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https://www.readbyqxmd.com/read/30338375/development-and-validation-of-a-prognostic-model-for-kidney-function-1-year-after-combined-pancreas-and-kidney-transplantation-using-pre-transplant-donor-and-recipient-variables
#1
Katharina S Zorn, Simon Littbarski, Ysabell Schwager, Alexander Kaltenborn, Jan Beneke, Jill Gwiasda, Thomas Becker, Felix Braun, Benedikt Reichert, Jürgen Klempnauer, Harald Schrem
PURPOSE: The widening gap between demand and supply of organs for transplantation provides extraordinary challenges for ethical donor organ allocation rules. The transplant community is forced to define favorable recipient/donor combinations for simultaneous kidney-pancreas transplantation. The aim of this study is the development of a prognostic model for the prediction of kidney function 1 year after simultaneous pancreas and kidney transplantation using pre-transplant donor and recipient variables with subsequent internal and external validation...
October 18, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/30337529/substantiating-freedom-from-parasitic-infection-by-combining-transmission-model-predictions-with-disease-surveys
#2
Edwin Michael, Morgan E Smith, Moses N Katabarwa, Edson Byamukama, Emily Grisworld, Peace Habomugisha, Thomson Lakwo, Edridah Tukahebwa, Emmanuel S Miri, Abel Eigege, Evelyn Ngige, Thomas R Unnasch, Frank O Richards
Stopping interventions is a critical decision for parasite elimination programmes. Quantifying the probability that elimination has occurred due to interventions can be facilitated by combining infection status information from parasitological surveys with extinction thresholds predicted by parasite transmission models. Here we demonstrate how the integrated use of these two pieces of information derived from infection monitoring data can be used to develop an analytic framework for guiding the making of defensible decisions to stop interventions...
October 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/30336699/managing-hcv-treatment-failure-and-the-potential-of-resistance-testing-in-informing-second-line-therapy-options
#3
Elisabetta Loggi, Ranka Vukotic, Pietro Andreone
Direct acting antivirals have completely changed the landscape of the treatment of chronic hepatitis C. The management of the few patients who relapse to a treatment with direct acting antivirals requires a careful analysis of the chances to achieve therapeutic success with a second antiviral course. In this context, the usefulness of viral resistances testing, able to detect resistance-associated substitutions in the viral sequence, is at present a matter of debate. Areas covered: The role of resistance associated substitutions is examined through the evaluation of the data from clinical trials that have assessed the impact of viral resistances on the treatment outcome...
October 19, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/30336133/feasibility-study-of-family-planning-services-screening-as-clinical-decision-support-at-an-urban-federally-qualified-health-center-network
#4
Seema D Shah, Linda Prine, Eve Waltermaurer, Susan E Rubin
OBJECTIVE: To assess the feasibility of an intervention introducing family planning services screening clinical decision support to improve provision of contraception and/or preconception services for women of reproductive age in our primary care Federally Qualified Health Center (FQHC) network. STUDY DESIGN: We implemented a family planning services screening prompt for support staff to ask women 13-44years at non-obstetric visits at specified time intervals. The response displayed in the electronic medical record for the provider to review, linked to a documentation tool...
October 15, 2018: Contraception
https://www.readbyqxmd.com/read/30334330/a-study-to-assess-the-feasibility-of-implementing-a-web-based-decision-aid-for-birth-after-cesarean-to-increase-opportunities-for-shared-decision-making-in-ethnically-diverse-settings
#5
Allison Shorten, Brett Shorten, Angela Fagerlin, Jessica Illuzzi, Holly Powell Kennedy, Christian Pettker, Dheeraj Raju, Robin Whittemore
INTRODUCTION: Decision aids are central to shared decision making and are recommended for value-sensitive pregnancy decisions, such as birth after cesarean. However, effective strategies for widespread decision aid implementation, with interactive web-based platforms, are lacking. This study tested the feasibility and acceptability of implementing a Health Insurance Portability and Accountability Act-secure, web-based decision aid to support shared decision making about birth choices after cesarean, within urban, ethnically diverse outpatient settings...
October 18, 2018: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/30328069/parent-empowerment-in-pediatric-healthcare-settings-a-systematic-review-of-observational-studies
#6
REVIEW
Laura Ellen Ashcraft, Miya Asato, Amy J Houtrow, Dio Kavalieratos, Elizabeth Miller, Kristin N Ray
BACKGROUND: Parent empowerment is often an expressed goal in clinical pediatrics and in pediatric research, but the antecedents and consequences of parent empowerment are not well established. OBJECTIVE: The objective of this systematic review was to synthesize potential antecedents and consequences of parent empowerment in healthcare settings. ELIGIBILITY CRITERIA: The inclusion criteria were (1) studies with results about parent empowerment in the context of children's healthcare or healthcare providers; and (2) qualitative studies, observational studies, and systematic reviews of such studies...
October 17, 2018: Patient
https://www.readbyqxmd.com/read/30327992/shared-decision-making-in-atrial-fibrillation-navigating-complex-issues-in-partnership-with-the-patient
#7
REVIEW
Peter A Noseworthy, Juan P Brito, Marleen Kunneman, Ian G Hargraves, Claudia Zeballos-Palacios, Victor M Montori, Henry H Ting
Atrial fibrillation (AF) is an important risk factor for stroke. Although anticoagulation is effective in mitigating this risk, many high-risk patients are not anticoagulated in routine practice. Furthermore, as many as 50% of those who are prescribed an anticoagulant stop treatment within a year. This under treatment may be due, in part, to difficulty in navigating difficult decisions about initiating potentially lifelong therapy with significant costs, potential risks, and impact on daily life. To address these challenges, the most recent American guidelines issued a class I recommendation to use shared decision-making (SDM) to individualize patients' antithrombotic care...
October 17, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/30326795/strengthening-health-technology-assessment-systems-in-the-global-south-a-comparative-analysis-of-the-hta-journeys-of-china-india-and-south-africa
#8
Kim MacQuilkan, Peter Baker, Laura Downey, Francis Ruiz, Kalipso Chalkidou, Shankar Prinja, Kun Zhao, Thomas Wilkinson, Amanda Glassman, Karen Hofman
BACKGROUND: Resource allocation in health is universally challenging, but especially so in resource-constrained contexts in the Global South. Pursuing a strategy of evidence-based decision-making and using tools such as Health Technology Assessment (HTA), can help address issues relating to both affordability and equity when allocating resources. Three BRICS and Global South countries, China, India and South Africa have committed to strengthening HTA capacity and developing their domestic HTA systems, with the goal of getting evidence translated into policy...
2018: Global Health Action
https://www.readbyqxmd.com/read/30325042/prediction-of-clinically-relevant-drug-induced-liver-injury-from-structure-using-machine-learning
#9
Felix Hammann, Verena Schöning, Jürgen Drewe
Drug-induced liver injury (DILI) is the most common cause of acute liver failure and often responsible for drug withdrawals from the market. Clinical manifestations vary, and toxicity may or may not appear dose-dependent. We present several machine-learning models (decision tree induction, k-nearest neighbor, support vector machines, artificial neural networks) for the prediction of clinically relevant DILI based solely on drug structure, with data taken from published DILI cases. Our models achieved corrected classification rates of up to 89%...
October 16, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/30322661/hypofractionated-radiation-therapy-for-localized-prostate-cancer-executive-summary-of-an-astro-asco-and-aua-evidence-based-guideline
#10
Scott C Morgan, Karen Hoffman, D Andrew Loblaw, Mark K Buyyounouski, Caroline Patton, Daniel Barocas, Soren Bentzen, Michael Chang, Jason Efstathiou, Patrick Greany, Per Halvorsen, Bridget F Koontz, Colleen Lawton, C Marc Leyrer, Daniel Lin, Michael Ray, Howard Sandler
PURPOSE: The aim of this guideline is to present recommendations regarding moderately hypofractionated (240-340 cGy per fraction) and ultrahypofractionated (500 cGy or more per fraction) radiation therapy for localized prostate cancer. METHODS AND MATERIALS: The American Society for Radiation Oncology convened a task force to address 8 key questions on appropriate indications and dose-fractionation for moderately and ultrahypofractionated radiation therapy, as well as technical issues, including normal tissue dose constraints, treatment volumes, and use of image guided and intensity modulated radiation therapy...
October 11, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/30322635/effect-of-video-based-telemedicine-on-transport-management-of-simulated-newborns
#11
Rachel A Umoren, Megan M Gray, Nathan Schooley, Zeenia Billimoria, Kendra M Smith, Taylor L Sawyer
OBJECTIVE: Video-based telemedicine is a reliable tool to assess the severity of respiratory distress in children, increasing the appropriateness of triage and disposition for acutely ill children. Telemedicine simulations may identify patterns in regional transport management and influence attitudes toward telemedicine. METHODS: The objective was to determine the effect of videos on simulated neonatal transport care compared with telephone management. Participants received information about a newborn requiring respiratory support by an audio recording and made management decisions based on only that information...
September 2018: Air Medical Journal
https://www.readbyqxmd.com/read/30321850/qsar-classification-based-virtual-screening-followed-by-molecular-docking-studies-for-identification-of-potential-inhibitors-of-5-lipoxygenase
#12
T K Shameera Ahamed, Vijisha K Rajan, K Sabira, K Muraleedharan
Developments of novel inhibitors to prevent the function of 5-lipoxygenase (5-LOX) proteins that are responsible for a variety of inflammatory and allergic disease are a major challenge in the scientific community. In this study, robust QSAR classification models for predicting 5-LOX activity were developed using machine learning algorithms. The Support Vector Machines (SVM), Logistic Regression, k-Nearest Neighbour (NN) and Decision Trees were adopted to improve the prediction ability of the classification models...
October 5, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/30321268/fact-box-decision-support-tools-reduce-decisional-conflict-about-antibiotics-for-pneumonia-and-artificial-hydration-in-advanced-dementia-a-randomized-controlled-trail
#13
Andrea J Loizeau, Nathan Theill, Simon M Cohen, Stefanie Eicher, Susan L Mitchell, Silvio Meier, Michelle McDowell, Mike Martin, Florian Riese
Background: fact Boxes are decision support tools that can inform about treatment effects. Objectives: to test whether Fact Box decision support tools impacted decisional conflict, knowledge and preferences about the use of antibiotics and artificial hydration in advanced dementia. Design: randomized controlled trial. Setting: Swiss-German region of Switzerland. Subjects: two hundred thirty-two participants (64 physicians, 100 relatives of dementia patients, 68 professional guardians) randomly allocated to intervention (N = 114) or control (N = 118)...
October 15, 2018: Age and Ageing
https://www.readbyqxmd.com/read/30321180/modification-and-optimization-of-the-fecpakg2-protocol-for-the-detection-and-quantification-of-soil-transmitted-helminth-eggs-in-human-stool
#14
Mio Ayana, Johnny Vlaminck, Piet Cools, Shaali Ame, Marco Albonico, Daniel Dana, Jennifer Keiser, Helen Manly, Leonardo F Matoso, Zeleke Mekonnen, Antonio Montresor, Rodrigo Correa-Oliveira, Laura Rinaldi, Somphou Sayasone, Lensa Tesfaye, Jozef Vercruysse, Greg Mirams, Bruno Levecke
BACKGROUND: Standard diagnosis of human soil-transmitted helminth (STH) infections is based on the microscopic detection of helminth eggs in stool and supports programmatic decision making in control programs. However, the current standard diagnostic techniques still show a number of limitations. Recently, the FECPAKG2 method was developed to detect helminth infections and asses drug efficacy in sheep or cattle. It includes a device that takes digital images of helminth eggs that have been concentrated into one microscopic field of view and stores these images online for future evaluation...
October 15, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/30320756/hydra-a-computer-based-platform-for-aiding-clinicians-in-cardiovascular-analysis-and-diagnosis
#15
Lucía Ramos, Jorge Novo, Noelia Barreira, José Rouco, Manuel G Penedo, Marcos Ortega
Cardiovascular diseases (CVDs) are the leading cause of death throughout the world. The total risk of developing CVD is determined by the combined effect of different cardiovascular risk factors (e.g., diabetes, raised blood pressure, unhealthy diet, tobacco use, stress, etc.) that commonly coexist and act multiplicatively. Most CVDs can be prevented by an early identification of the highest risk factors and an appropriate treatment. The stratification of cardiovascular risk factors involves a wide range of parameters and tests that specialists use in their clinical practice...
September 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30318309/strategy-of-port-baseline-surveys-pbs-in-the-adriatic-sea
#16
Romina Kraus, Živana Ninčević-Gladan, Rocco Auriemma, Mauro Bastianini, Luca Bolognini, Marina Cabrini, Magdalena Cara, Marijeta Čalić, Alessandra Campanelli, Ivan Cvitković, Marija Despalatović, Dragana Drakulović, Vesna Flander-Putrle, Fabio Grati, Mateja Grego, Federica Grilli, Andrej Jaklin, Ivica Janeković, Jerina Kolitari, Lovrenc Lipej, Erika Magaletti, Mauro Marini, Borut Mavrič, Josip Mikus, Patricija Mozetič, Martina Orlando-Bonaca, Slavica Petović, Robert Precali, Nastjenjka Supić, Benedetta Trabucco, Ana Travizi, Ante Žuljević
Port baseline surveys (PBS) provide species inventories in and around ports, with a focus on non-indigenous species that may have been introduced by vessels, primarily via ballast water. PBS are an essential tool to support effective management strategies for non-indigenous as well as native harmful aquatic organisms and pathogens (HAOP). This paper describes the methodology of PBS that were conducted in 12 Adriatic ports. The PBS employed existing protocols that were adapted to meet the characteristics of the Adriatic sites...
October 11, 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/30318178/a-systematic-evaluation-of-advance-care-planning-patient-educational-resources
#17
Priscilla K Gazarian, Julie Cronin, Jodi L Dalto, Kayla M Baker, Barbara J Friel, Winona Bruce-Baiden, Lesley Y Rodriguez
BACKGROUND: Advance care planning (ACP) conversations help individuals exercise autonomy and make informed decisions about their care. There are many ACP resources available to support the process of advance care planning, yet available resources not universally accepted and under-utilized in clinical practice. OBJECTIVE: This study aims to systematically evaluate commonly available general ACP patient educational resources using a comprehensive approach to assess elements ranging from resource inclusion to health literacy...
October 11, 2018: Geriatric Nursing
https://www.readbyqxmd.com/read/30317175/optimum-socio-environmental-flows-approach-for-reservoir-operation-strategy-using-many-objectives-evolutionary-optimization-algorithm
#18
Jafar Y Al-Jawad, Hassan M Alsaffar, Douglas Bertram, Robert M Kalin
Water resource system complexity, high-dimension modelling difficulty and computational efficiency challenges often limit decision makers' strategies to combine environmental flow objectives (e.g. water quality, ecosystem) with social flow objectives (e.g. hydropower, water supply and agriculture). Hence, a novel Optimum Social-Environmental Flows (OSEF) with Auto-Adaptive Constraints (AAC) approach introduced as a river basin management decision support tool. The OSEF-AAC approach integrates Socio-Environmental (SE) objectives with convergence booster support to soften any computational challenges...
October 6, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30316897/hypofractionated-radiation-therapy-for-localized-prostate-cancer-an-astro-asco-and-aua-evidence-based-guideline
#19
Scott C Morgan, Karen Hoffman, D Andrew Loblaw, Mark K Buyyounouski, Caroline Patton, Daniel Barocas, Soren Bentzen, Michael Chang, Jason Efstathiou, Patrick Greany, Per Halvorsen, Bridget F Koontz, Colleen Lawton, C Marc Leyrer, Daniel Lin, Michael Ray, Howard Sandler
PURPOSE: The aim of this guideline is to present recommendations regarding moderately hypofractionated (240-340 cGy per fraction) and ultrahypofractionated (500 cGy or more per fraction) radiation therapy for localized prostate cancer. METHODS AND MATERIALS: The American Society for Radiation Oncology convened a task force to address 8 key questions on appropriate indications and dose-fractionation for moderately and ultrahypofractionated radiation therapy, as well as technical issues, including normal tissue dose constraints, treatment volumes, and use of image guided and intensity modulated radiation therapy...
October 9, 2018: Journal of Urology
https://www.readbyqxmd.com/read/30316241/metrics-and-evaluation-tools-for-patient-engagement-in-healthcare-organization-and-system-level-decision-making-a-systematic-review
#20
Vadim Dukhanin, Rachel Topazian, Matthew DeCamp
BACKGROUND: Patient, public, consumer, and community (P2C2) engagement in organization-, community-, and systemlevel healthcare decision-making is increasing globally, but its formal evaluation remains challenging. To define a taxonomy of possible P2C2 engagement metrics and compare existing evaluation tools against this taxonomy, we conducted a systematic review. METHODS: A broad search strategy was developed for English language publications available from January 1962 through April 2015 in PubMed, Embase, Sociological Abstracts, PsycINFO, EconLit, and the gray literature...
May 16, 2018: International Journal of Health Policy and Management
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