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cardiopulmonary function testing

Joshua Newman, Max Liebo, Brian D Lowes, Haseeb Ilias Basha, Yael Peled, Emily Cendrowski, Ronald Zolty, Dylan Douglas, John Y Um, Edwin McGee, Alain Heroux, Eugenia Raichlin
BACKGROUND: Current guidelines recommend against the use of hearts from donors that abuse alcohol. We explored the effect of donor alcohol abuse (AA) on cardiac allograft function and outcomes in heart transplant (HTx) recipients. METHODS: Overall, 370 HTx recipients were divided into two groups: (1) the alcoholic donor group (AD, n=58), and (2) the non-alcoholic donor group (NAD, n=312). RESULTS: Recipients in the AD group had a slower heart rate (86±13 vs...
December 11, 2018: Clinical Transplantation
Maria Theresa D Opina, Tina E Brinkley, Michelle Gordon, Mary F Lyles, Barbara J Nicklas
Background: Adiposity-related ventilatory constraints in older adults can potentially contribute to greater risk of exercise intolerance and mobility disability. This study investigated whether ventilatory limitation, measured by breathing reserve at peak exercise (BR), is associated with body composition and physical function in older adults with obesity. Methods: This study was a cross-sectional analysis of data from a community-based cohort (n=177) of older men and women (65-79 years) with obesity (BMI=30-45 kg/m 2)...
December 8, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Paulo T Muller, Karina A M Utida, Tiago R L Augusto, Marcos V P Spreafico, Reiby C Mustafa, Ana W Xavier, Erlandson F Saraiva
BACKGROUND: Left ventricular diastolic dysfunction (LVDD) is highly prevalent in COPD and conflicting results have emerged regarding the consequences on exercise capacity in the 6MWT. We sought to examine the ventilatory efficiency and variability metrics as the primary endpoint and aerobic capacity (V'O2 ) as the secondary endpoint. METHODS: Forty subjects were included and submitted to comprehensive lung function tests, detailed pulsed-Doppler echocardiography, and cardiopulmonary exercise testing...
December 2018: Respiratory Medicine
Kristin Schjander Berntsen, Elisabeth Edvardsen, Bjørge Herman Hansen, Berit Flatø, Ivar Sjaastad, Helga Sanner
Objectives: To compare cardiorespiratory fitness (CRF) expressed as maximal oxygen uptake (VO2max) between patients with long-term JDM and controls and between patients with active and inactive disease, as well as to explore exercise limiting factors and associations between CRF and disease variables. Methods: JDM patients (n = 45) and age- and gender-matched controls (n = 45) performed a cardiopulmonary exercise test (CPET) on a treadmill until exhaustion. Physical activity was measured by accelerometers...
November 30, 2018: Rheumatology
Justin McNair Canada, Antonio Abbate, Rebecca Collen, Hayley Billingsley, Leo Francis Buckley, Salvatore Carbone, Cory Ross Trankle, Michael Ola Idowu, Dinesh Kadariya, Benjamin Van Tassell, Arun Jayant Sanyal, Mohammad Shadab Siddiqui
The purpose of this study was to determine the relation between liver histology, exercise tolerance, and diastolic function in patients with nonalcoholic fatty liver disease (NAFLD). Myocardial remodeling and diastolic dysfunction have been associated with NAFLD. However, its physiological impact and relationship to the histological severity of NAFLD is not known. Cardiopulmonary exercise testing and stress echocardiography was performed in subjects with biopsy-confirmed NAFLD. Maximal aerobic exercise capacity (peak oxygen consumption [VO2 ]) was related to diastolic function (mitral annulus Doppler velocity e' and ratio of early diastolic filling pressure [E] to e' [E/e']) at rest and peak exercise...
November 6, 2018: American Journal of Cardiology
Jidong Sung, Soo Jin Cho, Kyong Pyo Hong
BACKGROUND: There is a well-established relationship between cardiorespiratory fitness (CRF) and arterial stiffness. However, it is unclear whether this relationship differs significantly between hypertensive and non-hypertensive patients. METHODS: Adults without a history of ischemic heart disease or stroke and normal exercise test results who underwent health screening were included. Cardiopulmonary function test was performed using the Bruce protocol. Peak oxygen consumption (VO2peak) was measured...
November 30, 2018: Clinical and Experimental Hypertension: CHE
Mauro F F Mediano, Eric S Leifer, Lawton S Cooper, Steven J Keteyian, William E Kraus, Robert J Mentz, Jerome L Fleg
OBJECTIVES: This study sought to evaluate the influence of baseline physical activity (PA) on responses to aerobic exercise training and clinical events in outpatients with chronic systolic heart failure (HF) from the multicenter HF-ACTION (Exercise Training Program to Improve Clinical Outcomes in Individuals With Congestive Heart Failure) trial. BACKGROUND: The influence of baseline PA on exercise capacity, responses to exercise training and clinical outcomes in patients with chronic HF is unclear...
December 2018: JACC. Heart Failure
Kiran K Mirza, Mette H Jung, Per E Sigvardsen, Klaus F Kofoed, Marie B Elming, Kasper Rossing, Finn Gustafsson
Using four-dimensional (4D) cardiac computed tomography (CCT) scans at rest and immediately after exercise, we examined the right heart chamber sizes and systolic function and its association with exercise capacity in left ventricular assist device (LVAD) recipients. Fifteen patients with HeartMate (HM) II or 3 underwent echocardiography and maximal cardiopulmonary exercise test. Subsequently, contrast-enhanced CCT scans were performed at rest and immediately after two minutes of supine 25 Watt ergometer bike exercise...
November 27, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Yahui Zhang, Zhihao Jiang, Lin Qi, Lisheng Xu, Xingguo Sun, Xinmei Chu, Yanling Liu, Tianjing Zhang, Stephen E Greenwald
Objective: This study aimed to compare differences in cardiorespiratory function between untreated hypertensive subjects (UHS) and healthy subjects (HS) during cardiopulmonary exercise testing (CPET). Additionally, it also aimed to explore the potential mechanisms of different exercise responses in cardiorespiratory function before, during and after CPET. Methods: Thirty subjects (15 UHS and 15 HS) were enrolled. Photoplethysmography (PPG), respiratory signal, and ECG were simultaneously collected while subjects were performing CPET...
2018: Frontiers in Physiology
Suruchi Hasija, Sachin Talwar, Neeti Makhija, Sandeep Chauhan, Poonam Malhotra, Ujjwal Kumar Chowdhury, N Siva Krishna, Gaurav Sharma
OBJECTIVE: To determine the safety and efficacy of bivalirudin as an anticoagulant for pediatric open heart surgery (OHS) and to determine its appropriate dosage for this purpose. DESIGN: Prospective, randomized controlled trial. SETTING: Tertiary care hospital. PARTICIPANTS: Fifty acyanotic children aged 1-12 years undergoing OHS. INTERVENTIONS: The children were randomized to receive either 4 mg/kg of heparin (n = 25, group H) or 1 mg/kg of bivalirudin bolus followed by 2...
December 2018: Journal of Cardiothoracic and Vascular Anesthesia
Elena Bignami, Savino Spadaro, Francesco Saglietti, Antonio Di Lullo, Francesca Dalla Corte, Marcello Guarnieri, Giulio de Simone, Ilaria Giambuzzi, Alberto Zangrillo, Carlo Alberto Volta
BACKGROUND: Lung dysfunction commonly occurs after cardiopulmonary bypass (CPB). Randomized evidence suggests that the presence of expiratory flow limitation (EFL) in major abdominal surgery is associated with postoperative pulmonary complications. Appropriate lung recruitment and a correctly set positive end-expiratory pressure (PEEP) level may prevent EFL. According to the available data in the literature, an adequate ventilation strategy during cardiac surgery is not provided. The aim of this study is to assess whether a mechanical ventilation strategy based on optimal lung recruitment with a best PEEP before and after CPB and with a continuous positive airway pressure (CPAP) during CPB would reduce the incidence of respiratory complications after cardiac surgery...
November 26, 2018: Trials
Jane L Woodward, Mark Connolly, Patrick W Hennessy, Carey L Holleran, Gordhan B Mahtani, Gabrielle Brazg, Meghan Fahey, Kameswari Maganti, T George Hornby
Background: The 6-minute walk test (6MWT) is a common clinical assessment used to evaluate locomotor function in patients after stroke. Previous work suggests the 6MWT can estimate peak metabolic capacity (VO2peak) without cardiorespiratory assessments during graded exercise tests (GXTs) which may assist with exercise prescription. However, selected research also indicated increased heart rates (HRs) during 6MWTs beyond levels considered safe without GXTs. Objective: The goal of this study was to examine cardiorespiratory responses during 6MWTs and GXTs in individuals with chronic stroke and their associations with demographic or clinical characteristics...
November 26, 2018: Physical Therapy
Nicola Riccardo Pugliese, Iacopo Fabiani, Giulia Elena Mandoli, Giacinta Guarini, Gian Giacomo Galeotti, Mario Miccoli, Alberto Lombardo, Anca Simioniuc, Giovanni Bigalli, Roberto Pedrinelli, Frank L Dini
Aims: Peak cardiac power output-to-mass (CPOM) represents a measure of the rate at which cardiac work is delivered respect to the potential energy stored in left ventricular (LV) mass. We studied the value of CPOM and cardiopulmonary exercise test (CPET) in risk stratification of patients with heart failure (HF). Materials and results: We studied 159 patients with chronic HF (mean rest LV ejection fraction 30%) undergoing CPET and exercise stress echocardiography...
November 23, 2018: European Heart Journal Cardiovascular Imaging
Amandeep Kaur, Gabriëlla A M Ten Have, Bernadette Hritzo, Nicolaas E P Deutz, Cara Olsen, Maria Moroni
PURPOSE: Göttingen minipig (G-MP) displays classic gastrointestinal acute radiation syndrome (GI-ARS) following total body irradiation (TBI) at GI doses which are lethal by 10-14 days. In collaboration with BARDA, we are developing a hemi-body/partial body irradiation (PBI) model by exposing only the abdomen and lower extremities to study GI structure/function impairment, natural history of injury and recovery, as well as correlative biomarkers out to 30 days. MATERIALS AND METHODS: Twenty-four G-MP were exposed to either 12 or 16 Gy (LINAC Elekta); head, forelimbs, and thorax were outside the irradiation field, sparing ∼50% of the bone marrow...
November 26, 2018: International Journal of Radiation Biology
Adam W Powell, Wayne A Mays, Sandra K Knecht, Clifford Chin
BACKGROUND: A transannular patch is often used in the contemporary surgical repair of tetralogy of Fallot. This can lead to significant pulmonary insufficiency and increased right ventricular volumes and ultimately pulmonary valve replacement. Cardiopulmonary exercise testing is used to assess exercise capacity in tetralogy of Fallot patients before pulmonary valve replacement. There is only few published literatures on how lung function affects functional capacity in tetralogy of Fallot patients repaired with a transannular patch...
November 26, 2018: Cardiology in the Young
N Quillinan, A L Dingman, G Deng, S Tatum, J E Orfila, A C Clevenger, J Klawitter, R J Traystman, P S Herson
Each year there are approximately 7000 out of hospital cardiac arrests in the pediatric population, with 30% resuscitation rate and a 6-10% rate of survival to hospital discharge. Survivors of cardiac arrest exhibit learning and memory deficits that are devastating during the school years. Delayed neuronal cell death occurs in the hippocampus following cardiac arrest and likely contributes to memory impairments. Circulating endogenous estrogen in young adult females has been shown to provide protection against ischemic cell death, as does chronic exogenous administration of 17β-estradiol (E2)...
November 22, 2018: Neurochemistry International
Fernanda C Lanza, Rejane A S Castro, Anderson A de Camargo, Drielly J M Zanatta, Samia Rached, Rodrigo Athanazio, Alberto Cukier, Rafael Stelmach, Simone Dal Corso
The COPD assessment test (CAT) is a short questionnaire developed to help patients and clinicians to assess the impact of symptoms in routine clinical practice. We aimed to validate and to test the reproducibility of CAT in patients with bronchiectasis and correlate with the severity of dyspnea, aerobic and functional capacity, and physical activity in daily life. This is a cross-sectional study, patients with bronchiectasis underwent spirometry, cardiopulmonary exercise test (CPET), incremental shuttle walk test (ISWT), Saint George`s Respiratory Questionnaire (SGRQ), and received pedometer...
November 23, 2018: COPD
Ingunn Skjørten, Janne Mykland Hilde, Morten Nissen Melsom, Jonny Hisdal, Viggo Hansteen, Kjetil Steine, Sjur Humerfelt
Background: Pulmonary hypertension (PH) in patients with COPD is associated with reduced exercise capacity. A subgroup of COPD patients has normal mean pulmonary artery pressure (mPAP) at rest, but develops high mPAP relative to cardiac output (CO) during exercise, a condition we refer to as exercise-induced pulmonary hypertension (EIPH). We hypothesized that COPD patients with EIPH could be identified by cardiopulmonary exercise test (CPET) and that these patients have lower exercise capacity and more abnormal CPET parameters compared to COPD patients with normal hemodynamic exercise response...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Shahriar Sakhaei, Hassan Ebrahimpour Sadagheyani, Soryya Zinalpoor, Abdolah Khorami Markani, Hossein Motaarefi
BACKGROUND: Respiratory system, together with the cardiovascular and central nervous system, is responsible for all processes related to oxygenation and hemodynamics and the defect in the functioning of each of these systems, along with ageing, can have mutual effects on their performance and physiological symptoms. The use of Pursed-lips Breathing (PLB) training is an essential part of the treatment of patients with the obstructive pulmonary disease, PLB stimulates the autonomic nervous system and causes relaxation and improvement of physiological parameters...
October 25, 2018: Open Access Macedonian Journal of Medical Sciences
Daniel Yafit, Narin Nard Carmel-Neiderman, Nadav Levy, Avrham Abergel, Alexander Niv, Ravit Yanko-Arzi, Arik Zaretski, Anat Wengier, Dan M Fliss, Gilad Horowitz
OBJECTIVE: Myxedema coma is a serious complication of hypothyroidism that can be precipitated by major surgery. It is extremely rare, with only a few reports in the literature. This study aims to present a relatively large case series of post-surgical myxedema coma and to analyze medical and surgical risk factors. METHODS: Analysis of the patients' surgical records and medical charts. RESULTS: Four patients developed postoperative myxedema coma and were evaluated for risk factors...
November 16, 2018: Auris, Nasus, Larynx
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