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Ace i

Caroline Dal Mas, Michelle S Carvalho, Lucas A Marins, Camila M Yonamine, Quirino Cordeiro, Roger S McIntyre, Rodrigo B Mansur, Elisa Brietzke, Mirian A F Hayashi
BACKGROUND: Abnormal activity of two enzymes relevant to neurodevelopment, namely nuclear-distribution element-like 1 (Ndel1) and angiotensin I-converting enzyme (ACE), was reported in individuals with schizophrenia; to our knowledge, these oligopeptidases were never measured in bipolar disorder (BD). AIMS: Evaluate the enzyme activity of Ndel1 and ACE in euthymic individuals with BD type 1 which was compare to healthy control (HC) group. METHODS: Ndel1 and ACE activities were assessed in the serum of individuals with BD type 1 according to DSM-IV criteria (n = 70) and a HC group (n = 34)...
October 6, 2018: Journal of Affective Disorders
Krzysztof Łukawski, Grzegorz Raszewski, Stanisław J Czuczwar
It has been demonstrated that certain angiotensin-converting enzyme (ACE) inhibitors and angiotensin AT1 receptor antagonists can possess anticonvulsant activity. The purpose of the current study was to examine the effect of aliskiren, a direct renin inhibitor and a novel antihypertensive drug, against pentylenetetrazole (PTZ)-induced clonic seizures in mice and on the protective activity of conventional antiepileptic drugs (AEDs) in this seizure model. Effects of aliskiren on the PTZ threshold and the protective efficacy of AEDs such as clonazepam (CLO), phenobarbital (PB), valproate (VPA) and ethosuximide (ETX) in the PTZ test, were evaluated in adult Swiss mice...
October 12, 2018: Fundamental & Clinical Pharmacology
Mariyana Hristova, Spaska Stanilova, Lyuba Miteva
BACKGROUND: Renin-angiotensin system (RAS) is a complex network of enzymes and peptides with the essential role in blood pressure control. The relationships between RAS components, RAS-related genetic polymorphisms and therapy response in essential hypertension (EH) were widely explored but the results were inconclusive. AIM: The aim of this study was to explore the functional role of ACE insertion/deletion (I/D) polymorphism on the systemic quantity of angiotensin-converting enzyme (ACE), its homolog - ACE2, chymase and angiotensin II in EH patients with respect to achieved therapeutic blood pressure control...
October 11, 2018: Clinical and Experimental Hypertension: CHE
Ramazan Jabbarli, Daniela Pierscianek, Marvin Darkwah Oppong, Tako Sato, Philipp Dammann, Karsten H Wrede, Klaus Kaier, Martin Köhrmann, Michael Forsting, Christoph Kleinschnitz, Andreas Roos, Ulrich Sure
Delayed cerebral ischemia (DCI) is a severe complication of subarachnoid hemorrhage (SAH). Clinical and radiographic features of SAH may be helpful in identification of individuals prone to DCI. The aim of this systematic review was to analyze the present evidence on predictive value of blood and cerebrospinal fluid (CSF) biomarkers of DCI after SAH. We systematically searched in PubMed, Scopus, Web of Science, and Cochrane Library databases for publications before July 15, 2018, reporting correlations between blood/CSF biomarkers and occurrence of DCI and/or vasospasm in SAH patients...
October 10, 2018: Neurosurgical Review
Maryam Tanhapour, Badieh Falahi, Asad Vaisi-Raygani, Fariborz Bahrehmand, Amir Kiani, Zohreh Rahimi, Ali-Akbar Vaisi-Raygani, Ebrahim Shakiba, Tayebeh Pourmotabbed
Psoriasis is a chronic inflammatory skin condition and angiotensin-converting enzyme (ACE) is a key circulating enzyme converting angiotensin (Ang) I to the vasoactive peptide Ang II. The exact role of ACE insertion (I)/deletion (D) polymorphism (rs106180) in psoriasis is not clear. We aimed to examine whether the ACE I/D and Ang II type 1 receptor (AT1R) A1166 C-polymorphisms (rs106165), lipid profile, and stress oxidative are associated with susceptibility to psoriasis. One hundred patients with psoriasis and 100 sex- and age-matched unrelated healthy controls were recruited for this case-control study...
October 10, 2018: Journal of Cellular Biochemistry
Piotr Futyma, Jarosław Sander, Ryszard Głuszczyk, Marcin Maciołek, Marian Futyma, Piotr Kułakowski
BACKGROUND: Implantable cardioverter-defibrillator (ICD) offers an opportunity to examine vulnerability to ventricular tachycardia (VT) or ventricular fibrillation (VF) by performing non-invasive programmed ventricular stimulation (NIPS). Whether NIPS can predict VT/VF recurrences, has not yet been established. PURPOSE: To examine the predictive value of NIPS for identification of patients with VT/VF recurrences. METHODS: The study group consisted of consecutive 105 ICD recipients included in the prospective NIPS-ICD study (ClinicalTrials ID: NCT02373306) (88 males, age 65 ± 11 years)...
October 10, 2018: Pacing and Clinical Electrophysiology: PACE
O L Barbarash, T A Mulerova, V N Maksimov, A N Chigisova, M I Voevoda, M Y Ogarkov
OBJECTIVE: to establish associations of candidate genes ACE, AGT, AGTR1, ADRB1, ADRA2B, MTHFR and NOS3 polymorphisms with left ventricular myocardial hypertrophy (LVH) in patients with arterial hypertension (AH) among the indigenous (the Shors) and non-indigenous population of Mountain Shoria. MATERIALS AND METHODS: We examined 788 people in a clinical and epidemiological study of compactly living population in the remote areas of Mountain Shoria, located in the south of Western Siberia (468 members of indigenous ethnic group [the Shors], 320 members of non-indigenous ethnic group [90% Caucasian])...
September 2018: Kardiologiia
Michał Tymowski, Wojciech Kaspera, Joanna Metta-Pieszka, Łukasz Zarudzki, Piotr Ładziński
OBJECTIVE: The aim of the study was to establish the usefulness of various neuropsychological tests in patients undergoing surgery due to low-grade glioma (LGG) involving supplementary motor area (SMA). PATIENTS AND METHODS: 21 patients diagnosed with LGG involving the SMA underwent, before and after surgery, screening tests (Mini Mental State Examination - MMSE, Montreal Cognitive Assessment - MoCA and Frontal Assessment Battery - FAB), tests to assess language functions (Addenbrook's Cognitive Examination-III - ACE-III, phonetic fluency tests and semantic fluency tests), tests to assess memory functions (Rey's 15-word test - RAVLT and Diagnostic Test for Brain Damage by Hillers- DCS), tests to assess executive functions (Wisconsin Card Sorting Test - WCST, Ruff Figural Fluency Test - RFFT and Trail Making Test)...
September 26, 2018: Clinical Neurology and Neurosurgery
Tiara C Willie, Trace Kershaw, Tami P Sullivan
Women experiencing intimate partner violence (IPV) are at an increased risk of engaging in sexual risk behaviors and experiencing depressive and posttraumatic stress symptoms. Adverse childhood events (ACEs) can put women at increased risk of poor sexual and mental health. Women experiencing IPV report ACEs, but few studies have examined the heterogeneity in women's experiences of ACEs and its effects on sexual and mental health. Therefore, the current study used latent profile analysis to identify profiles of ACEs (i...
October 3, 2018: Journal of Interpersonal Violence
Yu-Hsin Lin, Guan-Wen Chen, Chin Hsi Yeh, Helena Song, Jenn-Shou Tsai
Hot water was used to obtain Chlorella sorokiniana hot water extract (HWE). Subsequently, this byproduct was freeze-dried, hydrolysed at 50 °C using Protease N to obtain C. sorokiniana protein hydrolysates (PN-1), and then digested with a gastrointestinal enzyme (PN-1G). The inhibitory effects of the HWE and hydrolysates against angiotensin I-converting enzyme (ACE) were investigated. The soluble protein and peptide contents were 379.9 and 179.7 mg/g, respectively, for HWE and 574.8 and 332.8 mg/g, respectively, for PN-1...
October 1, 2018: Nutrients
Sabrina R Liu, Maryam Kia-Keating, Karen Nylund-Gibson
Research has demonstrated the negative impact of Adverse Childhood Experiences (ACEs) on long-term trajectories of mental and physical health. Yet existing literature on this topic is limited in its understanding of outcomes among youth samples, optimal measurement items and methods, and differences in adverse experiences across race/ethnicity. The current study used a person-centered approach to measure ACEs and their impact on youth health outcomes across three different racial/ethnic groups from a large national database...
September 28, 2018: Child Abuse & Neglect
Guowei Shu, Jie Huang, Chunju Bao, Jiangpeng Meng, He Chen, Jili Cao
Angiotensin I-converting enzyme (ACE) peptides are bioactive peptides that have important value in terms of research and application in the prevention and treatment of hypertension. While widespread literature is concentrated on casein or whey protein for production of ACE-inhibitory peptides, relatively little information is available on selecting the proper proteases to hydrolyze the protein. In this study, skimmed cow and goat milk were hydrolyzed by four commercial proteases, including alkaline protease, trypsin, bromelain, and papain...
September 27, 2018: Biomolecules
Marie Smets, Miek Smeets, Steve Van den Bulck, Stefan Janssens, Bert Aertgeerts, Bert Vaes
BACKGROUND: Quality indicators (QIs) are used to measure and evaluate quality of care. However, QIs to evaluate care for HF patients in general practice in Belgium are lacking. Therefore, this study aimed to determine which QIs, rooted in the electronic health record (EHR), are useful to monitor quality of care for patients with HF in general practice. METHODS: The RAND/UCLA appropriateness method (a modified Delphi method) was used to define these assigned QIs...
September 27, 2018: Acta Cardiologica
Dorin Harpaz, Loo Pin Yeo, Francesca Cecchini, Trish H P Koon, Ariel Kushmaro, Alfred I Y Tok, Robert S Marks, Evgeni Eltzov
Artificial sweeteners have become increasingly controversial due to their questionable influence on consumers' health. They are introduced in most foods and many consume this added ingredient without their knowledge. Currently, there is still no consensus regarding the health consequences of artificial sweeteners intake as they have not been fully investigated. Consumption of artificial sweeteners has been linked with adverse effects such as cancer, weight gain, metabolic disorders, type-2 diabetes and alteration of gut microbiota activity...
September 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Stephen A Adefegha, Sunday I Oyeleye, Felix A Dada, Tosin A Olasehinde, Ganiyu Oboh
This study sought to compare the effects of quercetin and rutin on some enzymes linked to erectile function as well as antioxidant status in penile tissue of paroxetine - induced erectile dysfunction in rats. Animals were randomly divided into twelve groups: normal control (NC), sildenafil (SD), quercetin (QA) (25 and 50 mg/kg), rutin (RU) (25 and 50 mg/kg), PAR (10 mg/kg); PAR + SD; PAR + QA, PAR + RU (25 and 50 mg/kg). After 14 days' treatment, phosphodiesterase-5' (PDE-5'), arginase, adenosine deaminase (ADA), acetylcholinesterase (AChE) and angiotensin-I converting enzyme (ACE) activities as well as malondialdehyde (MDA) and non-protein thiol levels were determined in rat penile tissues...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Satoru Matsuura, Hidemasa Katsumi, Hiroe Suzuki, Natsuko Hirai, Hidetaka Hayashi, Kazuhiro Koshino, Takahiro Higuchi, Yusuke Yagi, Hiroyuki Kimura, Toshiyasu Sakane, Akira Yamamoto
Effective delivery of drug carriers selectively to the kidney is challenging because of their uptake by the reticuloendothelial system in the liver and spleen, which limits effective treatment of kidney diseases and results in side effects. To address this issue, we synthesized l-serine (Ser)-modified polyamidoamine dendrimer (PAMAM) as a potent renal targeting drug carrier. Approximately 82% of the dose was accumulated in the kidney at 3 h after i.v. injection of 111 In-labeled Ser-PAMAM in mice, while i.v...
October 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
Chun-Yung Huang, Yung-Hsiang Tsai, Yong-Han Hong, Shu-Ling Hsieh, Ren-Han Huang
Fish gelatin hydrolysates have been shown to possess various biological activities due to their unique Gly-Pro-Y and Gly-X-Hyp sequences. In the current study, fish gelatin was extracted from non-extruded milkfish scale (FSG1) or extrusion-pretreated milkfish scale (FSG2); extracted gelatins were hydrolyzed with different combinations of Flavourzyme and Alcalase to give four different hydrolysates, namely: FSGH1 (FSG1 hydrolyzed with Flavourzyme), FSGH2 (FSG1 hydrolyzed with Alcalase + Flavourzyme), FSGH3 (FSG2 hydrolyzed with Flavourzyme), and FSGH4 (FSG2 hydrolyzed with Alcalase + Flavourzyme)...
September 22, 2018: Marine Drugs
Todd A DeWees, John Nikitas, Sana Rehman, Jeffrey D Bradley, Cliff G Robinson, Michael C Roach
INTRODUCTION: Comparison of overall survival (OS) between SBRT and other treatments for early stage NSCLC is confounded by differences in age, performance status, and medical comorbidity. We sought to define the most robust measurement for this population amongst five indices: age, Eastern Cooperative Oncology Group (ECOG) performance status, Adult Comorbidity Evaluation-27 (ACE-27), Charlson Comorbidity Index (CCI), and age adjusted CCI (CCIa). METHODS: 548 patients with stage I NSCLC treated with SBRT were analyzed...
September 19, 2018: Practical Radiation Oncology
Aifen Liu, Sai Wang, Chunxiao Zhang, Di Sun, Xiaozheng Song
OBJECTIVE: This study aimed to investigate the relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and to understand sudden cardiac arrest (SCA) in the Chinese population. METHODS: In this study, 232 patients were divided into the SCA group and the coronary disease group with coronary disease, but no SCA occurred during the treatment period. After comparing the genotype frequencies of the two groups, all patients were further divided into three groups as the II homozygotes, ID heterozygotes, and DD homozygotes to investigate the relationship in ACE I/D polymorphism and other risk factors of SCA...
September 22, 2018: Journal of Cellular Biochemistry
Brigida E Annicchiarico, Concetta Santonocito, Massimo Siciliano, Margherita Scapaticci, Donatella Guarino, Carmine Di Stasi, Maria E Riccioni, Enrico Di Stasio, Ettore Capoluongo, Antonio Gasbarrini
BACKGROUND: In liver cirrhosis, the renin-angiotensin-aldosterone system is involved in the pathogenesis of portal hypertension. Its effector, angiotensin II, is generated by angiotensin-converting enzyme (ACE). Serum ACE levels are affected by I/D polymorphism of its gene, with alleles I and D being associated, respectively, with lesser and greater activity of the enzyme. In cirrhotic patients carrying the ACE I allele, an increased risk for gastro-oesophageal varices was observed. AIM: The aim of our study was to evaluate whether ACE I/D polymorphism influenced portal pressure...
August 28, 2018: Digestive and Liver Disease
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