Han Zhang, Guangdong Qi, Kexin Wang, Jiawen Yang, Yuntian Shen, Xiaoming Yang, Xin Chen, Xinlei Yao, Xiaosong Gu, Lei Qi, Chun Zhou, Hualin Sun
Oxidative stress, inflammation, mitochondrial dysfunction, reduced protein synthesis, and increased proteolysis are all critical factors in the process of muscle atrophy. In particular, oxidative stress is the key factor that triggers skeletal muscle atrophy. It is activated in the early stages of muscle atrophy and can be regulated by various factors. The mechanisms of oxidative stress in the development of muscle atrophy have not been completely elucidated. This review provides an overview of the sources of oxidative stress in skeletal muscle and the correlation of oxidative stress with inflammation, mitochondrial dysfunction, autophagy, protein synthesis, proteolysis, and muscle regeneration in muscle atrophy...
June 16, 2023: Biochemical Pharmacology