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lung diffusion

M Sanchis-Borja, J Pastré, S Mercier, K Juvin, A Benattia, D Israël-Biet
INTRODUCTION: Hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis (POIKTMP) is a recently described, extremely rare, entity belonging to the spectrum of inherited poikilodermas. It is provoked by a mutation of the FAM111B gene. Respiratory involvement has never been fully described but usually involves a restrictive respiratory pattern. We present here a case of pulmonary fibrosis associated with POIKTMP and describe the clinical, functional, radiological and evolutionary characteristics...
October 16, 2018: Revue des Maladies Respiratoires
Hee-Young Yoon, Sojung Park, Dong Soon Kim, Jin Woo Song
BACKGROUND: Phase 3 trials have shown that nintedanib reduces the decline in forced vital capacity (FVC) in patients with mild-to-moderate idiopathic pulmonary fibrosis (IPF) with acceptable safety profiles; however, its effects on advanced IPF are unclear. We investigated the efficacy and safety of nintedanib in patients with advanced IPF. METHODS: Prospective data were obtained from 108 IPF patients administered at least one dose of nintedanib. Of these patients, 47...
October 19, 2018: Respiratory Research
Ryuya Edahiro, Hiroyuki Kurebe, Saeko Nakatsubo, Yuki Hosono, Nobuhiko Sawa, Kohei Nishida, Yuko Ohara, Yohei Oshitani, Hiroyuki Kagawa, Kazuyuki Tsujino, Kenji Yoshimura, Keisuke Miki, Mari Miki, Seigo Kitada, Masahide Mori
Diffuse pulmonary ossification (DPO) is an uncommon diffuse lung disease characterized by metaplastic bone formation in the lung parenchyma and is rarely diagnosed in life. While DPO usually occurs as a secondary disease, idiopathic cases are extremely rare. We describe three cases of idiopathic DPO, two of which were definitively diagnosed by surgical lung biopsy. One case was observed in a 43-year-old man with a history of recurrent pneumothorax who developed pneumothorax after the surgical biopsy. Few reports have described cases of DPO with recurrent pneumothorax; however, pneumothorax should be considered as a potential complication when such patients are encountered...
October 17, 2018: Internal Medicine
Hee-Young Yoon, Dong Soon Kim, Jin Woo Song
BACKGROUND: Although phase 3 trials showed significant efficacy and acceptable safety profiles for pirfenidone in mild-to-moderate idiopathic pulmonary fibrosis (IPF), data on advanced IPF are limited. OBJECTIVES: The study aimed to evaluate the efficacy and safety of pirfenidone in advanced IPF patients. METHODS: The clinical data of 138 IPF patients (advanced group: 27%) treated with pirfenidone were retrospectively reviewed and compared between advanced and non-advanced groups...
October 17, 2018: Respiration; International Review of Thoracic Diseases
Jane Jx Lim, Angela Takano, Devanand Anantham
No abstract text is available yet for this article.
September 2018: Annals of the Academy of Medicine, Singapore
Young Wha Koh, Su Jin Lee, Seong Yong Park
OBJECTIVE: We explored the relationship between preoperative 18 F-FDG-PET parameters, tumor necrosis, and microvessel density (MVD) in patients with pulmonary adenocarcinomas. METHODS: A total of 164 patients, who underwent surgical resection for lung adenocarcinoma, were reviewed retrospectively. The maximum standardized uptake value (SUVmax ), peak SUV corrected for lean body mass (SULpeak ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) values were measured by preoperative 18 F-FDG-PET...
October 15, 2018: Annals of Nuclear Medicine
Tuhin K Roy, Timothy W Secomb
Under resting normoxic conditions, the healthy lung has ample oxygen uptake capacity relative to oxygen demand, but during exercise, increased oxygen demand and utilization become increasingly dependent on ventilation-perfusion matching. A mathematical model is used to investigate the effect of pulmonary flow heterogeneity, as characterized by the coefficient of variation (CV) of capillary blood flow, on pulmonary oxygen uptake in exercise. The model reveals that any level of heterogeneity up to a CV of 3 is consistent with the observed level of arterial oxygen tension under resting conditions, but that such high levels of heterogeneity are incompatible with the levels of oxygen uptake observed during exercise...
October 12, 2018: Respiratory Physiology & Neurobiology
Isabel Pino Peña, Veronika Cheplygina, Sofia Paschaloudi, Morten Vuust, Jesper Carl, Ulla Møller Weinreich, Lasse Riis Østergaard, Marleen de Bruijne
PURPOSE: A method for automatically quantifying emphysema regions using High-Resolution Computed Tomography (HRCT) scans of patients with chronic obstructive pulmonary disease (COPD) that does not require manually annotated scans for training is presented. METHODS: HRCT scans of controls and of COPD patients with diverse disease severity are acquired at two different centers. Textural features from co-occurrence matrices and Gaussian filter banks are used to characterize the lung parenchyma in the scans...
2018: PloS One
Aylin Oral, Bülent Yazıcı, Özgür Ömür
A sixty-two-year-old male patient underwent orchiectomy and was diagnosed with diffuse large B-cell lymphoma in the testicle and spermatic cord. 18 F-FDG positron emission tomography/computed tomography (PET/CT) scanning was performed for initial staging. 18 F-FDG PET/CT scan revealed multiple hyper-metabolic lymphadenopathies, lung lesions and mass lesions in the adrenal glands and kidneys. In addition, diffuse increased 18 F-FDG uptake suggesting lymphomatous infiltration on the right testicle, prostate and left testicular veins were detected...
October 9, 2018: Molecular Imaging and Radionuclide Therapy
Anastas Krassenov Demirev, Irena Dimitrova Kostadinova, Iliya Rumenov Gabrovski
Objectives: Radiation pneumonitis (RP) can be an adverse complication of radiotherapy (RT) and can limit the application of the already planned radiation dose. It is often associated with RT of lung carcinoma and is occasionally caused by radiation therapy of breast carcinoma and lymphomas located in the mediastinum. Positron emission tomography/computed tomography (PET/CT) emerges lately as a prospective modality for early diagnostics of RP. The aim of this study was to summarize the initial data from diagnostic application of PET/CT in patients suspicious of RP and to derive criteria, which can help differentiate RP from early recurrence of the disease and/or residual tumor...
October 9, 2018: Molecular Imaging and Radionuclide Therapy
Lazar Tosic, Dominik Baschera, Bastian Jentsch, Thomas Feuerstein, Alex Alfieri
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms commonly involving visceral or parietal pleura. We present the first report of tumor-to-tumor metastasis involving a pulmonary adenocarcinoma donor and an intradural SFT recipient. The patient presented with a 1 year history of diffuse back pain. A spinal intradural contrast-enhancing mass at the T9/10 level and a tumor of the lung were diagnosed radiologically. Bronchoscopic biopsy confirmed pulmonary adenocarcinoma in the right upper lung lobe...
October 13, 2018: Acta Neurochirurgica
Dandan Liang, Shaoshan Liang, Feng Xu, Mingchao Zhang, Xiaomei Li, Yiyao Tu, Zhihong Liu, Caihong Zeng
AIM: To explore the clinicopathological characteristics of patients with anti-GBM antibody-negative anti-GBM disease. METHODS: The clinical and renal pathological findings were retrospectively studied in 19 patients. All patients met the following inclusion criteria: linear GBM IgG deposition on immunofluorescence(IF); and lack of serum anti-GBM antibodies by ELISA and indirect immunofluorescence assay. RESULTS: There were 17 male and two female patients, with a median age of 36 years (range 15-61 years)...
October 12, 2018: Journal of Clinical Pathology
Leonardo Jönck Staub, Roberta Rodolfo Mazzali Biscaro, Erikson Kaszubowski, Rosemeri Maurici
BACKGROUND: Lung ultrasound can accelerate the diagnosis of life-threatening diseases in adults with respiratory symptoms. OBJECTIVE: Systematically review the accuracy of lung ultrasonography (LUS) for emergency diagnosis of pneumonia, acute heart failure, and exacerbation of chronic obstructive pulmonary disease (COPD)/asthma in adults. METHODS: PubMed, Embase, Scopus, Web of Science, and LILACS (Literatura Latino Americana e do Caribe em Ciências da Saúde; until 2016) were searched for prospective diagnostic accuracy studies...
October 9, 2018: Journal of Emergency Medicine
Pavol Sajgalik, Chul-Ho Kim, John M Stulak, Sudhir S Kushwaha, Simon Maltais, David L Joyce, Lyle D Joyce, Bruce D Johnson, John A Schirger
AIM: The lungs-and particularly the alveolar-capillary membrane-may be sensitive to continuous flow (CF) and pulmonary pressure alterations in heart failure (HF). We aimed to investigate long-term effects of CF pumps on respiratory function. METHODS AND RESULTS: We conducted a retrospective study of patients with end-stage HF at our institution. We analysed pulmonary function tests [e.g. forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1 )] and diffusing capacity of the lung for carbon monoxide (DLCO ) from before and after left ventricular assist device (LVAD) implantation and compared them with invasive haemodynamic studies...
October 12, 2018: ESC Heart Failure
Dimitri Stylemans, Sylvia Verbanck, Stefanie Vincken, Walter Vincken, Elke De Wachter, Eef Vanderhelst
BACKGROUND: While cystic fibrosis (CF) lung disease is generally considered to be an obstructive disorder, other pulmonary function patterns (PFP) may occur. Furthermore, little is known about possible associations between PFP and genotype or phenotypical characteristics. METHODS: Cross-sectional study including CF patients aged 16 years or more, identifying different PFP and exploring associations between PFP and genotype or phenotypical characteristics. RESULTS: Obstructive PFP was most prevalent in our population (n = 80), comprising obstructive lung disease (62...
October 12, 2018: Acta Clinica Belgica
Shikma Katz, Nissim Arish, Ariel Rokach, Yacov Zaltzman, Esther-Lee Marcus
BACKGROUND: Pulmonary function tests (PFTs) are routinely performed in the upright position due to measurement devices and patient comfort. This systematic review investigated the influence of body position on lung function in healthy persons and specific patient groups. METHODS: A search to identify English-language papers published from 1/1998-12/2017 was conducted using MEDLINE and Google Scholar with key words: body position, lung function, lung mechanics, lung volume, position change, positioning, posture, pulmonary function testing, sitting, standing, supine, ventilation, and ventilatory change...
October 11, 2018: BMC Pulmonary Medicine
Bruno Hochhegger, Matheus Zanon, Stephan Altmayer, Gabriel S Pacini, Fernanda Balbinot, Martina Z Francisco, Ruhana Dalla Costa, Guilherme Watte, Marcel Koenigkam Santos, Marcelo C Barros, Diana Penha, Klaus Irion, Edson Marchiori
Quantitative imaging in lung cancer is a rapidly evolving modality in radiology that is changing clinical practice from a qualitative analysis of imaging features to a more dynamic, spatial, and phenotypical characterization of suspected lesions. Some quantitative parameters, such as the use of 18F-FDG PET/CT-derived standard uptake values (SUV), have already been incorporated into current practice as it provides important information for diagnosis, staging, and treatment response of patients with lung cancer...
October 9, 2018: Lung
Sandip Honmane, Ashok Hajare, Harinath More, Riyaz Ali M Osmani, Sachin Salunkhe
The motive behind present work was to discover a solution for overcoming the problems allied with deprived oral bioavailability of salbutamol sulphate (SS) due to its first pass hepatic metabolism, shorter half life and systemic toxicity at high doses. Pulmonary delivery provides alternative route of administration to avoid hepatic metabolism of SS, moreover facilitated diffusion and prolonged retention can be achieved by incorporation into liposomes. Liposomes were prepared by thin film hydration technique using 32 full factorial design and formulation was optimized based on the vesicle size and percent drug entrapment (PDE) of liposomes...
October 8, 2018: Journal of Liposome Research
Isadora Cardoso, Eliana Almeida, Hector Allende-Cid, Alejandro C Frery, Rangaraj M Rangayyan, Paulo M Azevedo-Marques, Heitor S Ramos
BACKGROUND:  Diffuse lung diseases (DLDs) are a diverse group of pulmonary disorders, characterized by inflammation of lung tissue, which may lead to permanent loss of the ability to breathe and death. Distinguishing among these diseases is challenging to physicians due their wide variety and unknown causes. Computer-aided diagnosis (CAD) is a useful approach to improve diagnostic accuracy, by combining information provided by experts with Machine Learning (ML) methods. OBJECTIVES:  Exploring the potential of dimensionality reduction combined with ML methods for diagnosis of DLDs; improving the classification accuracy over state-of-the-art methods...
October 8, 2018: Methods of Information in Medicine
Apoorva Jayaranagaiah, Pramod Theetha Kariyanna, Naga Koteshwari Sucharitra Chidella, Navneet Singh, Jason Green, Moro O Salifu, Samy I McFarlane
Mesothelioma is a rare tumor of the pleura, peritoneum, pericardium or tunica vaginalis. About 2,500 cases are diagnosed annually in the United States. Mesothelioma often presents with pleuritic chest pain and dyspnea related to local invasion; distal metastasis and lymphadenopathy at the time of diagnosis is rare. Pericardial involvement in mesothelioma is related to direct invasion of the tumor. We here present a 71 year-old-male who presented with pleuritic chest pain and dyspnea, noted to have diffuse ST-segment elevation in EKG and cardiac tamponade physiology on 2D echocardiogram in who imaging subsequently revealed left upper lung mesothelioma...
2018: Clinical Case Reports and Reviews
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