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Hendrik Woehlk, Andrea Lauer, Vanessa Trouillet, Alexander Welle, Leonie Barner, James P Blinco, Kathryn E Fairfull-Smith, Christopher Barner-Kowollik
We introduce a substrate-independent and versatile coating platform for (spatially resolved) surface functionalizations based on nitroxide radical coupling (NRC) reactions and the formation of thermo-labile dynamic covalent alkoxyamine switches. Nitroxide decorated poly(glycidyl methacrylate) (PGMA) microspheres, obtained through bioinspired copolymer surface deposition using dopamine and a nitroxide functional dopamine derivative as monomers, were conjugated with small functional groups in a rewritable, dynamic covalent process...
October 17, 2018: Chemistry: a European Journal
Pavimol Angsantikul, Soracha Thamphiwatana, Qiangzhe Zhang, Kevin Spiekermann, Jia Zhuang, Ronnie H Fang, Weiwei Gao, Marygorret Obonyo, Liangfang Zhang
Inspired by the natural pathogen-host interactions and adhesion, this study reports on the development of a novel targeted nanotherapeutics for the treatment of Helicobacter pylori ( H. pylori ) infection. Specifically, plasma membranes of gastric epithelial cells (e.g. AGS cells) are collected and coated onto antibiotic-loaded polymeric cores, the resulting biomimetic nanoparticles (denoted AGS-NPs) bear the same surface antigens as the source AGS cells and thus have inherent adhesion to H. pylori bacteria...
June 2018: Advanced therapeutics
Pierangelo Gobbo, Avinash J Patil, Mei Li, Robert Harniman, Wuge H Briscoe, Stephen Mann
Although several new types of synthetic cell-like entities are now available, their structural integration into spatially interlinked prototissues that communicate and display coordinated functions remains a considerable challenge. Here we describe the programmed assembly of synthetic prototissue constructs based on the bio-orthogonal adhesion of a spatially confined binary community of protein-polymer protocells, termed proteinosomes. The thermoresponsive properties of the interlinked proteinosomes are used collectively to generate prototissue spheroids capable of reversible contractions that can be enzymatically modulated and exploited for mechanochemical transduction...
October 8, 2018: Nature Materials
Mahdiyeh Rashki Ghaleno, Mansour Ghaffari-Moghaddam, Mostafa Khajeh, Ali Reza Oveisi, Mousa Bohlooli
A bioinspired iron(III)porphyrinic Zr-MOF, PCN-222(Fe), was modified by post-synthetic cluster metalation with iron(III) chloride, as a cheap, earth-abundant, and environmentally friendly metal precursor, towards formation a new multifunctional MOF, namely Fe@PCN-222(Fe). The MOF consists of bimetallic (Zr-oxo-Fe) nodes linked by Fe(III)porphyrin struts. The cluster metalation and pre-activation treatment of PCN-222(Fe) were performed cooperatively using the FeCl3 . The respective MOF was characterized through various techniques, such as FT-IR, PXRD, ICP-AES, BET surface area, SEM, UV-Vis DRS, TGA/DSC, PL, and XPS analyses...
September 29, 2018: Journal of Colloid and Interface Science
Kristen Stout, Marketa Bernaskova, Gary W Miller, Antje Hufner, Wolfgang Schuehly
In traditional Asian medicinal systems, preparations of the root and stem bark of Magnolia species are widely used to treat anxiety and other nervous disturbances. The biphenyl-type neolignans honokiol and magnolol are the main constituents of Magnolia bark extracts. In the central nervous system, Magnolia bark preparations that contain honokiol are thought to primarily interact with γ-aminobutyric acid A (GABAA ) receptors. However, stress responses inherently involve the noradrenergic system, which has not been investigated in the pharmacological mechanism of honokiol...
October 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Tian-Yu Wang, Zhen-Yu He, Hao Liu, Lin Chen, Hao Zhu, Qing-Qing Sun, Shi-Jin Ding, Peng Zhou, David Wei Zhang
Artificial synaptic device with a continuous weights modulation behavior is fundamental to the hardware implementation of the bioinspired neuromorphic systems. Recent reported synaptic devices have less number of conductance states, which is not beneficial for continuous modulation of weights in neuromorphic computing. Preparing a device with as many conductance states as possible is of great significance to the development of brain-inspired neuromorphic computing. Here, we present a two-terminal flexible organic synaptic device with ultra multi-modulated conductance states, realizing a face recognition functionality with strong error-tolerant nature for the first time...
October 4, 2018: ACS Applied Materials & Interfaces
Yifan Si, Zhichao Dong, Lei Jiang
Bioinspired designs of superhydrophobic and superhydrophilic materials have been an important and fascinating area of research in recent years for their extensive potential application prospects from industry to our daily life. Despite extensive progress, existing research achievements are far from real applications. From biomimetic performance to service life, the related research has faced serious problems at present. A timely outlook is therefore necessary to summarize the existing research, to discuss the challenges faced, and to propose constructive advice for the ongoing scientific trend...
September 26, 2018: ACS Central Science
Nalinee Kanth Kadiyala, Badal Kumar Mandal, Shivendu Ranjan, Nandita Dasgupta
The development of novel functionalized reduced graphene oxide nanocomposite materials keeping in mind environmental and health perspectives via green approaches is currently gaining enormous research interest in the field of nanoscience and nanotechnology. Herein, we report a bio-inspired green synthesis approach for gold nanoparticles decorated reduced graphene oxide nanocomposite in which Syzygium cumini seed extract (SCSE) is applied as natural reducing and stabilizing agent for the simultaneous reduction of chloroauric acid and graphene oxide (GO)...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Jinjian Huang, Zongan Li, Qiongyuan Hu, Guopu Chen, Yanhan Ren, Xiuwen Wu, Jianan Ren
The anti-digestive features given to hydrogels can prolong their action time in gut environment; however, these types of hydrogels have rarely been reported. Inspired by indigestibility of dietary fibers, we introduced an injectable covalent hydrogel through photopolymerization of glycidyl methacrylate-modified xanthan. This newly synthesized hydrogel exhibited a specific concentration-dependent porosity, swelling ratio, and stiffness. The intestinal epithelial cells-6 could grow on the surface of the stiffer hydrogel, and achieved their gut barrier functions...
September 19, 2018: iScience
Dominique Yukie Toyama, Larissa Marcia Martins Alves, Gabriela Freitas Ramos, Tiago Moreira Bastos Campos, Getúlio de Vasconcelos, Alexandre Luiz Souto Borges, Renata Marques de Melo
Conventionally veneered zirconia restorations are susceptible to chipping and spalling of the veneering material. The novel translucent zirconias were developed to overcome such issues, although layered zirconia restorations can be re-designed to improve mechanical performance. Thus, the aim of this study was to analyze the strength and structural reliability of zirconia bilayers using conventional (porcelain ceramic under tensile stress) and bioinspired (zirconia under tensile stress) configurations. Sol-gel silica infiltration served as a smooth transition between the zirconia and veneering porcelain...
September 14, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Zhengzhi Wang, Kun Wang, Houbing Huang, Xiao Cui, Xiaoming Shi, Xingqiao Ma, Bei Li, Zuoqi Zhang, Xuhai Tang, Martin Y M Chiang
For mechanically protective coatings, the coating material usually requires sufficient stiffness and strength to resist external forces and meanwhile matched mechanical properties with the underneath substrate to maintain the structural integrity. These requirements generate a conflict that limits the coatings from achieving simultaneous surface properties (e.g., high wear-resistance) and coating/substrate interfacial durability. Herein this conflict is circumvented by developing a new manufacturing technique for functional gradient coatings (FGCs) with the material composition and mechanical properties gradually varying crossing the coating thickness...
October 2018: Small
Huihui Ren, Tianliang Xiao, Qianqian Zhang, Zhaoyue Liu
Inspired by the bifunctional utilization of light energy and a proton gradient in photosynthesis, we proposed conceptually an energy-harvesting device that is capable of converting light and a salinity gradient into electricity simultaneously. Our bioinspired concept provided a potential opportunity to harvest multiple renewable energies and maximize the overall power output.
October 1, 2018: Chemical Communications: Chem Comm
Haojian Lu, Mei Zhang, Yuanyuan Yang, Qiang Huang, Toshio Fukuda, Zuankai Wang, Yajing Shen
Developing untethered millirobots that can adapt to harsh environments with high locomotion efficiency is of interest for emerging applications in various industrial and biomedical settings. Despite recent success in exploiting soft materials to impart sophisticated functions which are not available in conventional rigid robotics, it remains challenging to achieve superior performances in both wet and dry conditions. Inspired by the flexible, soft, and elastic leg/foot structures of many living organisms, here we report an untethered soft millirobot decorated with multiple tapered soft feet architecture...
September 26, 2018: Nature Communications
Francis Forster, Martin Oestreich
Catalytic processes involving cooperativity have seen tremendous progress in recent years and impressive new synthetic methodologies have been developed. Inspired by the cooperative heterolytic H₂ splitting in [NiFe] hydrogenases, Ohki and Tatsumi designed cationic ruthenium thiolate complexes with a tethered sulfur ligand. Over the last decade, we have demonstrated the facile activation of main-group hydrides such as hydrosilanes, hydroboranes, DIBAL-H, and hydrostannanes by the Ru-S bond in Ohki-Tatsumi complexes...
September 1, 2018: Chimia
Caitlin E Bien, Kai K Chen, Szu-Chia Chien, Benjamin R Reiner, Li-Chiang Lin, Casey R Wade, W S Winston Ho
A Zn benzotriazolate metal-organic framework (MOF), [Zn(ZnO2 CCH3 )4 (bibta)3 ] (1, bibta2- = 5,5'-bibenzotriazolate), has been subjected to a mild CH3 CO2 - /HCO3 - ligand exchange procedure followed by thermal activation to generate nucleophilic Zn-OH groups that resemble the active site of α-carbonic anhydrase. The postsynthetically modified MOF, [Zn(ZnOH)4 (bibta)3 ] (2*), exhibits excellent performance for trace CO2 capture and can be regenerated at mild temperatures. IR spectroscopic data and density functional theory (DFT) calculations reveal that intercluster hydrogen bonding interactions augment a Zn-OH/Zn-O2 COH fixation mechanism...
October 2, 2018: Journal of the American Chemical Society
Zhishan Luo, Yidong Hou, Jinshui Zhang, Sibo Wang, Xinchen Wang
The development of efficient, robust and earth-abundant catalysts for photocatalytic conversions has been the Achilles' heel of solar energy utilization. Here, we report on a chemical approach based on ligand designed architectures to fabricate unique structural molecular catalysts coupled with appropriate light harvesters (e.g., carbon nitride and Ru(bpy)3 2+ ) for photoredox reactions. The "Co4 O4 " cubane complex Co4 O4 (CO2 Me)4 (RNC5 H4 )4 (R = CN, Br, H, Me, OMe), serves as a molecular catalyst for the efficient and stable photocatalytic water oxidation and CO2 reduction...
2018: Beilstein Journal of Organic Chemistry
Junqing Wang, Angela Zhe Wang, Peng Lv, Wei Tao, Gang Liu
Bioinspired lipid assemblies that mimic the elaborate architecture of natural membranes have fascinated researchers for a long time. These lipid assemblies have gone from being just an imperative platform for biophysical research to a pharmaceutical delivery system for biomedical applications. Despite success, these organized nanosystems are often subject to the mechanical instability and limited theranostic capability without adding any inconvenient modifications. To reach their advanced pharmaceutical potential, various bioinorganic hybrid lipid-based assembles, which provide new opportunities to synergistically complement and improve therapeutic/diagnostic potential of existing lipid-based nanomedicine with distinct mechanisms containing inorganic embedded surfactants, have recently been developed...
September 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Ying Guo, Zhiyuan Guo, Mengjuan Zhong, Pengbo Wan, Weixia Zhang, Liqun Zhang
Flexible wearable pressure sensors have drawn tremendous interest for various applications in wearable healthcare monitoring, disease diagnostics, and human-machine interaction. However, the limited sensing range (<10%), low sensing sensitivity at small strains, limited mechanical stability at high strains, and complicated fabrication process restrict the extensive applications of these sensors for ultrasensitive full-range healthcare monitoring. Herein, a flexible wearable pressure sensor is presented with a hierarchically microstructured framework combining microcrack and interlocking, bioinspired by the crack-shaped mechanosensory systems of spiders and the wing-locking sensing systems of beetles...
September 24, 2018: Small
Adila Nazli, Muhammad Waleed Baig, Muhammad Zia, Muhammad Ali, Zabta Khan Shinwari, Ihsan Ul Haq
Theranostic approach provides us a platform where diagnosis and treatment can be carried out simultaneously. Biosynthesis of theranostic-capable nanoparticles (NPs) can be carried out by phytoconstituents present inside the plants that can act as capping as well as stabilising agents by offering several advantages over chemical and physical methods. This article highlights the theranostic role of NPs with emphasis on potential of plants to produce these NPs through ecofriendly approach that is called 'Green synthesis'...
October 2018: IET Nanobiotechnology
Yiying Sun, Jingjing Zhao, Jiafu Shi, Shaohua Zhang, Zhongyi Jiang
Immobilization of enzyme on the surface of graphene-based composite cellular foams (GCCFs) is commonly prone to acquire stable and ultrahigh loading of enzymes and fast transport of substrates during the catalytic process. In this chapter, we reported a method of preparing GCCFs through combination of redox assembly and biomimetic mineralization with in situ enzyme immobilization. Briefly, GCCFs were first prepared through redox assembly of graphene oxide (GO) nanosheets enabled by polyethyleneimine (PEI). The cationic PEI in the resultant reduced GO/PEI (rGO/PEI) cellular foams acted as the mineralization-inducing agent could catalyze the condensation of silicate to form silica (biomimetic silicification) on the reduced graphene oxide (rGO) surface, where enzyme (with penicillin G acylase as model enzyme) is in situ entrapped and shielded within the silica network...
2018: Methods in Enzymology
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