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(Angiogenesis OR microvessel OR neovascularization OR neovessel) AND plaque

Priya T Rajan, T N Suresh, T S Rajashekar
Background: Psoriasis is a common chronic and immune-mediated skin disorder having a significant impact on the patient's quality of life. An analysis of the role of angiogenic vascular endothelial growth factor (VEGF) expression and microvessel density in psoriatic skin lesions may help in better understanding of the disease pathogenesis. The aim of this study was to examine the expression of vascular endothelial growth factor (VEGF) and microvessel density using CD34 antibodies in psoriatic skin lesions by immunohistochemical examination using normal skin of healthy individuals as controls...
November 2018: Indian Dermatology Online Journal
Xiaoling Liu, Jing Ma, Lianyue Ma, Fangfang Liu, Cheng Zhang, Yun Zhang, Mei Ni
The mechanisms leading to atherothrombosis from "vulnerable plaque" are more complex than initially proposed. We aimed to clarify whether plaque thrombogenicity is critical in atherothrombosis in mice. In a murine model of plaque destabilization, we enhanced plaque thrombogenicity by systemically overexpressing murine tissue factor (TF) by adenovirus-mediated gene transfer. The potential effects and mechanisms of TF on plaque destabilization were examined in cultured human aortic smooth muscle cells (HASMCs), RAW264...
November 27, 2018: Journal of Molecular and Cellular Cardiology
Giovanni Cimmino, Plinio Cirillo
For many years, the attention on tissue factor (TF) in human pathophysiology has been limited to its role as initiator of extrinsic coagulation pathway. Moreover, it was described as a glycoprotein located in several tissue including vascular wall and atherosclerotic plaque. However, in the last two decades, the discovery that TF circulates in the blood as cell-associated protein, microparticles (MPs) bound and as soluble form, is changing this old vessel-wall TF dogma. Moreover, it has been reported that TF is expressed by different cell types, even T lymphocytes and platelets, and different pathological conditions, such as acute and chronic inflammatory status, and cancer, may enhance its expression and activity...
October 2018: Cardiovascular Diagnosis and Therapy
Muyi Guo, Yan Cai, Chunliu He, Zhiyong Li
We propose a multiphysical mathematical model by fully coupling lipid deposition, monocytes/macrophages recruitment and angiogenesis to investigate the pathophysiological responses of an atherosclerotic plaque to the dynamic changes in the microenvironment. The time evolutions of cellular (endothelial cells, macrophages, smooth muscle cells, etc.) and acellular components (low density lipoprotein, proinflammatory cytokines, extravascular plasma concentration, etc.) within the plaque microenvironment are assessed quantitatively...
November 28, 2018: Annals of Biomedical Engineering
(no author information available yet)
OBJECTIVEThe relationship between intraplaque hypoxia and intraplaque hemorrhage (IPH) has been reported, but the details remain obscure. In this study, the authors aimed to clarify the relationship among intraplaque hypoxia, endothelial progenitor cells (EPCs), and neovascularization, which causes IPH. The histological findings of specimens obtained from carotid endarterectomy were assessed.METHODSThis study included 49 patients who underwent carotid endarterectomy. Magnetic resonance plaque imaging was performed to analyze the components of the carotid plaques, and surgical specimens were subjected to immunohistochemical analysis...
October 1, 2018: Journal of Neurosurgery
Suowen Xu, Danielle Kamato, Peter J Little, Shinichi Nakagawa, Jaroslav Pelisek, Zheng Gen Jin
Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and immune disorder in the vessel wall. As the atheromatous plaques develop into advanced stage, the vulnerable plaques are prone to rupture, which causes acute cardiovascular events, including ischemic stroke and myocardial infarction. Emerging evidence has suggested that atherosclerosis is also an epigenetic disease with the interplay of multiple epigenetic mechanisms...
November 12, 2018: Pharmacology & Therapeutics
I S Murashov, A M Volkov, G M Kazanskaya, E E Kliver, A M Chernyavsky, D B Nikityuk, E L Lushnikova
We performed a complex morphological study of samples of different types of unstable atherosclerotic plaques obtained from 33 men with occlusive coronary atherosclerosis, who underwent coronary artery endarterectomy during coronary artery bypass surgery. In the samples, expression of MMP-2 and MMP-9, collagen IV, CD31, CD34, factor VIII, and actin of smooth muscle cells was evaluated by morphometric and immunohistochemical methods. The maximum expression of MMP-9 was found in unstable plaques of the lipid type, where it 1...
November 2018: Bulletin of Experimental Biology and Medicine
Yuki Sato, Rena Watanabe, Nozomi Uchiyama, Nana Ozawa, Yui Takahashi, Remina Shirai, Kengo Sato, Yusaku Mori, Taka-Aki Matsuyama, Hatsue Ishibashi-Ueda, Tsutomu Hirano, Takuya Watanabe
Vasostatin-1,a chromogranin A-derived peptide (76 amino acids),is known to suppress vasoconstriction and angiogenesis.A recent study has shown that vasostatin-1 suppresses the adhesion of human U937 monocytes to human endothelial cells (HECs) via adhesion molecule downregulation. The present study evaluated the expression of vasostatin-1 in human atherosclerotic lesionsand its effects on inflammatory responses in HECs and human THP-1 monocyte-derived macrophages,macrophagefoam cell formation, migration and proliferation of human aortic smooth muscle cells (HASMCs) and extracellular matrix production by HASMCs, and atherogenesisin apolipoprotein E-deficient (ApoE-/- ) mice...
November 6, 2018: Clinical Science (1979-)
Sijing Wu, Wei Liu, Qian Ma, Wei Yu, Yonghe Guo, Yingxin Zhao, Dongmei Shi, Yuyang Liu, Zhiming Zhou, Jianlong Wang, Ruifang Liu, Yujie Zhou
We investigated the correlation between insulin resistance (IR) and optical coherence tomography and identified culprit plaque characteristics in patients with acute coronary syndrome (ACS). Patients with ACS who underwent selective coronary intervention were prospectively enrolled. A total of 159 culprit lesions were identified in 145 patients. Culprit plaque characteristics, including thin-cap fibroatheroma (TCFA) and spotty calcification, were analyzed. The IR was assessed using the homeostasis model assessment of IR (HOMA-IR)...
November 1, 2018: Angiology
Su Mae Ang, Lauren A Dalvin, Jacqueline Emrich, Lydia Komarnicky, Jerry A Shields, Carol L Shields
PURPOSE: To describe outcomes of 6 patients treated with plaque radiotherapy for medulloepithelioma. DESIGN: Retrospective review. METHODS: Computerized medical records were reviewed for cytopathologically confirmed medulloepithelioma treated with plaque radiotherapy from 1970 to 2017. Clinical and radiotherapy parameters along with outcomes of tumor regression, globe salvage, and metastatic disease were recorded. RESULTS: Of 6 patients with medulloepithelioma, plaque radiotherapy was primary (n = 5) or secondary (n = 1) treatment...
October 30, 2018: Asia-Pacific Journal of Ophthalmology
Vasileios Rafailidis, Ioannis Chryssogonidis, Chrysostomos Xerras, Irini Nikolaou, Thomas Tegos, Konstantinos Kouskouras, Dimitrios Rafailidis, Afroditi Charitanti-Kouridou
OBJECTIVES: To evaluate the diagnostic accuracy of color Doppler imaging (CDI) and contrast-enhanced ultrasound (CEUS) for diagnosing carotid ulceration, having multi-detector computed tomography angiography (MDCTA) as the reference method. METHODS: Patients with carotid disease referred for ultrasound (US), either due to the occurrence of neurovascular symptoms or for screening purposes, were included in this study if at least one plaque causing moderate (50-69%) or severe (70-99%) internal carotid artery stenosis was detected...
October 22, 2018: European Radiology
Max L Senders, Sophie Hernot, Giuseppe Carlucci, Jan C van de Voort, Francois Fay, Claudia Calcagno, Jun Tang, Amr Alaarg, Yiming Zhao, Seigo Ishino, Anna Palmisano, Gilles Boeykens, Anu E Meerwaldt, Brenda L Sanchez-Gaytan, Samantha Baxter, Laura Zendman, Mark E Lobatto, Nicolas A Karakatsanis, Philip M Robson, Alexis Broisat, Geert Raes, Jason S Lewis, Sotirios Tsimikas, Thomas Reiner, Zahi A Fayad, Nick Devoogdt, Willem J M Mulder, Carlos Pérez-Medina
OBJECTIVES: This study sought to develop an integrative positron emission tomography (PET) with magnetic resonance imaging (MRI) procedure for accurate atherosclerotic plaque phenotyping, facilitated by clinically approved and nanobody radiotracers. BACKGROUND: Noninvasive characterization of atherosclerosis remains a challenge in clinical practice. The limitations of current diagnostic methods demonstrate that, in addition to atherosclerotic plaque morphology and composition, disease activity needs to be evaluated...
October 12, 2018: JACC. Cardiovascular Imaging
Marco Magnoni, Enrico Ammirati, Francesco Moroni, Giuseppe D Norata, Paolo G Camici
BACKGROUND: Neovascularization is a marker of plaque vulnerability that can be assessed noninvasively using contrast-enhanced ultrasound (CEUS). The presence and extent of plaque neovascularization and their relation to cardiovascular risk factors and treatments were assessed in asymptomatic patients with carotid stenosis of intermediate severity and no indication for revascularization. METHODS: Sixty-six patients aged 69 ± 8 years (59% men) were prospectively enrolled...
October 16, 2018: Journal of the American Society of Echocardiography
Siegfried Bezdek, Lin Leng, Hauke Busch, Sadegh Mousavi, Dirk Rades, Markus Dahlke, Detlef Zillikens, Richard Bucala, Christian D Sadik
The immunomodulator Macrophage Migration Inhibitory Factor (MIF) exerts pleiotropic immunomodulatory activities and has been implicated in the pathogenesis of diverse inflammatory diseases. Expression levels of MIF are also significantly elevated in the skin and serum of psoriasis patients, but the pathogenic significance of MIF in psoriasis is unknown. We have therefore addressed the role of MIF in two mouse models of psoriasis, namely in the imiquimod-induced psoriasiform dermatitis (IIPD) and the IL-23-induced dermatitis model...
2018: Frontiers in Immunology
Shouyuan Ma, Shuxia Wang, Man Li, Yan Zhang, Ping Zhu
Cardiovascular disease (CVD) is a leading cause of death worldwide. Atherosclerosis is believed to be the major cause of CVD, characterized by atherosclerotic lesion formation and plaque disruption. Although remarkable advances in understanding the mechanisms of atherosclerosis have been made, the application of these theories is still limited in the prevention and treatment of atherosclerosis. Therefore, novel and effective strategies to treat high-risk patients with atherosclerosis require further development...
October 17, 2018: Lipids in Health and Disease
R E Kalinin, I A Suchkov, N D Mzhavanadze, É A Klimentova, A F Ncheĭe
Prevalence of atherosclerotic peripheral artery disease (PAD) has steadily been increasing all over the world, affecting approximately 10% of the population. PAD dramatically decreases the patients' quality of life and is accompanied by high risks of limb amputation and death. Reconstructive and restorative interventions make it possible to achieve the highest success in treatment of PAD. Their results largely depend on the state of the patient's peripheral bed. Currently, the periphery is objectively assessed by means of ultrasonographic duplex examination, digital subtraction angiography, roentgen computed tomographic angiography (CTA), and in a series of cases magnetic resonance tomographic angiography (MRA)...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Giuseppe Amato, Giorgio Romano, Roberto Puleio, Antonino Agrusa, Thorsten Goetze, Eliana Gulotta, Luca Gordini, Enrico Erdas, Piergiorgio Calò
Despite undisputed improvements, prosthetics hernia repair continues to be affected by unacceptable rates of complications. Postoperative adverse events such as discomfort and chronic pain represent a subject of increasing concern among the surgical community. Poor quality biologic response, stiff scar plates, and mesh shrinkage, a typical effect of conventional static meshes and plugs, are all indicated as the main reasons for many of the complications related to inguinal hernia repair. Even the conventional concept of treatment based upon a supposed reinforcement of the groin consequent to the fibrotic incorporation of meshes, would appear to be inadequate in the light of the latest scientific evidence concerning the degenerative genesis of inguinal hernia...
October 14, 2018: Artificial Organs
Yu V Belov, G V Sinyavin, E V Barinov, A M Grabuzdov
Problem of internal carotid artery disease diagnosis appears to be crucial today. Complications of this pathology are strokes and transient ischemic attacks. There is no technology for their prediction or at least stratifying risks. Some recent researches are devoted to a new diagnostic method. This new technology is called Contrast Enhanced Ultrasonography (CEUS) and followed by outstanding results in studying the morphological peculiarities of internal carotid artery plaques and predicting the probability of complications...
2018: Khirurgiia
Sang-Woong Choi, Hyungseop Kim, In-Cheol Kim, Cheol-Hyun Lee, Jongmin Hwang, Hyoung-Seob Park, Yun-Kyeong Cho, Hyuck-Jun Yoon, Chang-Wook Nam, Seongwook Han, Seung-Ho Hur
PURPOSE: Ultrasonographic contrast enhancement of carotid plaque (CECP) has been used to detect neovascularization of vasa vasorum and plaque. However, it is uncertain whether CECP can provide risk stratification of coronary artery disease (CAD). This study aimed to evaluate the relationship between CECP and manifestations of acute coronary syndrome (ACS) in established CAD patients and to explore the prognostic implication of CECP for cardiovascular (CV) clinical outcomes. METHODS: A medical record review revealed that contrast-enhanced ultrasonography was performed to evaluate carotid atherosclerosis in 209 coronary artery-stented and 105 non-stented patients...
September 2018: Journal of Clinical Ultrasound: JCU
Pauline Mury, Erica N Chirico, Mathilde Mura, Antoine Millon, Emmanuelle Canet-Soulas, Vincent Pialoux
Atherosclerosis, a complex cardiovascular disease, is a leading cause of mortality and morbidity worldwide. Oxidative stress and inflammation are both involved in the development of atherosclerotic plaque as they increase the biological processes associated with this pathology, such as endothelial dysfunction and macrophage recruitment and adhesion. Atherosclerotic plaque rupture leading to major ischemic events is the result of vulnerable plaque progression, which is a result of the detrimental effect of oxidative stress and inflammation on risk factors for atherosclerotic plaque rupture, such as intraplaque hemorrhage, neovascularization, and fibrous cap thickness...
December 2018: Sports Medicine
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