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Jacopo A Vitale, Giuseppe Banfi, Ennio Belli, Francesco Negrini, Antonio La Torre
BACKGROUND: Isolated patellar tendon rupture (PTR) is the final stage of a long-standing tendon chronic degeneration. PTR requires immediate repair in order to avoid important muscle retraction and tendon fibrosis. The aim was to describe the effects of a rehabilitation protocol after chronic-degenerative PTR on subjective functional outcomes, knee range of motion (ROM), size, and strength in a professional football player. CASE REPORT: A 26-years-old football player who experienced RPT after a 3-year history of proximal patellar tendinopathy...
December 14, 2018: European Journal of Physical and Rehabilitation Medicine
Caroline Desprès
The purpose of this article is to analyse healthcare pathways for precarious people, based on the results of a field study conducted in 2011 and 2012 in the north of France and Burgundy. About 40 semi-directed interviews were conducted in order to collect healthcare pathways narratives revolving around various health events during the subject's life, and putting them in perspective with individual, familial stories as well as their environment (social environment, healthcare organization, etc.).The results indicate various types of determinants, firstly concerning norms and rules determining access to health insurance and health services...
September 6, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
Robert A Yokel
The role and functional anatomy of the blood-brain barrier (BBB) is summarized to enable the investigator to appropriately address evaluation of nanomaterial interaction with, and distribution across, it into brain tissue (parenchyma). Transport mechanisms across the BBB are presented, in relation to nanomaterial physicochemical properties. Measures and test substances to assess BBB integrity/disruption/permeation are introduced, along with how they are used to interpret the results obtained with the presented methods...
2019: Methods in Molecular Biology
Vernon G Thomas
The chemical composition of non-lead, non-toxic, gunshot used for hunting waterfowl is regulated only in Canada and the USA. No nation regulates the composition of non-lead fishing weights, rifle bullets, and gunshot used for upland game hunting. Compositional criteria for these non-lead products are proposed here, based on established experimental toxicity protocols. Because of the demonstrated acute toxicity of ingested zinc shot to birds, fishing weights and gunshot should never be made of this pure metal...
December 13, 2018: Ambio
Toni Meier, Kira Gräfe, Franziska Senn, Patrick Sur, Gabriele I Stangl, Christine Dawczynski, Winfried März, Marcus E Kleber, Stefan Lorkowski
This study was performed to highlight the relationship between single dietary risk factors and cardiovascular diseases (CVDs) in the WHO European Region. We used the comparative risk assessment framework of the Global Burden of Disease Study to estimate CVD mortality attributable to diet; comprising eleven forms of CVDs, twelve food and nutrient groups and 27 risk-outcome pairs in four GBD regions including 51 countries by age and sex between 1990 and 2016. In 2016, dietary risks were associated with 2.1 million cardiovascular deaths (95% uncertainty interval (UI), 1...
December 14, 2018: European Journal of Epidemiology
Vito De Blasi, Silviu-Tiberiu Makkai-Popa, Luca Arru, Patrick Pessaux, Juan Santiago Azagra
PURPOSE: Our aim is to present a rare case of anatomic variation of the arterial blood supply to the liver because preoperative knowledge of hepatic vascular variations is mandatory in hepatic surgery and liver transplantation. METHODS: We present a case of unusual arterial blood supply to the liver, a right hepatic artery coming from the splenic artery, associated to a classical common hepatic artery and a left hepatic artery from the left gastric artery. Preoperative diagnosis was made using CT-scan and 3D reconstruction...
December 13, 2018: Surgical and Radiologic Anatomy: SRA
Guillaume P Ramstein, Sarah E Jensen, Edward S Buckler
In the past, plant breeding has undergone three major transformations and is currently transitioning to a new technological phase, Breeding 4. This phase is characterized by the development of methods for biological design of plant varieties, including transformation and gene editing techniques directed toward causal loci. The application of such technologies will require to reliably estimate the effect of loci in plant genomes by avoiding the situation where the number of loci assayed (p) surpasses the number of plant genotypes (n)...
December 13, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
José Raul Herance, Hermenegildo García, Patricia Gutiérrez-Carcedo, Sergio Navalón, Antonio Pineda-Lucena, Martina Palomino-Schätzlein
Gold nanoparticles have high potential in the biomedical area, especially in disease diagnosis and treatment. The application of these nanoparticles requires the presence of stabilizers to avoid their agglomeration. Nowadays, there is a lack of reliable methods for characterising the effect of stabilised nanoparticles on biological systems. To this end, in this study, we apply an experimental approach based on nuclear magnetic resonance spectroscopy to study the effect of gold nanoparticles, stabilised with cerium oxide or chitosan, on a human cancer cell model...
December 14, 2018: Analyst
Joseph L Laratta, Jamal N Shillingford, Joshua S Meredith, Lawrence G Lenke, Ronald A Lehman, Jeffrey L Gum
Achieving fixation and fusion across the lumbosacral junction has been a challenge for spinal deformity surgeons ever since the development of instrumentation. The S2 alar-iliac (S2AI) trajectory has been introduced as a method of pelvic fixation to decrease strain on S1 screws. The S2AI screws differ in several ways from traditional iliac screws. The trajectory of these screws helps avoid the use of offset connectors due to the screws alignment with the proximal pedicle screw instrumentation. Current literature shows that S2AI screws are effective with low complication rates, but the path of these screws is intimately associated with major neural and vascular structures...
September 2018: Journal of Spine Surgery (Hong Kong)
Chester J Donnally, Augustus J Rush, Sebastian Rivera, Rushabh M Vakharia, Ajit M Vakharia, Dustin H Massel, Frank J Eismont
Background: To determine if the timing of a lumbar epidural steroid injection (LESI) effects rates of post-operative infection in patients receiving a non-fusion lumbar decompression (LDC) due to degenerative disc disease (DDD). Lumbar pain due to DDD can frequently be temporized or definitively treated with epidural injections. While there is ample literature regarding the infection risks associated with corticosteroid injections prior to hip/knee replacements, there are few studies relating to the spine...
September 2018: Journal of Spine Surgery (Hong Kong)
Igor Larrañaga, Panos Stafylas, Ane Fullaondo, Gian Matteo Apuzzo, Javier Mar
Introduction: An integrated health and social care program for patients with heart failure (HF) was implemented at the Friuli-Venezia Giulia deployment site as part of the SmartCare European project. The objective of this study was to validate 2 different decision modeling techniques used to perform the economic evaluation. Methods: Data were collected during the SmartCare project which enrolled 108 patients with HF and followed for more than 6 months. The techniques used were Markov and discrete event simulation models...
January 2018: Health Services Research and Managerial Epidemiology
Ludger Klimek, Thomas Kündig, Matthias F Kramer, Sonja Guethoff, Erika Jensen-Jarolim, Carsten B Schmidt-Weber, Oskar Palomares, Mona O Mohsen, Thilo Jakob, Martin Bachmann
Background: Apart from active allergen avoidance, immunotherapy is regarded as the most effective form of treatment available for type I allergies. Such treatments involve the administration of allergen preparations in various forms and by various routes. Virus-like particles (VLPs) offer a very effective platform for immunization with the allergen and are characterized by high immunogenicity, low allergenicity and high clinical efficacy. Formulations that include Toll-like receptor ligands, T cell stimulatory epitopes and/or depot-forming adjuvants appear to enhance activation of the relevant immune cells...
2018: Allergo Journal International
Driss Raissi, Qian Yu, S Houssam Mardini
Endoscopic intervention is well validated for the control of upper gastrointestinal bleeding (UGIB). In cases of refractory bleeding, transarterial embolization is a safe and effective alternative. Ethylene vinyl alcohol (EVOH) commonly known as Onyx® is an inherently black liquid embolic approved for use in cerebrovascular arteriovenous malformations and is increasingly used as an embolic agent in multiple peripheral and visceral territories. Onyx® has a uniquely undesirable property of causing black color discoloration when used in peripheral applications adjacent to the skin akin to a "tattoo effect...
2018: Journal of Clinical Imaging Science
Elin Salemonsen, Britt Sætre Hansen, Georg Førland, Anne Lise Holm
Background: Overweight and obesity are complex conditions, associated with a wide range of serious health issues. In contemporary society, body size is an important part of a person's self-representation. Lifestyle changes are difficult and long-term weight management is associated with a high risk of failure. In primary health care in Norway, lifestyle interventions are offered by Healthy Life Centres (HLCs) to those seeking help with weight management. The aim of this study was to explore HLC participants' experiences of living with overweight or obesity and perceptions of seeking help to change dietary and activity habits...
2018: BMC Obesity
Chirn-Bin Chang, Hsiu-Yun Lai, Shinn-Jang Hwang, Shu-Yu Yang, Ru-Shu Wu, Hsing-Cheng Liu, Ding-Cheng Chan
Background: PIM-Taiwan criteria were first established in 2010 for potentially inappropriate medications (PIMs). Currently, updating of PIM criteria is mandatory because of newly established evidence and newly developed medications. This study aims to evaluate the prevalence of PIM based on country-specific PIM criteria and factors associated with PIM use by applying 2010 version and newly updating PIM-Taiwan criteria in a cohort with polypharmacy. Methods: The baseline data of Medication Safety Review Clinic Taiwan (MSRC-Taiwan) study were used to investigate the prevalence of PIMs...
December 2018: Therapeutic Advances in Drug Safety
Masaki Tatsumura, Hisanori Gamada, Ryu Ishimoto, Shun Okuwaki, Fumihiko Eto, Takeshi Ogawa, Takeo Mammoto, Atsushi Hirano
Objective: The aim of this study was to determine the prevalence of curable and pseudoarthrosis stages of adolescent lumbar spondylolysis under high school students complaining of and seeking medical consultation for low back pain. Patients and Methods: We analyzed age, sex, morbidity, presence of spina bifida occulta (SBO), and competitive sport discipline of patients with lumbar spondylolysis. We then stratified their pathological stage using a modified classification system via magnetic resonance imaging and computed tomography...
November 2018: Journal of Rural Medicine: JRM
Walter Schippinger, Anna Glechner, Karl Horvath, Ulrike Sommeregger, Thomas Frühwald, Peter Dovjak, Georg Pinter, Bernhard Iglseder, Peter Mrak, Walter Müller, Gerald Ohrenberger, Eva Mann, Birgit Böhmdorfer, Regina Roller-Wirnsberger
Purpose: Inappropriate use of diagnostic and therapeutic medical procedures is common and potentially harmful for older patients. The Austrian Society of Geriatrics and Gerontology defined a consensus of five recommendations to avoid overuse of medical interventions and to improve care of geriatric patients. Methods: From an initial pool of 147 reliable recommendations, 20 were chosen by a structured selection process for inclusion in a Delphi process to define a list of five top recommendations for geriatric medicine...
2018: European Geriatric Medicine
William R Aibinder, Bassem T Elhassan
Lower trapezius tendon transfer with Achilles tendon allograft augmentation may be used to treat patients with lack of active external rotation following shoulder paralysis or massive irreparable posterosuperior rotator cuff tears. In the setting of shoulder paralysis, the integrity of the ipsilateral lower trapezius may be compromised. In this instance, the contralateral lower trapezius may be used with reasonable results. In the setting of irreparable rotator cuff tears, the procedure may be performed through an open or arthroscopically assisted technique...
2018: Obere Extremität
Elisabet Lindgren, Francesca Harris, Alan D Dangour, Alexandros Gasparatos, Michikazu Hiramatsu, Firouzeh Javadi, Brent Loken, Takahiro Murakami, Pauline Scheelbeek, Andy Haines
Malnutrition in all forms, ranging from undernourishment to obesity and associated diet-related diseases, is one of the leading causes of death worldwide, while food systems often have major environmental impacts. Rapid global population growth and increases in demands for food and changes in dietary habits create challenges to provide universal access to healthy food without creating negative environmental, economic, and social impacts. This article discusses opportunities for and challenges to sustainable food systems from a human health perspective by making the case for avoiding the transition to unhealthy less sustainable diets (using India as an exemplar), reducing food waste by changing consumer behaviour (with examples from Japan), and using innovations and new technologies to reduce the environmental impact of healthy food production...
2018: Sustainability science
Muhammad Israr, Changqing Ye, Munira Taj Muhammad, Yajun Li, Hongli Bao
A copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction for the synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and terminal alkynes is reported. The alkyl carboxylic acids is for the first time being used as the alkyl azide precursors in the form of alkyl diacyl peroxides. This method avoids the necessity to handle organic azides, as they are generated in situ, making this protocol operationally simple. The Cu(I) catalyst not only participates in the alkyl diacyl peroxides decomposition to afford alkyl azides but also catalyzes the subsequent CuAAC reaction to produce the 1,2,3-triazoles...
2018: Beilstein Journal of Organic Chemistry
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