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https://www.readbyqxmd.com/read/30083536/clinical-practice-guidelines-and-evidence-for-the-efficacy-of-traditional-japanese-herbal-medicine-kampo-in-treating-geriatric-patients
#1
REVIEW
Shin Takayama, Ryutaro Arita, Akiko Kikuchi, Minoru Ohsawa, Soichiro Kaneko, Tadashi Ishii
Frailty is defined as a state of increased vulnerability to poor resolution of homeostasis following stress, which increases the risk of adverse outcomes such as falls, delirium, and disability in the elderly. Recently in Japan, clinical practice guidelines (CPG) have recommended kampo treatment. We conducted a search for reports on Japanese CPG and kampo medicine in the treatment of symptoms in the elderly. The search was performed using the databases PubMed, Ichushi Web, J-Stage, Japan Medical Publishers Association, Medical Information Network Distribution Service, and CPG containing kampo products in Japan; reports from January 1st, 2012 to October 31st, 2017 were reviewed...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/30065258/inflammageing-chronic-inflammation-in-ageing-cardiovascular-disease-and-frailty
#2
REVIEW
Luigi Ferrucci, Elisa Fabbri
Most older individuals develop inflammageing, a condition characterized by elevated levels of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability, frailty, and premature death. Potential mechanisms of inflammageing include genetic susceptibility, central obesity, increased gut permeability, changes to microbiota composition, cellular senescence, NLRP3 inflammasome activation, oxidative stress caused by dysfunctional mitochondria, immune cell dysregulation, and chronic infections...
September 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/30001354/cognitive-frailty-predicting-all-cause-mortality-among-community-living-older-adults-in-taiwan-a-4-year-nationwide-population-based-cohort-study
#3
Wei-Ju Lee, Li-Ning Peng, Chih-Kuang Liang, Ching-Hui Loh, Liang-Kung Chen
BACKGROUND: Cognitive frailty (CF) featured as frailty plus cognitive impairment was deemed to be a novel target for dementia and disable prevention. The study was intended to investigate the epidemiology of CF and the association between CF and all-cause mortality. METHODS: The national representative cohort study was comprised of 1,103 community-living middle-aged and older adults. CF was defined as the co-existence of dynapenia (weakness and/or slowness) and cognitive impairment (1...
2018: PloS One
https://www.readbyqxmd.com/read/29672647/mapping-the-knowledge-structure-of-frailty-in-journal-articles-by-text-network-analysis
#4
REVIEW
Youngji Kim, Soong-Nang Jang
BACKGROUNDS: This study was to understand the trends of frailty research and networking features of keywords from the academic articles focusing on frailty in the last four decades. METHOD: Keywords were extracted from articles (n = 6,424) retrieved from Web of Science, from 1981 to April 2016, using Bibexcel, and a social network analysis was conducted using Net Miner. RESULTS: The core-keywords of research on frailty are constantly changing over the last 40 years...
2018: PloS One
https://www.readbyqxmd.com/read/29562533/a-long-journey-into-aging-brain-aging-and-alzheimer-s-disease-following-the-oxidative-stress-tracks
#5
Patrizia Mecocci, Virginia Boccardi, Roberta Cecchetti, Patrizia Bastiani, Michela Scamosci, Carmelinda Ruggiero, Marta Baroni
The Editors of the Journal of Alzheimer's Disease invited Professor Patrizia Mecocci to contribute a review article focused on the importance and implications of her research on aging, brain aging, and senile dementias over the last years. This invitation was based on an assessment that she was one of the journal's top authors and a strong supporter of the concept that oxidative stress is a major contributor to several alterations observed in age-related conditions (sarcopenia, osteoporosis) and, more significantly, in brain aging suggesting a pivotal role in the pathogenesis and progression of one of the most dramatic age-related diseases, Alzheimer's disease (AD)...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29519962/-prevention-of-dementia-with-special-reference-to-lifestyle-and-vascular-risk-factors
#6
Haruo Hanyu
There is a wide range of potentially modifiable risk factors for Alzheimer's disease and dementia, including cardiovascular risk factors (e.g. hypertension, diabetes, dyslipidemia, obesity, sleep-apnea syndrome), psychosocial factors (e.g., depression), health behaviors (e.g., low level of physical or mental activity, smoking status), and head trauma. In the elderly, weight loss associated with frailty and sarcopenia is another risk factor for dementia. Recent epidemiological studies have shown that the prevalence of dementia has declined in the US and European countries during the last 20 years...
March 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29430248/decreased-muscle-strength-and-quality-in-diabetes-related-dementia
#7
Akito Tsugawa, Yusuke Ogawa, Naoto Takenoshita, Yoshitsugu Kaneko, Hirokuni Hatanaka, Eriko Jaime, Raita Fukasawa, Haruo Hanyu
Background/Aims: Diabetes-related dementia (DrD), a dementia subgroup associated with specific diabetes mellitus (DM)-related metabolic abnormalities, is clinically and pathophysiologically different from Alzheimer disease (AD) and vascular dementia. We determined whether skeletal muscle strength, quality, and mass decrease in individuals with DrD. Methods: We evaluated grip and knee extension strength, muscle mass, and gait speed in 106 patients with probable AD and without type 2 DM (AD[-DM] group), 74 patients with probable AD and with DM (AD[+DM] group), and 36 patients with DrD (DrD group)...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29183520/the-effect-of-sarcopenia-on-outcomes-in-geriatric-blunt-trauma
#8
Mahdi Malekpour, Kelly Bridgham, Kathryn Jaap, Ryan Erwin, Kenneth Widom, Megan Rapp, Diane Leonard, Susan Baro, James Dove, Marie Hunsinger, Joseph Blansfield, Mohsen Shabahang, Denise Torres, Jeffrey Wild
Elderly patients are at a higher risk of morbidity and mortality after trauma, which is reflected through higher frailty indices. Data collection using existing frailty indices is often not possible because of brain injury, dementia, or inability to communicate with the patient. Sarcopenia is a reliable objective measure for frailty that can be readily assessed in CT imaging. In this study, we aimed to evaluate the effect of sarcopenia on the outcomes of geriatric blunt trauma patients. Left psoas area (LPA) was measured at the level of the third lumbar vertebra on the axial CT images...
November 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29023081/frailty-predicts-adverse-outcomes-in-older-people-with-diabetes
#9
Joanna Ulley, Ahmed H Abdelhafiz
The greatest proportional increase in the number of people with diabetes by age group is predicted to occur in those aged 60 to 79. In older people living with diabetes, geriatric syndromes, which indicate frailty, are emerging as a third category of complications in addition to the traditional microvascular and macrovascular sequelae. Frailty is defined by the presence of three or more phenotypes (weight loss, weakness, decreased physical activity, exhaustion and slow gait speed). The presence of one or two phenotypes describes a pre-frail state, and the absence of phenotypes describes a non-frail person...
January 2017: Practitioner
https://www.readbyqxmd.com/read/28649100/-aging-and-homeostasis-sex-hormones-and-aging
#10
Keizo Ohnaka
The decline in sex hormones along with aging is suggested to be involved in age-associated diseases such as cardiovascular diseases, osteoporosis, and dementia. The decrease of estrogen level after menopause is related to osteoporosis in addition to climacteric disturbance in women, while that of testosterone to sarcopenia, osteoporosis and late-onset hypogonadism in men. New treatment strategy is expected for targeting age-associated diseases against the decreased level of sex hormones.
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28471944/geriatric-syndromes-new-frontiers-in-hiv-and-sarcopenia
#11
REVIEW
Kellie L Hawkins, Todd T Brown, Joseph B Margolick, Kristine M Erlandson
: HIV infection, in many circumstances, can now be managed as a chronic disease due to the marked increase in life expectancy since the introduction of combination antiretroviral therapy (ART). As the patients who first had access to combination ART age into their 50s and 60s, the effects of chronic HIV infection on health have become an important research focus in HIV infection. People living with HIV appear to exhibit an earlier occurrence of some aging-related conditions compared to people without HIV, in part due to higher rates of comorbidities, high-risk behaviors (e...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28386227/the-associations-among-insulin-resistance-hyperglycemia-physical-performance-diabetes-mellitus-and-cognitive-function-in-relatively-healthy-older-adults-with-subtle-cognitive-dysfunction
#12
Hiroyuki Umegaki, Taeko Makino, Kazuki Uemura, Hiroyuki Shimada, Takahiro Hayashi, Xian Wu Cheng, Masafumi Kuzuya
Insulin resistance (IR), diabetes mellitus (DM), sarcopenia, and cognitive dysfunction are thought to be mutually associated. We conducted a comprehensive assessment of the relationships among IR, gait speed, hyperglycemia, and DM by cross-sectionally analyzing the baseline data of an interventional study for cognitive preservation with physical exercise (the TOyota Preventional Intervention for Cognitive decline and Sarcopenia [TOPICS]). The participants (n = 444) were relatively healthy older individuals who had mild cognitive impairment without dementia, and 61 of the participants had DM...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28371474/muscle-mass-decline-arterial-stiffness-white-matter-hyperintensity-and-cognitive-impairment-japan-shimanami-health-promoting-program-study
#13
Katsuhiko Kohara, Yoko Okada, Masayuki Ochi, Maya Ohara, Tokihisa Nagai, Yasuharu Tabara, Michiya Igase
BACKGROUND: There is a close association between frailty and cognitive impairment. However, the underlying contribution of sarcopenia to the development of cognitive impairment is unclear. We investigated the possible association between muscle mass decline and cognitive impairment in a cross-sectional study of 1518 subjects aged 55 years or above. We also evaluated arterial stiffness and white matter hyperintensities (WMHs) as possible underlying mechanisms for this association. METHODS: Two sarcopenic indices were measured: thigh muscle cross-sectional area (CSA; calculated by computed tomography) and skeletal muscle mass (bioelectric impedance)...
August 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28202888/sarcopenia-and-its-relationship-with-falling-among-outpatients-attending-a-geriatric-and-memory-clinic-at-kyorin-university-hospital
#14
Masamichi Tanaka, Kumiko Nagai, Hitomi Koshiba, Toshifumi Matui, Koichi Kozaki
AIM: The aim of the present study was to investigate the prevalence of sarcopenia in outpatients attending a geriatric and memory clinic and to investigate its relationship with falling. METHODS: We investigated the prevalence of sarcopenia (according to the EWGSOP criteria) among 283 outpatients that were all ≥65 years of age, and who attended the geriatric and memory clinic at Kyorin University Hospital. We also examined comorbidities, CGA items, and fall-related measures, and analyzed the relationships between these factors and sarcopenia...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/27992013/advanced-dementia-in-a-sample-of-brazilian-elderly-sociodemographic-and-morbidity-analysis
#15
Marco Túlio Gualberto Cintra, Nilton Alves de Rezende, Henrique Oswaldo da Gama Torres
Introduction: To investigate the sociodemographic and morbidity profile of advanced dementia patients and sociodemographic data of their primary caregivers. Method: Data was obtained from 67 elderly recruited for an observational prospective study, through interviews performed with primary caregivers. For statistical analysis, the Statistical Package for the Social Sciences (SPSS(r)) for Windowsr, version 19.0. was employed. Results: Advanced dementia patients were mostly women, widows, and non-institutionalized, with low-income...
November 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27893087/targeting-functional-decline-in-alzheimer-disease-a-randomized-trial
#16
RANDOMIZED CONTROLLED TRIAL
Christopher M Callahan, Malaz A Boustani, Arlene A Schmid, Michael A LaMantia, Mary G Austrom, Douglas K Miller, Sujuan Gao, Denisha Y Ferguson, Kathleen A Lane, Hugh C Hendrie
Background: Alzheimer disease results in progressive functional decline, leading to loss of independence. Objective: To determine whether collaborative care plus 2 years of home-based occupational therapy delays functional decline. Design: Randomized, controlled clinical trial. (ClinicalTrials.gov: NCT01314950). Setting: Urban public health system. Patients: 180 community-dwelling participants with Alzheimer disease and their informal caregivers...
February 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27266148/-clinical-significance-of-comprehensive-geriatric-assessment-in-diabetic-elderly
#17
Koichi Yokono
No abstract text is available yet for this article.
April 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27102786/sarcopenia-as-a-predictor-of-future-cognitive-impairment-in-older-adults
#18
J H Moon, J H Moon, K M Kim, S H Choi, S Lim, K S Park, K W Kim, H C Jang
OBJECTIVES: We investigated the association between the indices of sarcopenia and future risk of cognitive impairment in older adults. DESIGN: Community-based prospective cohort study. SETTING: Community. PARTICIPANTS: A total of 297 participants aged ≥65 years without cognitive impairment at baseline (mean age, 71.9 ± 6.6 years; men:women, 158:139) and who underwent cognitive evaluation at the 5-year follow-up. MEASUREMENTS: Sarcopenia parameters including appendicular lean mass (ALM), handgrip strength, and the Short Physical Performance Battery (SPPB) score at baseline were compared according to the later progression of mild cognitive impairment (MCI) and/or dementia...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27025095/-frailty-and-sarcopenia-a-new-bridge-to-dementia
#19
Naoki Saji, Hidenori Arai, Takashi Sakurai, Kenji Toba
Frailty is a predictor of functional decline, falls, hospitalization, and mortality. Fried et al. developed the frailty index, which include 5 simple items: weight loss, weakness, exhaustion, slowness, and low activity. Likewise, sarcopenia indicates an age-related decline in skeletal muscle mass as well as muscle function, which may result in reduced physical capability, poorer quality of life, impaired cardiopulmonary performance, unfavorable metabolic effects, falls, disability, and mortality. Both frailty and sarcopenia could be associated with mild cognitive impairment which leads to dementia...
March 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/26863996/prevalence-and-associated-factors-of-sarcopenia-in-elderly-subjects-with-amnestic-mild-cognitive-impairment-or-alzheimer-disease
#20
Taiki Sugimoto, Rei Ono, Shunsuke Murata, Naoki Saji, Yasumoto Matsui, Shumpei Niida, Kenji Toba, Takashi Sakurai
BACKGROUND: To date, very little is known about the nature of sarcopenia in subjects with cognitive impairment. The aims of this study were firstly to clarify the prevalence of sarcopenia at various stages of cognitive impairment, and secondly to examine factors related to sarcopenia in men and women with cognitive impairment. METHOD: The subjects were 418 outpatients (normal cognition; NC: 35, amnestic mild cognitive impairment; aMCI: 40, Alzheimer disease; AD: 343) who attended the Memory Clinic at the National Center for Geriatrics and Gerontology of Japan during the period from October 2010 to July 2014...
2016: Current Alzheimer Research
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