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Ace i

Esther Kuperus, Jan C van der Meijden, Stijn L M In 't Groen, Marian A Kroos, Marianne Hoogeveen-Westerveld, Dimitris Rizopoulos, Monica Yasmin Nino Martinez, Michelle E Kruijshaar, Pieter A van Doorn, Nadine A M E van der Beek, Ans T van der Ploeg, W W M Pim Pijnappel
The majority of children and adults with Pompe disease in the population of European descent carry the leaky splicing GAA variant c.-32-13T>G (IVS1) in combination with a fully deleterious GAA variant on the second allele. The phenotypic spectrum of this patient group is exceptionally broad, with symptom onset ranging from early infancy to late adulthood. In addition, the response to enzyme replacement therapy (ERT) varies between patients. The insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) has been suggested to be a modifier of disease onset and/or response to ERT...
2018: PloS One
Anneke Kuipers, Gert N Moll, Elizabeth Wagner, Rick Franklin
Native angiotensin-(1-7) exerts many therapeutic effects. However, it is rapidly degraded by ACE and other peptidases. This drawback is largely eliminated for lanthionine-stabilized angiotensin-(1-7), termed cAng-(1-7), which is fully resistant to ACE and has strongly increased resistance to other peptidases. Goal of the present study was to test whether cAng-(1-7) has therapeutic activity in diabetes mouse models: in a multiple low dose streptozotocin-induced model of type I diabetes and / or in a db/db model of type II diabetes...
December 4, 2018: Peptides
Pieter Martens, Petra Nijst, Matthias Dupont, Wilfried Mullens
BACKGROUND: Progressive plasma volume (PV) expansion is a hallmark of chronic heart failure (HF), ultimately contributing to decompensated heart failure. Monitoring PV might offer prognostic information and might be a target for tailored therapy. METHODS: The correlation between technetium-(99 Tc)-labeled red blood cell measured PV and calculated PV was first determined in a validation cohort. The relationship between PV-status (PVS; a marker how much actual PV deviated from the ideal PV) and outcome was analyzed using cox-proportional modeling in a prospective CHF-population (the outcome cohort)...
December 4, 2018: Journal of Cardiac Failure
Minzi Qiu, Jiawen Li, Lishan Tan, Mengbi Zhang, Guang Zhou, Tao Zeng, Aiqing Li
The potential function of distal cerebrospinal fluid-contacting nucleus (dCSF-CNs) in chronic kidney disease (CKD) development is poorly understood. We hypothesized that dCSF-CNs might affect the renin-angiotensin system (RAS) in kidney injury progression, with dCSF-CNs ablation potentially alleviating local RAS and renal fibrosis in rats after five-sixths nephrectomy (5/6Nx). Part of rats were randomly administered artificial cerebrospinal fluid (aCSF) intracerebroventricularly (icv), followed by 5/6Nx or sham operation; and other part of rats were administered Cholera toxin B subunit conjugated with saporin (CB-SAP) for dCSF-CNs lesion before 5/6Nx...
2018: Frontiers in Physiology
Irma Isordia-Salas, David Santiago-Germán, Megan Carolina Cerda-Mancillas, Jesús Hernández-Juárez, Mariela Bernabé-García, Alfredo Leaños-Miranda, José Antonio Alvarado-Moreno, Abraham Majluf-Cruz
OBJECTIVE: The renin-angiotensin system (RAS) is a hormonal signaling mechanism implicated in the atherosclerosis and regulation of blood pressure. Angiotensin-converting enzyme (ACE) a key enzyme in the RAS, plays important roles in vascular remodeling atherosclerosis, and ischemic stroke. The aim of this study was to examine the possible contribution of the I/D in the ACE gene, M235T and T174M in the angiotensinogen (AGT) gene polymorphisms with ischemic stroke in young Mexican population...
December 3, 2018: Gene
Grace W K Ho, Athena C Y Chan, Wai-Tong Chien, Daniel T Bressington, Thanos Karatzias
Ample evidence supports significant and enduring associations between adverse childhood experiences (ACEs) and negative outcomes later in life. Subsets of ACEs (e.g. childhood maltreatment and household dysfunction) have been examined in Chinese populations, but no known study has comprehensively examined the full constellation of different types of ACEs or patterns of ACE exposure in Chinese samples. As a direct response to the call to establish a global ACEs surveillance framework, this study provides the first translation and validation of the World Health Organization ACE - International Questionnaire (ACE-IQ)...
December 1, 2018: Child Abuse & Neglect
Robert Mathew, Neelima Renjith, P S Mathuranath
Background: Cube copying test is often used as screening test for dementia. However, there is a paucity of an effectively scoring system, and very little is known about how healthy older adults perform on this test. In this study, we present a modified scoring system for the wire-cube copying, evaluate the performance of cognitively unimpaired elderly individuals, and generate norms on community-dwelling older adults. Materials and Methods: The task consisted of copying a three-dimensional printed cube (i...
November 2018: Neurology India
A Laudisio, S Giovannini, P Finamore, A Gemma, R Bernabei, R A Incalzi, G Zuccalà
BACKGROUND: Improved ability to treat chronic diseases have increased the interest in measuring health-related quality of life (HRQoL) in older adults. Hypertension and heart failure have been associated with decreased HRQoL. HYPOTHESIS: The aim of this study was to assess the association between health-related quality of life and use of angiotensin converting enzyme inhibitors in unselected community-dwelling elderly. METHODS: We analyzed data of all 387 subjects aged 75+ living in a rural Italian town, without exclusion criteria...
2018: Journal of Nutrition, Health & Aging
Itziar de Rojas, J Romero, O Rodríguez-Gomez, P Pesini, A Sanabria, A Pérez-Cordon, C Abdelnour, I Hernández, M Rosende-Roca, A Mauleón, L Vargas, M Alegret, A Espinosa, G Ortega, S Gil, M Guitart, A Gailhajanet, M A Santos-Santos, Sonia Moreno-Grau, O Sotolongo-Grau, S Ruiz, L Montrreal, E Martín, E Pelejà, F Lomeña, F Campos, A Vivas, M Gómez-Chiari, M A Tejero, J Giménez, V Pérez-Grijalba, G M Marquié, G Monté-Rubio, S Valero, A Orellana, L Tárraga, M Sarasa, A Ruiz, M Boada
BACKGROUND: Peripheral biomarkers that identify individuals at risk of developing Alzheimer's disease (AD) or predicting high amyloid beta (Aβ) brain burden would be highly valuable. To facilitate clinical trials of disease-modifying therapies, plasma concentrations of Aβ species are good candidates for peripheral AD biomarkers, but studies to date have generated conflicting results. METHODS: The Fundació ACE Healthy Brain Initiative (FACEHBI) study uses a convenience sample of 200 individuals diagnosed with subjective cognitive decline (SCD) at the Fundació ACE (Barcelona, Spain) who underwent amyloid florbetaben(18 F) (FBB) positron emission tomography (PET) brain imaging...
November 29, 2018: Alzheimer's Research & Therapy
Mansour Moghimi, Saeed Kargar, Mohammad Ali Jafari, Hossein Ahrar, Mohammad Hossein Jarahzadeh, Hossein Neamatzadeh, Jalal Sadeghizadeh- Yazdi
Background: A number of case-control studies were conducted to investigate the association of angiotensin converting enzyme insertion/deletion (ACE I/D) polymorphism with breast cancer. But the results remain controversial. This meta-analysis aims to comprehensively evaluate the association of ACE I/D polymorphism with breast cancer. Method: A comprehensive literature search on PubMed, Google Scholar, SCOPUS and ISI Web of Knowledge databases for studies published up to June 01, 2018 was performed. Summary odds ratios (ORs) and 95% confidence intervals (CI) were estimated...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Mysuru Natarajan Savitha, Jalahalli Mariswamy Siddesha, Kanve Nagaraj Suvilesh, Manjunath Yariswamy, Hamse Kameshwar Vivek, Cletus J M D'Souza, Muddegowda Umashankar, Bannikuppe Sannanaik Vishwanath
Hypertension is the fundamental cause of cardiovascular and cerebrovascular disorders. Several natural and synthetic peptides are being used as anti-hypertensive agents, which target angiotensin converting enzyme (ACE), the master regulator of angiotensin (Ang) II production. In this study, we have evaluated ACE-inhibitory potential of the tripeptide L-Phenylalanyl-D-Histidyl-L-Leucine (L-Phe-D-His-L-Leu) in vitro and its antihypertensive effect in rat model of dexamethasone-induced hypertension. L-Phe-D-His-L-Leu was custom-designed by changing the configuration of penultimate amino acid residue (histidine) from C-terminal of Ang I, the site at which ACE acts upon and generates Ang II...
November 24, 2018: Peptides
G Crippa, D Zabzuni, E Bravi, G Piva, I De Noni, E Bighi, F Rossi
OBJECTIVE: Grana Padano, an Italian protected designation of origin (PDO) semi-fat cheese, undergoes a long ripening period during which the proteolysis carried out by natural starter lactic acid bacteria releases peptides having sustained angiotensin-converting enzyme (ACE)-inhibitory activity. The length (generally 3-8 amino acid residues) and the sequence of these peptides are responsible for their ability to elicit ACE-inhibitory activity. The aim of this study has been the evaluation of the effect of a daily dietary supplement consisting in a small amount (30 g/day) of Grana Padano cheese, in terms of the lowering of the blood pressure (BP) of mild-moderate hypertensive subjects...
November 2018: European Review for Medical and Pharmacological Sciences
Cesarea Hulda Joel, Christoper C Y Sutopo, Arief Prajitno, Jui-Hsin Su, Jue-Liang Hsu
Peptides with angiotensin-I converting enzyme (ACE) inhibitory activity have received considerable interest due to their potential as antihypertensive agents and consumer concern over the safety of synthetic drugs. The objective of this study was to isolate ACE inhibitory (ACEI) peptides from Caulerpa lentillifera (known commonly as sea grape) protein hydrolysate. In this study, short-chain peptides were obtained after hydrolysis by various enzymes and subsequently by ultrafiltration. Thermolysin hydrolysate showed the highest ACEI activity...
November 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Piotr Gronek, Joanna Gronek, Ewelina Lulińska-Kuklik, Michał Spieszny, Marta Niewczas, Mariusz Kaczmarczyk, Miroslav Petr, Patricia Fischerova, Ildus I Ahmetov, Piotr Żmijewski
The purpose of this study was to investigate individually and in combination the association between the ACE (I/D), NOS3 (Glu298Asp), BDKRB2 (-9/+9), UCP2 (Ala55Val) and AMPD1 (Gln45Ter) variants with endurance performance in a large, performance-homogenous cohort of elite Polish half marathoners. The study group consisted of 180 elite half marathoners: 76 with time < 100 minutes and 104 with time > 100 minutes. DNA of the subjects was extracted from buccal cells donated by the runners and genotyping was carried out using an allelic discrimination assay with a C1000 Touch Thermal Cycler (Bio-Rad, Germany) instrument with TaqMan® probes (NOS3, UCP2, and AMPD1) and a T100™ Thermal Cycler (Bio-Rad, Germany) instrument (ACE and BDKRB2)...
September 2018: Journal of Human Kinetics
Yojiro Yutaka, Makoto Sonobe, Atsushi Kawaguchi, Masatsugu Hamaji, Daisuke Nakajima, Akihiro Ohsumi, Toshi Menju, Toyofumi F Chen-Yoshikawa, Toshihiko Sato, Hiroshi Date
OBJECTIVES: In high-risk operable geriatric patients undergoing palliative sublobar resection (SR), noncancerous comorbidities may contribute to unfavorable outcomes. The purpose of this retrospective study was to evaluate the perioperative safety and long-term survival of palliative SR in this patient population. MATERIALS AND METHODS: We reviewed 232 patients (141 male, 91 female) aged ≥75 years who underwent surgical resection of clinical stage I lung cancer from 2006 to 2014...
November 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Yanyan Zhang, Denis Clay, Maria Teresa Mitjavila-Garcia, Aurélie Alama, Benoit Menneson, Helene Bersenef, Fawzia Louache, Annelise Bennaceur, Estelle Oberlin
Despite advances to engineer transplantable hematopoietic stem and progenitor cells (HSPCs) for research and therapy, an in depth characterization of the developing human hematopoietic system is still lacking. The human embryonic liver is at the crossroad of several hematopoietic sites and harbors a complex hematopoietic hierarchy including the first, actively dividing HSPCs that will further seed the definitive hematopoietic organs. However few are known about the phenotypic and functional HSPC organization operating at these stages of development...
November 14, 2018: Stem Cells and Development
Fenny Crista A Panjaitan, Honey Lyn R Gomez, Yu-Wei Chang
Major proteins contained in dried giant grouper roe (GR) such as vitellogenin (from Epinephelus coioides ; NCBI accession number: AAW29031.1), apolipoprotein A-1 precursor (from Epinephelus coioides ; NCBI accession number: ACI01807.1) and apolipoprotein E (from Epinephelus bruneus ; NCBI accession number: AEB31283.1) were characterized through compiled proteomics techniques (SDS-PAGE, in-gel digestion, mass spectrometry and on-line Mascot database analysis). These proteins were subjected to in silico analysis using BLAST and BIOPEP-UWM database...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
M E Ougaard, H E Jensen, I D Thuen, E G Petersen, P H Kvist
INTRODUCTION: Chronic kidney disease (CKD) is a global health concern, but the current treatments only slow down the progression. Thus an improved understanding of the pathogenesis and novel treatments of CKD are needed. The nephrotoxic nephritis (NTN) model has the potential to study the pathogenesis of CKD as it resembles human CKD. The classical treatments with angiotensin II receptor blocker (ARB) or the angiotensin-converting enzyme inhibitor (ACE I) have shown a clinical effect in CKD...
November 2018: Renal Failure
M Díaz-Ricart, I M Isola, G Escolar
Hemophilia A is an X-linked bleeding disorder caused by defects in the gene encoding factor VIII (FVIII). Routine prophylaxis with exogenous FVIII requires frequent intravenous injections. One of the most challenging issues in the treatment of hemophilia A is the development of alloantibodies against infused FVIII. Presence of inhibitors results in an ineffective factor replacement therapy and increases the risk of morbidity and mortality in these patients. Therefore, there is growing interest in the development of new strategies for the prophylaxis and prevention of bleeding in patients with hemophilia to circumvent these drawbacks...
October 2018: Drugs of Today
Federico Innocenti, Chen Jiang, Alexander B Sibley, Amy S Etheridge, Ace J Hatch, Stefanie Denning, Donna Niedzwiecki, Ivo D Shterev, Jiaxing Lin, Yoichi Furukawa, Michiaki Kubo, Hedy L Kindler, J Todd Auman, Alan P Venook, Herbert I Hurwitz, Howard L McLeod, Mark J Ratain, Raluca Gordan, Andrew B Nixon, Kouros Owzar
Angiogenesis is essential in tumor biology and is regulated by vascular endothelial growth factor (VEGF) ligands and receptors. Here we aimed to discover genetic variants associated with levels of circulating angiogenic proteins in cancer patients. Plasma was collected at baseline in 216 pancreatic and 114 colorectal cancer patients. Thirty-one angiogenic proteins were measured by ELISA. 484,523 Single Nucleotide Polymorphisms (SNP) were tested for association with plasma levels for each protein in pancreatic cancer patients...
November 5, 2018: Scientific Reports
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