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Kun Zhao, Bangsen Ouyang, Ya Yang
The pyro-phototronic effect has been utilized to modulate photoexcited carriers, to enhance the photocurrent in semiconducting nanomaterials. However, most of these materials have low pyroelectric performances. Using radially polarized ferroelectric BaTiO3 materials with a pyroelectric coefficient of about 16 nC/cm2 K, we report a dramatic photocurrent enhancement due to ferro-pyro-phototronic effect. The fabricated device enables a fast sensing of 365-nm light illumination with a response time of 0.5 s at the rising edge, where the output current-time curve displays a sharp peak followed by a stable plateau...
May 25, 2018: iScience
Hiroya Taniguchi, Wataru Okamoto, Kei Muro, Kiwamu Akagi, Hiroki Hara, Tomohiro Nishina, Takeshi Kajiwara, Tadamichi Denda, Shuichi Hironaka, Toshihiro Kudo, Taroh Satoh, Takeharu Yamanaka, Yukiko Abe, Yoshiyuki Fukushima, Takayuki Yoshino
Detection of RAS and BRAF mutations is essential to determine the optimal treatment strategy for metastatic colorectal cancer (CRC). We prospectively evaluated the MEBGEN RASKET-B KIT (RASKET-B), a novel multiplex kit, simultaneously detecting 48 types of RAS mutations and the BRAF V600E mutation using Luminex xMAP technology. The aim was to obtain market approval for RASKET-B as an in vitro diagnostic (IVD) option in Japan. Genomic DNA was extracted from 302 formalin-fixed paraffin-embedded tissues obtained from CRC patients...
November 6, 2018: Neoplasia: An International Journal for Oncology Research
Ming Kong, Jianying Chao, Wei Zhuang, Peifang Wang, Chao Wang, Jun Hou, Zhaoshi Wu, Longmian Wang, Guang Gao, Yu Wang
Spatial and seasonal variations of particulate phosphorus (PP) in a large shallow, eutrophic Lake Taihu with different ecotypes (including a phytoplankton-dominated zone, lake center zone, estuary zone and macrophyte-dominated zone) were investigated. The results showed that particulate organic phosphorus (POP) was the dominant form of PP (>88.0%). The concentration of POP showed higher levels in the bloom-sensitive northwestern zone (phytoplankton-dominated zone and estuary zone) during warm seasons, phytoplankton blooms and input of exogenous particulate matter were the main sources of POP in the lake water...
October 25, 2018: International Journal of Environmental Research and Public Health
Kara M Harmatys, Marta Overchuk, Juan Chen, Lili Ding, Ying Chen, Martin G Pomper, Gang Zheng
We describe a simple and effective bioconjugation strategy to extend the plasma circulation of a low molecular weight targeted phototheranostic agent, which achieves high tumor accumulation (9.74 ± 2.26%ID/g) and high tumor-to-background ratio (10:1). Long-circulating pyropheophorbide (LC-Pyro) was synthesized with three functional building blocks: (1) a porphyrin photosensitizer for positron-emission tomography (PET)/fluorescence imaging and photodynamic therapy (PDT), (2) a urea-based prostate-specific membrane antigen (PSMA) targeting ligand, and (3) a peptide linker to prolong the plasma circulation time...
October 29, 2018: Bioconjugate Chemistry
Saeed Ahmad, Waheed Mumtaz Abbasi, Tayyeba Rehman
Background Belladonna and Pyrogenium are commonly used to treat fever in homeopathy. But in vivo antipyretic activity of these medicines is not reported yet. The study was conducted to evaluate the effectiveness of ultrahigh dilutions of Belladonna (Bell) and Pyrogenium (Pyro) in fever model of rabbits induced by Baker's yeast. Methods Healthy, local strain rabbits (♂ and ♀) were divided into seven groups (n=42): Normal control, negative control, standard control, pyro 1000c, pyro 200c, Bell 1000c and Bell 200c...
October 17, 2018: Journal of Complementary & Integrative Medicine
Yi-Chen Yu, Ying Jiang, Meng-Meng Yang, Sai-Nan He, Xia Xi, Ye-Tao Xu, Wen-Sheng Hu, Qiong Luo
BACKGROUND: Increasing epidemiological studies have confirmed the association between maternal preeclampsia and elevated blood pressure in their offspring. Though case-control or cohort studies have demonstrated long-term outcomes for the offspring of preeclampsia, it is still a question that how these changes were caused by genetic reasons or by preeclampsia itself. OBJECTIVE: In our study, we explored the potential epigenetic regulation of delta-like homolog 1-maternally expressed gene 3 (DLK1-MEG3) region in human umbilical vein endothelial cells (HUVECs), and its connection with endothelium-derived factors...
September 17, 2018: Journal of Hypertension
Bangsen Ouyang, Kewei Zhang, Ya Yang
Self-powered photodetectors are expected to play a crucial role in future nano-optoelectronic devices owing to their independent and sustainable operation. Based on the heterojunction between ZnO nanowires (NWs) and shuttle-like SnS, we design a self-powered photodetector exhibiting wide-range photoresponse and tunable spectral selectivity. Differently from conventional devices, a wavelength-induced photocurrent polarity is observed in the ZnO NWs/SnS photodetector, which enables the device to distinguish between photons in the UV and visible (VIS) regions...
March 23, 2018: iScience
Josephine Al-Alam, Ziad Fajloun, Asma Chbani, Maurice Millet
In order to assess the air quality in some Lebanese regions, a biomonitoring study based on honey as biomonitor candidate was conducted. For this, 18 samples of honey collected from four regions in Lebanon, were analyzed for their contamination by 16 polycyclic aromatic hydrocarbons (PAHs) and 22 polychlorinated biphenyls (PCBs). Samples were first extracted using a multi-residue extraction method based on the quick, easy, cheap, effective, rugged, and safe extraction method (QuEChERS) followed by a concentration step using Solid-phase microextraction (SPME) procedures...
September 10, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Xiao-Qiao Wang, Chuan Fu Tan, Kwok Hoe Chan, Xin Lu, Liangliang Zhu, Sang-Woo Kim, Ghim Wei Ho
Utilization of ubiquitous low-grade waste heat constitutes a possible avenue towards soft matter actuation and energy recovery opportunities. While most soft materials are not all that smart relying on power input of some kind for continuous response, we conceptualize a self-locked thermo-mechano feedback for autonomous motility and energy generation functions. Here, the low-grade heat usually dismissed as 'not useful' is used to fuel a soft thermo-mechano-electrical system to perform perpetual and untethered multimodal locomotions...
August 24, 2018: Nature Communications
Antoni Delpino-Rius, Diana Cosovanu, Jordi Eras, Francesca Vilaró, Mercè Balcells, Ramon Canela-Garayoa
A total of 48 chlorophylls and derivatives were identified and successfully determined in tea and processed vegetable and fruit foodstuff by UHPLC with photodiode-array and mass spectrometry detection. The method allowed the proper separation of chlorophyll derivatives resulting from demetallation, dephytilation, decarbomethoxylation, epimerisation and copperisation. The method was performed in less than 12 min, using an optimised ternary gradient (MeOH, iPrOH, MeCN and H2 O with 10 mM of ammonium acetate) on an ACQUITY HSS T3 column...
September 21, 2018: Journal of Chromatography. A
Zhan Zhou, Yuhui Zheng, Cheng Cheng Zhang, Jinwei Gao, Yiping Tang, Qianming Wang
Carbonaceous materials have long been developed to utilize "nano-spaces" and numerous guest species could be encapsulated. A remarkable fluorescence difference has been observed after newly designed pyropheophorbide-a-appended carbon nanohorns were incorporated in a cellular medium and confocal microscopy was employed for the determination of the intracellular localization. Our study supported the role of carbon nanohorns as carriers of photodynamic therapy (PDT) agents and their heating behavior was discussed...
October 10, 2018: Photochemical & Photobiological Sciences
Shixiang Yao, Chibuike C Udenigwe
Post-translational modifications (PTMs) often occur in proteins and play a regulatory role in protein function. There is an increasing interest in the bioactivity of food protein-derived peptides, but the occurrence of PTMs and their influence on food peptide structure and behaviour remain largely unknown. In this study, the shotgun-based peptidomics strategy was used to identify the occurrence of PTMs in peptides generated from potato protein hydrolysis using digestive proteases. Diverse PTMs were found in the potato peptides, including acetylation of lysine, N-terminal of proteins and peptides, C-terminal amidation, de-amidation of asparagine/glutamine, methylation and trimethylation, methionine oxidation and N-terminal pyro-glutamyl residue formation...
July 2018: Royal Society Open Science
Gabriela P F Arrifano, Rosa C R Martín-Doimeadios, María Jiménez-Moreno, Sergio Fernández-Trujillo, Marcus Augusto-Oliveira, José R Souza-Monteiro, Barbarella M Macchi, Jacqueline I Alvarez-Leite, José L M do Nascimento, Marcos T Amador, Sidney Santos, Ândrea Ribeiro-Dos-Santos, Liz C Silva-Pereira, Reinaldo B Oriá, Maria E Crespo-Lopez
Human exposure to mercury is a serious problem of public health in Amazon. As in other vulnerable populations throughout the world, Amazonian riverine populations are chronically exposed to this metal and some symptoms of mercury intoxication were already detected in these populations. However, studies on the genetic susceptibility to mercury toxicity in the Amazon are scarce, and they tested a limited number of individuals. In this context, apolipoprotein E gene ( APOE ) is a key element with a well-established association among their alleles and the neurodegenerative consequences of mercury intoxication...
2018: Frontiers in Genetics
Christian Bonhomme, Xiaoling Wang, Ivan Hung, Zhehong Gan, Christel Gervais, Capucine Sassoye, Jessica Rimsza, Jincheng Du, Mark E Smith, John V Hanna, Stéphanie Sarda, Pierre Gras, Christèle Combes, Danielle Laurencin
Natural abundance 43Ca solid state NMR experiments are reported for the first time at ultra-high magnetic field (35.2 T) on a series of Ca-(pyro)phosphate and Ca-oxalate materials, which are of biological relevance in relation to biomineralization processes and the formation of pathological calcifications. The significant gain in both sensitivity and resolution at 35.2 T leads to unprecedented insight into the structure of both crystalline and amorphous phases.
August 23, 2018: Chemical Communications: Chem Comm
Mohammad F Mehbub, Jason E Tanner, Stephen J Barnett, Jan Bekker, Christopher M M Franco, Wei Zhang
Sponge-bacteria interactions are very important due to their ecological and biological significance. To understand the impact of interactions between sponges and bacteria (both associated with and external to sponges) on sponge-associated microbial diversity, sponge metabolite profiles and bioactivity, we used a controlled aquarium system and designed an experimental approach that allows the study of sponge-bacteria interactions in a well-defined manner. To test the feasibility of this approach, this system was used to study the interaction between a sponge Aplysilla rosea and a marine bacterium commonly found in seawater, Vibrio natriegens...
August 7, 2018: Scientific Reports
Anastasiya V Sharko, Oliver Erhart, Harald Krautscheid, Kostiantyn V Domasevitch
Electronic distortions, which are inherent in the oxide fluoride anions [MOF5 ]2- (M = Nb and Ta), provide an origin of polar molecular arrangements for the development of new polar second-harmonic-generating, piezo-, pyro- and ferroelectric materials. It is still a challenge to expand this approach to the realm of metal-organic polymers, while insufficient control over the environment of the [MOF5 ]2- units results in their orientational disorder and loss of polarity. The structures of catena-poly[[tris(3,4,5-trimethyl-1H-pyrazole-κN2 )copper(II)]-μ-oxido-[tetrafluoridoniobium(V)]-μ-fluorido], [CuNbF5 O(C6 H10 N2 )3 ]n , (I), and its isostructural pentafluoridooxidotantalate(V) analogue, catena-poly[[tris(3,4,5-trimethyl-1H-pyrazole-κN2 )copper(II)]-μ-oxido-[tetrafluoridotantalum(V)]-μ-fluorido], [CuTaF5 O(C6 H10 N2 )3 ]n , (II), are the first examples of the strict orientational order of [MOF5 ]2- (M = Nb and Ta) in one-dimensional coordination chains...
August 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
Huilin You, Yanmin Jia, Zheng Wu, Feifei Wang, Haitao Huang, Yu Wang
Many 2D few-layer materials show piezoelectric or pyroelectric effects due to the loss-of-inversion symmetry induced by broken structure, although they are not piezoelectric or pyroelectric in the bulk. In this work, we find that the puckered graphene-like 2D few-layer black phosphorene is pyroelectric and shows a pyro-catalytic effect, where the pyroelectric charges generated under ambient cold-hot alternation are utilized for hydrogen evolution and dye molecule decomposition. Under thermal cycling between 15 °C and 65 °C, the 2D few-layer black phosphorene shows a direct hydrogen generation of about 540 μmol per gram of catalyst after 24 thermal cycles and about 99% decomposition of Rhodamine B dye after 5 thermal cycles...
July 23, 2018: Nature Communications
Isabel Viera, Kewei Chen, José J Ríos, Itziar Benito, Antonio Pérez-Gálvez, María Roca
SCOPE: The dietary intake of chlorophylls is estimated to be ≈50 mg d-1 . However, their first pass metabolism and systemic assimilation is not well characterized. METHODS AND RESULTS: A group of 30 mice are fed a diet rich in chlorophylls, while 10 mice received a standard diet without chlorophylls (control group). Liver extracts are analyzed every 15 days by HPLC-ESI(+)/APCI(+)-hrTOF- MS/MS to measure the accretion of specific chlorophyll metabolites. The chlorophyll profile found in the livers of mice fed a chlorophyll-rich diet shows that the formation and/or absorption of pheophorbides, pyro-derivatives, and phytyl-chlorin e6 require the occurrence of a precise first-pass metabolism...
September 2018: Molecular Nutrition & Food Research
Gopinath Rana
Experimental studies has been carried out to isolate and identify an active antifilarial compound from Vitex negundo L. plant as it has been used for treatment against filariasis in Indian traditional system of medicine. In vitro antifilarial assay has been carried out against adult filarial parasite Setaria cervi worms by both worm motility and MTT reduction assays. Levels of oxidative stress parameters MDA, carbonyl content and nitric oxide levels have been detected. The isolated compound exhibited significant antifilarial activity in dose dependent manner...
May 2018: Parasite Epidemiology and Control
Benjamin K Liebov, Alejandro D Arroyo, Natalia I Rubtsova, Sofya A Osharovich, E James Delikatny, Anatoliy V Popov
The near-infrared fluorescent activatable smart probe Pyro-phosphatidylethanolamine (PtdEtn)-QSY was synthesized and observed to selectively fluoresce in the presence of phosphatidylcholine-specific phospholipase C (PC-PLC). PC-PLC is an important biological target as it is known to be upregulated in a variety of cancers, including triple negative breast cancer. Pyro-PtdEtn-QSY features a QSY21 quenching moiety instead of the Black Hole Quencher-3 (BHQ-3) used previously because the latter contains an azo bond, which could lead to biological instability...
June 30, 2018: ACS Omega
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