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Psoas muscle and sarcopenia

Lenise C B C Fernandes, Italo M de Oliveira, Paula Frassinetti C B C Fernandes, João David de Souza Neto, Maria do Socorro Q Farias, Nilce A de Freitas, Nasser C Magalhães, Fernando Bacal
Background: To assess the impact of heart transplantation (HT) on the recovery of peripheral and respiratory muscle mass and strength in patients with congestive heart failure. Methods: The study included 23 patients with an indication for HT (patients in the waiting list [WL] group). These patients were monitored for 1.5 to 3 years after HT; 8 died before 6 months of follow-up, 15 patients completed the early follow-up period of 6 months after HT (FU6m group), 4 died between 6 months and 3 years after HT, and 11 patients completed the late follow-up period 1...
November 2018: Transplantation Direct
Carrie A Kubiak, Kavitha Ranganathan, Niki Matusko, Jon A Jacobson, Stewart C Wang, Pauline K Park, Benjamin L Levi
BACKGROUND: Morphomic studies have demonstrated a correlation between sarcopenia and clinical outcomes in septic patients. However, tendon morphomics has not yet been studied in this context. The purpose of the present study was to evaluate tendon morphology in septic patients through analytic morphomics. We hypothesized that morphomic analyses would reveal concomitant muscle and tendon wasting in sepsis patients. The results of this study may help to implement different rehabilitation modalities for critically ill patients...
February 2019: Journal of Surgical Research
Qin Cao, Yan Xiong, Zibiao Zhong, Qifa Ye
BACKGROUND: Computed tomography (CT)-assessed sarcopenia indexes have been reported to predict postoperative morbidity and mortality; however conclusions drawn from different indexes and studies remain controversial. AIM: The purpose of this meta-analysis was to evaluate various CT-assessed sarcopenia indexes as predictors of risk for major complications in patients undergoing hepatopancreatobiliary surgery for malignancy. METHODS: Medline/PubMed, Web of Science, and Embase databases were systematically searched to identify relevant studies published before June 2018...
December 4, 2018: Annals of Nutrition & Metabolism
Samantha Baker, Mary Glen Waldrop, Joshua Swords, Thomas Wang, Martin Heslin, Carlo Contreras, Sushanth Reddy
BACKGROUND: Estimating sarcopenia by measuring psoas muscle density (PMD) has been advocated as a method to accurately predict post-operative morbidity. The aim of the present study was to determine whether the Timed Stair Climb (TSC) could be used to replace PMD measurements in predicting morbidity. METHODS: Patients were prospectively enrolled from March 2014-2015 and were eligible if they were undergoing an abdominal operation. PMD was measured using pre-operative CT scans obtained within 90 days of surgery...
December 3, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Iisa Lindström, Niina Khan, Teemu Vänttinen, Mikko Peltokangas, Niko Sillanpää, Niku Oksala
BACKGROUND: Sarcopenia is associated with mortality after abdominal aortic aneurysm (AAA) repair. The reliability of computed tomography (CT) core muscle areas and quality i.e. densities and their association with postoperative survival in patients undergoing AAA treatment were retrospectively studied. METHODS: Psoas and multifidus areas (PMA, MFA) and densities (PMD, MFD) were measured from CT images and analysed to lean values. Results were standardized by z-scoring...
November 23, 2018: Annals of Vascular Surgery
Joshua Hsu, Aravind Krishnan, Cheng T Lin, Pali D Shah, Stephen R Broderick, Robert S D Higgins, Christian A Merlo, Errol L Bush
BACKGROUND: Sarcopenia, a known component of frailty, defined by diminished cross-sectional area of the psoas muscles, is associated with poor outcomes after a range of surgical procedures. However, little is known of the relationship between sarcopenia of the psoas muscles (SPM) and long-term mortality, decline in pulmonary function, and graft failure after lung transplantation. METHODS: We reviewed patients who underwent primary lung transplantation at our institution from 2011 to 2014...
November 14, 2018: Annals of Thoracic Surgery
Lisa M Francomacaro, Charles Walker, Kathryn Jaap, James Dove, Marie Hunsinger, Kenneth Widom, Denise Torres, Mohsen Shabahang, Joseph Blansfield, Jeffrey Wild
BACKGROUND: Emergent laparotomies are associated with higher rates of morbidity and mortality. Recent studies suggest sarcopenia predicts worse outcomes in elective operations. The purpose of this study is to examine outcomes following urgent exploratory laparotomy in sarcopenic patients. METHODS: This was a retrospective review of patients in a rural tertiary care facility between 2010 and 2014. Patients underwent a laparotomy within 72 h of admission and had an abdomen/pelvis CT scan were included...
November 6, 2018: American Journal of Surgery
Thomas Baum, Cristian Lorenz, Christian Buerger, Friedemann Freitag, Michael Dieckmeyer, Holger Eggers, Claus Zimmer, Dimitrios C Karampinos, Jan S Kirschke
Proton-density fat fraction (PDFF) of the paraspinal muscles, derived from chemical shift encoding-based water-fat magnetic resonance imaging, has emerged as an important surrogate biomarker in individuals with intervertebral disc disease, osteoporosis, sarcopenia and neuromuscular disorders. However, quantification of paraspinal muscle PDFF is currently limited in clinical routine due to the required time-consuming manual segmentation procedure. The present study aimed to develop an automatic segmentation algorithm of the lumbar paraspinal muscles based on water-fat sequences and compare the performance of this algorithm to ground truth data based on manual segmentation...
November 7, 2018: European radiology experimental
Jacob M Babu, Saisanjana Kalagara, Wesley Durand, Valentin Antoci, Matthew E Deren, Eric Cohen
BACKGROUND: Sarcopenia, an age-related loss of muscle mass and function, has been previously linked to an increased risk of morbidity, mortality, and infection after a variety of surgical procedures. This study is the first to evaluate the impact of the psoas-lumbar vertebral index (PLVI), a validated marker for central sarcopenia, on determining post-arthroplasty infection status. METHODS: This is a case-control, retrospective review of 30 patients with prosthetic joint infection (PJI) diagnosed by the Musculoskeletal Infection Society criteria compared to 69 control patients who underwent a total hip or knee arthroplasty...
September 20, 2018: Journal of Arthroplasty
Yoshinaga Okugawa, Yuji Toiyama, Akira Yamamoto, Tsunehiko Shigemori, Ayame Kitamura, Takashi Ichikawa, Shozo Ide, Takahito Kitajima, Hiroyuki Fujikawa, Hiromi Yasuda, Yoshiki Okita, Junichiro Hiro, Toshimitsu Araki, Donald C McMillan, Chikao Miki, Masato Kusunoki
BACKGROUND: The systemic inflammatory response (SIR) via host-tumor interactions has been termed the seventh hallmark of cancer, and several studies demonstrated that SIR might be a pivotal mediator for progression of cancer cachexia. The objective of this study was to clarify the correlation between sarcopenia and SIR in patients with colorectal cancer (CRC). METHODS: A total of 308 patients with CRC were enrolled in this study. Preoperative psoas muscle mass index and intramuscular adipose tissue content were evaluated using preoperative computed tomographic images, and the correlation between body composition status and several SIR markers, including C-reactive protein (CRP), serum albumin level, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and systemic immune-inflammation index (SII) was assessed using statistical methods...
October 18, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
Gregory Simpson, Alexander Parker, Philip Hopley, Jeremy Wilson, Conor Magee
INTRODUCTION: Emergency laparotomy in patients over the age of 80 is associated with high morbidity and mortality. Accurate risk prediction in this patient population is desirable. Sarcopenia has been shown to be associated with outcome in multiple clinical settings and the psoas major muscle as measured on computed tomography (CT) imaging has been demonstrated as a marker of sarcopenia. We aim to assess the use of psoas major measurement on pre-operative CT as a prognostic indicator in over-80s undergoing emergency laparotomy and compare this measurement to P-POSSUM...
October 13, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
D Takamoto, T Kawahara, T Mochizuki, K Makiyama, J Teranishi, H Uemura
BACKGROUND: Sarcopenia is a condition in which the amount of skeletal muscle decreases. Recent studies have suggested that sarcopenia is a risk factor for the incidence of postoperative complications, longer hospitalization, and a poorer prognosis. In this study, we examined the impact of sarcopenia in association with a history of hemodialysis in renal transplantation patients. METHODS: A total of 157 patients who underwent renal transplantation at Yokohama City University Medical Center (Yokohama, Japan) from 2005 to 2016 were analyzed in this study...
October 2018: Transplantation Proceedings
Natasha H Dolgin, Andrew J Smith, Samantha G Harrington, Babak Movahedi, Paulo N A Martins, Adel Bozorgzadeh
OBJECTIVES: A growing body of evidence shows that frailty and functional performance predict liver transplant outcomes. The Organ Procurement and Transplant Network uses the Karnofsky Performance Status scale to adjust for transplant center case mix in assessing quality measures. This study explores the strength of the relationship between Karnofsky Performance Status scores and objective measures of frailty. MATERIALS AND METHODS: This observational study includes 136 adult, first-time liver transplant recipients at UMass Memorial (2006-2015) who had 2 abdominal computed tomography scans available (at ≤ 90 days pretransplant and ≥ 7 days before that)...
October 5, 2018: Experimental and Clinical Transplantation
Takayuki Sugai, Tetsu Watanabe, Yoichiro Otaki, Jun Goto, Ken Watanabe, Taku Toshima, Tetsuya Takahashi, Miyuki Yokoyama, Harutoshi Tamura, Satoshi Nishiyama, Takanori Arimoto, Hiroki Takahashi, Tetsuro Shishido, Masafumi Watanabe
BACKGROUND: The prognosis of peripheral artery disease (PAD) and comorbid sarcopenia is poor. Some reports indicate that the computed tomography (CT) value of skeletal muscle, which reflects intramuscular fat deposition as well as skeletal muscle mass, is considered a marker of sarcopenia. However, it remains unclear if skeletal muscle area and CT value are associated with poor outcomes in patients with PAD. Methods and Results: Psoas muscle area and CT value were measured by manual trace at the level of the third lumbar vertebral body in 327 consecutive patients with PAD undergoing endovascular therapy (EVT)...
September 29, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Maryam Ebadi, Connie W Wang, Jennifer C Lai, Srinivasan Dasarathy, Matthew R Kappus, Michael A Dunn, Elizabeth J Carey, Aldo J Montano-Loza
BACKGROUND: Sarcopenia, characterized by low muscle mass, associates with mortality in patients with cirrhosis. Skeletal muscle area in a single computed tomography image at the level of the third lumbar vertebrate (L3) is a valid representative of whole body muscle mass. Controversy remains regarding applicability of psoas muscle to identify patients at greater risk of mortality. We aimed to determine psoas muscle index (PMI) association with skeletal muscle index (SMI) and to evaluate the capacity of PMI to predict liver transplant waitlist mortality...
December 2018: Journal of Cachexia, Sarcopenia and Muscle
Elizabeth S Aby, Edward Lee, Satvir S Saggi, Matthew R Viramontes, Jonathan F Grotts, Vatche G Agopian, Ronald W Busuttil, Sammy Saab
BACKGROUND: Malnutrition and muscle wasting are common in patients with end-stage liver disease (ESLD), yet go underdiagnosed. Frequently used indices of nutritional status, such as body mass index, are inflated in patients with ESLD due to a fluid overloaded state. Previous work has demonstrated a strong association between psoas muscle area, a surrogate for sarcopenia, and worse survival following liver transplantation; however, the impact of sarcopenia on post liver transplant outcomes in patients with nonalcoholic steatohepatitis (NASH) cirrhosis has not been evaluated...
September 1, 2018: Journal of Clinical Gastroenterology
Leandra A Barnes, Alexander Y Li, Derrick C Wan, Arash Momeni
BACKGROUND: Postoperative complication following ventral hernia repair (VHR) is a major clinical and financial burden. Preoperative risk assessment is necessary to minimize adverse outcomes following VHR. This study examines the ability of an independent parameter to predict postoperative morbidity following VHR. METHODS: A retrospective analysis of 58 patients who underwent VHR by component separation between January 2009 and December 2013 was performed. Preoperative abdominal CT scans were analyzed to assess sarcopenia...
September 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
James Tankel, Amir Dagan, Elena Vainberg, Elad Boaz, Liel Mogilevsky, Irit Hadas, Petachia Reissman, Menahem Ben Haim
BACKGROUND AND AIMS: Sarcopenia is the degenerative loss of skeletal muscle and has been associated with a variety of post-operative complications. We propose sarcopenia is associated with delayed gastric emptying (DGE) following elective pancreaticoduodenectomy (PD). METHODS: A retrospective analysis of a computerised database maintained in real time of all patients undergoing PD within our hepatobiliary unit was performed. The cross-sectional area of the psoas muscle at the upper border of L3 was calculated and corrected for patient height...
October 2018: Clinical Nutrition ESPEN
Homare Okamura, Naoyuki Kimura, Keisuke Tanno, Makiko Mieno, Harunobu Matsumoto, Atsushi Yamaguchi, Hideo Adachi
OBJECTIVE: Sarcopenia, age-related loss of muscle mass, is an objective and comprehensive marker of frailty. We aimed to clarify the influence of sarcopenia on the outcomes after heart valve surgery. METHODS: We retrospectively reviewed 1119 patients who underwent valve surgery via median sternotomy at our institution from June 2009 to December 2013. Patients aged <70 years, urgent/emergent cases, and patients without preoperative computed tomography of the abdomen were excluded...
July 27, 2018: Journal of Thoracic and Cardiovascular Surgery
Leon Lenchik, Kristin M Lenoir, Josh Tan, Robert D Boutin, Kathryn E Callahan, Stephen B Kritchevsky, Brian J Wells
Background: Opportunistic assessment of sarcopenia on CT examinations is becoming increasingly common. This study aimed to determine relationships between CT-measured skeletal muscle size and attenuation with one-year risk of mortality in older adults enrolled in a Medicare Shared Savings Program (MSSP). Methods: Relationships between skeletal muscle metrics and all-cause mortality were determined in 436 participants (52% women, mean age 75 years) who had abdominopelvic CT examinations...
August 16, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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