Xuerui Guo, Li Wang, Jinlong Zhang, Quan Liu, Bingmei Wang, Da Liu, Fei Gao, Gongga Lanzi, Yicheng Zhao, Yan Shi
Limitations in the clinical treatment of Staphylococcus aureus (S. aureus) infections have arisen due to the advent of antibiotic-resistant strains. Given the immense potential of therapeutic strategies targeting bacterial virulence, the role of MgrA as a pivotal virulence determinant in S. aureus-orchestrating resistance, adherence, and hundreds of virulence targets-becomes indispensable. In this investigation, leveraging advanced virtual screening and fluorescence anisotropy assays, we discerned methylophiopogonanone A (Mo-A), a flavonoid derivative, as a potent disruptor of the MgrA-DNA interaction nexus...
February 27, 2024: NPJ Biofilms and Microbiomes