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Rupture of membraned

Eliisa Ollikainen, Riikka Tulamo, Salla Kaitainen, Petri Honkanen, Satu Lehti, Timo Liimatainen, Juha Hernesniemi, Mika Niemelä, Petri T Kovanen, Juhana Frösen
Saccular intracranial aneurysm (sIA) rupture is often fatal. Rupture-prone sIA walls are infiltrated by macrophages expressing hemoglobin-receptor CD163, suggesting a role for erythrocyte lysis in the degenerative remodeling predisposing to rupture. We therefore studied erythrocyte remnants in 16 unruptured and 20 ruptured sIA walls using histology and immunohistochemistry. Glycophorin A (GPA), an erythrocyte membrane protein, was present in 34/36 (94%) sIA walls and correlated with loss of αSMA+ cells, reflecting loss of mural smooth muscle cells ([SMCs]; r = -0...
July 17, 2018: Journal of Neuropathology and Experimental Neurology
Amber M Wood, Sarah K Dotters-Katz, Brenna L Hughes
OBJECTIVE:  To evaluate the risk of preterm birth in low-risk women with cervical length (CL) ≤25 mm on transvaginal ultrasound (TVUS) managed with vaginal progesterone (VagP) therapy versus cerclage. STUDY DESIGN:  This is a retrospective cohort of women with no prior history of preterm birth or cervical insufficiency and CL ≤ 25 mm on TVUS, managed with either VagP therapy alone or cerclage (with or without VagP). The primary outcome was rate of preterm delivery < 37 weeks gestational age (GA)...
August 15, 2018: American Journal of Perinatology
Bing Song, Qingli Hua, Hongwei Sun, Bingyu Hu, Xin Dong, Li Sun
Pathogenic bacteria and inflammatory factors in neonatal purulent meningitis (PM) were investigated to explore the diagnostic value of inflammatory factors in PM, to clarify the etiology, and to provide evidence for rational clinical treatment. Seventy-four neonates who were diagnosed with PM and were bacteriogically positive in Daqing Longnan Hospital from January 2012 to December 2015 were retrospectively analyzed and used as observation group. Another 74 neonates simultaneously hospitalized with non-PM factors were selected as control group...
August 2018: Experimental and Therapeutic Medicine
Xiu-Min Jiang, Qi-Yan Chen, Sheng-Bin Guo, Li-Zhu Jin, Xin-Xin Huang, Xiu-Wu Liu, Jin-Xiu Hong, Hai-Bin Qu, Rong-Fang Hu
BACKGROUND: The high caesarean section rate is a prominent public health problem in China. AIM: This study aimed to determine the effects of midwife-led care during labour on birth outcomes for healthy primiparas. DESIGN: Randomized controlled trial. SETTING: The Obstetrics Department of Fujian Provincial Maternity and Child Health Hospital. METHODS: A total of 666 primiparas in labour were randomly divided into an intervention and control group (333 in each group)...
August 14, 2018: International Journal of Nursing Practice
Birju A Shah, James F Padbury, Michael P Anderson, Michael F Holick, Edgardo Szyld, Catherine M Gordon
OBJECTIVE: To evaluate vitamin D inadequacy among extremely low-birth-weight (ELBW, <1000 g) infants and the association between circulating vitamin D concentrations and perinatal-neonatal outcomes. STUDY DESIGN: Prospective cohort study of ELBW infants in the neonatal ICU. Blood was collected within the first 3 days after birth after obtaining informed consent. Circulating 25-hydroxyvitamin D concentrations (25(OH)D) were quantified using liquid chromatography-tandem mass spectroscopy and classified as vitamin D deficient, insufficient, or adequate ( < 20, 20-30, or > 30 ng/mL, respectively)...
August 14, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Deborah Money, Victoria M Allen
OBJECTIVE: To review the evidence in the literature and to provide recommendations on the management of pregnant women in labour for the prevention of early-onset neonatal group B streptococcal disease. The key revisions in this updated guideline include changed recommendations for regimens for antibiotic prophylaxis, susceptibility testing, and management of women with pre-labour rupture of membranes. OUTCOMES: Maternal outcomes evaluated included exposure to antibiotics in pregnancy and labour and complications related to antibiotic use...
August 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Joanna Joyce, J Embree, H Pymar, V Poliquin
BACKGROUND: Neonatal herpes simplex virus (HSV) infection and its implications have been well defined. Several methods are recommended to mitigate the risk of maternal transmission of HSV to the neonate, including CS, suppressive antiviral therapy for the mother, and prophylaxis for the infant. The utility of CS in women who present with a duration of rupture of membranes greater than 4 hours remains a question. CASE: We present a case of a woman who presented following 10 hours of rupture of membranes with HSV genital lesions, suspected to be the result of untreated recurrent infection...
August 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Matthew M Finneran, Devin D Smith, Catalin S Buhimschi
OBJECTIVE:  To quantify the potential cost savings if azithromycin is substituted for erythromycin in women with preterm premature rupture of membranes (PPROM). STUDY DESIGN:  Secondary analysis of a multicentered study investigating magnesium sulfate for the prevention of cerebral palsy in premature infants. All patients with PPROM who received antibiotics for prophylaxis were included in the analysis. The number of expected doses each patient would have received was calculated for erythromycin, multidose azithromycin, and single-dose azithromycin regimens accounting for latency from PPROM to delivery...
August 13, 2018: American Journal of Perinatology
Ahmed Ghallab, Ute Hofmann, Selahaddin Sezgin, Nachiket Vartak, Reham Hassan, Ayham Zaza, Patricio Godoy, Kai Markus Schneider, Georgia Guenther, Yasser A Ahmed, Aya A Abbas, Verena Keitel, Lars Kuepfer, Steven Dooley, Frank Lammert, Christian Trautwein, Michael Spiteller, Dirk Drasdo, Alan F Hofmann, Peter L M Jansen, Jan G Hengstler, Raymond Reif
Bile duct ligation (BDL) is an experimental procedure that mimics obstructive cholestatic disease. One of the early consequences of BDL in rodents are so-called 'bile infarcts' that correspond to Charcot-Gombault necrosis in human cholestasis. The mechanisms causing bile infarcts and their pathophysiological relevance are unclear. Therefore, intravital two-photon-based imaging of bile duct-ligated mice was performed with fluorescent bile salts (BS) and non-BS organic anion analogues. Key findings were followed-up by MALDI imaging, clinical chemistry, immunostaining, and gene expression analyses...
August 13, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Aneesha Varrey, Roberto Romero, Bogdan Panaitescu, Derek Miller, Tinnakorn Chaiworapongsa, Manasi Patwardhan, Jonathan Faro, Percy Pacora, Sonia S Hassan, Chaur-Dong Hsu, Nardhy Gomez-Lopez
PROBLEM: Human β-defensins (HBDs) are antimicrobial peptides that participate in the soluble innate immune mechanisms against infection. Herein, we determined whether HBD-1 was present in amniotic fluid during normal pregnancy and whether its concentrations change with intra-amniotic inflammation and/or infection. METHOD OF STUDY: Amniotic fluid was collected from 219 women in the following groups: (a) midtrimester who delivered at term (n = 35); (b) term with (n = 33) or without (n = 17) labor; (c) preterm labor with intact membranes who delivered at term (n = 29) or who delivered preterm with (n = 19) and without (n = 29) intra-amniotic inflammation and infection or with intra-amniotic inflammation but without infection (n = 21); and (d) preterm prelabor rupture of membranes (pPROM) with (n = 19) and without (n = 17) intra-amniotic inflammation/infection...
August 12, 2018: American Journal of Reproductive Immunology: AJRI
Rosa M Alvarez, Ioannis Biliatis, Andrea Rockall, Eleni Papadakou, S Aslam Sohaib, Nandita M deSouza, John Butler, Marielle Nobbenhuis, Desmond J P Barton, John H Shepherd, Thomas E J Ind
OBJECTIVE: To determine the association between the residual cervix measured on post-operative MRI after radical vaginal trachelectomy (RVT) and adverse obstetric outcomes. DESIGN: Observational study. SETTING: Referral Cancer centre. POPULATION: Women who conceived after RVT for cervical cancer at the Royal Marsden Hospital, London, between 1995 and 2015. METHODS: Post-operative MRI scans were analysed by three researchers...
August 12, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Yuze Ma, Jiaxuan Jiang, Yuan Gao, Tianshu Shi, Xiaobo Zhu, Kaijia Zhang, Ke Lu, Bin Xue
Pyroptosis, characterized by proinflammation, has been defined as a new type of programmed cell death in recent years. Inflammasomes are activated by the corresponding pathogen-associated molecular patterns (PAMPS) or damage-associated molecular patterns (DAMPS), followed up by the cleavage of pro-interleukin-1β (pro-IL-1β), pro-interleukin-18 (pro-IL-18) and gasdermin D. The N-terminal fragment of gasdermin D gives rise to the destruction of cell membrane, leading to cell rupture as well as the efflux of proinflammatory cytokines...
2018: American Journal of Translational Research
Kazuki Nakagawa, Haruhiko Yamada, Hidetsugu Mori, Keiko Toyama, Kanji Takahashi
This study aimed to investigate the differences between images obtained by optical coherence tomography angiography (OCTA) with those from immunohistochemical labeling of laser-induced choroidal neovascularization (CNV) in a mouse model. CNV was induced by laser photocoagulation (GYC-2000, NIDEK; wavelength 532 nm) in the left eyes of 10 female C57BL/6J mice aged 6 weeks. The laser parameters included a 100-μm spot, 100-ms pulse duration and 200-mW incident power to rupture Bruch's membrane. OCT and OCTA CNV images were obtained using the RS-3000 Advance (NIDEK) 5 days post-laser photocoagulation...
2018: PloS One
Maria Del Pilar Quintana, Jun-Hong Ch'ng, Arash Zandian, Maryam Imam, Kjell Hultenby, Michael Theisen, Peter Nilsson, Ulrika Qundos, Kirsten Moll, Sherwin Chan, Mats Wahlgren
Plasmodium falciparum invasion into red blood cells (RBCs) is a complex process engaging proteins on the merozoite surface and those contained and sequentially released from the apical organelles (micronemes and rhoptries). Fundamental to invasion is the formation of a moving junction (MJ), a region of close apposition of the merozoite and the RBC plasma membranes, through which the merozoite draws itself before settling into a newly formed parasitophorous vacuole (PV). SURFIN4.2 was identified at the surface of the parasitized RBCs (pRBCs) but was also found apically associated with the merozoite...
2018: PloS One
Amir Monemian Esfahani, Weiwei Zhao, Jennifer Y Chen, Changjin Huang, Ning Xi, Jun Xi, Ruiguo Yang
We previously reported the finding of a linear correlation between the change of energy dissipation (ΔD) of adhered cells measured with the quartz crystal microbalance with dissipation monitoring (QCM-D) and the level of focal adhesions of the cells. To account for this correlation, we have developed a theoretical framework for assessing the ΔD-response of adhered cells. We rationalized that the mechanical energy of an oscillating QCM-D sensor coupled with a cell monolayer is dissipated through three main processes: the interfacial friction through the dynamic restructuring (formation and rupture) of cell-extracellular matrix (ECM) bonds, the interfacial viscous damping by the liquid trapped between the QCM-D sensor and the basal membrane of the cell layer, and the intracellular viscous damping through the viscous slip between the cytoplasm and stress fibers as well as among stress fibers themselves...
August 8, 2018: Analytical Chemistry
Yining Tan, Xiaoling Chen, Chengbang Ma, Xinping Xi, Lei Wang, Mei Zhou, James F Burrows, Hang Fai Kwok, Tianbao Chen
The skin secretions of the subfamily Phyllomedusinae have long been known to contain a number of compounds with antimicrobial potential. Herein, a biosynthetic dermaseptin-precursor cDNA was obtained from a Phyllomedusa sauvagii skin secretion-derived cDNA library, and thereafter, the presence of the mature peptide, namely dermaseptin-PS3 (DPS3), was confirmed by LC⁻MS/MS. Moreover, this naturally occurring peptide was utilized to design two analogues, K5, 17 -DPS3 (introducing two lysine residues at positions 5 and 17 to replace acidic amino acids) and L10, 11 -DPS3 (replacing two neutral amino acids with the hydrophobic amino acid, leucine), improving its cationicity on the polar/unipolar face and hydrophobicity in a highly conserved sequence motif, respectively...
August 7, 2018: Toxins
Sean Burgess, Aleksey Vishnyakov, Christopher Tsovko, Alexander V Neimark
Tension-induced rupture of DMPC lipid membranes with encapsulated hydrophobic nanoparticles is elucidated using dissipative particle dynamics simulations. The dynamics of hole formation is studied and a nanoparticle size dependent relationship is established for the probability of membrane rupture within a given time as a function of the membrane tension. Two mechanisms of hole formation are explored: homogeneous nucleation and heterogeneous nucleation at the nanoparticle surface. While the kinetics of homogeneous nucleation in unloaded membranes complies with the predictions of the classical Deryagin-Gutop (DG) theory, the heterogeneous nucleation causes progressively lower lysis tensions as the particle size increases...
August 7, 2018: Journal of Physical Chemistry Letters
Veronika Aleksandrovych, Paweł Basta, Krzysztof Gil
Adenomyosis seems to be the most widespread coexistent pathology included under the umbrella of common benign disorders of the human uterus. The incidence of adenomyosis is under discussion since different imaging criteria are used. In the majority of cases, prevalence is determined among women with uterine fibroids and endometriosis or severe gynecological symptoms. This common benign pathology is asymptomatic in 1/3 of cases. Up to 50% of women with infertility are affected by adenomyosis. It seems to be an important risk factor for spontaneous pre-term delivery and pre-term premature rupture of the membranes...
August 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Bernadette Geißel, Veronika Loiko, Isabel Klugherz, Zhaojun Zhu, Nikola Wagener, Oliver Kurzai, Cees A M J J van den Hondel, Johannes Wagener
Azole antifungals inhibit the fungal ergosterol biosynthesis pathway, resulting in either growth inhibition or killing of the pathogen, depending on the species. Here we report that azoles have an initial growth-inhibitory (fungistatic) activity against the pathogen Aspergillus fumigatus that can be separated from the succeeding fungicidal effects. At a later stage, the cell wall salvage system is induced. This correlates with successive cell integrity loss and death of hyphal compartments. Time-lapse fluorescence microscopy reveals excessive synthesis of cell wall carbohydrates at defined spots along the hyphae, leading to formation of membrane invaginations and eventually rupture of the plasma membrane...
August 6, 2018: Nature Communications
Youhei Tsunoda, Takehiko Fukami, Koichi Yoneyama, Ikuno Kawabata, Toshiyuki Takeshita
OBJECTIVE: To examine whether the presence of amniotic fluid sludge (AFS) could increase the risk of preterm delivery in women with a cervical length of less than 25 mm. MATERIALS AND METHODS: This is a retrospective cohort study of 110 women who were 14-30 weeks pregnant with a singleton gestation and a cervical length of less than 25 mm. The primary outcomes were defined as preterm delivery before 34 weeks and preterm delivery before 37 weeks. The secondary outcome was defined as preterm premature rupture of membranes (PPROM) prior to preterm delivery...
August 6, 2018: Journal of Maternal-fetal & Neonatal Medicine
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