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Perfusion blood volume

Chongwei Yang, Lei Huang, Xinyu Li, Jiye Zhu, Xisheng Leng
BACKGROUND: To investigate the effects of retrograde reperfusion on the intraoperative internal environment and hemodynamics in classic orthotopic liver transplantation (OLT). METHODS: Thirty patients were undergone classic OLT using retrograde reperfusion in our center. Blood sampling was done at different time points including: Before blood venting via the portal vein (PV), 10 mL of blood was collected from the inferior vena cava (T0 ); During retrograde reperfusion through the inferior vena cava (IVC), 10 mL of blood was collected when the volume of blood venting reached 10 mL (T1 ), 100 mL (T2 ), and 200 mL (T3 ), respectively...
December 12, 2018: BMC Surgery
Dong-Chao Shen, Yin-Yan Xu, Bo Hou, Hong-Fei Tai, Kang Zhang, Shuang-Wu Liu, Zhi-Li Wang, Feng Feng, Ming-Sheng Liu, Li-Ying Cui
Background: Ongoing efforts have been made to identify new neuroimaging markers to track amyotrophic lateral sclerosis (ALS) progression. This study aimed to explore the monitoring value of multimodal magnetic resonance imaging (MRI) in the disease progression of ALS. Methods: From September 2015 to March 2017, ten patients diagnosed with ALS in Peking Union Medical College Hospital completed head MRI scans at baseline and during follow-up. Multimodal MRI analyses, including gray matter (GM) volume measured by voxel-based morphometry; cerebral blood flow (CBF) evaluated by arterial spin labeling; functional connectivity, including low-frequency fluctuation (fALFF) and regional homogeneity (ReHo), measured by resting-state functional MRI; and integrity of white-matter (WM) fiber tracts evaluated by diffusion tensor imaging, were performed in these patients...
December 20, 2018: Chinese Medical Journal
Mingyue Liu, Qingdong Zeng, Yongnan Li, Gang Liu, Bingyang Ji
Brain injury associated with deep hypothermic circulatory arrest (DHCA) has been recognized in patients with congenital heart diseases and those undergoing aortic arch surgeries. However, the preclinical investigation of long-term cerebral injury and recovery mechanisms related to DHCA has been restricted to a satisfactory recovery animal model with a determined recovery time. This study aimed to evaluate the feasibility of a long-term surviving DHCA model without blood priming in rats, in order to investigate the pathophysiology of long-term complications in further studies...
December 8, 2018: Artificial Organs
Makiko Komori, Yuriko Samejima, Keiko Okamura, Junko Ichikawa, Mitsuharu Kodaka, Keiko Nishiyama, Yasuko Tomizawa
OBJECTIVE: The effects of hydroxyethyl starch (HES) on microcirculation, central venous oxygen saturation (ScvO2 ), and the central venous-to-arterial carbon dioxide gap (dCO2 ) are studied in a rabbit model of hemorrhagic shock for elucidating the advantages and drawbacks of resuscitation with HES compared with crystalloids. METHODS: An ear chamber and sublingual mucosa were used to examine blood vessels by intravital microscopy. Hemorrhagic shock was induced by removing nearly half of the blood volume...
December 10, 2018: Journal of Anesthesia
Alvard Ter-Karapetyan, Simon M F Triphan, Bertram J Jobst, Angela F Anjorin, Julia Ley-Zaporozhan, Sebastian Ley, Oliver Sedlaczek, Jürgen Biederer, Hans-Ulrich Kauczor, Peter M Jakob, Mark O Wielpütz
PURPOSE: 4D perfusion magnetic resonance imaging (MRI) with intravenous injection of contrast agent allows for a radiation-free assessment of regional lung function. It is therefore a valuable method to monitor response to treatment in patients with chronic obstructive pulmonary disease (COPD). This study was designed to evaluate its potential for monitoring short-term response to hyperoxia in COPD patients. MATERIALS AND METHODS: 19 prospectively enrolled COPD patients (median age 66y) underwent paired dynamic contrast-enhanced 4D perfusion MRI within 35min, first breathing 100% oxygen (injection 1, O2) and then room air (injection 2, RA), which was repeated on two consecutive days (day 1 and 2)...
2018: PloS One
Syed Ali Raza, Clara M Barreira, Gabriel M Rodrigues, Michael R Frankel, Diogo C Haussen, Raul G Nogueira, Srikant Rangaraju
BACKGROUND: Age, neurologic deficits, core volume (CV), and clinical core or radiographic mismatch are considered in selection for endovascular therapy (ET) in anterior circulation emergent large vessel occlusion (aELVO). Semiquantitative CV estimation by Alberta Stroke Programme Early CT Score (CT ASPECTS) and quantitative CV estimation by CT perfusion (CTP) are both used in selection paradigms. OBJECTIVE: To compare the prognostic value of CTP CV with CT ASPECTS in aELVO...
December 7, 2018: Journal of Neurointerventional Surgery
Yuchi Liu, Jesse Hamilton, Sanjay Rajagopalan, Nicole Seiberlich
Cardiovascular magnetic resonance is a versatile tool that enables noninvasive characterization of cardiac tissue structure and function. Parametric mapping techniques have allowed unparalleled differentiation of pathophysiological differences in the myocardium such as the delineation of myocardial fibrosis, hemorrhage, and edema. These methods are increasingly used as part of a tool kit to characterize disease states such as cardiomyopathies and coronary artery disease more accurately. Currently conventional mapping techniques require separate acquisitions for T1 and T2 mapping, the values of which may depend on specifics of the magnetic resonance imaging system hardware, pulse sequence implementation, and physiological variables including blood pressure and heart rate...
December 2018: JACC. Cardiovascular Imaging
Ben Korman, Ranjan K Dash, Philip J Peyton
The second gas effect (SGE) occurs when nitrous oxide enhances the uptake of volatile anesthetics administered simultaneously. Recent work shows that the SGE is greater in blood than in the gas phase, that this is due to ventilation-perfusion mismatch, that as mismatch increases, the SGE increases in blood but is diminished in the gas phase, and that these effects persist well into the period of nitrous oxide maintenance anesthesia. These modifications of the SGE are most pronounced with the low soluble agents in current use...
December 6, 2018: Journal of Applied Physiology
Jeroen P Kooman, Frank M van der Sande
BACKGROUND: Abnormalities in fluid status in hemodialysis (HD) patients are highly prevalent and are related to adverse outcomes. SUMMARY: The inherent discontinuity of the HD procedure in combination with an often compromised cardiovascular response is a major contributor to this phenomenon. In addition, systemic inflammation and endothelial dysfunction are related to extracellular fluid overload (FO). Underlying this relation may be factors such as hypoalbuminemia and an increased capillary permeability, leading to an altered fluid distribution between the blood volume (BV) and the interstitial fluid compartments, compromising fluid removal during dialysis...
December 5, 2018: Blood Purification
Laetitia Desplanque, Florent Hamaide-Defrocourt, Ilham Berkia, Tiffany Tourneur, Souha Albinni, Mirela Bojan
PURPOSE: Measurement of lactate concentrations during cardiac surgery with cardiopulmonary bypass (CPB) is a reliable monitoring tool for the assessment of the adequacy of perfusion, and a predictor of poor outcome. However, increased lactate production, which is multifactorial (anaerobic metabolism, hyperglycemia), increased lactate load by packed red blood cell (PRBC) transfusions, and decreased lactate clearance may all result in hyperlactatemia. The aim of this study was to estimate the clearance of lactate in infants undergoing surgery with CPB, using the lactate load from the PRBCs transfusions received during CPB...
December 4, 2018: Artificial Organs
Jasmin Steinmeyer, Simon Becker, Murat Avsar, Jawad Salman, Klaus Höffler, Axel Haverich, Gregor Warnecke, Christian Mühlfeld, Matthias Ochs, Anke Schnapper-Isl
BACKGROUND: Ex vivo lung perfusion (EVLP) is used by an increasing number of transplant centres. It is still controversial whether an acellular or cellular (erythrocyte enriched) perfusate is preferable. The aim of this paper was to evaluate whether acellular (aEVLP) or cellular EVLP (cEVLP) preserves functional lung ultrastructure better and to generate a hypothesis regarding possible underlying mechanisms. METHODS: Lungs of 20 pigs were assigned to 4 groups: control, ischaemia (24 h), aEVLP and cEVLP (both EVLP groups: 24 h ischaemia + 12 h EVLP)...
December 4, 2018: Respiratory Research
Dao Pei Zhang, Hao Ran Li, Qian Kun Ma, Suo Yin, Yan Fang Peng, Huai Liang Zhang, Min Zhao, Shu Ling Zhang
Background and Purpose: The aim of this study was to determine the prevalence and associated factors of stroke and hypoperfusion among patients with isolated vertigo and vascular risk factors. Methods: We studied 157 patients with isolated vertigo who had undergone multimodal magnetic resonance imaging. Magnetic resonance angiography (MRA) was used to measure the diameters of vertebrobasilar arteries and to evaluate morphologic changes to vessels. Measurements obtained included length of the basilar artery and curvature index for the vertebral artery (VA)...
2018: Frontiers in Neurology
(no author information available yet)
OBJECTIVEThe purpose of this study was to prospectively investigate outcome and differences in peritumoral MRI characteristics of glioblastomas (GBMs) that were in contact with the ventricles (ventricle-contacting tumors) and those that were not (noncontacting tumors). GBMs are heterogeneous tumors with variable survival. Lower survival is suggested for patients with ventricle-contacting tumors than for those with noncontacting tumors. This might be supported by aggressive peritumoral MRI features. However, differences in MRI characteristics of the peritumoral environment between ventricle-contacting and noncontacting GBMs have not yet been investigated...
October 1, 2018: Journal of Neurosurgery
Wolfgang M Thaiss, Ulrike Haberland, Sascha Kaufmann, Tobias Hepp, Maximilian Schulze, Anya C Blum, Dominik Ketelsen, Konstantin Nikolaou, Marius Horger, Alexander W Sauter
RATIONALE AND OBJECTIVES: We assessed the value of iodine concentration (IC) as a perfusion-derived response marker for hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) in comparison with volume perfusion computed tomography (VPCT) parameters. MATERIALS AND METHODS: Forty-one HCC lesions in 32 patients examined before and after TACE were analyzed retrospectively. VPCT-parameters were calculated and lesion iodine-maps were computed using subtraction of the baseline and the scan 7 seconds after aortic peak enhancement from the corresponding 80 kVp-VPCT data set...
October 25, 2018: Academic Radiology
Anderson Chun On Tsang, Stephanie Lenck, Christopher Hilditch, Patrick Nicholson, Waleed Brinjikji, Timo Krings, Vitor M Pereira, Frank L Silver, Joanna D Schaafsma
PURPOSE: There is increasing use of automated computed tomography perfusion (CTP) to aid thrombectomy decision in emergent large vessel occlusion. It is important to understand the performance of these software packages in predicting ischemic core and tissue-at-risk in the real-world setting. The aim of this study was to evaluate whether ischemic core on non-contrast CT (NCCT) and automated CTP correspond and predict infarct extent after thrombectomy for ischemic stroke. METHODS: Consecutive patients with acute anterior circulation large vessel occlusion undergoing successful thrombectomy (TICI 2b/3) were studied...
November 23, 2018: Clinical Neuroradiology
Maria Marcella Laganà, Laura Mendozzi, Laura Pelizzari, Niels Peter Bergsland, Luigi Pugnetti, Pietro Cecconi, Giuseppe Baselli, Mario Clerici, Raffaello Nemni, Francesca Baglio
Background Grey matter (GM) atrophy has been extensively described in Multiple Sclerosis (MS) patients, while cerebral hypoperfusion has been less consistently reported. Since hypoperfusion might be related to atrophy, we evaluated the presence of both damages. Objective We aimed to assess if the regions of altered perfusion and atrophy overlapped with one another and if the two parameters were locally related. Method 3D-T1 weighted and arterial spin labelling sequences were acquired using a 1.5T Magnetic Resonance Imaging scanner from 26 relapsing remitting MS patients and 26 healthy controls (HC)...
November 23, 2018: Current Neurovascular Research
J Narvid, D McCoy, S M Dupont, A Callen, D Tosun, J Hellmuth, V Valcour
BACKGROUND AND PURPOSE: The aging HIV-infected (HIV+ ) population has increased vascular comorbidities, including stroke, and increased cognitive deficits compared with the general population. Arterial spin-labeling is a technique to measure cerebral blood flow and is more sensitive than regional volume loss in assessing neurodegenerative diseases and cognitive aging. Previous studies have found global cerebral perfusion abnormalities in the HIV+ participants. In this study, we evaluated the specific regional pattern of CBF abnormalities in older HIV+ participants using quantitative whole-brain arterial spin-labeling...
November 22, 2018: AJNR. American Journal of Neuroradiology
Yong Un Shin, Dong Eik Lee, Min Ho Kang, Mincheol Seong, Joo-Hark Yi, Sang-Woong Han, Heeyoon Cho
The purpose of this study is to evaluate the effect of haemodialysis on perfused vessel density, choroidal thickness (CT), and retinal thickness in end-stage renal disease (ESRD) using swept-source optical coherence tomography angiography (SS-OCTA). We studied twenty-nine eyes of 29 ESRD patients by ophthalmologic examination and SS-OCTA before and after haemodialysis. The colour-coded perfusion density maps were generated and perfused vessel density was calculated. Changes in systemic and other ocular parameters such as retinal and choroidal thickness were measured and analysed...
November 21, 2018: Scientific Reports
Dai-Yin Lu, Hulya Yalçin, Sanjay Sivalokanathan, Gabriela V Greenland, Nestor Vasquez, Fatih Yalçin, Min Zhao, Ines Valenta, Peter Ganz, Miguel Hernandez Pampaloni, Stefan Zimmerman, Thomas H Schindler, Theodore P Abraham, M Roselle Abraham
BACKGROUND: Vasodilator-induced transient left ventricular cavity dilation (LVCD) by positron emission tomography (PET) is associated with microvascular dysfunction in hypertrophic cardiomyopathy (HCM). Here we assessed whether HCM patients who develop LVCD by PET during vasodilator stress also develop LV cavity dilation by echocardiography (ECHO-LVCD) following exercise stress. METHODS: A retrospective analysis of cardiac function and myocardial blood flow (MBF) was conducted in 108 HCM patients who underwent perfusion-PET and exercise-ECHO as part of their clinical evaluation...
November 19, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Alfred H Stammers, Eric A Tesdahl, Linda B Mongero, Andrew Stasko
BACKGROUND: Previous studies have shown that women undergoing isolated coronary artery bypass graft (CABG) surgery have an increased risk for postoperative morbidity and mortality when compared to men. Additionally, recent evidence suggests that blood transfusions are independently associated with an increased risk of adverse outcome. METHODS: We evaluated gender differences in the risk of intraoperative red blood cell (RBC) transfusion during CABG surgery. Consecutive, non-reoperative CABG procedures performed across 196 institutions between April 2012 and May 2015 were retrospectively reviewed...
November 16, 2018: Perfusion
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