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Ace i

S A Kozin, V I Polshakov, Y V Mezentsev, A S Ivanov, S S Zhokhov, M M Yurinskaya, M G Vinokurov, A A Makarov, V A Mitkevich
Intact amyloid-β peptides (Aβ) may undergo prion-like aggregation when they interact with chemically or structurally modified variants of Aβ present in extracellular pathohistological inclusions (amyloid plaques). This aggregation is regarded as one of the key molecular mechanisms of Alzheimer's disease (AD) pathogenesis. Zinc ions are involved in the pathological dimerization and oligomerization of natural Aβ isoforms, and zinc-induced oligomers can also initiate the pathological aggregation of Aβ. Based on the earlier found molecular mechanism of zinc-dependent oligomerization of Aβ, it has been suggested that the targeted inhibition of the 11EVHH14 site in one Aβ molecule from zinc-mediated interactions with the same site of another Aβ molecule can effectively inhibit the oligomerization and aggregation of Aβ...
July 2018: Molekuliarnaia Biologiia
Ahmed Abdelaal Ahmed Mahmoud, Mark Campbell, Margarita Blajeva
The current case report represents a warning against serious hyperkalaemia and acidosis induced by ACE-I during surgical stress while normal renal function could deceive the attending anaesthetist. Arterial gas analysis for follow-up of haemoglobin loss accidentally discovered hyperkalaemia and acidosis. Glucose-insulin and furosemide successfully corrected hyperkalaemia after 25 minutes and acidosis after 3 hours. These complications could be explained by a deficient steroid stress response to surgery secondary to suppression by ACE-I...
2018: Case Reports in Anesthesiology
Le Wang, Xiang Li, Yingnan Li, Wenying Liu, Xiaoyun Jia, Xiaoling Qiao, Chao Qu, Xiaoyu Cheng, Shouwei Wang
Xuanwei ham is especially rich in a large amount of peptides and free amino acids under the action of protein degradation. Some of these peptides can potentially exert bioactivities of interest for human health. Traditionally, Xuanwei ham should undergo Chinese household cooking treatments before eating. However, it has not been known how its bioactivity changes after cooking and gastrointestinal digestion. Herein, Xuanwei ham is analysed before and after cooking, as well as gastrointestinal digestion being simulated so as to evaluate and compare its effect on antioxidant and angiotensin I-converting enzyme (ACE) inhibitory activities...
July 2018: Royal Society Open Science
Takatoyo Kiko, Akiomi Yoshihisa, Yuki Kanno, Tetsuro Yokokawa, Satoshi Abe, Makiko Miyata-Tatsumi, Tomofumi Misaka, Masayoshi Oikawa, Atsushi Kobayashi, Takafumi Ishida, Yasuchika Takeishi
Sarcoidosis is a systemic granulomatous disease including heart (cardiac sarcoidosis, CS). It has recently been reported that isolated CS, which presenting primarily cardiac symptoms without clinical evidence of sarcoid involvement in other organs. Diagnostic and prognostic biomarkers of CS, especially in isolated CS, have not yet been established.We studied plasma levels of angiotensin-converting enzyme (ACE), soluble interleukin-2 receptor (sIL-2R), B-type natriuretic peptide (BNP) and cardiac troponin I (cTnI) in consecutive 172 patients with diagnosed sarcoidosis...
August 11, 2018: International Heart Journal
Thomas J Schofield, M Brent Donnellan, Melissa T Merrick, Katie A Ports, Joanne Klevens, Rebecca Leeb
OBJECTIVES: To understand the role of the community environment on intergenerational continuity in adverse childhood experiences (ACEs) among a rural White sample. METHODS: Parents in 12 counties in rural Iowa reported retrospectively on their own ACEs in 1989. We measured their child's ACEs retrospectively and prospectively across adolescence (n = 451 families). We measured structural and social process-related measures of community environment (i.e., community socioeconomic status, parents' perception of community services, perceived community social cohesion, and neighborhood alcohol vendor density) on multiple occasions during the child's adolescence...
September 2018: American Journal of Public Health
Bruno Censori, T Partziguian, V Bonito, M Sgarzi, R Riva, D Alimonti, E Agazzi, M Vedovello, B Frigeni, E Venturelli, S La Gioia, V Barcella, L Daleffe, L Longhi, F Ferri, R Cosentini, M R Rottoli
INTRODUCTION: Orolingual angioedema (OA) is a known adverse effect of intravenous (i.v.) alteplase. We analyzed all patients treated with i.v. alteplase for stroke at our hospital since approval of i.v. thrombolysis in Italy in 2004 to assess the incidence of this complication. PATIENTS AND RESULTS: Four hundred thirty-three patients received alteplase for stroke from April 2004 to May 2017. Two women developed OA (0.4%; 95% confidence interval 0.1 to 1.6%). Angioedema was mild in one case and severe in the other, with massive swelling of the lips, tongue, and oropharyngeal mucosa, and oropharyngeal bleeding, requiring intubation...
August 6, 2018: Neurological Sciences
Lukmanul Hakkim, Seemaisamy Revathi, Govind Rajan, Gattu Sampath, Ramesh Kumar, Mohammed Al Buloshi, Sidgi Syed Anwar, Hamid Bakshi, Kayalvizhi Nagarajan
BACKGROUND: Colon cancer is the most aggressive form of cancers, that causes 0.5 million deaths per year around the globe. Targeting colon cancer by conventional therapeutic options elicits toxicity. Traditional medicines take lead to alleviate the existing clinical challenges. OBJECTIVE: To investigate anti bacterial activity against Helicobacter Pylori and in vitro anti colon cancer activity by Acacia nilotica extract (ACE) and its active constituent pyrogallol...
August 5, 2018: Anti-cancer Agents in Medicinal Chemistry
Shun-Jin Liu, Xiao-Yu Liu, Jing-Hui Li, Jing Guo, Fan Li, Yang Gui, Xiu-Hua Li, Li Yang, Chun-Yun Wu, Yun Yuan, Juan-Juan Li
Microglia activation and its mediated production of proinflammatory mediators play important roles in different neurodegenerative diseases; hence, modulation of microglia activation has been considered a potential therapeutic strategy to ameliorate neurodegeneration. This study was aimed to determine whether Gastrodin, a common herbal agent known to possess neuroprotective property, can attenuate production of proinflammatory mediators in activated microglia through the renin-angiotensin system (RAS) and Sirtuin3 (SIRT3)...
July 31, 2018: Neurochemistry International
Vlasios Goulas, Demetra Nicolaou, George Botsaris, Alexandra Barbouti
Numerous studies provide robust evidence for a protective effect of red wine against many diseases. This bioactivity has been mainly associated with phenolic fractions of wines. However, the health effects of melanoidins in red sweet wines has been ignored. The goal of the present work was to unravel the antioxidant, antimicrobial, and angiotensin-I-converting enzyme (ACE) inhibitory properties of straw sweet wine melanoidins. Results demonstrated that melanoidins have a potential antioxidant activity, determined by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and Ferric reducing antioxidant power (FRAP) assays...
August 2, 2018: Biomedicines
Rubén Vilcacundo, Cristina Martínez-Villaluenga, Beatriz Miralles, Blanca Hernández-Ledesma
BACKGROUND: The multifactorial origin of many chronic diseases provides a new framework for the development of multifunctional foods. In this study, the effect of in vitro simulated gastrointestinal digestion of kiwicha (Amaranthus caudatus) proteins on the release of multifunctional peptides was evaluated. RESULTS: Gastric digest showed higher angiotensin-I converting enzyme (ACE) inhibitory activity while 60 minutes gastroduodenal digest showed the highest antioxidant, dipeptidyl peptidase IV (DPP-IV), α-amylase, and Caco-2 cell viability inhibitory activities...
July 31, 2018: Journal of the Science of Food and Agriculture
Ehab A M El-Shoura, Basim A S Messiha, Souty M Z Sharkawi, Ramadan A M Hemeida
Localized tissue renin-angiotensin system (RAS) is an interesting pathway of organ damage. Here, the effect of the brain-penetrating angiotensin converting enzyme (ACE) inhibitor perindopril was studied on lipopolysaccharide (LPS)-induced brain damage, with and without exogenous angiotensin (Ang)-II administration. Animals were divided into 6 groups; a normal control group, an LPS control group (LPS, 3 mg/kg, i.p., single dose), two treatment groups receiving perindopril (1 and 2 mg/kg/day, i.p.) for 7 days before LPS administration, and two Ang-II/perindopril/LPS groups receiving perindopril and LPS, followed by a single dose of Ang-II solution (5 µl, i...
September 5, 2018: European Journal of Pharmacology
Muaamar Al-Gobari, Sinaa Al-Aqeel, François Gueyffier, Bernard Burnand
OBJECTIVES: To summarise and synthesise the current evidence regarding the effectiveness of drug interventions to prevent sudden cardiac death (SCD) and all-cause mortality in patients with heart failure with reduced ejection fraction (HFrEF). DESIGN: Overview of systematic reviews. DATA SOURCES: MEDLINE, Embase, ISI Web of Science and Cochrane Library from inception to May 2017; manual search of references of included studies for potentially relevant reviews...
July 28, 2018: BMJ Open
Sophie L M Walker, Tom E F Abbott, Katherine Brown, Rupert M Pearse, Gareth L Ackland
Background: Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) are the most commonly prescribed antihypertensive medications in higher-risk surgical patients. However, there is no clinical consensus on their use in the perioperative period, in part, due to an inconsistent evidence-base. To help inform the design of a large multi-centre randomized controlled trial (ISRCTN17251494), we undertook a questionnaire-based survey exploring variability in ACEi/ARB prescribing in perioperative practice...
2018: PeerJ
Renáta Konášová, Dušan Koval, Jana Jaklová Dytrtová, Václav Kašička
Affinity capillary electrophoresis (ACE) is typically used for the determination of stability constant, Kst , of weak to moderately strong complexes. Sensitive detection such as mass spectrometry (MS) is required for extension of ACE methodology for estimation of Kst of stronger complexes. Consequently, an efficient interface for hyphenation of CE with MS detection is necessary. For evaluation of interfaces for electrospray ionization mass spectrometric (ESI/MS) detection in ACE conditions, potassium-crown ether complexation was used as model system...
July 19, 2018: Journal of Chromatography. A
Julio Scharfstein
PURPOSE OF REVIEW: During Chagas disease, Trypanosoma cruzi alternates between intracellular and extracellular developmental forms. After presenting an overview about the roles of the contact system in immunity, I will review experimental studies showing that activation of the kallikrein-kinin system (KKS) translates into mutual benefits to the host/parasite relationship. RECENT FINDINGS: T. cruzi trypomastigotes initiate inflammation by activating tissue-resident innate sentinel cells via the TLR2/CXCR2 pathway...
September 2018: Current Opinion in Hematology
Stephen J Greene, Javed Butler, Nancy M Albert, Adam D DeVore, Puza P Sharma, Carol I Duffy, C Larry Hill, Kevin McCague, Xiaojuan Mi, J Herbert Patterson, John A Spertus, Laine Thomas, Fredonia B Williams, Adrian F Hernandez, Gregg C Fonarow
BACKGROUND: Guidelines strongly recommend patients with heart failure with reduced ejection fraction (HFrEF) be treated with multiple medications proven to improve clinical outcomes, as tolerated. The degree to which gaps in medication use and dosing persist in contemporary outpatient practice is unclear. OBJECTIVES: This study sought to characterize patterns and factors associated with use and dose of HFrEF medications in current practice. METHODS: The CHAMP-HF (Change the Management of Patients with Heart Failure) registry included outpatients in the United States with chronic HFrEF receiving at least 1 oral medication for management of HF...
July 24, 2018: Journal of the American College of Cardiology
Vineeta Gupta, Sunil Kumar Singh, Vikas Agrawal, Tej Bali Singh
BACKGROUND: Several measures including drugs have been tried to reduce anthracycline cardiotoxicity. The lack of randomized trials prompted this study to assess the role of an angiotensin converting enzyme (ACE) inhibitor (enalapril) in anthracycline-induced cardiotoxicity in children with hematological malignancies. METHODS: A randomized, double-blind, placebo-controlled trial was conducted on 84 patients with leukemia (41) and lymphoma (43) who received anthracyclines (doxorubicin and/or daunorubicin) at cumulative dose ≥200 mg/m2 ...
July 15, 2018: Pediatric Blood & Cancer
Adham Elmously, Andreas R de Biasi, Donald A Risucci, Berhane Worku, Evelyn M Horn, Arash Salemi
Background: Elevated systemic blood pressure (SBP) has been linked to complications in Continuous-flow left ventricular assist devices (CF-LVADs), including stroke and pump thrombosis. We queried Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) to describe the response of SBP to CF-LVAD implantation and to delineate contemporary trends in antihypertensive (AH) utilization for patients with these pumps. Methods: We identified all CF-LVAD implantations in patients older than 18 years from 2006-2014, excluding those whose durations were less than 30 days...
May 2018: Journal of Thoracic Disease
Shehu Muhammad Auwal, Mohammad Zarei, Chin Ping Tan, Mahiran Basri, Nazamid Saari
Bromelain-generated biopeptides from stone fish protein exhibit strong inhibitory effect against ACE and can potentially serve as designer food (DF) with blood pressure lowering effect. Contextually, the DF refer to the biopeptides specifically produced to act as ACE-inhibitors other than their primary role in nutrition and can be used in the management of hypertension. However, the biopeptides are unstable under gastrointestinal tract (GIT) digestion and need to be stabilized for effective oral administration...
July 10, 2018: Scientific Reports
Norfazilah Ahmad, Rahman Jamal, Shamsul Azhar Shah, Abdul Halim Abdul Gafor, Nor Azian Abdul Murad
BACKGROUND: The association of polymorphisms in the renin-angiotensin-aldosterone system candidate genes, namely angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensinogen (AGT) M235T and angiotensin II receptor type 1 (AGTR1) A1166C with diabetic nephropathy (DN) has been studied for decades. OBJECTIVE: This meta-analysis aimed to assess the updated pooled effects of these polymorphisms with DN among Asian populations with type 2 diabetes mellitus...
July 8, 2018: Current Diabetes Reviews
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