records of 243 eyes with uveal melanoma, treated by iodine brachytherapy between 1996 and 2016 at a single center were analyzed. Clinical and radiotherapy data were extracted from a dedicated database...
August 2018: Journal of Contemporary Brachytherapy
Muertiza Halimulati, Bagedati Duman, Julaiti Nijiati, Abudoureyimu Aizezi
Acute coronary syndrome caused by the rupture of atherosclerotic plaques is one of the primary causes of major cardiovascular events, and neovascularization within the plaque is closely associated with its stability. Long noncoding RNA (lncRNAs) is a type of noncoding RNA that serves a crucial role in regulating vascular endothelial cells (VECs). The aim of the present study was to investigate the effect of lncRNA TCONS_00024652 on the proliferation and angiogenesis of VECs following stimulation with TNF-α...
October 2018: Experimental and Therapeutic Medicine
Runtai Chen, Zhenchun Huang, Junyi Wang, Xiaoying Chen, Yucai Fu, Wei Wang
BACKGROUND: This study aimed to investigate the interactions between silent information regulator 1 (SIRT1) and mammalian target of rapamycin (mTOR) in intraplaque angiogenesis and their potential mechanisms through in vivo and in vitro studies. METHODS: An atherosclerosis model was established in 12 rabbits on a high-cholesterol diet. The rabbits were equally divided into 3 groups: a control group (high-lipid diet), RAP group (high-lipid diet supplemented with rapamycin) and RAP + NAM group (high-lipid diet supplemented with rapamycin and nicotinamide)...
August 2018: American Journal of the Medical Sciences
Masashi Hoshino, Takahiro Shimizu, Hana Ogura, Yuta Hagiwara, Naoki Takao, Kaima Soga, Noriko Usuki, Junji Moriya, Hisao Nakamura, Yasuhiro Hasegawa
Carotid artery atherosclerosis is one of the major risk factors for ischemic stroke. Intraplaque neovascularization (IPN) is one of the steps toward the development of vulnerable plaque. Superb microvascular imaging (SMI) is a new ultrasonographic technique for visualizing low-velocity and microvascular flow by clutter suppression to extract flow signals from large to small vessels and enables visualization of intraplaque microvascular flow (IMVF) without echo contrast media. We aimed to investigate the association between IMVF signal in SMI and MRI plaque imaging among patients with atherosclerotic carotid stenosis...
September 6, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Mario D'Oria, Stefano Chiarandini, Marco D Pipitone, Maurizio Fisicaro, Cristiano Calvagna, Rossana Bussani, Alice Rotelli, Barbara Ziani
OBJECTIVES: Contrast enhanced ultrasound (CEUS) has been suggested as an imaging tool for detection of asymptomatic carotid atherosclerotic disease (ACAD) at high risk of cerebral embolisation. The objective of this study was to evaluate CEUS and immunohistochemical (IHC) patterns in ACAD (i.e., without any neurologic symptoms in the last 6 months) and their correlations with histology. METHODS: CEUS analysis was classified on a semiquantitative basis using a three-point classification scale...
September 4, 2018: European Journal of Vascular and Endovascular Surgery
Xia Xie, Zhi-Yong Bai, Yue Liu, Hua-Bin Zhang
Objective To explore the diagnostic value of superb micro-vascular imaging (SMI) for patients with vulnerable plaque of carotid artery. Methods Totally 69 patient with carotid hypoechoic or predominantly hypoechoic plaque (108 plaques),which were identified by conventional ultrasound,underwent SMI and contrast-enhanced ultrasound (CEUS). Based on the scores of CEUS and SMI (0,1,and 2 points),the consistency of SMI and CEUS in detecting plaque neovascularization was assessed. Results SMI could more clearly display the profile and morphology of the plaques than conventional ultrasound...
August 30, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
Zhou-Ying Guo, Bai Zhang, Yan-Hong Yan, Shang-Shang Gao, Jing-Jing Liu, Lan Xu, Pin-Jing Hui
The rupture of atherosclerotic plaque provokes the majority of acute cerebrovascular events. Studies have demonstrated that various matrix metalloproteinases (MMPs) may promote atherosclerotic plaque progression and rupture. However, results have been incongruous and the mechanisms of this remain obscured. Therefore, in the current study, carotid plaques were characterized by assessing the levels of MMPs and calcification factors, and evaluating their association with plaque vulnerability. Human carotid plaques were obtained from carotid endarterectomies, and classified into stable and vulnerable groups by ultrasonography and histological analyses...
September 2018: Experimental and Therapeutic Medicine
Rong Yuan, Wei-Li Shi, Qi-Qi Xin, Ke-Ji Chen, Wei-Hong Cong
Effectively improving myocardial blood flow and controlling atherosclerotic plaque have always been key and difficult points in the prevention and treatment of coronary artery disease (CAD). Although "therapeutic angiogenesis" is regarded as a promising approach for ischemic heart disease by improving blood flow, angiogenesis itself can induce the destabilization of atherosclerotic plaque, which reflects the double-edged role of angiogenesis. Modulating the balance of angiogenesis can be an important target for CAD treatment...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Lan Ma, Jin Dai, Jie Chen, Hong-Wen Cai, Jia-Ying Li, Xin-Yao Li, Shen-Jie Chen, Wei Mao
Angiogenesis in atherosclerotic plaque plays a critical role in the mechanism of atherosclerotic physiopathology. Present consensus shows that angiogenesis in atherosclerotic plaque is mainly resulted in hypoxia, inflammation and some pro-angiogenic factors. The homeostasis in plaque, which is hypoxic and infiltrated by inflammatory cells, may lead to angiogenesis, increase the plaque instability and the incidence rate of vascular events. This article reviews the progression of pathogenetic mechanism, physiopathological significance, relevant detecting technique and corresponding therapeutic methods of Chinese and Western medicine of angiogenesis in atherosclerotic plaque, so as to provide more theoretical basis for atherosclerotic clinical treatment...
September 4, 2018: Chinese Journal of Integrative Medicine
Veronika A Myasoedova, Dimitry A Chistiakov, Andrey V Grechko, Alexander N Orekhov
Matrix metalloproteinases (MMPs) is a family of Zn2+ endopeptidases that process various components of the extracellular matrix. These enzymes are also involved in activation and inhibition of signaling cascades through proteolytic cleavage of surface receptors. Moreover, MMPs play a key role in tissue remodeling and and repair. Dysregulation of MMPs is observed in patholofgical conditions, including atherosclerosis, which is associated with hyperactivation of MMPs, aberrant tissue remodeling and neovascularization of the growing atherosclerotic plaques...
August 30, 2018: Journal of Molecular and Cellular Cardiology
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