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JOURNAL ARTICLE
Michael Carstens, Jessy Trujillo, Yanury Dolmus, Carlos Rivera, Santos Calderwood, Judith Lejarza, Carlos López, Kenneth Bertram
BACKGROUND AIMS: Long coronavirus disease (COVID) is estimated to occur in up to 20% of patients with coronavirus disease 2019 (COVID-19) infections, with many having persistent pulmonary symptoms. Mesenchymal stromal cells (MSCs) have been shown to have powerful immunomodulatory and anti-fibrotic properties. Autologous adipose-derived (AD) stromal vascular fraction (SVF) contains MSC and other healing cell components and can be obtained by small-volume lipoaspiration and administered on the same day...
April 4, 2024: Cytotherapy
#22
JOURNAL ARTICLE
Hita Rangarajan, Irfan Ismail Ayub, Sridevi Padmanabhan
OBJECTIVES: To evaluate maximal inspiratory (MIP) and expiratory (MEP) pressures, which are reflective of respiratory muscle strength, in skeletal Class II patients with different growth patterns (horizontal, average, and vertical) and to correlate those with airway dimension. MATERIALS AND METHODS: Patients with a Class II skeletal base seeking orthodontic treatment were assigned to the following groups: average, horizontal, and vertical growth pattern. The control group (n = 14) comprised patients with a Class I skeletal base and average growth pattern...
May 1, 2024: Angle Orthodontist
#23
JOURNAL ARTICLE
Kamila Resova, Lukas Knybel, Tereza Parackova, Marian Rybar, Karel Cwiertka, Jakub Cvek
BACKGROUND: Stereotactic ablative radiotherapy (SABR) is the standard treatment for medically inoperable early-stage non-small cell lung cancer (ES-NSCLC), but which patients benefit from stereotactic radiotherapy is unclear. The aim of this study was to analyze prognostic factors for early mortality. METHODS: From August 2010 to 2022, 617 patients with medically inoperable, peripheral or central ES-NSCLC were treated with SABR at our institution. We retrospectively evaluated the data from 172 consecutive patients treated from 2018 to 2020 to analyze the prognostic factors associated with overall survival (OS)...
April 18, 2024: Radiation Oncology
#24
JOURNAL ARTICLE
Yangli Liu, Fengjia Chen, Zhimin Zeng, Chengcheng Lei, Dubo Chen, Xiaoyu Zhang
BACKGROUND AND OBJECTIVE: Endothelial dysfunction has been widely recognized in chronic airway diseases, including chronic obstructive pulmonary disease (COPD) and asthma; however, it remains unclear in asthma-COPD overlap (ACO). Neopterin (NP), a metabolite of guanosine triphosphate, is a novel biomarker for identifying the increased risk of adverse cardiovascular events. This study aims to investigate the association of NP with endothelial dysfunction and impaired lung function in COPD, asthma, and ACO patients...
April 18, 2024: Respiratory Research
#25
JOURNAL ARTICLE
Rodrigo Abensur Athanazio, Laura Bernal Villada, Sergey N Avdeev, Hao-Chien Wang, Alejandra Ramírez-Venegas, Martín Sivori, Jorge Dreyse, Manuel Pacheco, Sin Kit Man, Lorena Noriega-Aguirre, Hisham Farouk
INTRODUCTION: The <u>EXA</u>cerbations of <u>C</u>hronic obstructive lung disease (COPD) and their <u>O</u>utcome<u>S</u> (EXACOS) International Study aimed to quantify the rate of severe exacerbations and examine healthcare resource utilisation (HCRU) and clinical outcomes in patients with COPD from low-income and middle-income countries. METHODS: EXACOS International was an observational, cross-sectional study with retrospective data collection from medical records for a period of up to 5 years...
April 18, 2024: BMJ Open Respiratory Research
#26
JOURNAL ARTICLE
Jing Peng, Gang Guo, Zhonghui Wang, Li Zhuang, Yuhui Ma, Bin Yuan, Mingxiong Zhang, Qunfen Tao, Yanqiu Zhao, Li Zhao, Xingxiang Dong
INTRODUCTION: This study is a retrospective study. This study aims to explore the association between lobectomy in lung cancer patients and subsequent compensatory lung growth (CLG), and to identify factors that may be associated with variations in CLG. METHODS: 207 lung cancer patients who underwent lobectomy at Yunnan Cancer Hospital between January 2020 and December 2020. All patients had stage IA primary lung cancer and were performed by the same surgical team...
April 17, 2024: Journal of Surgical Research
#27
JOURNAL ARTICLE
Angelina L P Pieters, Tjeerd van der Veer, Jennifer J Meerburg, Eleni-Rosalina Andrinopoulou, Menno M Vd Eerden, Pierluigi Ciet, Stefano Aliberti, Pierre-Regis Burgel, Megan L Crichton, Amelia Shoemark, Pieter C Goeminne, Michal Shteinberg, Michael R Loebinger, Charles S Haworth, Francesco Blasi, Harm Awm Tiddens, Daan Caudri, James D Chalmers
RATIONALE: Chest computed tomography -scans (CTs) are essential to diagnose and monitor bronchiectasis (BE). To date, little quantitative data is available about the nature and extent of structural lung abnormalities (SLA) on CTs of BE patients. OBJECTIVES: to investigate SLA on CTs of patients with bronchiectasis and the relationship of SLAs to clinical features using the European Bronchiectasis Registry (EMBARC) Methods: CTs from BE patients included in the EMBARC registry were analyzed using the validated Bronchiectasis Scoring Technique for CT (BEST-CT)...
April 18, 2024: American Journal of Respiratory and Critical Care Medicine
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JOURNAL ARTICLE
Muhammad Musaab Munir, Selamawit Woldesenbet, Yutaka Endo, Mary Dillhoff, Susan Tsai, Timothy M Pawlik
BACKGROUND: The association of hospital market competition, financial costs, and quality of oncologic care has not been well-defined. This study sought to evaluate variations in patient outcomes and financial expenditures after complex cancer surgery across high- and low-competition markets. METHODS: Medicare 100% Standard Analytic Files were used to identify patients with lung, esophageal, gastric, hepatopancreaticobiliary, or colorectal cancer who underwent surgical resection between 2018 and 2021...
April 18, 2024: Annals of Surgical Oncology
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JOURNAL ARTICLE
Paolo Morgagni, Maria Bencivenga, Fatima Carneiro, Stefano Cascinu, Sarah Derks, Maria Di Bartolomeo, Claire Donohoe, Clarisse Eveno, Suzanne Gisbertz, Peter Grimminger, Ines Gockel, Heike Grabsh, Paulo Kassab, Rupert Langer, Sara Lonardi, Marco Maltoni, Sheraz Markar, Markus Moehler, Daniele Marrelli, Maria Antonietta Mazzei, Davide Melisi, Carlo Milandri, Paul Stefan Moenig, Bianca Mostert, Gianni Mura, Wojciech Polkowski, John Reynolds, Luca Saragoni, Mark I Van Berge Henegouwen, Richard Van Hillegersberg, Michael Vieth, Giuseppe Verlato, Lorena Torroni, Bas Wijnhoven, Guido Alberto Massimo Tiberio, Han-Kwang Yang, Franco Roviello, Giovanni de Manzoni
BACKGROUND: Many gastric cancer patients in Western countries are diagnosed as metastatic with a median overall survival of less than twelve months using standard chemotherapy. Innovative treatments, like targeted therapy or immunotherapy, have recently proved to ameliorate prognosis, but a general agreement on managing oligometastatic disease has yet to be achieved. An international multi-disciplinary workshop was held in Bertinoro, Italy, in November 2022 to verify whether achieving a consensus on at least some topics was possible...
April 18, 2024: Gastric Cancer
#30
JOURNAL ARTICLE
Nicola Lambri, Giorgio Longari, Daniele Loiacono, Ricardo Coimbra Brioso, Leonardo Crespi, Carmela Galdieri, Francesca Lobefalo, Giacomo Reggiori, Roberto Rusconi, Stefano Tomatis, Luisa Bellu, Stefania Bramanti, Elena Clerici, Chiara De Philippis, Damiano Dei, Pierina Navarria, Carmelo Carlo-Stella, Ciro Franzese, Marta Scorsetti, Pietro Mancosu
BACKGROUND: Total marrow (lymphoid) irradiation (TMI/TMLI) is a radiotherapy treatment used to selectively target the bone marrow and lymph nodes in conditioning regimens for allogeneic hematopoietic stem cell transplantation. A complex field geometry is needed to cover the large planning target volume (PTV) of TMI/TMLI with volumetric modulated arc therapy (VMAT). Five isocenters and ten overlapping fields are needed for the upper body, while, for patients with large anatomical conformation, two specific isocenters are placed on the arms...
April 18, 2024: Medical Physics
#31
JOURNAL ARTICLE
Benjamin Stoecklin, Chiara Veneroni, Y Jane Choi, J Jane Pillow, Raffaele L Dellacà
Data on static compliance of the chest wall ( C cw ) in preterm infants are scarce. We characterised the static compliance of the lung ( CL ) and C cw to determine their relative contribution to static compliance of the respiratory system ( C rs ) in very preterm infants at 36 weeks' postmenstrual age (PMA). We also aimed to investigate how these compliances were influenced by the presence of bronchopulmonary dysplasia (BPD) and impacted breathing variables. Airway opening pressure, esophageal pressure, and tidal volume ( V T ) were measured simultaneously during a short apnea evoked by the Hering-Breuer reflex...
April 18, 2024: Journal of Applied Physiology
#32
JOURNAL ARTICLE
Madison Bradley-Cronkwright, Sarah Moore, Lily Hou, Susanne Cote, Campbell Rolian
Distantly related mammals (e.g. jerboa, tarsiers, kangaroos) have convergently evolved elongated hindlimbs relative to body size. Limb elongation is hypothesized to make these species more effective jumpers by increasing their kinetic energy output (through greater forces or acceleration distances), thereby increasing take-off velocity and jump distance. This hypothesis, however, has rarely been tested at the population level, where natural selection operates. We examined the relationship between limb length, muscular traits, and dynamics using Longshanks mice, which were selectively bred over 22 generations for longer tibiae...
April 18, 2024: Journal of Experimental Biology
#33
JOURNAL ARTICLE
Jip A Spekman, Joël Israëls, Ilja de Vreede, Mady Los, Miranda J J Geelhoed, Erik W van Zwet, Monique C Haak, Arno A W Roest, Jeanine M M van Klink, Enrico Lopriore, Sophie G Groene
BACKGROUND: Fetal growth restriction (FGR) can negatively affect lung development, leading to increased respiratory morbidity and reduced lung function later in life. Studies regarding the impact of FGR on lung function in singletons are influenced by genetic, obstetric, and maternal factors. To overcome these confounding factors, we aim to investigate lung function in identical twins with selective FGR (sFGR). METHODS: Lung function assessments were performed in identical twins with sFGR born in our centre between March 1, 2002, and December 31, 2017, aged between 5 and 17 years...
June 2024: EClinicalMedicine
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JOURNAL ARTICLE
Mikael Björnson, Ann Mari Svensson, Cecilia He, Magnus Sköld, Sven Nyrén, Malin Nygren-Bonnier, Judith Bruchfeld, Michael Runold, Francesca Campoccia Jalde, Anna Kistner
BACKGROUND: Few studies consider both radiological and functional outcomes in COVID-19 survivors treated in the intensive care unit (ICU). We investigated clinical findings and pulmonary abnormalities on chest computed tomography (CT) and compared outcomes of severe versus mild-moderate acute respiratory distress syndrome (ARDS) on long-term follow-up. METHODS: This longitudinal cohort study included 118 COVID-19 patients (median age, 58 years; 79% men). Thoracic CT scans were performed 4, 10, and 22 months after hospital discharge...
2024: Frontiers in Medicine
#35
JOURNAL ARTICLE
Shin Tanaka, Eiji Nakata, Toshifumi Ozaki, Shinichi Toyooka
BACKGROUND: Very large chest wall resections can lead to acute thoracic insufficiency syndrome due to the interdependence of lung expansion and thoracic volume. Chest wall tumor surgeries often encounter complications, with the size of the chest wall defect being a significant predictor. Several methods for large chest wall reconstruction have been described, aiming to provide stability, prevent flail chest, and ensure airtight closure. However, no single method fulfills all requirements...
April 18, 2024: Journal of Cardiothoracic Surgery
#36
JOURNAL ARTICLE
Minghui Shi, Shiwei Qumu, Siyuan Wang, Yaodie Peng, Lulu Yang, Ke Huang, Ruoxi He, Feng Dong, Hongtao Niu, Ting Yang, Chen Wang
BACKGROUND: Despite being a prognostic predictor, cardiac autonomic dysfunction (AD) has not been well investigated in chronic obstructive pulmonary disease (COPD). We aimed to characterise computed tomography (CT), spirometry, and cardiopulmonary exercise test (CPET) features of COPD patients with cardiac AD and the association of AD with CT-derived vascular and CPET-derived ventilatory efficiency metrics. METHODS: This observational cohort study included stable, non-severe COPD patients...
April 17, 2024: BMC Pulmonary Medicine
#37
JOURNAL ARTICLE
Julius Lars Daniel Bastian, Philip Zeuschner, Michael Stöckle, Kerstin Junker, Johannes Linxweiler
In this study, we aimed to establish a technique for intraprostatic implantation of prostate cancer (PCa) spheroids and to identify the impact of three-dimensional organization of PCa cells on tumor progression and metastasis in a representative in vivo model. 40,000 LNCaP cells were implanted into the prostate of immunodeficient SCID mice either as single cells (n = 8) or as preformed 3D spheroids (n = 8). For a follow up of 20 weeks, tumor growth was monitored by serum PSA and high-resolution 3D ultrasonography...
April 17, 2024: Scientific Reports
#38
JOURNAL ARTICLE
Glenio B Mizubuti, Sarah Maxwell, Sergiy Shatenko, Heather Braund, Rachel Phelan, Anthony M-H Ho, Nancy Dalgarno, Hailey Hobbs, Adam Szulewski, Faizal Haji, Ramiro Arellano
PURPOSE: Point-of-care ultrasound (POCUS) allows for rapid bedside assessment and guidance of patient care. Recently, POCUS was included as a mandatory component of Canadian anesthesiology training; however, there is no national consensus regarding the competencies to guide curriculum development. We therefore aimed to define national residency competencies for basic perioperative POCUS proficiency. METHODS: We adopted a Delphi process to delineate relevant POCUS competencies whereby we circulated an online survey to academic anesthesiologists identified as POCUS leads/experts (n = 25) at all 17 Canadian anesthesiology residency programs...
April 17, 2024: Canadian Journal of Anaesthesia
#39
JOURNAL ARTICLE
Jaime Mazón Ruiz, Eduardo Josue Banegas, Jose Luis Pérez Canga, Luis Bravo González-Blas, Natalia Menéndez García, Adriana Cavada Bustamante, Mara Serrano Soto, Emilio Sánchez Álvarez, Roberto Alcázar Arroyo, Gregorio A Romero-González
Hyponatremia is a multifactorial disorder defined as a decrease in plasma sodium concentration. Its differential diagnosis requires an adequate evaluation of the extracellular volume (ECV). However, ECV determination, simply based on the clinical history, vital signs, physical examination, and laboratory findings can leads to misdiagnosis and inappropriate treatment. The use of Point-of-Care Ultrasound (POCUS), through the combination of Lung Ultrasound (LUS), Venous Excess UltraSound (VExUS) and Focused Cardiac Ultrasound (FoCUS), allows a much more accurate holistic assessment of the patient's ECV status in combination with the other parameters...
April 16, 2024: Nefrología
#40
JOURNAL ARTICLE
Jiongjie Wang, Jichao Guo, Haizhan Shi, Xiangru Chen, Wenxin He, Zhixin Li
OBJECTIVES: The right lower sleeve lobectomy is a rarely performed major lung resection.This study aims to evaluate the safety and effectiveness of this procedure by comparing to right lower bilobectomy in non-small cell lung cancer patients. METHODS: We retrospectively reviewed a prospective database of non-small cell lung cancer patients who underwent right lower sleeve lobectomy (group S) or right lower bilobectomy (group B) from January 2014 to January 2020 in Shanghai Pulmonary Hospital...
April 16, 2024: Journal of Cardiothoracic Surgery
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