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Kusum Kapila, Preetha Alath, Govind H Hebbar, Mohammed Jaragh, Sara S George, Ayesha AlJassar
OBJECTIVE: Ultrasound-guided fine-needle aspiration cytology (USG-FNAC) is used for the detection of axillary lymph node (ALN) metastasis in patients with breast carcinoma (BC). US findings have a good diagnostic accuracy with high sensitivity and specificity. The aim of this study is to correlate the detection of ALN metastases on US with FNAC in BC patients. STUDY DESIGN: In 75 BC patients, over a period of 9 months (January to September 2017), the size, cortical thickness (CT), presence or absence of hilar fat, and length/width ratio of ALN on US were reviewed and correlated with FNAC findings...
December 5, 2018: Acta Cytologica
David Dilworth, Cheryl H Arrowsmith
In this issue of Structure, Haddad et al. (2018) solve the high-resolution trimeric crystal structure of human COMPASS-like components Dpy-30 and Ash2L (2:1) to unravel an uncharacterized interaction surface required for competent H3K4 methylation in cells and clarify Dpy-30's role in the allosteric regulation of KMT2 enzymes.
December 4, 2018: Structure
James G Dolan, Peter J Veazie
PURPOSE: In the process of developing an evidence-based decision dashboard to support treatment decisions for patients with newly diagnosed prostate cancer, we found that the clinical evidence base is insufficient to provide high-quality comparative outcome data. We therefore sought to determine if clinically acceptable outcome estimates could be created using a modified version of the Sheffield Elicitation Framework (SHELF), a formal method for eliciting judgments regarding probability distributions of expected decision outcomes...
December 5, 2018: Medical Decision Making: An International Journal of the Society for Medical Decision Making
Sebastian Walpole, Antonia L Pritchard, Colleen M Cebulla, Robert Pilarski, Meredith Stautberg, Frederick H Davidorf, Arnaud de la Fouchardière, Odile Cabaret, Lisa Golmard, Dominique Stoppa-Lyonnet, Erin Garfield, Ching-Ni Njauw, Mitchell Cheung, Joni A Turunen, Pauliina Repo, Reetta-Stiina Järvinen, Remco van Doorn, Martine J Jager, Gregorius P M Luyten, Marina Marinkovic, Cindy Chau, Miriam Potrony, Veronica Höiom, Hildur Helgadottir, Lorenza Pastorino, William Bruno, Virginia Andreotti, Bruna Dalmasso, Giulia Ciccarese, Paola Queirolo, Luca Mastracci, Karin Wadt, Jens Folke Kiilgaard, Michael R Speicher, Natasha van Poppelen, Emine Kilic, Rana'a T Al-Jamal, Irma Dianzani, Marta Betti, Carsten Bergmann, Sandro Santagata, Sonika Dahiya, Saleem Taibjee, Jo Burke, Nicola Poplawski, Sally J O'Shea, Julia Newton-Bishop, Julian Adlard, David J Adams, Anne-Marie Lane, Ivana Kim, Sonja Klebe, Hilary Racher, J William Harbour, Michael L Nickerson, Rajmohan Murali, Jane M Palmer, Madeleine Howlie, Judith Symmons, Hayley Hamilton, Sunil Warrier, William Glasson, Peter Johansson, Carla Daniela Robles-Espinoza, Raul Ossio, Annelies de Klein, Susana Puig, Paola Ghiorzo, Maartje Nielsen, Tero T Kivelä, Hensin Tsao, Joseph R Testa, Pedram Gerami, Marc-Henri Stern, Brigitte Bressac-de Paillerets, Mohamed H Abdel-Rahman, Nicholas K Hayward
Background: The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 encoding a tumor suppressor associated with uveal melanoma, mesothelioma, cutaneous melanoma, renal cell carcinoma, and cutaneous BAP1-inactivated melanocytic tumors. However, the full spectrum of tumors associated with the syndrome is yet to be determined. Improved understanding of the BAP1-TPDS is crucial for appropriate clinical management of BAP1 germline variant carriers and their families, including genetic counseling and surveillance for new tumors...
December 4, 2018: Journal of the National Cancer Institute
Daniel O'Reilly, Zachary J Kartje, Eman A Ageely, Elise Malek-Adamian, Maryam Habibian, Annabelle Schofield, Christopher L Barkau, Kushal J Rohilla, Lauren B DeRossett, Austin T Weigle, Masad J Damha, Keith T Gagnon
CRISPR (clustered regularly interspaced short palindromic repeat) endonucleases are at the forefront of biotechnology, synthetic biology and gene editing. Methods for controlling enzyme properties promise to improve existing applications and enable new technologies. CRISPR enzymes rely on RNA cofactors to guide catalysis. Therefore, chemical modification of the guide RNA can be used to characterize structure-activity relationships within CRISPR ribonucleoprotein (RNP) enzymes and identify compatible chemistries for controlling activity...
December 4, 2018: Nucleic Acids Research
Rebekah L Gardner, Emily Cooper, Jacqueline Haskell, Daniel A Harris, Sara Poplau, Philip J Kroth, Mark Linzer
Objective: To quantify how stress related to use of health information technology (HIT) predicts burnout among physicians. Methods: All 4197 practicing physicians in Rhode Island were surveyed in 2017 on their HIT use. Our main outcome was self-reported burnout. The presence of HIT-related stress was defined by report of at least 1 of the following: poor/marginal time for documentation, moderately high/excessive time spent on the electronic health record (EHR) at home, and agreement that using an EHR adds to daily frustration...
December 5, 2018: Journal of the American Medical Informatics Association: JAMIA
James O Westgard, Sten A Westgard
Objectives: To establish an objective, scientific, evidence-based process for planning statistical quality control (SQC) procedures based on quality required for a test, precision and bias observed for a measurement procedure, probabilities of error detection and false rejection for different control rules and numbers of control measurements, and frequency of QC events (or run size) to minimize patient risk. Methods: A Sigma-Metric Run Size Nomogram and Power Function Graphs have been used to guide the selection of control rules, numbers of control measurements, and frequency of QC events (or patient run size)...
December 5, 2018: American Journal of Clinical Pathology
Márcia Marques Dos Santos Felix, Maria Beatriz Guimarães Ferreira, Lucas Felix de Oliveira, Elizabeth Barichello, Patricia da Silva Pires, Maria Helena Barbosa
OBJECTIVE: to evaluate the effect of relaxation therapy with guided imagery on state anxiety and cortisol in the immediate preoperative period in patients submitted to bariatric surgery by videolaparoscopy. METHOD: a randomized, triple-blind clinical trial in a large teaching hospital in the interior of Minas Gerais. Twenty-four patients who would undergo video-laparoscopic bariatric surgery were randomly allocated in two groups, namely 12 in the control group and 12 in the experimental group...
November 29, 2018: Revista Latino-americana de Enfermagem
Paula Hino, Aline Aparecida Monroe, Renata Ferreira Takahashi, Káren Mendes Jorge de Souza, Tania Maria Ribeiro Monteiro de Figueiredo, Maria Rita Bertolozzi
PURPOSE: to present the opinion of professionals about street dwellers undergoing treatment of tuberculosis and identify strategies of control of tuberculosis in this population. METHOD: an exploratory and descriptive study involving 17 health professionals working in street clinics. A semi-structured study composed of closed questions and a guiding question. The statements were analyzed using the discourse analysis technique, resulting in the identification of two analytical categories: 1...
November 29, 2018: Revista Latino-americana de Enfermagem
Andreia Barcelos Teixeira Macedo, Caren de Oliveira Riboldi, Karen Schein da Silva, Thiane Mergen, Isabel Cristina Echer, Sônia Beatriz Cócaro de Souza
OBJECTIVE: To propose parameters to qualify the filling of the Patient Classification System proposed by Perroca. METHOD: Validation study by consensus held in 2014, in a university hospital. The sample included 10 specialist nurses, four teachers and a computer science professional, all knowledgeable in the Classification System. The information was collected and analyzed through meetings registration, where strategies were discussed to enable the systematic application of the instrument in the institution...
November 29, 2018: Revista Gaúcha de Enfermagem
Edlamar Kátia Adamy, Denise Antunes de Azambuja Zocche, Carine Vendruscolo, José Luis Guedes Dos Santos, Miriam de Abreu Almeida
OBJECTIVE: To present the validation of a theoretical model through conversation circles in a qualitative research guided by the Grounded Theory. METHOD: Study carried out from a thesis developed in a reference hospital in the south region of Brazil. Two conversation circles happened, with participation of representatives of the "Training Prism", in the months of October and November, 2016. RESULTS: The conversation circle enabled an in depth dialogic approach of the subject of research, broadening the vision on the phenomenon and on the research...
November 2018: Revista Brasileira de Enfermagem
Lívia Tech Dos Santos, Fernanda Ludmilla Rossi Rocha, Maria Helena Palucci Marziale
OBJECTIVE: To identify in the literature the efficacy of needlesticks with safety devices to reduce the occurrence of occupational accidents with exposure to biological material among health workers. METHOD: Integrative literature review, structured in the stages: Guiding question, search, categorization of studies, evaluation, discussion and interpretation of results, and synthesis of knowledge. Search for original articles and systematic reviews on the main bases of the Health area, published from 2000 to 2016 in Portuguese, English and Spanish, with descriptors: needlesticks injuries, exposure to biological agents, needles, protective devices, occupational accidents, accident prevention and health personnel...
November 2018: Revista Brasileira de Enfermagem
Sarah Vieira Figueiredo, Letícia Alexandre Lima, Débora Pena Batista E Silva, Raquel de Maria Carvalho Oliveira, Macedônia Pinto Dos Santos, Ilvana Lima Verde Gomes
OBJECTIVE: To know the main health guidance needs of family members of children with sickle cell disease. METHOD: Qualitative research, developed in a pediatric reference hospital of Ceará State, between April and May 2017, through the participation of 12 family members of children with sickle cell disease. The data were collected through semi-structured interviewees and analyzed according to the Bardin's Thematic Categorical Analysis. RESULTS: The relatives had divergent opinions about what this pathology would be and expressed the expectation of being broadly guided, from general information (signs and symptoms) to more complex ones about the disease, including major complications and ways of preventing them...
November 2018: Revista Brasileira de Enfermagem
Delano Gurgel Silveira, Márcio Alencar Barreira, Luiz Gonzaga de Moura Junior, Charles Jean Gomes de Mesquita, Hermano Alexandre Lima Rocha, Gleydson Cesar de Oliveira Borges
PURPOSE: To discuss the use of models of hepatic retraction by laparoscopy, to present a new Hepatic Retractor (HR) and to evaluate its practicality, efficacy and safety in Esophageal Hiatus Exposure (EHE). METHODS: Experimental cross - sectional study with a quantitative character. It was carried out in the Laboratory of Health Training of Christus University Center. The sample consisted of 12 livers of adult pigs weighing between 30 and 45 kg. A circular-shaped HR, 5 cm diameter and deformable materials was developed with a polypropylene cloth, metallic guide wire, epidural needle plastic guide and nylon string...
November 2018: Acta Cirúrgica Brasileira
Maria Cristina de Menezes Borrego, Mara Behlau
PURPOSE: Present a mapping of the Speech-language Pathology (SLP) practice pathway in verbal expressivity in the work of communicative competence. METHODS: Study participants were 40 volunteer speech-language pathologists with extensive experience in the area of voice. They responded to questions about duration of work, number of participants, evaluation instruments, and training of the speech language pathologists who work in this area. They discussed specific issues related to the strategies of expressivity proposed and the vocal resources, exercises and terminology used...
November 29, 2018: CoDAS
Jay Panchal, Gerard Malanga, Mitchell Sheinkop
The aim of this study was to evaluate the safety and efficacy of using autologous, micro-fractured, minimally manipulated adipose tissue in patients with refractory knee osteoarthritis (OA). A total of 17 subjects (26 knees) with a median age of 72 years (range: 54-78 years) and a history of knee OA (Kellgren-Lawrence, grade of 3 or 4) underwent treatment with ultrasound-guided injection of micro-fractured adipose tissue. Micro-fractured fat was obtained using a minimal manipulation technique in a closed system (Lipogems), without the addition of enzymes or any other additives...
November 2018: American Journal of Orthopedics
Lobna Bouacida, Vanessa Suin, Veronik Hutse, Michaël Boudewijns, Reinoud Cartuyvels, Laurent Debaisieux, Emmanuel De Laere, Marie Hallin, Nicolas Hougardy, Katrien Lagrou, Els Oris, Elizaveta Padalko, Marijke Reynders, Gatien Roussel, Jean-Marc Senterre, Michel Stalpaert, Dominique Ursi, Carl Vael, Dolores Vaira, Jos Van Acker, Walter Verstrepen, Steven Van Gucht, Benoit Kabamba, Sophie Quoilin, Gaëtan Muyldermans
BACKGROUND: The knowledge of circulating HCV genotypes and subtypes in a country is crucial to guide antiviral therapy and to understand local epidemiology. Studies investigating circulating HCV genotypes and their trends have been conducted in Belgium. However they are outdated, lack nationwide representativeness or were not conducted in the general population. METHODS: In order to determine the distribution of different circulating HCV genotypes in Belgium, we conducted a multicentre study with all the 19 Belgian laboratories performing reimbursed HCV genotyping assays...
2018: PloS One
Yingting Yu, Qiaojun Situ, Wangyue Jia, Junxiang Li, Qiong Wu, Jinzhi Lei
Coculture of mesenchymal stem cells (MSCs) and vascular endothelial cells (ECs) in vitro leads to the formation of a capillary-like reticular structure by ECs, which has great potential as a better substitute for artificial blood vessels in terms of stability and functionality. To investigate the mechanisms of the early neovascularization induced by MSCs, we analyzed the kinematic features of the motion of ECs and concluded that the dynamic interaction between cells and the extracellular matrix would reveal the capillary-like structure formation...
December 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Yi Liu, Zhengjie Wang, Xiang Li, Xiaowei Ma, Shuailiang Wang, Fei Kang, Weidong Yang, Wenhui Ma, Jing Wang
The complete excision of glioblastomas with maximal retention of surrounding normal tissues can significantly improve patient prognosis. Near-infrared fluorescence (NIRF) optical imaging of the tumor vasculature offers a non-invasive method for detection of early-stage glioblastoma and efficient monitoring of therapeutic responses. The aim of this study was to develop a novel NIRF imaging probe as a visualization tool for image-guided surgical resection of orthotopic glioblastoma. In this study, Cy5.5-RKL, Cy5...
December 5, 2018: Molecular Pharmaceutics
Zhengyan Guo, Pengwei Li, Guozhu Chen, Chao Li, Zhenju Cao, Yuwei Zhang, Jinwei Ren, Hua Xiang, Shuangjun Lin, Jianhua Ju, Yihua Chen
Alboflavusins (AFNs) are a group of cyclohexapeptides with moderate antibacterial and antitumor activities from Streptomyces alboflavus sp. 313. In vivo and in vitro studies proposed that AFNs are biosynthesized by a non-ribosomal peptide synthetase machinery, and the 6-Cl-L-Trp precursor is supplied by a tryptophan halogenase gene locating outside the afn gene cluster. Guided by the structure-activity relationship knowledge about the AFN-like cyclohexapeptides, two Dimeric AFNs (Di-AFNs) with regiospecific biaryl linkages were designed and generated biotechnologically by expressing the P450 gene hmtS or clpS in S...
December 5, 2018: Journal of the American Chemical Society
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