keyword
https://read.qxmd.com/read/38530893/feedforward-and-feedback-mechanisms-cooperatively-regulate-rapid-experience-dependent-response-adaptation-in-a-single-thermosensory-neuron-type
#21
JOURNAL ARTICLE
Tyler J Hill, Piali Sengupta
Sensory adaptation allows neurons to adjust their sensitivity and responses based on recent experience. The mechanisms that mediate continuous adaptation to stimulus history over seconds- to hours-long timescales, and whether these mechanisms can operate within a single sensory neuron type, are unclear. The single pair of AFD thermosensory neurons in Caenorhabditis elegans exhibits experience-dependent plasticity in their temperature response thresholds on both minutes- and hours-long timescales upon a temperature upshift...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38528044/effects-of-the-interplay-between-topology-and-function-of-an-integrated-urban-development-on-patterns-of-user-movement
#22
JOURNAL ARTICLE
Ajaykumar Manivannan, Wei Chien Benny Chin, Srilalitha Gopalakrishnan, Daniel K H Wong, Thomas Schroepfer, Roland Bouffanais
With the advent of distributed multi-sensory networks of devices, vast troves of real-time data can be gathered about our interactions with the built environment. These rich data sets can be mined to achieve improved and informed data-driven designs of buildings, neighborhoods, and potentially entire cities. Among those, integrated developments have the peculiarity of combining multiple functions within a compact space and, as such, behave as microcosms of a city that can help address the problem of urban sprawl and density...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38526742/type-of-auditory-cues-and-apparatus-influence-how-healthy-young-adults-integrate-sounds-for-dynamic-balance
#23
JOURNAL ARTICLE
Liraz Arie, Agnieszka Roginska, Yi Wu, Delong Lin, Alvaro F Olsen, Daphna Harel, Anat V Lubetzky
It is unclear whether the brain handles auditory cues similarly to visual cues for balance. We investigated the influence of headphones and loudspeaker reproduction of sounds on dynamic balance performance when an individual is facing a cognitive challenge. Twenty participants (16 females, aged 19-36) were asked to avoid a ball according to a specific visual rule. Visuals were projected from the HTC Vive head-mounted display in an acoustically controlled space. We varied the environment by adding congruent sounds (sounds coincide with the visual rule) or incongruent sounds (sounds may or may not coincide with the visual rule) as well as creating a multimodal (visual and congruent sounds) vs...
March 25, 2024: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://read.qxmd.com/read/38525884/reliability-of-a-clinical-sensory-test-battery-in-patients-with-spine-related-leg-and-arm-pain
#24
JOURNAL ARTICLE
Cedric Bender, Sven Karstens, Fabian Muth, Georgios Baskozos, Annina B Schmid
BACKGROUND: The current standard to evaluate the presence of somatosensory dysfunctions is quantitative sensory testing, but its clinical utility remains limited. Low-cost and time-efficient clinical sensory testing (CST) batteries have thus been developed. Recent studies show moderate to substantial reliability in populations with neuropathic pain. This study evaluates the inter- and intra-tester reliability of people with spine-related leg and arm pain, representing mixed pain mechanisms...
March 25, 2024: European Journal of Pain: EJP
https://read.qxmd.com/read/38525681/effects-of-musical-training-in-music-therapy-following-cochlear-implantation-a-case-report
#25
Astrid Magele, Bianca Wirthner, Philipp Schoerg, Georg M Sprinzl
The most prevalent sensory impairment impacting the elderly is age-related hearing loss (HL), which affects around 65% of individuals over the age of 60 years. This bilateral, symmetrical sensorineural impairment profoundly affects auditory perception, speech discrimination, and the overall understanding of auditory signals. Influenced by diverse factors, age-related HL can substantially influence an individual's quality of life and mental health and can lead to depression. Cochlear implantation (CI) stands as a standard intervention, yet despite advancements, music perception challenges persist, which can be addressed with individualized music therapy...
February 22, 2024: Audiology Research
https://read.qxmd.com/read/38525141/comparison-of-the-sugar-and-organic-acid-components-of-seventeen-table-grape-varieties-produced-in-ankara-t%C3%A3-rkiye-a-study-over-two-consecutive-seasons
#26
JOURNAL ARTICLE
Birhan Kunter, Osman Batur Unal, Sıddık Keskin, Harlene Hatterman-Valenti, Ozkan Kaya
Sugars and organic acids not only have a significant impact on taste balance and sensory acceptance by consumers but also play a crucial role in the chemical equilibrium of grape juices and wines. Therefore, this study aimed to quantify the content and composition of sugars and organic acids in 17 grape varieties over two consecutive years using high-performance liquid chromatography. The variability in all the parameters studied was strongly influenced by both the grape cultivars and specific years ( p ≤ 0...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38524301/individual-differences-in-environmental-sensitivity-associations-between-cognitive-emotion-regulation-and-mental-health
#27
JOURNAL ARTICLE
Kosuke Yano, Kazuo Oishi
INTRODUCTION: Environmental sensitivity is defined as the ability to perceive and process internal and external information. Previous studies have suggested that mental health-related factors differ by sensitivity level. This study aimed to investigate whether environmental sensitivity moderates the associations between cognitive emotion regulation strategies (e.g., rumination and blaming others ) and mental health. MATERIALS AND METHODS: In this three-wave longitudinal study, participants ( N  = 1,233, 585, and 349 at Times 1, 2, and 3, respectively) completed the Cognitive Emotion Regulation Questionnaire-short and Kessler 10 scale at all the measurement points as well as the 10-item version of the Highly Sensitive Person scale and some covariates only at Time 1...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38523822/infected-femoral-artery-pseudoaneurysm-ligation-and-revascularisation-a-case-report
#28
Mohammed Alsagheer Alhewy, Ehab Abd Elmoneim Ghazala, Hassan Gado, Wael Abdo Abdo Abd-Elgawad, Ahmed Atef Khamis
KEY CLINICAL MESSAGE: Although ligating femoral pseudoaneurysm is a safe procedure, some cases require revascularization, and the appropriate treatment should be tailored to the patient. ABSTRACT: In this case report, we highlight the challenge in treating infected femoral artery pseudoaneurysm. The patient, a 37-year-old male intravenous drug abuser, presented to the emergency department with a 2-month history of a progressively growing lump over his right groin...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38523371/the-contribution-of-the-nervous-system-in-the-cancer-progression
#29
Hongryeol Park, Chan Hee Lee
Cancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME). The TME comprises of diverse cell types, such as cancer cells, immune cells, stromal cells, and neuronal cells. These cells mutually influence each other through various factors, including cytokines, vascular perfusion, and matrix stiffness. In the initial or developmental stage of cancer, neurotrophic factors such as nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor are associated with poor prognosis of various cancers by communicating with cancer cells, immune cells, and peripheral nerves within the TME...
March 25, 2024: BMB Reports
https://read.qxmd.com/read/38522790/acute-macrocystic-thoracic-schwannoma-systematic-review-and-illustrative-case-example
#30
REVIEW
Grace R Fassina, Spencer J Oslin, Helen H Shi, John F Burke, Caple A Spence, Christopher S Graffeo
BACKGROUND: Schwannomas are benign peripheral nerve sheath tumors arising from myelinating Schwann cells. Although macrocystic changes are regularly encountered in schwannoma variants such as vestibular nerve tumors, they are exceedingly rare among spinal neoplasms. METHODS: Case report and systematic review of four databases (Ovid Medline, PubMed, Science Direct, and SCOPUS) from inception to present. All peer-reviewed publications reporting intradural cystic thoracic schwannoma were included...
March 22, 2024: World Neurosurgery
https://read.qxmd.com/read/38522512/dynamics-driven-allosteric-stimulation-of-diguanylate-cyclase-activity-in-a-red-light-regulated-phytochrome
#31
JOURNAL ARTICLE
Quang Hieu Tran, Oliver Maximilian Eder, Andreas Winkler
Sensor-effector proteins integrate information from different stimuli and transform this into cellular responses. Some sensory domains, like red-light responsive bacteriophytochromes, show a remarkable modularity regulating a variety of effectors. One effector domain is the GGDEF diguanylate cyclase catalysing the formation of the bacterial second messenger cyclic-dimeric-guanosine monophosphate. While critical signal integration elements have been described for different phytochromes, a generalized understanding of signal processing and communication over large distances, roughly 100 Angstrom in phytochrome diguanylate cyclases, is missing...
March 22, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38521212/unravelling-the-multisensory-learning-advantage-different-patterns-of-within-and-across-frequency-specific-interactions-drive-uni-and-multisensory-neuroplasticity
#32
JOURNAL ARTICLE
Evangelos Paraskevopoulos, Alexandra Anagnostopoulou, Nikolas Chalas, Maria Karagianni, Panagiotis Bamidis
In the field of learning theory and practice, the superior efficacy of multisensory learning over uni-sensory is well-accepted. However, the underlying neural mechanisms at the macro-level of the human brain remain largely unexplored. This study addresses this gap by providing novel empirical evidence and a theoretical framework for understanding the superiority of multisensory learning. Through a cognitive, behavioral, and electroencephalographic assessment of carefully controlled uni-sensory and multisensory training interventions, our study uncovers a fundamental distinction in their neuroplastic patterns...
March 21, 2024: NeuroImage
https://read.qxmd.com/read/38520939/a-nationwide-survey-of-facial-onset-sensory-and-motor-neuronopathy-in-japan
#33
JOURNAL ARTICLE
Senri Ko, Ryo Yamasaki, Tasuku Okui, Wataru Shiraishi, Mitsuru Watanabe, Yu Hashimoto, Yuko Kobayakawa, Susumu Kusunoki, Jun-Ichi Kira, Noriko Isobe
The epidemiology and etiology of facial onset sensory and motor neuronopathy (FOSMN), a rare syndrome that initiates with facial sensory disturbances followed by bulbar symptoms, remain unknown. To estimate the prevalence of FOSMN in Japan and establish the characteristics of this disease, we conducted a nationwide epidemiological survey. In the primary survey, we received answers from 604 facilities (49.8%), leading to an estimated number of 35.8 (95% confidential interval: 21.5-50.2) FOSMN cases in Japan...
March 11, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38518920/a-retrospective-analysis-of-perioperative-complications-of-lateral-approach-lumbar-interbody-fusion-in-patients-with-prior-abdominal-surgery-or-a-history-of-colonic-inflammatory-disease
#34
JOURNAL ARTICLE
Michael D Shost, Edward Barksdale, Mina Huerta, Karrington Seals, Nicholas Rabah, Bilal Butt, Michael Steinmetz
BACKGROUND CONTEXT: Lateral approaches for lumbar interbody fusion (LIF) allow for access to the lumbar spine and disk space by passing through a retroperitoneal corridor either pre- or trans-psoas. A contraindication for this approach is the presence of retroperitoneal scarring that may occur from prior surgical intervention in the retroperitoneal space or from inflammatory conditions with fibrotic changes and pose challenges for the mobilization and visualization needed in this approach...
March 20, 2024: Spine Journal: Official Journal of the North American Spine Society
https://read.qxmd.com/read/38518094/neuropsychiatric-symptoms-in-systemic-lupus-erythematosus-mixed-methods-analysis-of-patient-derived-attributional-evidence-in-the-international-inspire-project
#35
JOURNAL ARTICLE
Melanie Sloan, Thomas A Pollak, Efthalia Massou, Guy Leschziner, Laura Andreoli, Rupert Harwood, Michael Bosley, Mervi Pitkanen, Wendy Diment, Alessandra Bortoluzzi, Michael S Zandi, Mandeep Ubhi, Caroline Gordon, David Jayne, Felix Naughton, Colette Barrere, Chris Wincup, James Brimicombe, James A Bourgeois, David D'Cruz
OBJECTIVE: Attribution of neuropsychiatric symptoms in systemic lupus erythematosus (SLE) relies heavily on clinician assessment. Limited clinic time, variable knowledge, and symptom under-reporting contributes to discordance between clinician assessments and patient symptoms. We obtained attributional data directly from patients and clinicians in order to estimate and compare potential levels of direct attribution to SLE of multiple neuropsychiatric symptoms using different patient-derived measures...
March 22, 2024: Rheumatology
https://read.qxmd.com/read/38516471/the-efficacy-of-trigger-site-surgery-in-the-elimination-of-chronic-migraine-headache-an-update-in-the-rate-of-success-and-failure
#36
REVIEW
Eyad Faizo, Ahmad Fallata, Iman Mirza, Ahmed K Koshak, Yasmeen T Bucklain, Reema Alharbi, Abdulrahman Tasji, Taha Tasji, Ahmed Kabbarah
Migraine headache (MH) is a prevalent neurovascular disorder that affects approximately 15% of the global population. They are more common in women and typically affect young and middle-aged individuals. Chronic MH is characterized by headaches occurring on ≥15 days per month for over three months. While only 5% of MHs are refractory, about 20%-50% do not respond to pharmacologic treatments. As a result, surgical interventions have emerged as an alternative method to eliminate MH since 2000 AD. These surgical treatments primarily target the peripheral mechanisms of MH, focusing on common trigger sites...
February 2024: Curēus
https://read.qxmd.com/read/38515832/a-potentially-ecosustainable-hazelnut-carob-based-spread
#37
JOURNAL ARTICLE
Laura Principato, Daniele Carullo, Alice Gruppi, Guillermo Duserm Garrido, Gianluca Giuberti, Milena Lambri, Giorgia Spigno, Andrea Bassani
Commercial cocoa and hazelnut-based sweet spreads typically present a poor nutribiochemical level due to their ingredients and recipes, while nowadays, there is the need of developing sustainable food products addressing both an improved nutritional and environmental profile. The aim of this work was then to develop an innovative hazelnut/carob-based spread with potential high sustainability and nutritional profile, including the exploitation of grape-processing residues (grape skin flour and grapeseed oil) and carob pulp as cocoa surrogate...
2024: International Journal of Food Science
https://read.qxmd.com/read/38515445/safety-tolerability-and-efficacy-estimate-of-evoked-gamma-oscillation-in-mild-to-moderate-alzheimer-s-disease
#38
JOURNAL ARTICLE
Mihály Hajós, Alyssa Boasso, Evan Hempel, Monika Shpokayte, Alex Konisky, Chandran V Seshagiri, Vitella Fomenko, Kim Kwan, Jessie Nicodemus-Johnson, Suzanne Hendrix, Brent Vaughan, Ralph Kern, Jonathan T Megerian, Zach Malchano
BACKGROUND: Alzheimer's Disease (AD) is a multifactorial, progressive neurodegenerative disease that disrupts synaptic and neuronal activity and network oscillations. It is characterized by neuronal loss, brain atrophy and a decline in cognitive and functional abilities. Cognito's Evoked Gamma Therapy System provides an innovative approach for AD by inducing EEG-verified gamma oscillations through sensory stimulation. Prior research has shown promising disease-modifying effects in experimental AD models...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38514686/a-gps-assisted-translocation-experiment-to-study-the-homing-behavior-of-red-deer
#39
JOURNAL ARTICLE
Václav Silovský, Lukas Landler, Monika Faltusová, Luca Börger, Hynek Burda, Mark Holton, Ondřej Lagner, Erich Pascal Malkemper, Astrid Olejarz, Magdalena Spießberger, Adam Váchal, Miloš Ježek
Many animals return to their home areas (i.e., 'homing') after translocation to sites further away. Such translocations have traditionally been used in behavioral ecology to understand the orientation and migration behavior of animals. The movement itself can then be followed by marking and recapturing animals or by tracking, for example, using GPS systems. Most detailed studies investigating this behavior have been conducted in smaller vertebrates (e.g., birds, amphibians, and mice), whereas information on larger mammals, such as red deer, is sparse...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38514147/pancreatic-quantitative-sensory-testing-to-predict-treatment-response-of-endoscopic-therapy-or-surgery-for-painful-chronic-pancreatitis-with-pancreatic-duct-obstruction-study-protocol-for-an-observational-clinical-trial
#40
JOURNAL ARTICLE
Anna Evans Phillips, Elham Afghani, Venkata Sandeep Akshintala, Panayiotis Y Benos, Rohit Das, Asbjørn Mohr Drewes, Jeffrey Easler, Mahya Faghih, Charles Gabbert, Vivek Halappa, Mouen A Khashab, Søren Schou Olesen, Jami L Saloman, Biatta Sholosh, Adam Slivka, Tianxiu Wang, Dhiraj Yadav, Vikesh K Singh
INTRODUCTION: Treatment for abdominal pain in patients with chronic pancreatitis (CP) remains challenging in the setting of central nervous system sensitisation, a phenomenon of remodelling and neuronal hyperexcitability resulting from persistent pain stimuli. This is suspected to render affected individuals less likely to respond to conventional therapies. Endotherapy or surgical decompression is offered to patients with pancreatic duct obstruction. However, the response to treatment is unpredictable...
March 21, 2024: BMJ Open
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