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cardiopulmonary function testing

Lian Duan, Guohuang Hu, Meng Jiang, Chengliang Zhang
To investigate the incidence of postoperative abnormal liver function test (aLFT) for the children with heart surgery, and to analyze the clinical characteristics and risk factors.
 Methods: A total of 143 children younger than 18 years old who underwent heart surgery in 2017 were enrolled in this study. The liver function were examined one day preoperation and consecutive 5 days after operation. The clinical data of perioperative period were recorded and the risk factors for aLFT were analyzed.
 Results: There were 43/143 (30%) cases had aLFT, including 5/143 (3...
September 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Hongyan Yang, Yuanhua Liu, Huan Zheng, Guanghui Liu, Aihong Mei
INTRODUCTION: Regular exercise is confirmed as a lifestyle treatment option for all obstructive sleep apnea (OSA) patients. It has beneficial effects other than weight loss, although the mechanisms remain unclear. Autonomic function imbalance plays an important role in OSA, so that it is meaningful to observe the effect of exercise on autonomic function. METHODS: Seventy mild to moderate OSA patients were divided into two groups. The exercise group received a 12-week exercise program prescribed according to their first cardiopulmonary exercise tests, while the control group kept previous lifestyle...
October 16, 2018: Sleep & Breathing, Schlaf & Atmung
Massimo Caputo, Katie Pike, Sarah Baos, Karen Sheehan, Kathleen Selway, Lucy Ellis, Serban Stoica, Andrew Parry, Gemma Clayton, Lucy Culliford, Gianni D Angelini, Ragini Pandey, Chris A Rogers
OBJECTIVE: To compare normothermic (35°C-36°C) versus hypothermic (28°C) cardiopulmonary bypass (CPB) in paediatric patients undergoing open heart surgery to test the hypothesis that normothermic CPB perfusion maintains the functional integrity of major organ systems leading to faster recovery. METHODS: Two single-centre, randomised controlled trials (known as Thermic-1 and Thermic-2 , respectively) were carried out to compare the effectiveness and acceptability of normothermic versus hypothermic CPB in children with congenital heart disease undergoing open heart surgery...
October 15, 2018: Heart: Official Journal of the British Cardiac Society
John S Kim, Jon Kaufman, Sonali S Patel, Marilyn Manco-Johnson, Jorge Di Paola, Eduardo M da Cruz
BACKGROUND: Ketorolac is used for pediatric analgesia after surgery despite its known platelet inhibition via the arachidonic acid (AA) pathway. The degree of platelet inhibitory effect after cardiac surgery is not well characterized. Thromboelastography with platelet mapping (TEG-PM) is emerging as a frequently used test to evaluate platelet inhibition via the AA pathway. METHODS: Post hoc analysis of a data set collected in a prospective observational cohort study evaluating platelet inhibition in children after congenital heart surgery with cardiopulmonary bypass (CPB)...
November 2018: World Journal for Pediatric & Congenital Heart Surgery
Helge Hebestreit, Erik Hj Hulzebos, Jane E Schneiderman, Chantal Karila, Steven R Boas, Susi Kriemler, Tiffany Dwyer, Margareta Sahlberg, Don S Urquhart, Larry C Lands, Felix Ratjen, Tim Takken, Liobou Varanistkaya, Viktoria Rücker, Alexandra Hebestreit, Jakob Usemann, Thomas Radtke
RATIONALE: The prognostic value of cardiopulmonary exercise testing (CPET) for survival in cystic fibrosis (CF) in the context of current clinical management, when controlling for other known prognostic factors is unclear. OBJECTIVES: To determine the prognostic value of CPET-derived measures beyond peak oxygen uptake (VO2peak) following rigorous adjustment for other predictors. MEASUREMENTS AND MAIN RESULTS: Data from 10 CF-centers in Australia, Europe and North America were collected retrospectively...
October 15, 2018: American Journal of Respiratory and Critical Care Medicine
Kristof Vandekerckhove, Kathleen De Waele, Aurelie Minne, Ilse Coomans, Katya De Groote, Joseph Panzer, Catherine Dhooge, Victoria Bordon, Daniel De Wolf, Jan Boone
BACKGROUND: Physical fitness is an important determinant of quality of life (QOL) after hematopoietic stem cell transplantation. Cardiac function can influence exercise performance. The aim of this study was to assess these factors and their interrelationship. PROCEDURE: Children underwent cardiopulmonary exercise testing (CPET) at least 1 year after hematopoietic stem cell transplantation (HSCT) and were compared with healthy controls. Systolic and diastolic heart function and left ventricle (LV) wall dimensions were measured...
October 14, 2018: Pediatric Blood & Cancer
Ankit B Shah, Jodi Zilinski, Marcel G Brown, Jennifer H Neary, Rory B Weiner, Adolph M Hutter, Fred S Apple, Michael H Picard, James L Januzzi, Aaron L Baggish
Endurance exercise training (ET) stimulates eccentric left ventricular hypertrophy (LVH) with left atrial dilation. To date, the biochemical correlates of exercise-induced cardiac remodelling (EICR) remain incompletely understood. Collegiate male rowers (n = 9) were studied with echocardiography and maximal-effort cardiopulmonary exercise testing (MECPET) before and after 90 days of ET intensification. Mid-regional pro-atrial natriuretic peptide (MR-proANP), N-terminal pro B-type natriuretic peptide (NT-proBNP), and high-sensitivity troponin T (hscTn) were measured at rest, peak MECPET, and 60 minutes post-MECPET at both study time points...
October 11, 2018: Journal of Applied Physiology
Jianfeng Xu, Hao Pan, Xuemeng Xie, Jincheng Zhang, Yun Wang, Guangtian Yang
Brain damage is a leading cause of death in patients with cardiac arrest (CA). The accumulation of succinate during ischemia by succinate dehydrogenase (SDH) is an important mechanism of ischemia-reperfusion injury. It was unclear whether inhibiting the oxidation of accumulated succinate could also mitigate brain damage after CA. In this study, rats were subjected to a 6 min of CA, and cardiopulmonary resuscitation (CPR) was performed with administration of normal saline or dimethyl malonate (DMM, a competitive inhibitor of SDH)...
October 6, 2018: Neuroscience
Henric Nilsson, Eva Nylander, Sabina Borg, Éva Tamás, Kristofer Hedman
Aortic valve surgery is the definitive treatment for aortic stenosis (AS). No specific recommendation is available on how exercise training should be conducted and evaluated after aortic valve replacement (AVR). This study aimed to examine the effect of aerobic exercise training on exercise capacity following AVR. In addition to our primary outcome variable, peak oxygen uptake (peakVO2 ), the effect on submaximal cardiopulmonary variables including oxygen uptake kinetics (tau), oxygen uptake efficiency slope (OUES) and ventilatory efficiency (VE/VCO2 slope) was evaluated...
October 8, 2018: Clinical Physiology and Functional Imaging
Eitezaz Mahmood, Jelliffe Jeganathan, Ruby Feng, Maria Saraf, Kamal Khabbaz, Faraz Mahmood, Senthilnathan Venkatachalam, David Liu, Louis Chu, Samir M Parikh, Robina Matyal
BACKGROUND: The mechanism of mitochondrial dysfunction following cardiopulmonary bypass (CPB) in diabetics lacks understanding. We hypothesized that impaired beta-oxidation of fatty acids leads to worsened stress response in this patient population after cardiac surgery. METHODS: After IRB approval, right atrial tissue samples were collected from 35 diabetic and 33 non-diabetics pre- and post-CPB. Patients with HbA1c ≥ 6.0 and a clinical diagnosis of diabetes mellitus were considered to be diabetic...
October 3, 2018: Annals of Thoracic Surgery
Maurizio Rizzi, Dejan Radovanovic, Pierachille Santus, Andrea Airoldi, Francesca Frassanito, Silvia Vanni, Andrea Cristiano, Piercarlo Sarzi-Puttini, Fabiola Atzeni
The 6-minute walk test (6MWT) is a standardised, feasible and reliable measure of sub-maximal exercise capacity that has never been fully validated in systemic sclerosis (SSc). A variety of data suggest that many non-pulmonary aspects of SSc contribute to the test results, thus blunting the ability of the 6MWT to measure changes in lung function. Sources of variability are a training effect, technician experience, subject encouragement, medication, other activities on day of testing, deconditioning and the effects of musculoskeletal conditions and pain...
July 2018: Clinical and Experimental Rheumatology
Luís Fernando Deresz, Marlus Karsten, Isadora Faraco Corrêa, Anelise Sonza, Maria Letícia Rodrigues Ikeda, Candissa Silva da Silva, Pedro Dal Lago
To verify and compare the responses of the cardiopulmonary variables to the incremental test in physically inactive people living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) (PLWHA) with well-controlled disease and physically inactive healthy subjects (non-HIV/AIDS). Participants performed a cardiopulmonary exercise test (CPX) on a treadmill. Data were analyzed using the Mann-Whitney test and Spearman correlation. Nine PLWHA (5 women) and 9 non-HIV/AIDS gender and activity level-matched controls were included in the data analysis...
August 2018: Journal of Exercise Rehabilitation
Vivien M Hsu, Lorinda Chung, Laura K Hummers, Ami Shah, Robert Simms, Marcy Bolster, Faye N Hant, Richard M Silver, Aryeh Fischer, Monique E Hinchcliff, John Varga, Avram Z Goldberg, Chris T Derk, Elena Schiopu, Dinesh Khanna, Lee S Shapiro, Robyn T Domsic, Thomas Medsger, Maureen D Mayes, Daniel Furst, Mary Ellen Csuka, Jerry A Molitor, Lesley Ann Saketkoo, Christian R Salazar, Virginia D Steen
OBJECTIVE: We sought to identify predictors of mortality and cardiopulmonary hospitalizations in patients at risk for pulmonary hypertension (PH) and enrolled in PHAROS, a prospective cohort study to investigate the natural history of PH in systemic sclerosis (SSc). METHODS: The at-risk population for PH was defined by the following entry criteria: echocardiogram systolic pulmonary arterial pressure > 40 mmHg, or DLCO < 55% predicted or ratio of % forced vital capacity/%DLCO > 1...
October 1, 2018: Journal of Rheumatology
Adrienne H Kovacs, Tina M Kaufman, Craig S Broberg
Owing to significant medical advances, it is now estimated that more than 90% of persons born with congenital heart disease (CHD) will reach adulthood. Medically appropriate physical activity represents an opportunity to improve physical functioning as well as quality of life and psychosocial outcomes. By reviewing published CHD research and clinical recommendations, herein we first summarize how adults with CHD are known to be less physically active and have reduced exercise capacity compared with healthy peers...
October 2018: Canadian Journal of Cardiology
Ricardo Fontes-Carvalho, Francisco Sampaio, Madalena Teixeira, Catarina Ruivo, José Ribeiro, Ana Azevedo, Adelino Leite-Moreira, Vasco Gama Ribeiro
INTRODUCTION: Left atrial (LA) size and function are associated with outcome after myocardial infarction (MI). In this study we aimed to assess the impact of LA function as a predictor of exercise capacity through speckle tracking echocardiography. METHODS: A total of 94 patients (mean age 54.8±11.0 years; 82% male) were enrolled one month after MI. Echocardiography was used to assess LA volumes and various indices of LA conduit, contraction and reservoir function...
September 27, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Tsung-Chien Lu, Yi Chen, Te-Wei Ho, Yao-Ting Chang, Yi-Ting Lee, Yu-Siang Wang, Yen-Pin Chen, Chia-Ming Fu, Wen-Chu Chiang, Matthew Huei-Ming Ma, Cheng-Chung Fang, Feipei Lai, Anne M Turner
INTRODUCTION: High-quality cardiopulmonary resuscitation (CPR) is a key factor affecting cardiac arrest survival. Accurate monitoring and real-time feedback are emphasized to improve CPR quality. The purpose of this study was to develop and validate a novel depth estimation algorithm based on a smartwatch equipped with a built-in accelerometer for feedback instructions during CPR. METHODS: For data collection and model building, researchers wore an Android Wear smartwatch and performed chest compression-only CPR on a Resusci Anne QCPR training manikin...
September 27, 2018: Journal of Biomedical Informatics
Aleksandra Trzebiatowska-Krzynska, Eva Swahn, Lars Wallby, Niels Erik Nielsen, Carl Johan Carlhäll, Lars Brudin, Jan E Engvall
BACKGROUND: Prior studies suggested that myocardial deformation is superior to conventional measures for assessing ventricular function. This study aimed to evaluate right ventricular (RV) myocardial deformation in response to increased afterload. Patients with the RV in the systemic position were compared with patients with the RV in the sub-pulmonic position with normal or only slightly elevated systolic right ventricular pressure. Correlations between global longitudinal strain (GLS), radial strain, atrioventricular plane displacement (AVPD), and exercise capacity were evaluated...
2018: PloS One
Michael G Katz, Anthony S Fargnoli, Charles Yarnall, Angel Perez, Alice Isidro, Roger J Hajjar, Charles R Bridges
Cardiopulmonary bypass (CPB) featuring complete heart isolation and continuous cardiac perfusion is a very promising approach for solving the problem of efficient gene delivery. In the technique presented here, separate pumps are used for the systemic and cardiac circuits. This system permits continuous isolated arrested heart perfusion through optimizing a number of delivery parameters including temperature, flow rate, driving pressure, ionic composition, and exposure time to the cardiac vessels. During complete cardiac isolation, the blood vector concentration trended from 11...
September 2018: Journal of Extra-corporeal Technology
Erik H Van Iterson, Chul-Ho Kim, Katelyn Uithoven, Thomas P Olson
Background Exercise intolerance, obesity, and low hemoglobin (hemoglobin<13 and <12 g/dl, men/women, respectively) are common features of heart failure. Despite serving as potent contributors to metabolic dysfunction, the impact of obesity and low hemoglobin on exercise intolerance is unknown. This study tested the hypotheses, compared with non-obese (NO) heart failure with normal hemoglobin, (a) counterparts with low hemoglobin and obesity or non-obesity will demonstrate reduced peak exercise oxygen uptake; (b) obese with normal hemoglobin will demonstrate decreased peak exercise oxygen uptake; (c) compared across stratifications, obese with low hemoglobin will demonstrate the sharpest decrement in peak exercise oxygen uptake...
September 24, 2018: European Journal of Preventive Cardiology
Thomas Edwards, Robert W Motl, Emerson Sebastião, Lara A Pilutti
BACKGROUND: Exercise training has been shown to be beneficial for persons with multiple sclerosis (MS). Adapted exercise modalities are needed to accommodate those with severe mobility impairment (Expanded Disability Status Scale [EDSS] scores 5.5-6.5). Functional electrical stimulation (FES) cycling is one such exercise modality; however, few studies have examined the feasibility and potential benefits of FES cycling for people with MS with severe mobility impairment. OBJECTIVE: Determine the feasibility of FES cycling exercise for people with MS with severe mobility impairment, and the efficacy of FES cycling exercise for improving mobility and physiological fitness...
September 8, 2018: Multiple Sclerosis and related Disorders
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