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Weifeng Zeng, Nikita O Shulzhenko, Aaron M Dingle, Samuel O Poore
No abstract text is available yet for this article.
August 18, 2018: Journal of Reconstructive Microsurgery
Carina Lundmark, Simon Matti, Annica Sandström
The aim of this study is to examine the transformative capacity of top-down imposed collaborative institutions on participants' beliefs and coordination patterns. First, do collaborative arenas enhance learning in terms of belief change and belief convergence among participating actors? Second, what types of beliefs are changed and, third, how are changes in beliefs reflected in the formation of coalitions? To answer these questions, a longitudinal study encompassing three collaborative decision-making arenas in the highly adversarial system for wildlife management in Sweden is performed...
August 1, 2018: Journal of Environmental Management
Tobias Zuchelli, Cyrus Piraka
No abstract text is available yet for this article.
August 15, 2018: Clinical Gastroenterology and Hepatology
Shi Yang, Dominick A Leone, Asok Biswas, April Deng, Drazen Jukic, Rajendra Singh, Uma Sundram, Meera Mahalingam
Despite the efficacy of BRAF-targeted and PD-L1-related immune therapies in tackling metastatic melanoma, a significant number of patients exhibit resistance. Given this, the objective of the current study was to ascertain concordance of somatic mutations in BRAF/ NRAS/TERT and, immunohistochemical PD-L1 and CD8 in matched primary cutaneous and metastatic melanoma. A total of 43 archival paired samples with sufficient material for genetic and immunohistochemical analyses met criteria for inclusion in the study...
August 15, 2018: Human Pathology
Ji Young Bang, Bryce Sutton, Robert H Hawes, Shyam Varadarajulu
BACKGROUND AND AIMS: Although frequently performed, the efficacy of endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) for palliation of pain in pancreatic cancer is suboptimal. Recently, endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) has been proposed as a palliative treatment option for pancreatic neoplasms. We performed a single-blind, randomized trial to compare the effectiveness of EUS-CPN and EUS-RFA for palliation of pain in pancreatic cancer. METHODS: Patients with abdominal pain due to locally advanced or metastatic pancreatic cancer underwent EUS-CPN (n=14) or EUS-RFA (n=12)...
August 15, 2018: Gastrointestinal Endoscopy
Shaffer R S Mok, David L Diehl, Amitpal S Johal, Harshit S Khara, Bradley D Confer, Prashant R Mudireddy, H Lester Kirchner, Zong-Ming E Chen
BACKGROUND AND AIMS: As EUS-guided liver biopsy (EUS-LB) becomes more widely used, further studies have investigated ways to improve tissue yields. Use of a heparin primed needle may lead to less clotting of blood within the needle, improve tissue recovery, and decrease fragmentation. The purpose of this study was to prospectively evaluate wet suction using a heparin primed needle for EUS-LB. METHODS: This was a prospective cross-over study evaluating wet suction for EUS-LB in parenchymal liver disease...
August 15, 2018: Gastrointestinal Endoscopy
Kejie Wang, Sixi Chen, Congjie Zhang, Jiatao Huang, Jia Wu, Huaibin Zhou, Liqin Jin, Xu Qian, Jinlong Jin, Jianxin Lyu
Growing evidence shows that enhanced reactive oxygen species (ROS) production is an important contributor to obesity and its co-morbidities, but the functional link between ROS and obesity remains elusive. In this study we used the model animal Caenorhabditis elegans to explore the role of ROS in obesity. Initially, when ROS production was enhanced by treatment with low concentration of paraquat or juglone, both abnormal high fat accumulation and fatty acid composition were observed in wild type worms. We found that the abnormal fat accumulation was associated with increased expression of fat-5, which encodes an isoform of stearoyl-CoA synthetase, and which is regulated by daf-16 encoding the forkhead transcription factor and being activated by downregulation daf-2...
August 15, 2018: Experimental Gerontology
Jin Woo Lee, Qinghao Jin, Hari Jang, Jun Gu Kim, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang
Bioactivity-guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of eighteen lathyrane-type diterpenoids including a new one, Euphorbia Factor L29 (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR, and HR-ESI-MS as well as CD data. All isolates (1-18) were found to inhibit the nitric oxide production in LPS-induced RAW 264.7 macrophages, with their IC50 values in the range of 11.2 - 52.2 μM. This article is protected by copyright...
August 18, 2018: Chemistry & Biodiversity
Melissa R Laub, Stacy A Crow, Heather Personett, Ross Dierkhising, Barry Boilson, Raymund Razonable
Tacrolimus is a cornerstone of immunosuppression after transplantation but is highly susceptible to changes from interacting variables and has a narrow therapeutic index. Clotrimazole troches are commonly used as a non-systemic antifungal to prevent oral candidiasis. Studies suggest that clotrimazole troches, though minimally absorbed systemically, may affect tacrolimus concentrations by inhibition of metabolic enzyme activity in the intestines. However, the magnitude of the impact of clotrimazole on tacrolimus dosing requirements to maintain goal levels is not well described...
August 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Pierre Maurage, Séverine Lannoy, Valérie Dormal, Marine Blanco, Jean-Baptiste Trabut
BACKGROUND: Decision-making impairments have been repeatedly evaluated in severe alcohol use disorders (SAUD) using the Iowa Gambling Task (IGT). The IGT, capitalizing on strong theoretical background and ecological significance, allowed identifying large-scale deficits in this population and is now a standard decision-making assessment in therapeutic settings. However, the clinical usefulness of the IGT, particularly regarding its ability to predict relapse and its link with key cognitive-physiological deficits, remains to be clarified...
August 18, 2018: Alcoholism, Clinical and Experimental Research
Wei Feng, Rui Shi, Chao Zhang, Shaojun Liu, Tingting Yu, Dan Zhu
To realize visualization of the skin microvascular dysfunction of type 1 diabetic mice, we combined laser speckle contrast imaging and hyperspectral imaging to simultaneously monitor the noradrenaline (NE)-induced responses of vascular blood flow and blood oxygen with the development of diabetes through optical clearing skin window. The main results showed that venous and arterious blood flow decreased without recovery after injection of NE; furthermore, the decrease of arterious blood oxygen induced by NE greatly weakened, especially for 2- and 4-week diabetic mice...
August 2018: Journal of Biomedical Optics
Jenna Kroeker, Jay Keith, Hailey Carruthers, Cherry Hanna, Natasha Qureshi, Masa Calic, Meagan Kaye, Marissa Solow, James Coey, Sara Sulaiman
INTRODUCTION: Protocol advocates the use of rigid cervical collars (RCCs) in head trauma patients as they are at risk of concomitant cervical spine injury. Literature has shown RCCs to be a potential cause of venous outflow obstruction, changing internal jugular vein (IJV) cross-sectional area (CSA), and raising intracranial pressure (ICP). This study aims to investigate the effects of applying a RCC, for a period of four hours, on the dimensions of the IJV, in healthy participants. MATERIALS AND METHODS: Seventeen participants (nine male, eight female) took part in this study...
August 17, 2018: Clinical Anatomy
György Jermendy, Zoltán Kiss, György Rokszin, Zsolt Abonyi-Tóth, István Wittmann, Péter Kempler
INTRODUCTION: Adequate persistence to antidiabetic treatment is highly important to achieve proper glycemic control. In this study we evaluate the persistence to treatment with dipeptidyl peptidase-4 inhibitors, sodium-glucose co-transporter-2 inhibitors, and glucagon-like peptide-1 receptor agonists in a nationwide cohort of patients with type 2 diabetes. METHODS: Using a central database in Hungary, we analyzed the persistence to the treatment with dipeptidyl peptidase-4 inhibitors (n = 59,900), sodium-glucose co-transporter-2 inhibitors (n = 26,052), and glucagon-like peptide-1 receptor agonists (n = 17,332) at treatment intensification between 2014 and 2016...
August 17, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Gessyka Rayana S Pereira, Stephania F Taveira, Marcilio Cunha-Filho, Ricardo Neves Marreto
The effects of excipients on the accuracy of tablet subdivision are severely underinvestigated. In this study, placebo tablets were prepared using a combined mixture design of fillers and binders to evaluate the effect of these excipients on subdivision accuracy. The responses assessed were mass loss, mass variation, tablet fragmentation, and increased friability. Dicalcium phosphate dihydrate (DCP) gave rise to more uniform and denser tablets than microcrystalline cellulose (MCC), thus resulting in greater subdivision accuracy...
August 17, 2018: AAPS PharmSciTech
Tam Truong Donnelly, Jassim Mohd Al Suwaidi, Awad Al-Qahtani, Nidal Asaad, Rajvir Singh
Cardiovascular diseases are the leading cause of death worldwide. Among cardiovascular patients, depression is associated with an increased morbidity and mortality. Understanding how depression is conceptualized from cardiovascular patients' perspective can help with prevention, early detection, and treatment for depression. This might reduce cardiovascular morbidity and mortality, and save health care costs. To the best of our knowledge, there is no study in the Gulf region exploring depression among Arab cardiovascular patients...
August 17, 2018: Journal of Immigrant and Minority Health
Mathieu Pinelli, Sonia Pellissier, Clémentine Bry
We tested a field-adapted priming procedure (a technique used to subtly activate mental representations and guide behavior) on a ski slope, with the goal of reducing risk behavior in winter sports. At cableway stations, skiers were initially exposed eight times to a prevention poster displaying a logo and a "slow down" message. The "slow down" concept was activated on the ski slope by exposing skiers (or not) 10 times to the logo featured on the poster. We used a radar device to measure the skiers' speed data just before a slope intersection...
August 17, 2018: Journal of Primary Prevention
Phillip Weeks, Adam Sieg, Indranee Rajapreyar, Sriram Nathan, Marwan Jumean, Manish Patel, Rajko Radovancevic, Biswajit Kar, Igor Gregoric
Pump thrombosis remains a serious complication of implantable ventricular assist device therapy and is associated with increased risk of morbidity and mortality. Optimal management strategies remain controversial and are guided largely by limited literature and expert opinion. Medical management of pump thrombosis, including the use of direct thrombin inhibitors, has been associated with mixed results. The purpose of this study is to report the outcomes associated with bivalirudin therapy in LVAD patients with suspected pump thrombosis...
August 17, 2018: Journal of Thrombosis and Thrombolysis
Eduardo Guimarães Hourneaux de Moura, Igor Braga Ribeiro, Mariana Souza Varela Frazão, Luiz Henrique Mazzonetto Mestieri, Diogo Turiani Hourneaux de Moura, Creusa Maria Roveri Dal Bó, Vitor Ottoboni Brunaldi, Eduardo Turiani Hourneaux de Moura, Gabriel Cairo Nunes, Fábio Alberto Castillo Bustamante, Manoel Dos Passos Galvão Neto, Sergio Eiji Matuguma, Wanderley Marques Bernardo, Marco Aurélio Santo
BACKGROUND: Obesity is a disease that is highly prevalent in Brazil, and the associated comorbidities represent a major global public health challenge. Botulinum toxin type A (BTX-A) is a potent neurotoxin and inhibitor of gastric smooth muscle activity. In theory, BTX-A administration should promote early satiety and weight loss because it delays gastric emptying by inhibiting acetylcholine-mediated peristalsis, which is primarily responsible for gastric motility. Because results in the literature are discrepant, the efficacy of intragastric injections of BTX-A as a primary treatment for obesity remains unknown...
August 17, 2018: Obesity Surgery
Naoki Kamitani, Akihiko Watanabe, Yuki Kirihataya, Saiho Ko
BACKGROUND: Skeletal muscle metastasis from gastric cancer is extremely rare and often accompanied with synchronous metastasis to any other organs. We herein report a case of rapidly developing multiple skeletal metastases from gastric cancer without any other organ metastases. CASE PRESENTATION: A 47-year-old man underwent distal gastrectomy for advanced gastric cancer. Pathological diagnosis was poorly differentiated adenocarcinoma, T2N1M0, Stage IIA. The patient presented with a history of left dorsal tenderness 12 months after the operation...
August 17, 2018: Surgical Case Reports
Li Tian, An-Liu Tang, Lei Zhang, Xiao-Wen Liu, Jing-Bo Li, Fen Wang, Shou-Rong Shen, Xiao-Yan Wang
The HTML version of this article was updated to indicate that the copyright is with The Author(s).
August 17, 2018: Surgical Endoscopy
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