Noor Adra, Lisa W Dümmer, Luis Paixao, Ryan A Tesh, Haoqi Sun, Wolfgang Ganglberger, Mike Westmeijer, Madalena Da Silva Cardoso, Anagha Kumar, Elissa Ye, Jonathan Henry, Sydney S Cash, Erin Kitchener, Catherine L Leveroni, Rhoda Au, Jonathan Rosand, Joel Salinas, Alice D Lam, Robert J Thomas, M Brandon Westover
Sleep electroencephalogram (EEG) signals likely encode brain health information that may identify individuals at high risk for age-related brain diseases. Here, we evaluate the correlation of a previously proposed brain age biomarker, the "brain age index" (BAI), with cognitive test scores and use machine learning to develop and validate a series of new sleep EEG-based indices, termed "sleep cognitive indices" (SCIs), that are directly optimized to correlate with specific cognitive scores. Three overarching cognitive processes were examined: total, fluid (a measure of cognitive processes involved in reasoning-based problem solving and susceptible to aging and neuropathology), and crystallized cognition (a measure of cognitive processes involved in applying acquired knowledge toward problem-solving)...
July 15, 2023: Scientific Reports