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Psoas muscle and sarcopenia

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https://www.readbyqxmd.com/read/30048632/albumin-is-predictive-of-1-year-mortality-after-transcatheter-aortic-valve-replacement
#1
Katherine R Hebeler, Heike Baumgarten, John J Squiers, Jordan Wooley, Benjamin D Pollock, Cecile Mahoney, Giovanni Filardo, Brian Lima, J Michael DiMaio
BACKGROUND: A validated model for predicting 1-year outcomes after transcatheter aortic valve replacement (TAVR) does not exist. TAVR-specific risk models may benefit from frailty markers, and sarcopenia may represent an objective frailty marker. This study assessed the predictive ability of sarcopenia and frailty markers on 1-year mortality after TAVR. METHODS: We evaluated 470 patients undergoing TAVR at a single center. Frailty was assessed using 4 markers (gait speed, handgrip strength, serum albumin, and Katz activities of daily living)...
July 23, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30040184/relationship-between-total-body-protein-and-cross-sectional-skeletal-muscle-area-in-liver-cirrhosis-is-influenced-by-overhydration
#2
Cameron I Wells, John L McCall, Lindsay D Plank
Sarcopenia as defined by reduced skeletal muscle area (SMA) on cross-sectional abdominal imaging has been proposed as an objective measure of malnutrition, and is associated with both waitlist mortality and post-transplant complications in patients with cirrhosis. SMA, however, has never been validated against the gold-standard measurement of total body protein (TBP) by in vivo neutron activation analysis (IVNAA). Furthermore, overhydration is common in cirrhosis and its effect on muscle area measurement remains unknown...
July 24, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/30014202/association-of-paraspinal-muscle-water-fat-mri-based-measurements-with-isometric-strength-measurements
#3
Sarah Schlaeger, Stephanie Inhuber, Alexander Rohrmeier, Michael Dieckmeyer, Friedemann Freitag, Elisabeth Klupp, Dominik Weidlich, Georg Feuerriegel, Florian Kreuzpointner, Ansgar Schwirtz, Ernst J Rummeny, Claus Zimmer, Jan S Kirschke, Dimitrios C Karampinos, Thomas Baum
OBJECTIVES: Chemical shift encoding-based water-fat MRI derived proton density fat fraction (PDFF) of the paraspinal muscles has been emerging as a surrogate marker in subjects with sarcopenia, lower back pain, injuries and neuromuscular disorders. The present study investigates the performance of paraspinal muscle PDFF and cross-sectional area (CSA) in predicting isometric muscle strength. METHODS: Twenty-six healthy subjects (57.7% women; age: 30 ± 6 years) underwent 3T axial MRI of the lumbar spine using a six-echo 3D spoiled gradient echo sequence for chemical shift encoding-based water-fat separation...
July 16, 2018: European Radiology
https://www.readbyqxmd.com/read/30005446/the-ratio-between-estimated-glomerular-filtration-rates-egfr-of-creatinine-and-cystatin-c-predicts-overall-survival-in-patients-with-hepatocellular-carcinoma
#4
Yasuyuki Tamai, Motoh Iwasa, Yuya Kawasaki, Naohiko Yoshizawa, Suguru Ogura, Ryosuke Sugimoto, Akiko Eguchi, Norihiko Yamamoto, Kazushi Sugimoto, Hiroshi Hasegawa, Yoshiyuki Takei
AIM: Hepatocellular carcinoma (HCC) patients with sarcopenia have a poor survival, but there are no predictive markers for survival relating to muscle mass and liver function. Therefore, we investigated whether the ratio between estimated glomerular filtration rates of serum creatinine (Scre) and serum cystain C (Scys) (eGFRcre/eGFRcys) can be used as a predictive marker of survival in HCC patients. METHODS: First, the correlation between Scre/Scys ratio and muscle mass was examined in 50 patients with chronic liver disease...
July 13, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29991895/muscle-fat-infiltration-assessed-by-total-psoas-density-on-computed-tomography-predicts-mortality-in-cirrhosis
#5
Maria Kalafateli, Andreas Karatzas, Georgios Tsiaoussis, Efstratios Koutroumpakis, Paraskevi Tselekouni, Nikolaos Koukias, Christos Konstantakis, Stelios Assimakopoulos, Charalambos Gogos, Konstantinos Thomopoulos, Christina Kalogeropoulou, Christos Triantos
Background: Ongoing evidence suggests that sarcopenia adversely affects outcomes in cirrhosis. The aim of this study was to evaluate muscle fat infiltration as a component of sarcopenia and its prognostic value in this setting. Methods: In 98 consecutive patients with cirrhosis, muscle density was measured during a computed tomography scan at the level of the fourth to fifth lumbar (L4) vertebrae. Univariate and multivariate Cox regression analysis was used to determine predictors of survival...
July 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29805792/preoperative-evaluation-of-skeletal-muscle-mass-in-the-risk-assessment-for-the-short-term-outcome-of-elderly-colorectal-cancer-patients-undergoing-colectomy
#6
Hiroshi Tamagawa, Toru Aoyama, Kenta Iguchi, Hirohito Fujikawa, Sho Sawazaki, Tsutomu Sato, Hiroyuki Musiake, Takashi Oshima, Norio Yukawa, Yasushi Rino, Munetaka Masuda
The prevalence of colorectal cancer in the elderly population is increasing; therefore, surgical interventions with a risk of potential complications are more frequently performed. The aim of the present study was to elucidate whether sarcopenia has a clinical impact on short-term outcomes, such as morbidity and hospital stay after surgery, in elderly patients with colorectal cancer. A total of 82 elderly patients undergoing colectomy for colorectal cancer between January 2011 and December 2015 in our institute were included in the study, and skeletal muscle mass was measured as total psoas area at the level of the third lumbar vertebra (L3) using enhanced computed tomography scans...
June 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29789798/the-relation-between-sarcopenia-and-mortality-in-patients-at-intensive-care-unit
#7
Mehmet Toptas, Mazhar Yalcin, İbrahim Akkoc, Eren Demir, Cagatay Metin, Yildiray Savas, Muhsin Kalyoncuoglu, Mehmet Mustafa Can
Background and Aim: Psoas muscle area (PMA) can reflect the status of skeletal muscle in the whole body. It has been also reported that decreased PMA was associated with postoperative mortality or morbidity after several surgical procedures. In this study, we aimed to investigate the relation between PMA and mortality in all age groups in intensive care unit (UNIT). Materials and Method: The study consists of 362 consecutive patients. The demographic characteristics of patients, indications for ICU hospitalization, laboratory parameters, and clinical parameters consist of mortality and length of stay, and surgery history was obtained from intensive care archive records...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29761898/clinical-impact-of-muscle-quantity-and-quality-in-colorectal-cancer-patients-a-propensity-score-matching-analysis
#8
Yoshinaga Okugawa, Yuji Toiyama, Akira Yamamoto, Tsunehiko Shigemori, Chengzeng Yin, Aya Narumi, Yusuke Omura, Shozo Ide, Takahito Kitajima, Hiroyuki Fujikawa, Hiromi Yasuda, Junichiro Hiro, Shigeyuki Yoshiyama, Minako Kobayashi, Toshimitsu Araki, Donald C McMillan, Chikao Miki, Masato Kusunoki
BACKGROUND: Sarcopenia is defined as the loss of skeletal muscle mass, accompanied by decreased muscle strength, and consists of myopenia and myosteatosis. Recent evidence has suggested the predictive value of sarcopenia for the risk of perioperative and oncological outcomes in various malignancies. The aim of this study was to clarify the clinical impact of myopenia and myosteatosis in colorectal cancer (CRC) patients. METHODS: We analyzed the preoperative psoas muscle mass index and intramuscular adipose tissue content using preoperative computed tomography images from 308 CRC patients using statistical methods...
May 15, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29751134/sarcopenia-in-resected-nsclc-effect-on-postoperative-outcomes
#9
Ryota Nakamura, Yoshihisa Inage, Rika Tobita, Satoshi Yoneyama, Takeshi Numata, Kyoko Ota, Hidetoshi Yanai, Takeo Endo, Yukinori Inadome, Shingo Sakashita, Hiroaki Satoh, Kenji Yuzawa, Toru Terashima
INTRODUCTION: Skeletal muscle depletion, referred to as sarcopenia, has recently been identified as a risk factor for poor outcomes in various malignancies. However, the prognostic significance of sarcopenia in patients with NSCLC after surgery has not been adequately determined. This study investigated the impact of sarcopenia in patients undergoing pulmonary resection for lung cancer. METHODS: This retrospective study consisted of 328 patients with pathologically confirmed NSCLC who underwent curative resection between January 2005 and April 2017...
July 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29740069/sarcopenia-as-a-predictor-of-post-transplant-tumor-recurrence-after-living-donor-liver-transplantation-for-hepatocellular-carcinoma-beyond-the-milan-criteria
#10
Young Ri Kim, Sukhee Park, Sangbin Han, Joong Hyun Ahn, Seonwoo Kim, Dong Hyun Sinn, Woo Kyoung Jeong, Justin S Ko, Mi Sook Gwak, Gaab Soo Kim
To evaluate the association between sarcopenia and tumor recurrence after living donor liver transplantation (LDLT) in patients with advanced hepatocellular carcinoma (HCC), we analyzed 92 males who underwent LDLT for treating HCC beyond the Milan criteria. Sarcopenia was defined when the height-normalized psoas muscle thickness was <15.5 mm/m at the L3 vertebra level on computed tomography based on an optimum stratification method using the Gray's test statistic. Survival analysis was performed with death as a competing risk event...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29706058/clinical-usefulness-of-psoas-muscle-thickness-for-the-diagnosis-of-sarcopenia-in-patients-with-liver-cirrhosis
#11
Dae Hoe Gu, Moon Young Kim, Yeon Seok Seo, Sang Gyune Kim, Han Ah Lee, Tae Hyung Kim, Young Kul Jung, Altay Kandemir, Ji Hoon Kim, Hyunggin An, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun, Soon Ho Um
Background/Aims: The most widely used method for diagnosing sarcopenia is the skeletal muscle index (SMI). Several studies have suggested that psoas muscle thickness per height (PMTH) is also effective for detecting sarcopenia and predicting prognosis in patients with cirrhosis. The aim of this study was to evaluate the optimal cutoff values of PMTH for detecting sarcopenia in cirrhotic patients. Methods: All cirrhotic patients who underwent abdominal computed tomography (CT) scan including L3 and umbilical levels for measuring SMI and transverse psoas muscle thickness, respectively, were included...
April 30, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29703441/usefulness-of-psoas-muscle-area-and-volume-and-frailty-scoring-to-predict-outcomes-after-transcatheter-aortic-valve-implantation
#12
Pawel Kleczynski, Tomasz Tokarek, Artur Dziewierz, Danuta Sorysz, Maciej Bagienski, Lukasz Rzeszutko, Dariusz Dudek
Numerous scales were implemented for frailty assessment. However, limited evidence and recommendations for frailty tools for everyday clinical practice in patients who underwent transcatheter aortic valve implantation (TAVI) exist. Thus, we aimed to determine the long-term predictive value of different frailty scores and objective assessment of sarcopenia by imaging techniques in patients after TAVI. Frailty indexes according to Valve Academic Research Consortium-2 (VARC-2) recommendations, as well as other available scales of frailty, were assessed at baseline...
July 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29691621/clinical-impact-of-preoperative-sarcopenia-on-the-postoperative-outcomes-after-pancreas-transplantation
#13
Yasunari Fukuda, Tadafumi Asaoka, Hidetoshi Eguchi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Toshinori Ito, Yutaka Takeda, Masahiro Tanemura, Masaki Mori, Yuichiro Doki
BACKGROUND: The importance of evaluating sarcopenia is increasingly being recognized in the field of transplantation because sarcopenia can have an adverse effect on the treatment outcomes. However, the clinical significance of preoperative sarcopenia on the postoperative outcomes following pancreas transplantation (PTx) has been largely unknown. The objective of this study was to investigate the role of preoperative sarcopenia in predicting the postoperative outcomes following PTx in recipients with type 1 diabetes mellitus (T1D)...
April 24, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29662835/preoperative-low-muscle-mass-and-low-muscle-quality-negatively-impact-on-pulmonary-function-in-patients-undergoing-hepatectomy-for-hepatocellular-carcinoma
#14
Hisaya Shirai, Toshimi Kaido, Yuhei Hamaguchi, Atsushi Kobayashi, Shinya Okumura, Siyuan Yao, Shintaro Yagi, Naoko Kamo, Kojiro Taura, Hideaki Okajima, Shinji Uemoto
Background: Sarcopenia is a prognostic factor for mortality in digestive surgery. However, the correlation between preoperative cardiopulmonary function and sarcopenia in patients undergoing hepatectomy for hepatocellular carcinoma (HCC) remains unclear. Methods: The present study investigated the impact of preoperative sarcopenia on cardiopulmonary function in 402 patients who underwent first hepatectomy for HCC between April 2005 and April 2015. The quantity and quality of skeletal muscle were evaluated using psoas muscle index (PMI) and intramuscular adipose tissue content (IMAC), respectively, as determined from preoperative computed tomography imaging...
March 2018: Liver Cancer
https://www.readbyqxmd.com/read/29564168/impact-of-sarcopenia-in-borderline-resectable-and-locally-advanced-pancreatic-cancer-patients-receiving-stereotactic-body-radiation-therapy
#15
William H Jin, Eric A Mellon, Jessica M Frakes, Gilbert Z Murimwa, Pamela J Hodul, Jose M Pimiento, Mokenge P Malafa, Sarah E Hoffe
Background: Total psoas area (TPA), a marker of sarcopenia, has been used as an independent predictor of clinical outcomes in gastrointestinal (GI) cancers as a proxy for frailty and nutritional status. Our study aimed to evaluate whether TPA, in contrast to traditional measurements of nutrition like body mass index (BMI) and body surface area (BSA), was predictive of outcomes in borderline resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC) patients receiving stereotactic body radiation therapy (SBRT)...
February 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29541620/longitudinal-ct-study-of-sarcopenia-due-to-hepatic-failure-after-living-donor-liver-transplantation
#16
Takahiro Onuma, Tamotsu Kamishima, Tsuyoshi Shimamura, Norio Kawamura, Kenichiro Yamashita, Kenneth Sutherland, Hiroshi Takeda
Background: The quantity and quality of skeletal muscle have been observed to be closely related with post-transplantation mortality in patients undergoing living donor liver transplantation (LDLT). However, the effect of LDLT on skeletal muscle has not been thoroughly investigated. The aim of this study was to investigate the change of trunk muscle mass and adiposity in recipients of LDLT. Methods: The study population included LDLT recipients at Hokkaido University Hospital who underwent pre- and post-operative computed tomography (CT) scans (31 recipients; 14 males, and 17 females)...
February 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29533306/sarcopenia-is-predictive-of-1-year-mortality-after-acetabular-fractures-in-elderly-patients
#17
Phillip M Mitchell, Cory A Collinge, David E OʼNeill, Jesse E Bible, Hassan R Mir
OBJECTIVES: To determine whether sarcopenia is an independent predictor of mortality in geriatric acetabular fractures. DESIGN: Retrospective cohort. SETTING: American College of Surgeons Level I trauma center. PATIENTS/PARTICIPANTS: One hundred and forty-six patients over the age 60 with acetabular fractures treated at our institution over a 12-year period. MAIN OUTCOME MEASUREMENTS: The primary outcome was 1-year mortality, collected using the Social Security Death Index...
June 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29530777/psoas-muscle-size-predicts-risk-adjusted-outcomes-after-surgical-aortic-valve-replacement
#18
Robert B Hawkins, J Hunter Mehaffey, Eric J Charles, John A Kern, D Scott Lim, Nicholas R Teman, Gorav Ailawadi
BACKGROUND: Frailty is an important predictor of outcomes after cardiac surgery, but utility is limited by difficult assessment and quantification. We hypothesize that sarcopenia defined as psoas muscle cross-sectional area is a useful predictor of surgical aortic valve replacement outcomes in moderate to high-risk patients. METHODS: Moderate to high risk patients (predicted risk of mortality greater than 3%) who underwent surgical aortic valve replacement with or without coronary artery bypass were extracted from an institutional database (2009 to 2016)...
July 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29500672/preoperative-detection-of-sarcopenic-obesity-helps-to-predict-the-occurrence-of-gastric-leak-after-sleeve-gastrectomy
#19
Martin Gaillard, Hadrien Tranchart, Sophie Maitre, Gabriel Perlemuter, Panagiotis Lainas, Ibrahim Dagher
BACKGROUND: Sleeve gastrectomy (SG) has become the primary procedure for many bariatric teams and staple-line leak represents its most feared complication. Sarcopenic obesity combines the risks of obesity and depleted lean mass leading possibly to an inferior surgical outcome after abdominal surgery. OBJECTIVES: The aim of this study was to evaluate the existence of a potential link between radiologically determined sarcopenic obesity and staple-line leak risk after SG...
August 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29484416/prognostic-impact-of-sarcopenia-and-its-correlation-with-circulating-mir-21-in-colorectal-cancer-patients
#20
Yoshinaga Okugawa, Li Yao, Yuji Toiyama, Akira Yamamoto, Tsunehiko Shigemori, Chengzeng Yin, Yusuke Omura, Shozo Ide, Takahito Kitajima, Tadanobu Shimura, Hiroyuki Fujikawa, Hiromi Yasuda, Junichiro Hiro, Shigeyuki Yoshiyama, Minako Kobayashi, Koji Tanaka, Yasuhiro Inoue, Toshimitsu Araki, Chikao Miki, Masato Kusunoki
Severe malnutrition accompanied by sarcopenia and cachexia, is strongly associated with the surgical and oncological outcomes in cancer patients. The aim of the present study was to clarify the clinical significance of sarcopenia and its correlation with sarcopenia-associated miRNA in colorectal cancer (CRC). A total of 167 CRC patients were enrolled in the present study. We evaluated psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC). The expression of miR-21 in CRC tissues and preoperative serum was evaluated using quantitative PCR...
April 2018: Oncology Reports
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