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https://www.readbyqxmd.com/read/30513021/decreased-gene-expression-of-epstein-barr-virus-induced-gene-3-ebi-3-may-contribute-to-the-pathogenesis-of-rheumatoid-arthritis
#1
Nasrin Iranshahi, Shirin Assar, Seyed Mojtaba Amiri, Parisa Zafari, Adel Fekri, Mahdi Taghadosi
BACKGROUND: Interleukin-35 (IL-35) is a member of the IL-12 family of heterodimeric cytokines produced by regulatory T (Treg) cells. This immunosuppressive cytokine can prevent exaggerated inflammatory responses like those responsible for the development of rheumatoid arthritis (RA). This study aims to determine the correlation between the gene expression of Epstein-Barr virus-induced gene 3 (EBI-3) and IL-12A (p35) subunits of IL-35 in peripheral blood leukocytes with immunological and clinical parameters in RA patients...
December 4, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/30511171/-higher-prevalence-of-depressive-and-anxiety-symptoms-in-early-arthritis-patients-in-comparison-to-the-normal-population
#2
D Freier, M Englbrecht, V Höhne-Zimmer, J Detert, G-R Burmester
BACKGROUND: Many studies and registry data confirm that depression, often associated with anxiety disorders is very often found in patients with rheumatoid arthritis (RA). To what extent these psychiatric disorders are already relevant at a very early stage of the disease, has currently not been adequately investigated. METHODS: In this study 176 patients with early joint symptoms (<1 year) were surveyed in an early arthritis consultation (EAC). The hospital anxiety and depression scale (HADS) was completed by the patients to examine the prevalence of depressive and anxiety symptoms...
December 3, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/30508444/how-would-you-manage-this-patient-with-gout-grand-rounds-discussion-from-beth-israel-deaconess-medical-center
#3
Risa B Burns, C Christopher Smith, Robert H Shmerling, Anjala Tess
Gout is the most common form of inflammatory arthritis. In 2012, the American College of Rheumatology (ACR) issued a guideline, which was followed in 2017 by one from the American College of Physicians (ACP). The guidelines agree on treating acute gout with a corticosteroid, nonsteroidal anti-inflammatory drug, or colchicine and on not initiating long-term urate-lowering therapy (ULT) for most patients after a first gout attack and in those whose attacks are infrequent (<2 per year). However, they differ on treatment of both recurrent gout and problematic gout...
December 4, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30506466/advances-in-rheumatology-practice-in-brazil
#4
REVIEW
Francisco Airton Castro Rocha, Joaquim Ivo Vasques Dantas Landim, Leila Nascimento da Rocha
Despite resilient inequities, Brazil has seen progressive improvement in health care in the last 25 years. Infectious diseases rendered place to chronic non-communicable diseases as a major cause of death. Existence of traditional schools of medicine and training services in rheumatology helped form a reasonable number of specialists, though irregular distribution due to the economic issues favoring their clustering in major cities. The Brazilian Society of Rheumatology provides continued medical education, helps training rheumatologists, family physicians and other health professionals and has worked to publish national recommendations for the diagnosis and treatment of major rheumatic diseases...
December 1, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30504554/focus-on-neuro-beh%C3%A3-et-s-disease-a-review
#5
REVIEW
Paola Caruso, Rita Moretti
Behçet's disease (BD) is a multisystemic vasculitis disorder of almost unknown etiology, which involves small and large vessels and affects both veins and arteries. BD is characterized by recurrent oral aphthae (the main and most recurrent symptoms), genital ulcers, variable skin lesions, arthritis, uveitis, and thrombophlebitis. Other reported symptoms concern the involvement of the gastrointestinal and the central nervous system. Neuro-Behçet's disease (NBD) is one of the main causes of long-term morbidity and mortality, making its prompt recognition and treatment fundamental to attaining a better outcome...
November 2018: Neurology India
https://www.readbyqxmd.com/read/30499364/disease-activity-treatment-and-long-term-prognosis-of-adult-juvenile-idiopathic-arthritis-patients-compared-with-rheumatoid-arthritis-patients
#6
Takumi Matsumoto, Toshihiro Matsui, Fumio Hirano, Shigeto Tohma, Masaaki Mori
OBJECTIVE: To evaluate the difference between adult juvenile idiopathic arthritis (JIA, starting at <16 years) and rheumatoid arthritis (RA) . METHODS: Data on 128 adult JIA patients were from the National Database of Rheumatic Diseases in Japan (NinJa), 2014, divided into 4 groups by period of disease onset (Group 1: 2000-2013, n = 32; Group 2: 1981-1999, n = 32; Group 3: 1966-1980, n = 31; Group 4: ∼1965, n = 33). Disease activity, treatment and long-term prognosis of adult JIA patients was compared with RA patients matched for sex- and disease duration in each era...
November 30, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30499259/2018-american-college-of-rheumatology-national-psoriasis-foundation-guideline-for-the-treatment-of-psoriatic-arthritis
#7
Jasvinder A Singh, Gordon Guyatt, Alexis Ogdie, Dafna D Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J Mease, Joseph F Merola, Julie Miner, Christopher T Ritchlin, Bernadette Siaton, Benjamin J Smith, Abby S Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C Coates, Alice Gottlieb, Marina Magrey, W Benjamin Nowell, Ana-Maria Orbai, Soumya M Reddy, Jose U Scher, Evan Siegel, Michael Siegel, Jessica A Walsh, Amy S Turner, James Reston
OBJECTIVE: To develop an evidence-based guideline for the pharmacologic and nonpharmacologic treatment of psoriatic arthritis (PsA), as a collaboration between the American College of Rheumatology (ACR) and the National Psoriasis Foundation (NPF). METHODS: We identified critical outcomes in PsA and clinically relevant PICO (population/intervention/comparator/outcomes) questions. A Literature Review Team performed a systematic literature review to summarize evidence supporting the benefits and harms of available pharmacologic and nonpharmacologic therapies for PsA...
November 30, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/30499246/2018-american-college-of-rheumatology-national-psoriasis-foundation-guideline-for-the-treatment-of-psoriatic-arthritis
#8
Jasvinder A Singh, Gordon Guyatt, Alexis Ogdie, Dafna D Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J Mease, Joseph F Merola, Julie Miner, Christopher T Ritchlin, Bernadette Siaton, Benjamin J Smith, Abby S Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C Coates, Alice Gottlieb, Marina Magrey, W Benjamin Nowell, Ana-Maria Orbai, Soumya M Reddy, Jose U Scher, Evan Siegel, Michael Siegel, Jessica A Walsh, Amy S Turner, James Reston
OBJECTIVE: To develop an evidence-based guideline for the pharmacologic and nonpharmacologic treatment of psoriatic arthritis (PsA), as a collaboration between the American College of Rheumatology (ACR) and the National Psoriasis Foundation (NPF). METHODS: We identified critical outcomes in PsA and clinically relevant PICO (population/intervention/comparator/outcomes) questions. A Literature Review Team performed a systematic literature review to summarize evidence supporting the benefits and harms of available pharmacologic and nonpharmacologic therapies for PsA...
November 30, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/30482636/assessment-of-the-clinical-relevance-of-pharmacists-interventions-performed-during-medication-review-in-a-rheumatology-ward
#9
Anne-Laure Yailian, Elsa Revel, Cléa Tardy, Aurélie Fontana, Charline Estublier, Evelyne Decullier, Claude Dussart, Roland Chapurlat, Christine Pivot, Audrey Janoly-Dumenil
BACKGROUND: Pharmacists contribute to reduce the number of medication errors during medication review. Nevertheless, few French studies report the potential clinical impact of pharmacists' interventions performed after detecting drug-related problems. The objective was to evaluate the clinical relevance of pharmacists' interventions in a rheumatology ward from medical and pharmaceutical perspectives. METHOD: The analysis was conducted on pharmacists' interventions performed between January 1 and December 31, 2015 in a French teaching hospital...
October 25, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/30478638/-non-drug-treatment-of-rheumatoid-arthritis-an-analysis-of-claims-data-and-a-survey-of-insured-persons-project-proclair
#10
H Jacobs, J Callhoff, F Hoffmann, A Zink, K Albrecht
BACKGROUND: Only small amounts of data are available on the prescription frequency of physical therapies (PT) for patients with rheumatoid arthritis (RA). OBJECTIVE: The aim of the study was to evaluate prescription frequencies of PT considering functional status and sociodemographic factors. MATERIAL AND METHODS: A total of 98,963 adults diagnosed with RA in 2013 were identified in claims data from the BARMER health insurance. A questionnaire was sent to a representative sample of 6193 people requesting information on the disease status...
November 26, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/30476299/comment-on-the-ability-of-rheumatologists-blinded-to-prior-workup-to-diagnose-rheumatoid-arthritis-only-by-clinical-assessment-a-cross-sectional-study-reply
#11
Boris Ehrenstein, Georg Pongratz, Martin Fleck, Wolfgang Hartung
No abstract text is available yet for this article.
November 22, 2018: Rheumatology
https://www.readbyqxmd.com/read/30476268/comment-on-the-ability-of-rheumatologists-blinded-to-prior-workup-to-diagnose-rheumatoid-arthritis-by-clinical-assessment-only-a-cross-sectional-study
#12
https://www.readbyqxmd.com/read/30474868/metabolic-syndrome-and-psoriatic-arthritis-among-patients-with-psoriasis-vulgaris-quality-of-life-and-prevalence
#13
Cacilda S Souza, Caio C S de Castro, Francisca R O Carneiro, Jane M N Pinto, Lincoln H Z Fabricio, Luna Azulay-Abulafia, Ricardo Romiti, Tania F Cestari, Cláudia E Suzuki, Priscila M Biegun, Luciana S Guedes, Luiza K M Oyafuso
Interest has increased in comorbidities associated with psoriasis and their effects on health-related quality of life (HRQoL). This study aimed to evaluate the prevalence of metabolic syndrome (MetS) and psoriatic arthritis (PsA) and to investigate HRQoL and the prevalence of hypertension, type 2 diabetes mellitus (T2DM), obesity and dyslipidemia. In a cross-sectional design, patients diagnosed with plaque psoriasis answered an interview and standardized questionnaires (Dermatology Life Quality Index questionnaire [DLQI], 36-Item Short Form Health Survey [SF-36] and EuroQol Five-Dimension Questionnaire Three-Level version [EQ-5D-3L])...
November 26, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30470723/diagnosis-of-attenuated-mucopolysaccharidosis-vi-clinical-biochemical-and-genetic-pitfalls
#14
Filippo Pinto E Vairo, Erin Conboy, Carolina Fischinger Moura de Souza, Amie Jones, Sarah S Barnett, Eric W Klee, Brendan C Lanpher
Mucopolysaccharidosis type VI (MPS VI) is a clinically heterogeneous lysosomal disease, which can be divided into 2 main categories on the basis of age of onset and severity of symptoms. The diagnosis of the attenuated form is often delayed given subtle facial features rather than the typical coarse facial features of the classic form. Here, we discuss the difficulties in establishing the diagnosis of MPS VI on the basis of the report of 4 individuals. The most common signs and symptoms in our series were bone abnormalities and hip pain as initial manifestations and cardiac changes detected after follow-up studies...
November 23, 2018: Pediatrics
https://www.readbyqxmd.com/read/30470636/recommendations-by-the-spanish-society-of-rheumatology-on-osteoporosis
#15
Antonio Naranjo Hernández, Petra Díaz Del Campo Fontecha, María Pilar Aguado Acín, Luis Arboleya Rodríguez, Enrique Casado Burgos, Santos Castañeda, Jordi Fiter Aresté, Laia Gifre, Carmen Gómez Vaquero, Núria Guañabens Gay
OBJECTIVE: To update the recommendations on osteoporosis (OP) of the Spanish Society of Rheumatology (SER) based on the best possible evidence. METHODS: A panel of nine expert rheumatologists in OP was created, previously selected by the SER through an open call. The phases of the work were: identification of the key areas for updating the previous consensus, analysis and synthesis of the scientific evidence (using the SIGN levels of evidence) and formulation of recommendations based on this evidence and consensus techniques...
November 20, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/30468376/multidisciplinary-approach-for-hidradenitis-suppurativa-patients
#16
Stefano Veraldi, Elena Guanziroli, Valentina Benzecry, Gianluca Nazzaro
Hidradenitis suppurativa or acne inversa is an inflammatory, chronic disease of the hair follicles located in specific areas of the skin surface (axillae, submammary, inguinal and intergluteal folds, pubis, genitalia and buttocks). The diagnosis and the management of this disease are usually made by the dermatologist. However, the frequent association of hidradenitis suppurativa or acne inversa with important systemic comorbidities needs the cooperation with a number of specialists. In particular, the cooperation with rheumatologists, gastroenterologists, endocrinologists, microbiologists/infectivologists, psychologists/psychiatrics and plastic surgeons is often helpful or necessary...
June 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/30466449/feasibility-of-a-musculoskeletal-ultrasound-intervention-to-improve-adherence-in-juvenile-idiopathic-arthritis-a-proof-of-concept-trial
#17
Leslie A Favier, Tracy V Ting, Avani C Modi
BACKGROUND: Non-adherence is a prevalent and modifiable issue in juvenile idiopathic arthritis (JIA) that currently lacks provider-based intervention. Education surrounding disease status is one way in which families remain engaged in their care. Musculoskeletal ultrasound is one such form of demonstrative, real-time education that may impact the way patients and caregivers self-manage their disease. The aims of this study are to 1) assess the feasibility, acceptability and perceived usefulness of musculoskeletal ultrasound as a non-adherence intervention tool and 2) to examine changes in methotrexate adherence in adolescents with JIA following the ultrasound...
November 22, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/30457059/new-insight-into-the-diagnostic-cut-off-value-of-serum-anti-toxocara-igg-for-ocular-toxocariasis-in-uveitis-patients
#18
N F Abd El-Aal, M A A Basha, A M Eid
Uveitis is one of the commonest causes of vision loss worldwide and its exact etiology is still not clarified in most patients. The current study is a trial to assess the efficacy of serum anti-Toxocara immunoglobulin G (IgG) by enzyme-linked immunosorbent assay (ELISA) as a diagnostic tool for ocular toxocariasis (OT) and to detect OT prevalence and the associated ocular manifestations in sera of patients with uveitis. One hundred and twelve patients (62 females and 50 males) with uveitis were diagnosed by ophthalmologists, radiologists and rheumatologists according to ocular manifestations, laboratory and radiological investigations...
November 20, 2018: Journal of Helminthology
https://www.readbyqxmd.com/read/30452119/authors-reply-to-diagnostic-pitfalls-and-treatment-challenges-in-interstitial-pneumonia-with-autoimmune-features
#19
Erin M Wilfong, Kevin W Byram, Leslie J Crofford
We thank Dr. Novikov and colleagues for their thoughtful comments on our recent review. We agree that the ATS/ERS classification criteria for IPAF will most certainly need to be reviewed, revised, and validated moving forward. We also agree whole-heartedly with the critical collaboration between rheumatologists and pulmonologists in the management of these patients. In our ongoing prospective longitudinal cohort, >93% of patients are co-managed by rheumatology and pulmonology. We strongly advocate this approach worldwide both to provide accurate classification/diagnosis at the time of presentation and to monitor for the emergence of a clearly defined connective tissue disease (CTD)...
November 19, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/30449652/palliative-and-end-of-life-care-in-rheumatology-high-symptom-prevalence-and-unmet-needs
#20
Jiacai Cho, Jamie Zhou, Dominic Lo, Anselm Mak, Sen Hee Tay
OBJECTIVES: To determine the extent of end-of-life suffering and predictors of high symptom prevalence in the last one year of life in patients with systemic rheumatic diseases (SRDs) and the extent of supportive care received. METHODS: We identified adult patients with SRDs who died between 1 April 2006 and 1 April 2016. We collected data within 1 year before their death, on the following: (i) cumulative symptom prevalence, (ii) rates of Advance Care Planning (ACP), Do-Not-Resuscitate (DNR) orders and referral to a palliative physician...
November 2, 2018: Seminars in Arthritis and Rheumatism
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