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Perfusion blood volume

Xiaoyang Tao, Yin Liu, Jun Chen, Li Xu, Zhijie Zhou, Haiyan Lei, Yiming Yin
BACKGROUND Moyamoya disease (MMD) is an idiopathic disease caused by progressive steno-occlusion of the distal internal carotid artery. Ideal surgical treatment for adult patients with ischemic-type MMD has not been achieved. The aim of this study was to evaluate the efficacy of single-barrel superficial temporal artery-middle cerebral artery (STA-MCA) bypass in treatment for adult patients with ischemic-type MMD by analyzing clinical and radiological data retrospectively. MATERIAL AND METHODS The present study included 37 patients with non-hemorrhagic MMD, including 21 women and 16 men (21~55 years old, mean age 38...
October 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Mansour Ashoor, Abdollah Khorshidi, Leila Sarkhosh
Aim: One of the most important microvasculatures' geometrical variables is number of pores per capillary length that can be evaluated using MRI. The transportation of blood from inner to outer parts of the capillary is studied by the pores and the relationship among capillary wall thickness, size and the number of pores is examined. Background: Characterization of capillary space may obtain much valuable information on the performance of tissues as well as the angiogenesis...
January 2019: Reports of Practical Oncology and Radiotherapy
Michał Elwertowski, Jerzy Leszczyński, Piotr Kaszczewski, Krzysztof Lamparski, Stella Sin Yee Ho, Zbigniew Gałązka
AIM: An assessment of increased compensatory blood flow in the brain-supplying arteries in patients with significant carotid artery stenosis. MATERIALS AND METHODS: Doppler ultrasound was performed in 218 patients over 60 years of age to evaluate both the degree of brain-supplying artery stenosis as well as the blood flow volume balance in all vessels supplying the brain: the internal carotid artery, the external carotid artery and the vertebral artery. The control group included 94 patients with no stenosis in the extracranial segments and no neurological manifestations, in whom blood flow values were calculated (the internal carotid artery - 290 mL/min, the external carotid artery - 125 mL/min, the vertebral artery - 80 mL/min); the total mean blood flow in the brain-supplying arteries was 985 mL/min...
2018: Journal of Ultrasonography
Ahmed A Khalil, Kersten Villringer, Vivien Filleböck, Jiun-Yiing Hu, Andrea Rocco, Jochen B Fiebach, Arno Villringer
Relative delays in blood-oxygen-level-dependent (BOLD) signal oscillations can be used to assess cerebral perfusion without using contrast agents. However, little is currently known about the utility of this method in detecting clinically relevant perfusion changes over time. We investigated the relationship between longitudinal BOLD delay changes, vessel recanalization, and reperfusion in 15 acute stroke patients with vessel occlusion examined within 24 h of symptom onset (D0) and one day later (D1). We created BOLD delay maps using time shift analysis of resting-state functional MRI data and quantified perfusion lesion volume changes (using the D1/D0 volume ratio) and severity changes (using a linear mixed model) over time...
October 18, 2018: Journal of Cerebral Blood Flow and Metabolism
Yugeesh R Lankadeva, Roger G Evans, Junko Kosaka, Lindsea C Booth, Naoya Iguchi, Rinaldo Bellomo, Clive N May
Expansion of extracellular fluid volume with crystalloid solutions is a common medical intervention, but its effects on renal cortical and medullary oxygenation are poorly understood. Therefore, we instrumented sheep under general anesthesia to enable continuous measurement of systemic and renal hemodynamics, global renal oxygen delivery and consumption, and intra-renal tissue perfusion and oxygen tension (pO2 ) in conscious animals (n=7). The effects of three sequential intermittent infusions of 500 mL of compound sodium lactate solution, administered at hourly intervals, were determined...
October 17, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Ma XiaoHui, Wei Li, Guo Wei, Liu XiaoPing, Jia Xin, Zhang Hongpeng, Wang Lijun
Introduction Endovascular intervention involving the aortic arch, particularly in thoracic aortic dissection, remains challenging and controversial at current time when there is no commercially suitable grafts on most of the international markets. This study compared two endovascular treatments that maintain left subclavian artery perfusion using two modified techniques for type-B aortic dissection patients. Methods Consecutive cases utilizing chimney or in situ fenestration techniques to preserve left subclavian artery in type B AD from 2006 to 2015 in our single institution were retrospectively reviewed...
October 14, 2018: Vascular
S M Li, Z L Gao, X T Lyu, J Jia, P Zhu, Y Chen, Y L Liu, Z X Zhang
Objective: To investigate the diagnostic value of whole liver CT perfusion imaging in the quantitative evaluation of hemodynamic changes before and after transcatheter arterial chemoembolization (TACE). Methods: Twenty-six patients with hepatocellular carcinoma underwent TACE therapies were recruited. Whole -liver computed tomographic perfusion imaging (CTPI) was performed 2~3 days before TACE and 1 month after TACE. We measured the following perfusion parameters: hepatic arterial perfusion (HAP), portal venous perfusion (PVP), total liver perfusion (TLP), hepatic arterial perfusion index (HAPI), and time-to-peak (TTP)...
June 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Stefania Elena Navone, Fabio Martino Doniselli, Paul Summers, Laura Guarnaccia, Paolo Rampini, Marco Locatelli, Rolando Campanella, Giovanni Marfia, Antonella Costa
BACKGROUND: Angiogenesis has been shown to be strictly related to tumor malignancy. Glioblastoma (GBM) is highly vascularized and von Willebrand Factor (VWF) plays a potent pro-angiogenic role. Dynamic contrast enhanced (DCE-) and dynamic susceptibility contrast (DSC-) MRI represent a widely accepted method to assess GBM microvasculature. Our aim was to investigate the correlation between plasma VWF:Ag, permeability and perfusion MRI parameters, and examine their potential in predicting GBM patient prognosis...
October 9, 2018: World Neurosurgery
Erkki Pesonen, Petru Liuba, Elhadi H Aburawi
AIM: The aim of this review was to develop a deeper knowledge of the physiology of coronary blood flow and coronary flow reserve in young patients with congenital heart disease and inflammatory diseases. METHODS: We searched for papers published in English on coronary blood flow and coronary flow reserve using the PubMed and google search databases. This identified 42 papers extending back to 1976 and a book from 2008 (ref 10). RESULTS: Our review showed that the implications of coronary blood flow and coronary flow reserve in paediatric patients with congenital heart disease and inflammatory diseases are still not fully understood...
October 12, 2018: Acta Paediatrica
Ayman Yosry, Zeinab A Soliman, Rasha Eletreby, Iman Hamza, Alaa Ismail, Mohammad A Elkady
BACKGROUND AND AIMS: Albumin infusion reduces the incidence of postparacentesis circulatory dysfunction among patients with cirrhosis and tense ascites compared with no treatment. Less costly treatment alternatives such as vasoconstrictors have been investigated, but the results are controversial. Midodrine, an oral α1-adrenergic agonist, increases effective circulating blood volume and renal perfusion by increasing systemic and splanchnic blood pressure. Our aim is to assess whether or not morbidity in terms of renal dysfunction, hyponatremia, systemic, or portal hemodynamics derangement or mortality differed in patients receiving albumin versus midodrine...
October 11, 2018: European Journal of Gastroenterology & Hepatology
Christian Schoenfeld, Jan B Hinrichs, Karen M Olsson, Martin-Alexander Kuettner, Julius Renne, Till Kaireit, Christoph Czerner, Frank Wacker, Marius M Hoeper, Bernhard C Meyer, Jens Vogel-Claussen
OBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) can be treated with balloon pulmonary angioplasty (BPA) in inoperable patients. Sensitive non-invasive imaging methods are missing to detect treatment response after a single BPA treatment session. Therefore, the aim of this study was to measure treatment response after a single BPA session using cardio-pulmonary MRI. MATERIALS AND METHODS: Overall, 29 patients with CTEPH were examined with cardio-pulmonary MRI before and 62 days after their initial BPA session...
October 11, 2018: European Radiology
Zhen Xing, Hongjie Huang, Zebin Xiao, Xiefeng Yang, Yu Lin, Dairong Cao
OBJECTIVE: With the hypothesis that the combination of CT, conventional, and functional MRI can indicate a possible diagnosis of skull lymphoma, this study aimed to systematically explore CT, conventional, and functional MRI features of this rare entity. MATERIALS AND METHODS: This retrospective study included eight patients with pathologically confirmed skull lymphomas. CT and conventional MRI findings, including the location, size, attenuation/signal intensity, cystic/necrosis, hemorrhage, calcification, enhancement, skull change, brain parenchyma edema and adjacent structure invasion, were reviewed...
October 11, 2018: Skeletal Radiology
S Vulcu, F Wagner, Santos A Fernandes, R Reitmeir, N Söll, D Schöni, C Fung, R Wiest, A Raabe, J Beck, W J Z Graggen
BACKGROUND: Delayed cerebral infarction after aneurysmal subarachnoid hemorrhage (aSAH) still remains the leading cause of disability in patients that survive the initial ictus. It has been shown that CT perfusion (CTP) imaging can detect hypoperfused brain areas. The aim of this study was to evaluate if a single acute CTP examination at time of neurological deterioration is sufficient or if an additional baseline CTP increases diagnostic accuracy. METHODS: Retrospective analysis of acute and baseline (within 24 hours after aneurysm treatment) CTP examinations of patients with neurological deterioration because of vasospasm-related hypoperfusion...
October 8, 2018: World Neurosurgery
Innocent Safeukui, Pierre A Buffet, Guillaume Deplaine, Sylvie Perrot, Valentine Brousse, Alain Sauvanet, Beatrice Aussilhou, Safi Dokmak, Anne Couvelard, Dominique Cazals-Hatem, Odile Mercereau-Puijalon, Geneviève Milon, Peter H David, Narla Mohandas
The current paradigm in the pathogenesis of several hemolytic red blood cell disorders is that reduced cellular deformability is a key determinant of splenic sequestration of affected red cells. Three distinct features regulate cellular deformability: membrane deformability, surface area-to-volume ratio (cell sphericity), and cytoplasmic viscosity. By perfusing normal human spleens ex vivo, we had previously showed that red cells with increased sphericity are rapidly sequestered by the spleen. Here, we assessed the retention kinetics of red cells with decreased membrane deformability but without marked shape changes...
October 23, 2018: Blood Advances
Francesca Di Giuliano, Eliseo Picchi, Fabrizio Sallustio, Valentina Ferrazzoli, Fana Alemseged, Laura Greco, Silvia Minosse, Valerio Da Ros, Marina Diomedi, Francesco Garaci, Simone Marziali, Roberto Floris
Background and purpose Computed tomography perfusion (CTP) and multiphase CT angiography (mCTA) help selection for endovascular treatment (EVT) in anterior ischemic stroke (AIS). Our aim was to investigate the ability of perfusion maps and collateral score to predict functional outcome after EVT. Patients and methods Patients with M1-middle cerebral artery occlusion, evaluated by mCTA and CTP and treated with EVT within six hours of onset, were enrolled. Perfusion parametric maps of cerebral blood flow (CBF), cerebral blood volume (CBV) and time to maximum of tissue residue function ( Tmax ) were generated; areas of altered perfusion were manually outlined to obtain volumes CBFv , CBVv , [Formula: see text] and [Formula: see text]...
October 10, 2018: Neuroradiology Journal
Girolamo Crisi, Silvano Filice, Umberto Scoditti
BACKGROUND AND PURPOSE: This study aims to investigate the significance of regional hyperperfusion (RH) detected by arterial spin labeling (ASL) in a group of untreated stroke patients, within 24-36 hours after symptom onset. The relationship between RH volume and infarcted volume (DIV) as defined on diffusion weighted images (DWIs) was evaluated. METHODS: Of the 346 consecutive acute stroke patients who attended our center, we retrospectively reviewed MRI studies of 47 patients who were ineligible for standard treatment with intravenous tissue plasminogen activator...
October 9, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Amir Sedigh, Sofia Nordling, Fredrik Carlsson, Erik Larsson, Bo Norlin, Norbert Lübenow, Fredrik Lennmyr, Gunnar Tufveson, Peetra U Magnusson, Tomas Lorant
BACKGROUND: Previously we have been able to demonstrate the possibility of coating the inner surface of the renal arteries in porcine kidneys with a heparin conjugate during hypothermic machine perfusion (HMP). The purpose of this study was to assess the efficacy of this treatment in reducing early ischemia-reperfusion injury. METHOD: Brain death was induced in male landrace pigs by stepwise volume expansion of an epidural balloon catheter until negative cerebral perfusion pressure was obtained...
October 6, 2018: Transplantation
Junjie Wu, Amit M Saindane, Xiaodong Zhong, Deqiang Qiu
PURPOSE: To study a multiband multi-echo EPI (M2-EPI) sequence for dynamic susceptibility contrast (DSC) perfusion imaging with leakage correction and vascular permeability measurements, and to evaluate the benefits of increased temporal resolution provided by this acquisition strategy on the accuracy of perfusion and permeability estimations. METHODS: A novel M2-EPI sequence was developed, and a pharmacokinetic model accounting for contrast agent extravasation was used to produce perfusion maps and additional vascular permeability maps...
October 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Sarah J Willis, Laurent Alvarez, Fabio Borrani, Grégoire P Millet
The aim was to evaluate changes in peripheral and cerebral oxygenation, cardiorespiratory, and performance differences, as well as neuromuscular fatigue across multiple levels of blood flow restriction (BFR) during a repeated cycling sprint test to exhaustion (RST). Participants performed three RST (10-sec maximal sprints with 20-sec recovery until exhaustion) with measurements of power output and V̇O2peak as well as oxygenation (near-infrared spectroscopy) of the vastus lateralis and prefrontal cortex. Neuromuscular fatigue was assessed by femoral nerve stimulation to evoke the vastus lateralis...
September 2018: Physiological Reports
Dong Wook Lee, Nakwon Choi, Jong Hwan Sung
Perfusion flow is one of the essential elements and advantages of organ-on-a-chip technology. For example, microfluidics have enabled implementation of perfusion flow and recapitulation of fluidic environment for vascular endothelial cells. The most prevalent method of implementing flow in a chip is to use a pump, which requires elaborate manipulation and complex connections, and accompanies a large amount of dead volume. Previously we devised a gravity-induced flow system which does not require tubing connections, but this method results in bidirectional flow to enable recirculation, which is somewhat different from physiological blood flow...
October 7, 2018: Biotechnology Progress
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