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JOURNAL ARTICLE
Jiarui Zhang, Qun Yi, Chen Zhou, Yuanming Luo, Hailong Wei, Huiqing Ge, Huiguo Liu, Jianchu Zhang, Xianhua Li, Xiufang Xie, Pinhua Pan, Mengqiu Yi, Lina Cheng, Hui Zhou, Liang Liu, Adila Aili, Yu Liu, Lige Peng, Jiaqi Pu, Haixia Zhou
BACKGROUND: Noninvasive mechanical ventilation (NIV) is recommended as the initial mode of ventilation to treat acute respiratory failure in patients with AECOPD. The Noninvasive Ventilation Outcomes (NIVO) score has been proposed to evaluate the prognosis in patients with AECOPD requiring assisted NIV. However, it is not validated in Chinese patients. METHODS: We used data from the MAGNET AECOPD Registry study, which is a prospective, noninterventional, multicenter, real-world study conducted between September 2017 and July 2021 in China...
2024: Chronic Respiratory Disease
#2
JOURNAL ARTICLE
Monica Aggarwal, Brian G Hutchison, Kristina M Kokorelias, Vivian R Ramsden, Noah M Ivers, Andrew Pinto, Ross E G Uphsur, Sabrina T Wong, Nick Pimlott, Steve Slade
BACKGROUND: The generation of research evidence and knowledge in primary health care (PHC) is crucial for informing the development and implementation of interventions and innovations and driving health policy, health service improvements, and potential societal changes. PHC research has broad effects on patients, practices, services, population health, community, and policy formulation. The in-depth exploration of the definition and measures of research impact within PHC is essential for broadening our understanding of research impact in the discipline and how it compares to other health services research...
April 23, 2024: JMIR Research Protocols
#3
JOURNAL ARTICLE
Farjana Parvin, Samuel Haglund, Bettina Wegenast-Braun, Mathias Jucker, Takashi Saito, Takaomi C Saido, K Peter R Nilsson, Per Nilsson, Sofie Nyström, Per Hammarström
Amyloid plaques composed of fibrils of misfolded Aβ peptides are pathological hallmarks of Alzheimer's disease (AD). Aβ fibrils are polymorphic in their tertiary and quaternary molecular structures. This structural polymorphism may carry different pathologic potencies and can putatively contribute to clinical phenotypes of AD. Therefore, mapping of structural polymorphism of Aβ fibrils and structural evolution over time is valuable to understanding disease mechanisms. Here, we investigated how Aβ fibril structures in situ differ in Aβ plaque of different mouse models expressing familial mutations in the AβPP gene...
April 23, 2024: ACS Chemical Neuroscience
#4
JOURNAL ARTICLE
Shalina Nair, José E Rodríguez, Samantha Elwood, Elisabeth Wilson, Annamalai Ramanathan, Debra Stulberg, Belinda Vail, Kristen Rundell, C J Peek
PROBLEM: Equity, diversity, and inclusion (EDI) efforts have accelerated over the past several years, without a traditional guidebook that other missions often have. To evaluate progress over time, departments of family medicine are seeking ways to measure their current EDI state. Across the specialty, unity regarding which EDI metrics are meaningful is absent, and discordance even exists about what should be measured. APPROACH: This paper provides a general metrics framework, including a wide array of possibilities to consider measuring, for assessing individual departmental progress in this broad space...
April 16, 2024: Family Medicine
#5
JOURNAL ARTICLE
Dickran Kazandjian, Benjamin Diamond, Marios Papadimitriou, Elizabeth Hill, Romanos Sklavenitis-Pistofidis, Bachisio Ziccheddu, Patrick Blaney, Monika Chojnacka, Michael Durante, Kylee Maclachlan, Ryan Young, Saad Usmani, Faith Davies, Gad Getz, Irene Ghobrial, Neha Korde, Gareth Morgan, Francesco Maura, Ola Landgren
PURPOSE: Early intervention for High-Risk Smoldering Multiple Myeloma (HR-SMM) achieves deep and prolonged responses. It is unclear if beneficial outcomes are due to treatment of less complex, susceptible disease or inaccuracy in clinical definition of cases entered. EXPERIMENTAL DESIGN: Here, we interrogated whole genome and whole exome sequencing for 54 patients across two HR-SMM interventional studies (NCT01572480, NCT02279394). RESULTS: We reveal that the genomic landscape of treated HR-SMM is generally simple as compared to Newly Diagnosed (ND)MM counterparts with less inactivation of tumor suppressor genes, RAS pathway mutations, MYC disruption, and APOBEC contribution...
April 23, 2024: Clinical Cancer Research
#6
JOURNAL ARTICLE
Melissa A Rudolph, Shawn G Ehlers, Glen C Morris
Given the high variability of secondary agricultural teacher background and facility constraints, the instruction of tractor (and similar agricultural machinery) component identification, function, maintenance, and corresponding safety precautions oftentimes prove difficult and/or inconsistent. This study focused on the development and plausible application of quick response codes, commonly referred to as QR codes, placed on a demonstration tractor or machine to be used as a self-guided student learning experience for training the next generation of safe operators...
April 23, 2024: Journal of Agromedicine
#7
JOURNAL ARTICLE
Mohsen Besanjideh, Masoud Rezaeian, Amir Shamloo, Siamak Kazemzadeh Hannani
We demonstrate an innovative method to catch the desired droplets from a train of droplets and immobilize them in traps located in an integrated microfluidic device. To this end, water-in-oil droplets are generated in a flow-focusing junction and then guided to a channel connected to chambers designated for on-demand droplet trapping. Each chamber is connected to a side channel through a batch of microposts. The side channels are also connected to the flexible poly(vinyl chloride) tubes, which can be closed by attaching binder clips...
April 23, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
#8
JOURNAL ARTICLE
Sushant Sharma Chaudhary, Andrew Toivonen, Gaurav Waratkar, Geoffrey Mo, Deep Chatterjee, Sarah Antier, Patrick Brockill, Michael W Coughlin, Reed Essick, Shaon Ghosh, Soichiro Morisaki, Pratyusava Baral, Amanda Baylor, Naresh Adhikari, Patrick Brady, Gareth Cabourn Davies, Tito Dal Canton, Marco Cavaglia, Jolien Creighton, Sunil Choudhary, Yu-Kuang Chu, Patrick Clearwater, Luke Davis, Thomas Dent, Marco Drago, Becca Ewing, Patrick Godwin, Weichangfeng Guo, Chad Hanna, Rachael Huxford, Ian Harry, Erik Katsavounidis, Manoj Kovalam, Alvin K Y Li, Ryan Magee, Ethan Marx, Duncan Meacher, Cody Messick, Xan Morice-Atkinson, Alexander Pace, Roberto De Pietri, Brandon Piotrzkowski, Soumen Roy, Surabhi Sachdev, Leo P Singer, Divya Singh, Marek Szczepanczyk, Daniel Tang, Max Trevor, Leo Tsukada, Verónica Villa-Ortega, Linqing Wen, Daniel Wysocki
Multimessenger searches for binary neutron star (BNS) and neutron star-black hole (NSBH) mergers are currently one of the most exciting areas of astronomy. The search for joint electromagnetic and neutrino counterparts to gravitational wave (GW)s has resumed with ALIGO's, AdVirgo's and KAGRA's fourth observing run (O4). To support this effort, public semiautomated data products are sent in near real-time and include localization and source properties to guide complementary observations. In preparation for O4, we have conducted a study using a simulated population of compact binaries and a mock data challenge (MDC) in the form of a real-time replay to optimize and profile the software infrastructure and scientific deliverables...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
#9
JOURNAL ARTICLE
Haoyang Xin, Yiduo Wang, Wenli Zhang, Bao Yu, Pavel Neumann, Yihang Ning, Tao Zhang, Yufeng Wu, Ning Jiang, Jiming Jiang, Mengli Xi
Centromeres in most multicellular eukaryotes are composed of long arrays of repetitive DNA sequences. Interestingly, several transposable elements, including the well-known long terminal repeat (LTR) retrotransposon CRM (centromeric retrotransposon of maize), were found to be enriched in functional centromeres marked by the centromeric histone H3 (CENH3). Here we report a centromeric long interspersed nuclear element (LINE), Celine, in Populus species. Celine has colonized preferentially in the CENH3-associated chromatin of every poplar chromosome, with 84% of the Celine elements localized in the CENH3-binding domains...
April 23, 2024: Plant Physiology
#10
JOURNAL ARTICLE
Alexander Leff, Catherine Doogan, John Bentley, Bani Makkar, Luisa Zenobi-Bird, Amy Sherman, Simon Grobler, Jennifer Crinion
BACKGROUND: The field of human expert performance teaches us that high quality, high-dose guided practice is required to make large gains in cognitively driven acts. The same also seems to be true for people with acquired brain injury, yet therapy services for people with aphasia (PWA) have traditionally not been designed with this in mind. Intensive Comprehensive Aphasia Programmes (ICAPs) are one way to address the chronic under-dosing of therapy that most PWA experience. AIMS: There are several ways to deliver an ICAP; here we describe two iterations of our Queen Square ICAP...
December 6, 2023: Aphasiology
#11
RANDOMIZED CONTROLLED TRIAL
Sarah Cohn, Raed Farhat, Nidal El Khatib, Majd Asakly, Ashraf Khater, Alaa Safia, Marwan Karam, Saqr Massoud, Taiser Bishara, Yaniv Avraham, Adi Sharabi-Nov, Shlomo Merchavy
BACKGROUND: Thyroid nodules are common in the general population. Ultrasonography is the most efficient diagnostic approach to evaluate thyroid nodules. The US FNAC procedure can be performed using either the short axis (perpendicular), or a long axis (parallel) approach to visualize the needle as it is advanced toward the desired nodule. The main aim of this study was to compare the percentage of non-diagnostic results between the long and short axis approach. METHODS: A prospective study that included a randomized controlled trial and was divided into two arms-the short axis and the long axis-was conducted...
2024: American Journal of Otolaryngology
#12
JOURNAL ARTICLE
Chang Liu, Lixin Tang, Kainan Zhang, Xuanqi Xu
In industrial production processes, the mechanical properties of materials will directly determine the stability and consistency of product quality. However, detecting the current mechanical property is time-consuming and labor-intensive, and the material quality cannot be controlled in time. To achieve high-quality steel materials, developing a novel intelligent manufacturing technology that can satisfy multitask predictions for material properties has become a new research trend. This article proposes a multiobjective evolutionary learning method based on a two-stage model with topological sparse autoencoder (TSAE) and ensemble learning...
April 23, 2024: IEEE Transactions on Neural Networks and Learning Systems
#13
JOURNAL ARTICLE
Nikhil Tej Kantu, Ryan Osswald, Amit Kandel, Jiyeon Kang
Individuals with neurological disorders often exhibit altered manual dexterity and muscle weakness in their upper limbs. These motor impairments with tremor lead to severe difficulties in performing Activities of Daily Living (ADL). There is a critical need for ADL-focused robotic training that improves individual's strength when engaging with dexterous ADL tasks. This research introduces a new approach to training ADLs by employing a novel robotic rehabilitation system, Spherical Parallel INstrument for Daily Living Emulation (SPINDLE), which incorporates Virtual Reality (VR) to simulate ADL tasks...
April 23, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
#14
JOURNAL ARTICLE
Shaolun Ruan, Zhiding Liang, Qiang Guan, Paul Griffin, Xiaolin Wen, Yanna Lin, Yong Wang
With the rapid development of Quantum Machine Learning, quantum neural networks (QNN) have experienced great advancement in the past few years, harnessing the advantages of quantum computing to significantly speed up classical machine learning tasks. Despite their increasing popularity, the quantum neural network is quite counter-intuitive and difficult to understand, due to their unique quantum-specific layers (e.g., data encoding and measurement) in their architecture. It prevents QNN users and researchers from effectively understanding its inner workings and exploring the model training status...
April 23, 2024: IEEE Transactions on Visualization and Computer Graphics
#15
JOURNAL ARTICLE
Laura Collignon, Kenn Holmbeck, Ashley Just, Lieven Verhoye, Rodrigo Velázquez-Moctezuma, Ulrik Fahnøe, Thomas H R Carlsen, Mansun Law, Jannick Prentoe, Troels K H Scheel, Judith M Gottwein, Philip Meuleman, Jens Bukh
BACKGROUND AIMS: HCV infection continues to be a major global health burden, despite effective antiviral treatments. The urgent need for a protective vaccine is hindered by the scarcity of suitable HCV permissive animal models tractable in vaccination and challenge studies. Currently, only antibody neutralization studies in infectious cell culture systems or studies of protection by passive immunization of human-liver chimeric mice offer the possibility to evaluate the effect of vaccine-induced antibodies...
April 23, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#16
JOURNAL ARTICLE
Gokhan Yildiz, Gevher Rabia Genc Perdecioglu, Damla Yuruk, Ezgi Can, Omer Taylan Akkaya
OBJECTIVE: Ultrasound-guided tibial nerve pulsed radiofrequency (US-TN PRF) and fluoroscopy-guided intralesional radiofrequency thermocoagulation (FL-RFT) adjacent to the painful calcaneal spur are two interventions for pain management in painful calcaneal spur (PCS) and plantar fasciitis (PF). This study aimed to compare the effectiveness of the two procedures. DESIGN: A prospective, randomized, single-blind study. SETTING: Single-center pain clinic...
April 23, 2024: Pain Medicine
#17
JOURNAL ARTICLE
Jonathan L Nazari, Victoria Kulbokas, Mary H Smart, Tara R Hensle, Todd A Lee, A Simon Pickard
RATIONALE: The shift toward virtual academic detailing (AD) was accelerated by the COVID-19 pandemic. AIMS AND OBJECTIVES: We aimed to examine the role of external, contextual, and intrinsic programme-specific factors in virtual engagement of healthcare providers (HCPs) and delivery of AD. METHODS: AD groups throughout North America were contacted to participate in semistructured interviews. An interview guide was constructed by adapting the Consolidated Framework for Implementation Research (CFIR)...
April 23, 2024: Journal of Evaluation in Clinical Practice
#18
JOURNAL ARTICLE
Qinzhi Hou, Liqing Yao, Jibing Ou
BACKGROUND: Dysphagia, a common complication after stroke, significantly hampers the recovery process of patients, both due to dysphagia itself and the additional complications it causes. Although a large number of articles have been published on post-stroke dysphagia (PSD), bibliometric analysis in this field is still lacking. This study aimed to provide a comprehensive understanding of the research hotspots and trends in PSD, thereby guiding future research efforts. METHODS: The Web of Science Core Collection (WoSCC) database was searched for articles related to PSD from 2003 to 2022...
April 23, 2024: Journal of Evaluation in Clinical Practice
#19
JOURNAL ARTICLE
Dalnim Cho, Michael Roth, Susan K Peterson, Kristofer Jennings, Seokhun Kim, Shiao-Pei Weathers, Sairah Ahmed, J Andrew Livingston, Carlos Barcenas, Y Nancy You, Kathrin Milbury
BACKGROUND: Cancer is a life-threatening, stressful event, particularly for young adults due to delays and disruptions in their developmental transitions. Cancer treatment can also cause adverse long-term effects, chronic conditions, psychological issues, and decreased quality of life (QoL) among young adults. Despite numerous health benefits of health behaviors (eg, physical activity, healthy eating, no smoking, no alcohol use, and quality sleep), young adult cancer survivors report poor health behavior profiles...
April 23, 2024: JMIR Research Protocols
#20
JOURNAL ARTICLE
Godwin Denk Giebel, Carina Abels, Felix Plescher, Christian Speckemeier, Nils Frederik Schrader, Kirstin Börchers, Jürgen Wasem, Silke Neusser, Nikola Blase
BACKGROUND: Since fall 2020, mobile health (mHealth) apps have become an integral part of the German health care system. The belief that mHealth apps have the potential to make the health care system more efficient, close gaps in care, and improve the economic outcomes related to health is unwavering and already partially confirmed. Nevertheless, problems and barriers in the context of mHealth apps usually remain unconsidered. OBJECTIVE: The focus groups and interviews conducted in this study aim to shed light on problems and barriers in the context of mHealth apps from the perspective of patients...
April 23, 2024: Journal of Medical Internet Research
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