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Tapio Nevalainen, Arttu Autio, Binisha Hamal Mishra, Saara Marttila, Marja Jylhä, Mikko Hurme
Human endogenous retroviruses (HERV) are relics of ancient retroviral infections in our genome. Most of them have lost their coding capacity, but proviral RNA or protein have been observed in several disease states (e.g. in inflammatory and autoimmune diseases and malignancies). However, their clinical significance as well as their mechanisms of action have still remained elusive. As human aging is associated with several biological characteristics of these diseases, we now analyzed the aging-associated expression of the individual proviruses of two HERV families, HERV-K (91 proviruses) and HERV-W (213 proviruses) using genome-wide RNA-sequencing (RNA-seq)...
2018: PloS One
Edoardo Frola, Emanuele Ferrero, Pia Cumbo, Fabiana Zandrino, Andrea Gaggiano
Atherosclerotic superficial femoral artery (SFA) true aneurysm is rare, often associated with others aortic or peripheral aneurysms and usually discovered when have reached a considerable diameter or become symptomatic. We present the case of a 92-year old woman admitted in the emergency department with a huge ruptured SFA aneurysm. The patient underwent successful aneurysmectomy followed by bypass grafting. Degenerative SFA aneurysms differs from other peripheral aneurysms, being usually larger and symptomatic at presentation and occurring in old people and could representing life-threatening situations...
November 27, 2018: Annals of Vascular Surgery
Bakzaza Oualid, Arsalane Adil, Almaghraoui Oussama, Benbakh Soukaina, Zidane Abdelfatah, Belhadj Ayoub, Alaoui Mustapha
Tuberculosis of the aorta is rare, and its localization in the isthmus is exceptional. Tuberculous aortic pseudoaneurysms have a high risk of rupture with a severe prognosis. Conventional treatment is based on a combination of surgery and anti-tuberculosis chemotherapy. The endovascular approach with stent graft placement can be an attractive and less invasive alternative, like in our case where conventional surgery was considered to be at risk in this nonagenarian patient.
November 26, 2018: Annals of Vascular Surgery
Aline Iskandar, Samer Mowakeaa, Mayank Sardana, Timothy P Fitzgibbons, Dennis A Tighe, Matthew W Parker, Nikolaos Kakouros, David McManus, Gerard P Aurigemma
BACKGROUND: Nonagenarians (NON) are a growing segment of the population and have a high prevalence of cardiac disease. Many findings encountered on their echocardiograms are also found in younger individuals with valvular or myocardial disease. Therefore, the purpose of this study was to describe this distinct echocardiographic phenotype. METHODS: We identified our study population by querying our echo database to identify unique septuagenarians (SEPT) and nonagenarians (NON) who underwent a transthoracic echocardiogram (TTE) from January 1, 2010 to December 31, 2014...
November 15, 2018: Echocardiography
Jose M Mostaza, Carlos Lahoz, Miguel A Salinero-Fort, Juan Cardenas
AIMS: Nonagenarians are a fast growing segment of industrialized countries' populations. Despite a greater risk of cardiovascular disease, there are limited data about their use of preventive therapies and factors guiding decisions regarding their prescription. The aim of this study was to evaluate the prevalence of cardiovascular diseases and the patterns of use of cardiovascular treatments in subjects ≥90 years old. METHODS: Population-based, cross-sectional study, in all nonagenarians residing in the Community of Madrid (Spain)...
November 14, 2018: European Journal of Preventive Cardiology
Gang Jee Ko, Yoshitsugu Obi, Melissa Soohoo, Tae Ik Chang, Soo Jeong Choi, Csaba P Kovesdy, Elani Streja, Connie M Rhee, Kamyar Kalantar-Zadeh
BACKGROUND: The population of elderly end-stage renal disease patients initiating dialysis is rapidly growing. Although longer treatment is supposed to benefit for hemodialysis (HD) patients through more solute clearance and slower fluid removal, it is not yet clear how treatment session length affects mortality risk in octogenarians and nonagenarians. METHODS: In a cohort of 112,026 incident HD patients between 2007 and 2011, we examined the association of treatment session length with all-cause mortality, adjusting for demographics and comorbid conditions...
2018: American Journal of Nephrology
Michelle C Odden, William Jen Hoe Koh, Alice M Arnold, Andreea M Rawlings, Bruce M Psaty, Anne B Newman
The US population aged 90 years and older is growing rapidly and there are limited data on their health. The Cardiovascular Health Study is a prospective study of black and white adults ≥65 years recruited in two waves (1989-90 and 1992-93) from Medicare eligibility lists in Forsyth County, North Carolina; Sacramento County, California; Washington County, Maryland; and Pittsburgh, Pennsylvania. We created a synthetic cohort of the 1,889 participants who had reached age 90 at baseline or during follow-up through July 16th, 2015...
November 8, 2018: American Journal of Epidemiology
Oriol Miralles, Diana Ariza, Évora Betancor, Benito J Fontecha
No abstract text is available yet for this article.
October 31, 2018: Revista Española de Geriatría y Gerontología
R Hakim, C Thuaire, C Saint-Etienne, P Marcollet, S Chassaing, P Dequenne, C Laure, S Gautier, J Akkoyun-Farinez, P Motreff, G Rangé
PURPOSE: To compare the clinical, angiographic, therapeutic and prognostic characteristics of nonagenarians presenting with non-ST elevation acute coronary syndrome with those of patients under 90 years of age. METHODS: We used the CRAC register database including 6 catheterization laboratories in the Center Val-de-Loire region. Only patients with positive-troponin non-ST elevation ACS included in the registry from 2014 to 2017 were selected for epidemiological and procedural data...
October 31, 2018: Annales de Cardiologie et D'angéiologie
Ingela Thylén, Debra K Moser, Anna Strömberg
BACKGROUND: Elderly individuals are increasingly represented among patients with implantable cardioverter defibrillators (ICD), but data describing life with an ICD are scarse among octo- and nonagenarians. Moreover, few studies have reported those elderly patients' perspective on timly discussions concerning what shock deactivation involves, preferences on battery replacement, and their attitudes about turning off the ICD nearing end-of-life. Consequently, the aim of the study was to describe outlooks on life and death in octo- and nonagenarian ICD-recipients...
October 20, 2018: BMC Geriatrics
Erdem A Sezgin, Otto Robertsson, Annette W-Dahl, Lars Lidgren
Background and purpose - The nonagenarian (those aged 90 years and older) population is expected to double in the next 20 years. This demographic age quake may have a significant impact on the incidence of total knee arthroplasty (TKA), although current literature provides limited data. We examined death and revision rates, patient-reported outcomes (PROs) and bias on patient selection of nonagenarian patients operated on with TKA for osteoarthritis (OA) between 2000 and 2016. Patients and methods - The Swedish national knee arthroplasty register was used to identify 329 nonagenarians (mean age, 92 years)...
October 18, 2018: Acta Orthopaedica
Maarit Venermo
No abstract text is available yet for this article.
November 2018: European Journal of Vascular and Endovascular Surgery
Tetsuji Morishita, Yusuke Sato, Yoshitomo Fukuoka, Kentaro Ishida, Ryotaro Urabe, Ryohei Shigehara, Yoshiki Minegishi, Hiroyasu Uzui, Hiroshi Tada
The number of implantations of cardiac implantable electrophysiological devices (CIEDs) has increased over the past several years. However, the aging population and expansion of indications for CIEDs have led to an increase in associated infections. We experienced a case of a 99-year-old man presenting with skin erosion at the pocket site, where a 6-month-old implantable pacemaker was replaced. He was referred for pacemaker pocket infection and presented with fever accompanied by pain and swelling around pacemaker generator...
August 2018: Journal of Cardiology Cases
Montserrat Barceló, Esther Francia, Carlos Romero, Domingo Ruiz, Jordi Casademont, Olga H Torres
INTRODUCTION: Centenarians and nonagenarians constitute a rapidly growing age group in Western countries and they are expected to be admitted to hospital with hip fractures. The aim of this study was to compare outcomes of centenarian and nonagenarian patients following a hip fracture and to identify risk factors related to in-hospital and post-discharge mortality in both groups. PATIENTS AND METHODS: A prospective evaluation of centenarian patients and nonagenarian controls admitted to a tertiary university hospital in Barcelona with hip fractures over a period of 5 years and 9 months...
September 26, 2018: Injury
Etienne L Couture, Paul Farand, Michel Nguyen, Catherine Allard, George A Wells, Samer Mansour, Stéphane Rinfret, Jonathan Afilalo, Mark Eisenberg, Martine Montigny, Simon Kouz, Marc Afilalo, Claude Lauzon, Jean-Pierre Dery, Philippe L'Allier, Erick Schampaert, Jean-Claude Tardif, Thao Huynh
BACKGROUND: Published data about nonagenarians with acute coronary syndrome (ACS) were mainly descriptive and limited by small sample sizes and unadjusted outcomes. We aim to describe the characteristics, management, and the impact of an invasive strategy on major adverse events in elderly patients hospitalized with ACS with focus on the nonagerians. METHODS AND RESULTS: We analyzed data collected as part of the AMI-OPTIMA study, a cluster-randomized study of knowledge translation intervention versus usual care on optimal discharge medications in patients admitted with ACS at 24 Canadian hospitals...
September 30, 2018: Catheterization and Cardiovascular Interventions
Takehiro Sejima, Shuichi Morizane, Katsuya Hikita, Masashi Honda, Atsushi Takenaka
Backgrounds: Surgical procedures in the elderly are associated with higher perioperative morbidity and mortality rates than in younger patients. This is especially significant because elderly individuals are more likely to be operated on now than in the past because they represent the fastest growing subset of the population in advanced countries. Our cases are three nonagenarian patients with renal malignancy in poor general condition and were effectively treated by laparoscopic surgery. Case Presentation: Case 1 was a 91-year-old male patient with a right renal cell carcinoma of pT1b N0 M0...
2018: Journal of Endourology Case Reports
Ilaria Franco, Nicola de'Angelis, Florence Canoui-Poitrine, Bertrand Le Roy, Lise Courtot, Thibault Voron, Razvan Aprodu, Ephrem Salamé, Nour Bou Saleh, Anne Berger, Mehdi Ouaïssi, Donato Francesco Altomare, Denis Pezet, Didier Mutter, Francesco Brunetti, Riccardo Memeo
BACKGROUND: Laparoscopy for colorectal cancer treatment is widely accepted. However, there is no consensus as to whether or not laparoscopy can be considered the preferred treatment strategy in octogenarian and nonagenarian patients with colon cancer. The aim of this study was to compare operative and postoperative outcomes of laparoscopic right colectomy between oldest-old (≥80 years) and younger (<80 years) patients with colon cancer. METHODS: The study population was sampled from the CLIMHET Study Group cohort...
November 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Duc Dang, Vincent Galand, Aurélie Loirat, Vincent Auffret, Nathalie Behar, Philippe Mabo, Jean-Claude Daubert, Christophe Leclercq, Raphaël P Martins
BACKGROUND: The rate of pacemaker (PM) implantations is constantly growing. Since life expectancy of the population is projected to increase, a large number of nonagenarian patients will need PM implantation. We aimed at analyzing short- and long-term outcomes after PM implantation in nonagenarians. METHODS: Patients aged ≥90 years referred for PM implantation from 2004 to 2017 were included. The primary clinical endpoint was total mortality. Secondary endpoints included procedure-related and in-hospital complications...
October 2018: Clinical Cardiology
Kashish Goel, Tanush Gupta, Rajiv Gulati, Malcolm R Bell, Dhaval Kolte, Sahil Khera, Deepak L Bhatt, Charanjit S Rihal, David R Holmes
OBJECTIVES: This study sought to assess temporal trends and outcomes of percutaneous coronary intervention (PCI) in nonagenarians. BACKGROUND: With increasing life expectancy, nonagenarians requiring PCI are increasing even though outcomes data are limited. METHODS: The National Inpatient Sample was used to identify all hospitalizations for PCI in patients aged ≥90 years from January 1, 2003, to December 31, 2014. The primary outcome was in-hospital mortality...
September 24, 2018: JACC. Cardiovascular Interventions
Kirill Berezhnoi, Leonid Kokov, Aleksandr Vanyukov, Yongcheol Kim
No abstract text is available yet for this article.
2018: Cardiology Journal
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