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Endothelial progenitor cells

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https://www.readbyqxmd.com/read/29330760/oxidized-phospholipids-stimulate-production-of-stem-cell-factor-via-nrf2-dependent-mechanisms
#1
Taras Afonyushkin, Olga V Oskolkova, Valery N Bochkov
Receptor tyrosine kinase c-Kit and its ligand stem cell factor (SCF) regulate resident vascular wall cells and recruit circulating progenitors. We tested whether SCF may be induced by oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) known to accumulate in atherosclerotic vessels. Gene expression analysis demonstrated OxPAPC-induced upregulation of SCF mRNA and protein in different types of endothelial cells (ECs). Elevated levels of SCF mRNA were observed in aortas of ApoE-/- knockout mice. ECs produced biologically active SCF because conditioned medium from OxPAPC-treated cells stimulated activation (phosphorylation) of c-Kit in naïve ECs...
January 12, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29328364/genetically%C3%A2-modified-stem-cells-in-treatment-of-human-diseases-tissue-kallikrein-klk1-%C3%A2-based-targeted-therapy-review
#2
Marina Devetzi, Maria Goulielmaki, Nicolas Khoury, Demetrios A Spandidos, Georgia Sotiropoulou, Ioannis Christodoulou, Vassilis Zoumpourlis
The tissue kallikrein‑kinin system (KKS) is an endogenous multiprotein metabolic cascade which is implicated in the homeostasis of the cardiovascular, renal and central nervous system. Human tissue kallikrein (KLK1) is a serine protease, component of the KKS that has been demonstrated to exert pleiotropic beneficial effects in protection from tissue injury through its anti‑inflammatory, anti‑apoptotic, anti‑fibrotic and anti‑oxidative actions. Mesenchymal stem cells (MSCs) or endothelial progenitor cells (EPCs) constitute populations of well‑characterized, readily obtainable multipotent cells with special immunomodulatory, migratory and paracrine properties rendering them appealing potential therapeutics in experimental animal models of various diseases...
January 3, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29316425/hedgehog-pathway-drives-fusion-negative-rhabdomyosarcoma-initiated-from-non-myogenic-endothelial-progenitors
#3
Catherine J Drummond, Jason A Hanna, Matthew R Garcia, Daniel J Devine, Alana J Heyrana, David Finkelstein, Jerold E Rehg, Mark E Hatley
Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma that histologically resembles embryonic skeletal muscle. RMS occurs throughout the body and an exclusively myogenic origin does not account for RMS occurring in sites devoid of skeletal muscle. We previously described an RMS model activating a conditional constitutively active Smoothened mutant (SmoM2) with aP2-Cre. Using genetic fate mapping, we show SmoM2 expression in Cre-expressing endothelial progenitors results in myogenic transdifferentiation and RMS...
January 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29312602/tanshinone-iia-inhibits-angiogenesis-in-human-endothelial-progenitor-cells-in-vitro-and-in-vivo
#4
Hsiang-Ping Lee, Yueh-Ching Liu, Po-Chun Chen, Huai-Ching Tai, Te-Mao Li, Yi-Chin Fong, Chih-Shiang Chang, Min-Huan Wu, Li-Pin Chiu, Chia-Jung Wang, Yi-Hsuan Chen, Yih-Jer Wu, Chih-Hsin Tang, Shih-Wei Wang
Accumulating evidence reports that bone marrow-derived endothelial progenitor cells (EPCs) regulate angiogenesis, postnatal neovascularization and tumor metastasis. It has been suggested that understanding the molecular targets and pharmacological functions of natural products is important for novel drug discovery. Tanshinone IIA is a major diterpene quinone compound isolated from Danshen (Salvia miltiorrhiza) and is widely used in traditional Chinese medicine (TCM). Evidence indicates that tanshinone IIA modulates angiogenic functions in human umbilical vein endothelial cells...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29311692/surface-functionalization-of-electrospun-scaffolds-using-recombinant-human-decorin-attracts-circulating-endothelial-progenitor-cells
#5
Svenja Hinderer, Katrin Sudrow, Maria Schneider, Monika Holeiter, Shannon Lee Layland, Martina Seifert, Katja Schenke-Layland
Decorin (DCN) is an important small leucine-rich proteoglycan present in the extracellular matrix (ECM) of many organs and tissues. Endothelial progenitor cells (EPCs) are able to interact with the surrounding ECM and bind to molecules such as DCN. Here, we recombinantly produced full-length human DCN under good laboratory practice (GLP) conditions, and after detailed immunological characterization, we investigated its potential to attract murine and human EPCs (mEPCs and hECFCs). Electrospun polymeric scaffolds were coated with DCN or stromal cell-derived factor-1 (SDF-1α) and were then dynamically cultured with both cell types...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311656/defining-murine-organogenesis-at-single-cell-resolution-reveals-a-role-for-the-leukotriene-pathway-in-regulating-blood-progenitor-formation
#6
Ximena Ibarra-Soria, Wajid Jawaid, Blanca Pijuan-Sala, Vasileios Ladopoulos, Antonio Scialdone, David J Jörg, Richard C V Tyser, Fernando J Calero-Nieto, Carla Mulas, Jennifer Nichols, Ludovic Vallier, Shankar Srinivas, Benjamin D Simons, Berthold Göttgens, John C Marioni
During gastrulation, cell types from all three germ layers are specified and the basic body plan is established 1 . However, molecular analysis of this key developmental stage has been hampered by limited cell numbers and a paucity of markers. Single-cell RNA sequencing circumvents these problems, but has so far been limited to specific organ systems 2 . Here, we report single-cell transcriptomic characterization of >20,000 cells immediately following gastrulation at E8.25 of mouse development. We identify 20 major cell types, which frequently contain substructure, including three distinct signatures in early foregut cells...
January 8, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29310805/basic-components-of-vascular-connective-tissue-and-extracellular-matrix
#7
Jaroslava Halper
Though the composition of the three layers constituting the blood vessel wall varies among the different types of blood vessels, and some layers may even be missing in capillaries, certain basic components, and properties are shared by all blood vessels, though each histologically distinct layer contains a unique complement of extracellular components, growth factors and cytokines, and cell types as well. The structure and composition of vessel layers informs and is informed by the function of the particular blood vessel...
2018: Advances in Pharmacology
https://www.readbyqxmd.com/read/29304136/effect-of-intensive-multifactorial-treatment-on-vascular-progenitor-cells-in-hypertensive-patients
#8
Charbel Maroun-Eid, Adriana Ortega-Hernández, Javier Modrego, María Abad-Cardiel, José Antonio García-Donaire, Leonardo Reinares, Nieves Martell-Claros, Dulcenombre Gómez-Garre
BACKGROUND: Most hypertensive patients, despite a proper control of their cardiovascular risk factors, have cardiovascular complications, evidencing the importance of controlling and/or reversing target-organ damage. In this sense, endothelial dysfunction has been associated with the presence of cardiovascular risk factors and related cardiovascular outcomes. Since hypertension often clusters with other risk factors such as dyslipemia, diabetes and obesity, in this study we have investigated the effect of intensive multifactorial treatment on circulating vascular progenitor cell levels on high-risk hypertensive patients...
2018: PloS One
https://www.readbyqxmd.com/read/29300991/effects-of-hypoglycaemia-on-circulating-stem-and-progenitor-cells-in-diabetic-patients
#9
Gian Paolo Fadini, Federico Boscari, Roberta Cappellari, Silvia Galasso, Mauro Rigato, Benedetta Maria Bonora, Marianna D'Anna, Daniela Bruttomesso, Angelo Avogaro
Context: Iatrogenic hypoglycaemia is the most common acute diabetic complication and it significantly increases morbidity. In people with diabetes, reduction in the levels of circulating stem and progenitor cells predicts adverse outcomes. Objective: To evaluate whether hypoglycaemia in diabetes affects circulating stem cells and endothelial progenitor cells (EPCs). Design: We performed an experimental hypoglycaemia study (study 1) and a case-control study (study 2)...
December 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29298774/kidney-transplantation-in-a-patient-lacking-cytosolic-phospholipase-a2-proves-renal-origins-of-urinary-pgi-m-and-tx-m
#10
Jane Mitchell, Rebecca B Knowles, Nicholas S Kirkby, Daniel M Reed, Matthew L Edin, William E White, Melissa V Chan, Hilary Longhurst, Magdi Yaqoob, Ginger L Milne, Darryl C Zeldin, Timothy D Warner
Rationale: The balance between vascular prostacyclin which is anti-thrombotic and platelet thromboxane A2 which is pro-thrombotic is fundamental to cardiovascular health. Prostacyclin and thromboxane A2 are formed following the concerted actions of cytosolic phospholipase A2 (cPLA2α) and cyclooxygenase. Urinary 2,3-dinor-6-keto PGF1α (PGI-M) and 11-dehydro-TXB2 (TX-M) have been taken as biomarkers of prostacyclin and thromboxane A2 formation with the circulation and used to explain cyclooxygenase biology and patient phenotypes, despite concerns that urinary PGI-M and TX-M originate in the kidney...
January 3, 2018: Circulation Research
https://www.readbyqxmd.com/read/29296963/novel-tpo-receptor-agonist-ta-316-contributes-to-platelet-biogenesis-from-human-ips-cells
#11
Ayako Aihara, Tomo Koike, Natsuki Abe, Sou Nakamura, Akira Sawaguchi, Takanori Nakamura, Naoshi Sugimoto, Hiromitsu Nakauchi, Taito Nishino, Koji Eto
Signaling by thrombopoietin (TPO) in complex with its receptor, c-MPL, is critical for hematopoietic stem cell (HSC) homeostasis and platelet generation. Here we show that TA-316, a novel chemically synthesized c-MPL agonist (CMA), is useful for ex vivo platelet generation from human-induced pluripotent stem (iPS) cell-derived immortalized megakaryocyte progenitor cell lines (imMKCLs). Moreover, the generation is clinically applicable, because self-renewal expansion and platelet release is tightly controllable...
February 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29296840/two-distinct-cxcr4-antagonists-mobilize-progenitor-cells-in-mice-by-different-mechanisms
#12
Andia N Redpath, Moïra François, Suet-Ping Wong, Dominique Bonnet, Sara M Rankin
Pharmacological mobilization of hematopoietic progenitor cells (HPCs) is used clinically to harvest HPCs for bone marrow transplants. It is now widely accepted that the CXCR4:CXCL12 chemokine axis plays a critical role in the retention of HPCs in the bone marrow, and CXCR4 antagonists have been developed for their mobilization. The first of this class of drugs to be US Food and Drug Administration-approved was the bicyclam AMD3100. In addition to mobilizing HPCs and leukocytes in naïve mice, AMD3100 has been shown to mobilize mesenchymal progenitor cells (MPCs) in vascular endothelial growth factor (VEGF-A) pretreated mice...
October 10, 2017: Blood Advances
https://www.readbyqxmd.com/read/29296222/effect-of-cilostazol-on-plasma-levels-of-proprotein-convertase-subtilisin-kexin-type-9
#13
I-Chih Chen, Wei-Kung Tseng, Yi-Heng Li, Shih-Ya Tseng, Ping-Yen Liu, Ting-Hsing Chao
The protein complex proprotein convertase subtilisin/kexin type 9 (PCSK9) serves as an important target for the prevention and treatment of atherosclerosis and lipid homeostasis. This study investigated the effect of cilostazol on plasma PCSK9 concentrations. We performed a post hoc analysis of two prospective, double-blind, randomized controlled trials including 115 patients of whom 61 received cilostazol 200 mg/day and 54 received placebo for 12 weeks. Linear regression analysis was performed to determine the associations between several parameters and changes in PCSK9 levels...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288170/atorvastatin-enhances-bone-marrow-endothelial-cell-function-in-corticosteroid-resistant-immune-thrombocytopenia-patients
#14
Yuan Kong, Xie-Na Cao, Xiao-Hui Zhang, Min-Min Shi, Yue-Yun Lai, Yu Wang, Lan-Ping Xu, Ying-Jun Chang, Xiao-Jun Huang
The pathogenesis of corticosteroid-resistant immune thrombocytopenia (ITP), a clinically challenging condition in which patients exhibit either no response to corticosteroids or are corticosteroid-dependent, remains poorly understood. Murine studies suggest that bone marrow (BM) endothelial progenitor cells (EPCs) play a crucial role in regulating megakaryocytopoiesis. However, little is known regarding the number and function of BM EPCs or how to improve impaired BM EPCs in corticosteroid-resistant ITP patients...
December 29, 2017: Blood
https://www.readbyqxmd.com/read/29278309/monotropein-promotes-angiogenesis-and-inhibits-oxidative-stress-induced-autophagy-in-endothelial-progenitor-cells-to-accelerate-wound-healing
#15
Chenggui Wang, Cong Mao, Yiting Lou, Jianxiang Xu, Qingqing Wang, Zengjie Zhang, Qian Tang, Xiaolei Zhang, Huazi Xu, Yongzeng Feng
Attenuating oxidative stress-induced damage and promoting endothelial progenitor cell (EPC) differentiation are critical for ischaemic injuries. We suggested monotropein (Mtp), a bioactive constituent used in traditional Chinese medicine, can inhibit oxidative stress-induced mitochondrial dysfunction and stimulate bone marrow-derived EPC (BM-EPC) differentiation. Results showed Mtp significantly elevated migration and tube formation of BM-EPCs and prevented tert-butyl hydroperoxide (TBHP)-induced programmed cell death through apoptosis and autophagy by reducing intracellular reactive oxygen species release and restoring mitochondrial membrane potential, which may be mediated viamTOR/p70S6K/4EBP1 and AMPK phosphorylation...
December 26, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29274477/intrafibrillar-silicified-collagen-scaffold-promotes-in-situ-bone-regeneration-by-activating-the-monocyte-p38-signaling-pathway
#16
Jin-Long Sun, Kai Jiao, Qun Song, Chu-Fan Ma, Chao Ma, Franklin R Tay, Li-Na Niu, Ji-Hua Chen
Intrafibrillar silicified collagen scaffold (SCS) is a promising biomaterial for bone regeneration because it promotes cell homing and angiogenesis in bone defects via monocyte modulation. In the present study, a rat femoral defect model was used to examine the contribution of monocyte signaling pathways to SCS modulation. Activation of the monocyte p38 signaling pathway by SCS resulted in monocyte differentiation into TRAP-positive mononuclear cells. These cells demonstrated increased secretion of SDF-1α, VEGFa and PDGF-BB, which, in turn, promoted homing of bone marrow stromal cells (BMSCs) and endothelial progenitor cells (EPCs), as well as local vascularization...
December 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29274061/tgf%C3%AE-signaling-reinforces-pericyte-properties-of-the-non-endocrine-mouse-pituitary-cell-line-ttt-gf
#17
Takehiro Tsukada, Saishu Yoshida, Keiji Kito, Ken Fujiwara, Hideji Yako, Kotaro Horiguchi, Yukinobu Isowa, Takashi Yashiro, Takako Kato, Yukio Kato
The non-endocrine TtT/GF mouse pituitary cell line was derived from radiothyroidectomy-induced pituitary adenoma. In addition to morphological characteristics, because the cells are S100β-positive, they have been accepted as a model of folliculostellate cells. However, our recent microarray analysis indicated that, in contrast to folliculostellate cells, TtT/GF cells might not be terminally differentiated, as they share some properties with stem/progenitor cells, vascular endothelial cells and pericytes. The present study investigates whether transforming growth factor beta (TGFβ) can elicit further differentiation of these cells...
December 22, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29273744/pitavastatin-nanoparticle-engineered-endothelial-progenitor-cells-repair-injured-vessels
#18
Huanyun Liu, Pang Bao, Lufeng Li, Yuqing Wang, Chunxin Xu, Mengyang Deng, Jihang Zhang, Xiaohui Zhao
Endothelial progenitor cells (EPC) participate in vessel recovery and maintenance of normal endothelial function. Therefore, pitavastatin-nanoparticles (NPs)-engineered EPC may be effective in repairing injured vasculature. Pitavastatin-loaded poly(lactic-co-glycolic) acid (PLGA) NPs were obtained via ultrasonic emulsion solvent evaporation with PLGA as the carrier encapsulating pitavastatin. The effects and mechanism of pitavastatin-NPs on EPC proliferation in vitro were evaluated. Then, EPC that internalized pitavastatin-NPs were transplanted into rats after carotid artery injury...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29273331/systemic-biopolymer-delivered-vascular-endothelial-growth-factor-promotes-therapeutic-angiogenesis-in-experimental-renovascular-disease
#19
Alejandro R Chade, Maxx L Williams, Erika Guise, Luke J Vincent, Taylor W Harvey, Marija Kuna, Fakhri Mahdi, Gene L Bidwell
We recently developed a therapeutic biopolymer composed of an elastin-like polypeptide (ELP) fused to vascular endothelial growth factor (VEGF) and showed long-term renoprotective effects in experimental renovascular disease after a single intra-renal administration. Here, we sought to determine the specificity, safety, efficacy, and mechanisms of renoprotection of ELP-VEGF after systemic therapy in renovascular disease. We tested whether kidney selectivity of the ELP carrier would reduce off-target binding of VEGF in other organs...
December 19, 2017: Kidney International
https://www.readbyqxmd.com/read/29259281/effects-of-resistance-exercise-on-endothelial-progenitor-cell-mobilization-in-women
#20
Fernando Ribeiro, Ilda P Ribeiro, Ana C Gonçalves, Alberto J Alves, Elsa Melo, Raquel Fernandes, Rui Costa, Ana B Sarmento-Ribeiro, José A Duarte, Isabel M Carreira, Sarah Witkowski, José Oliveira
This study aimed to determine the effect of a single bout of resistance exercise at different intensities on the mobilization of circulating EPCs over 24 hours in women. In addition, the angiogenic factors stromal cell-derived factor 1 (SDF-1α), vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1α) and erythropoietin (EPO) were measured as potential mechanisms for exercise-induced EPCs mobilization. Thirty-eight women performed a resistance exercise session at an intensity of 60% (n = 13), 70% (n = 12) or 80% (n = 13) of one repetition maximum...
December 19, 2017: Scientific Reports
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