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Vitamins intensive care

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https://www.readbyqxmd.com/read/30101993/vitamin-d-status-is-associated-with-development-of-hospital-acquired-pressure-injuries-in-critically-ill-surgical-patients
#1
Tiffany M N Otero, Cecilia Canales, D Dante Yeh, Ali Elsayes, Donna M Belcher, Sadeq A Quraishi
BACKGROUND: Hospital-acquired pressure injuries (HAPIs) typically develop following critical illness due to immobility and suboptimal perfusion. Vitamin D helps to maintain epithelial cell integrity, particularly at barrier sites such as skin. It is unclear whether vitamin D status is a modifiable risk factor for HAPIs in critically ill patients. Our goal was to investigate the relationship between admission 25-hydroxyvitamin D (25OHD) levels with the development of HAPIs in surgical intensive care unit (ICU) patients...
August 13, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/30099920/genetic-polymorphism-of-vkorc1-1639-in-children-with-intracranial-hemorrhage-due-to-vitamin-k-deficiency
#2
Uğur Berber, Mehmet Akif Özdemir, Ekrem Unal, Serpil Taheri, Serkan Yildiz, Keziban Korkmaz Bayramov, Yunus Güler, Hüseyin Per
Intracranial hemorrhage due to vitamin K deficiency is a serious disease that can lead to morbidity, mortality, and mental retardation. Our goal in this study is to determine the frequency of VKORC1-1639 G>A polymorphism in patients who have undergone intracranial hemorrhage due to vitamin K deficiency bleeding (VKDB). To study VKORC1-1639 G>A polymorphism, blood was drawn from patients (n = 51, age 8:0 ± 6:5 years) followed at the Pediatric Neurology and Hematology section, Faculty of Medicine, Erciyes University, between 1990 and 2016, diagnosed with VKDB as idiopathic or from patients diagnosed with intracranial hemorrhage due to secondary vitamin K deficiency and also from volunteers (n = 51, age 11 ± 4...
August 13, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/30088558/evaluation-of-the-bleeding-intensity-of-patients-anticoagulated-with-warfarin-or-dabigatran-undergoing-dental-procedures
#3
Marcus Vinicius Santos Andrade, Luciana Azevedo Prata Andrade, Alan Freitas Bispo, Luana de Alencar Freitas, Milena Quadros Sampaio Andrade, Gilson Soares Feitosa, Gilson Soares Feitosa-Filho
BACKGROUND: Thrombotic disorders remain one of the leading causes of death in the Western world. Dabigatran appeared as an alternative to warfarin for anticoagulation in the treatment of atrial fibrillation (AF). The risk associated with bleeding due to its use has been documented in several randomized clinical trials, but no large study has examined in detail the risk of bleeding during dental extraction and other dental procedures involving bleeding. OBJECTIVE: To compare the intensity of bleeding in individuals taking dabigatran or vitamin K antagonist (warfarin) and undergoing dental procedures...
August 6, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/30060468/vitamin-c-to-improve-organ-dysfunction-in-cardiac-surgery-patients-review-and-pragmatic-approach
#4
REVIEW
Aileen Hill, Sebastian Wendt, Carina Benstoem, Christina Neubauer, Patrick Meybohm, Pascal Langlois, Neill Kj Adhikari, Daren K Heyland, Christian Stoppe
The pleiotropic biochemical and antioxidant functions of vitamin C have sparked recent interest in its application in intensive care. Vitamin C protects important organ systems (cardiovascular, neurologic and renal systems) during inflammation and oxidative stress. It also influences coagulation and inflammation; its application might prevent organ damage. The current evidence of vitamin C's effect on pathophysiological reactions during various acute stress events (such as sepsis, shock, trauma, burn and ischemia-reperfusion injury) questions whether the application of vitamin C might be especially beneficial for cardiac surgery patients who are routinely exposed to ischemia/reperfusion and subsequent inflammation, systematically affecting different organ systems...
July 27, 2018: Nutrients
https://www.readbyqxmd.com/read/30029205/combined-vitamin-c-hydrocortisone-and-thiamine-therapy-for-patients-with-severe-pneumonia-who-were-admitted-to-the-intensive-care-unit-propensity-score-based-analysis-of-a-before-after-cohort-study
#5
Won-Young Kim, Eun-Jung Jo, Jung Seop Eom, Jeongha Mok, Mi-Hyun Kim, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Kwangha Lee
PURPOSE: To evaluate the efficacy of combined vitamin C, hydrocortisone, and thiamine in patients with severe pneumonia. MATERIALS AND METHODS: All consecutive patients with severe pneumonia who were treated with the vitamin C protocol (6 g of vitamin C per day) in June 2017-January 2018 (n = 53) were compared to all consecutive patients with severe pneumonia who were treated in June 2016-January 2017 (n = 46). Propensity score analysis was used to adjust for potential baseline differences between the groups...
July 5, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/30021102/applications-of-vitamin-d-in-sepsis-prevention
#6
Fernanda A C Takeuti, Fernando de S F Guimaraes, Paulo de S F Guimaraes
Vitamin D (VD) is a steroid prohormone that regulates the body's calcium and phosphate levels in bone mineralization. It is also well described as a fat-soluble vitamin playing an important role in immunomodulation, regulation of cytokines, and cell proliferation. Thus, VD is a powerful hormone with pleiotropic effects, which acts to maintain optimal health. Recent studies demonstrate that VD deficiency is associated with the development of cardiovascular diseases, autoimmune disorders, and various types of cancer, each associated with increased mortality rates...
June 2018: Discovery Medicine
https://www.readbyqxmd.com/read/30016204/mild-therapeutic-hypothermia-increases-glutathione-levels-in-postcardiac-arrest-patients
#7
Fernanda S Hackenhaar, Tássia M Medeiros, Fernanda M Heemann, Camile S Behling, Camila D Mahl, Cleber Verona, Ana Carolina A Silva, Vanessa Martins Oliveira, Diego F M Riveiro, Silvia R R Vieira, Mara S Benfato
Ischemia-reperfusion (I/R)-induced oxidative stress is one of the main mechanisms of tissue injury after cardiac arrest (CA). A decrease in antioxidant defenses may contribute to I/R injury. The present study aims to investigate the influence of mild therapeutic hypothermia (MTH) on levels of nonenzymatic antioxidants after CA. We investigated antioxidant levels at 6, 12, 36, and 72 hours after CA in central venous blood samples of patients admitted to intensive care. The sample consisted of 31 patients under controlled normothermia (36°C) and 11 patients treated with 24 hours of MTH (33°C)...
July 17, 2018: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/30016025/results-of-the-implementation-of-a-nutritional-support-protocol-for-major-burn-pediatric-patients-hospitalized-in-the-intensive-care-unit
#8
Nidia Tramonti, Jimena Lema, María B Araujo, Hugo Basílico, Rosa M Villasboas, Santiago Laborde, Gabriela D'Isa, Carolina Caminiti
INTRODUCTION: "Major burn" is used to describe a person who suffers thermal damage affecting more than 30% of his/her total body surface area (TBSA). The secondary hypercatabolism causes lean body mass loss and delayed wound healing. OBJECTIVE: To describe and analyze the results of implementing a nutritional support protocol for pediatric burn patients hospitalized in the intensive care unit in the first 6 weeks. POPULATION AND METHODS: Analytical, prospective, observational, and longitudinal design...
August 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/30006615/vitamin-d-deficiency-and-clinical-outcomes-related-to-septic-shock-in-children-with-critical-illness-a-systematic-review
#9
REVIEW
Yu Wang, Changsong Shi, Zhongwen Yang, Fengmin Chen, Li Gao
PURPOSE: Low vitamin D blood levels are related to many clinical outcomes in children with critically illness. However, the relationship of it and septic shock has not been systematically analyzed. The objective of this review was to evaluate the effect of vitamin D on septic shock and predict if vitamin D administration can improve prognosis of it. MATERIALS AND METHODS: Online databases were searched up to June 1st, 2017 for studies on the relation of vitamin D deficiency (VDD) and clinical outcomes on septic shock in children with critical illness...
July 13, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30003852/association-of-vitamin-d-deficiency-with-an-increased-risk-of-late-onset-neonatal-xepsis
#10
Rajeshwari Dhandai, Mamta Jajoo, Amitabh Singh, Anirban Mandal, Rahul Jain
Background Vitamin D deficiency in mothers and neonates is being recognised increasingly as a leading cause of many adverse health effects in the newborn infant, including sepsis. Methods A prospective observational study was conducted at a tertiary care Paediatric teaching hospital in northern India to assess vitamin D deficiency as a possible risk factor for late-onset sepsis (LOS) in term and late preterm neonates and also to examine the correlation between maternal and infant vitamin D levels during the neonatal period...
July 13, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29978524/low-serum-vitamin-d-level-is-associated-with-intrahepatic-cholestasis-of-pregnancy
#11
Gulenay Gençosmanoğlu Türkmen, Zehra Vural Yilmaz, Korkut Dağlar, Özgür Kara, Cem Yaşar Sanhal, Aykan Yücel, Dilek Uygur
AIM: Intrahepatic cholestasis of pregnancy (ICP) is a unique hepatic disorder of pregnancy and is related to adverse maternal and perinatal outcomes. The pathogenesis of the disease is not clear and appears to be multifactorial. There is increasing evidence that vitamin D (Vit D) plays a role in hepatobiliary homeostasis and in various liver diseases. We aimed to investigate the association between serum Vit D level and ICP. METHODS: A total of 40 pregnant women with ICP and 40 healthy pregnant women were included in this controlled cross-sectional study...
July 6, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29968401/vitamin-c-deficiency-in-australian-hospitalized-patients-an-observational-study
#12
Yogesh Sharma, Michelle Miller, Rashmi Shahi, Adrienne Doyle, Chris Horwood, Paul Hakendorf, Campbell Thompson
BACKGROUND: Vitamin C has anti-oxidant properties and acts as a co-factor for a number of enzymes. Hypovitaminosis C has been associated with bleeding, endothelial dysfunction and death. The prevalence of hypovitaminosis C is unknown in Australian hospitalized patients and its clinical relevance is uncertain. AIMS: To determine prevalence, characteristics and clinical outcomes of hospitalized patients with hypovitaminosis C. METHODS: This observational study included general-medical inpatients in a tertiary-level hospital in Australia...
July 3, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29914229/effect-of-vitamin-d-deficiency-in-korean-patients-with-acute-respiratory-distress-syndrome
#13
Sojung Park, Min Gi Lee, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin Won Huh
Background/Aims: Vitamin D modulates innate and adaptive immune responses, and vitamin D deficiency is associated with increased mortality in hospitalized patients with pneumonia. We evaluated the prevalence of vitamin D deficiency in Korean patients with acute respiratory distress syndrome (ARDS) and its effect on the clinical outcomes of ARDS. Methods: We retrospectively analyzed the data of 108 patients who had a measured serum level of 25-hydroxy vitamin D3 (25(OH)D3) at the time of diagnosis with ARDS...
June 20, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29898141/selenium-vitamin-c-and-n-acetylcysteine-do-not-reduce-the-risk-of-acute-kidney-injury-after-off-pump-cabg-a-randomized-clinical-trial
#14
Shahram Amini, Hojat Naghavi Robabi, Mohammad Abbasi Tashnizi, Vida Vakili
OBJECTIVE: The aim of this study was to investigate the impact of perioperative administration of N-acetylcysteine, selenium and vitamin C on the incidence and outcomes of acute kidney injury after off-pump coronary bypass graft surgery. METHODS: 291 patients requiring elective off-pump coronary bypass graft surgery were randomized to receive either N-acetylcysteine, vitamin C and selenium 600 mg, 1500 mg, 0.5 mg, and nothing orally twice a day, respectively, from the day before to 2 days after surgery...
March 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29871746/effect-of-calcitriol-on-in-vitro-whole-blood-cytokine-production-in-critically-ill-dogs
#15
J A Jaffey, J Amorim, A E DeClue
Hypovitaminosis D has been identified as a predictor of mortality in human beings, dogs, cats and foals. However, the immunomodulatory effects of vitamin D in critically ill dogs has not been evaluated. The aim of this study was to evaluate the effect of calcitriol on cytokine production from whole blood collected from critically ill dogs in vitro. Twelve critically ill dogs admitted to a veterinary intensive care unit (ICU) were enrolled in a prospective cohort study. Whole blood from these dogs was incubated with calcitriol (2×10-7 M) or ethanol (control) for 24h...
June 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29813153/association-between-vitamin-d-supplementation-during-pregnancy-and-offspring-growth-morbidity-and-mortality-a-systematic-review-and-meta-analysis
#16
Wei Guang Bi, Anne Monique Nuyt, Hope Weiler, Line Leduc, Christina Santamaria, Shu Qin Wei
Importance: Whether vitamin D supplementation during pregnancy is beneficial and safe for offspring is unclear. Objective: To systematically review studies of the effects of vitamin D supplementation during pregnancy on offspring growth, morbidity, and mortality. Data Sources: Searches of Medline, Embase, and the Cochrane Database of Systematic Reviews were conducted up to October 31, 2017. Key search terms were vitamin D, pregnancy, randomized controlled trials, and offspring outcomes...
July 1, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29800180/effect-of-vitamin-d-supplementation-on-recurrent-wheezing-in-black-infants-who-were-born-preterm-the-d-wheeze-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Anna Maria Hibbs, Kristie Ross, Leigh Ann Kerns, Carol Wagner, Mamta Fuloria, Sharon Groh-Wargo, Teresa Zimmerman, Nori Minich, Curtis Tatsuoka
Importance: Black infants born preterm face high rates of recurrent wheezing throughout infancy. Vitamin D supplementation has the potential to positively or negatively affect wheezing through modulation of the pulmonary and immune systems. Objective: To assess the effectiveness of 2 vitamin D dosing strategies in preventing recurrent wheezing. Design, Setting, and Participants: A randomized clinical trial enrolled 300 black infants born at 28 to 36 weeks' gestation between January 2013 and January 2016 at 4 sites in the United States, and followed them up through March 2017...
May 22, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29795471/early-weight-loss-outcomes-from-a-newly-established-hospital-affiliated-specialized-obesity-care-delivery-model-in-central-florida
#18
Gitanjali Srivastava, Cynthia Buffington
SIGNIFICANCE: We evaluated weight loss outcomes in a newly established hospital-affiliated, physician-directed multidisciplinary, and personalized obesity care model. METHODS: Fifty established patients in a specialized obesity medicine practice underwent intensive lifestyle intervention ±adjunctive pharmacotherapy (46/50) for >6 consecutive months and when required, psychological intervention. We identified demographics, obesity-related comorbidities, anthropometric changes over time, and laboratory screen...
May 24, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29792375/knowledge-and-attitudes-of-family-doctors-dermatologists-and-endocrinologists-on-sun-exposure-and-vitamin-d
#19
Arif Abu-Abed, Said Azbarga, Roni Peleg
OBJECTIVES: Vitamin D is an important component of bone metabolism. Skin cells synthesize vitamin D when exposed to the sun. However, prolonged sun exposure damages the skin and increases the risk for skin cancer. The objective is to evaluate and compare the attitudes and recommendations of family doctors, dermatologists, and endocrinologists on exposure to the sun and vitamin D. METHODS: In a cross-sectional study, a questionnaire was completed by personal interview in a study population of 78 family doctors, 21 dermatologists, and 22 endocrinologists...
June 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29775620/a-monoclonal-antibody-sandwich-elisa-for-vitamin-d-binding-protein-vdbp-is-unaffected-by-gc-globulin-phenotype-peptides-and-actin-and-demonstrates-reduced-levels-in-sepsis-and-non-sepsis-intensive-care-patients
#20
Katrina Hong, Christopher M Florkowski, Matthew P Doogue, Peter A Elder, John G Lewis
The measurement of vitamin D-binding protein (VDBP) by immunoassay has been confounded by variable antibody recognition of the Gc1s, Gc1F and Gc2 phenotypes. This has led to spurious conclusions regarding vitamin D status in different ethnic groups. In order to overcome these problems there is a requirement for VDBP antibodies that are unaffected by phenotype status. Here we report the generation and testing of three monoclonal antibodies to VDBP which recognise linear epitopes and are unaffected by vast molar excesses of synthetic peptides spanning these phenotypic domains...
September 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
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