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photothermal therapy review

Akshayya Pawar, Priyanka Prabhu
The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities...
December 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jing-Jing Hu, Ying-Jia Cheng, Xian-Zheng Zhang
Nowadays, photothermal therapy (PTT) utilizing photothermal conversion agents (PTAs) to generate sufficient heat under near-infrared (NIR) light irradiation for tumor ablation has attracted extensive research attention. Despite the great advancement, the therapeutic efficacy of PTT in tumor treatment is still compromised by several obstacles, such as low photothermal conversion efficiency, poor stability of PTAs, inadequate tumor accumulation and cellular uptake, and thermal-resistance of tumors, as well as tumor recurrence and metastasis...
November 30, 2018: Nanoscale
Yong Li, Xiaosong Li, Feifan Zhou, Austin Doughty, Ashley R Hoover, Robert E Nordquist, Wei R Chen
Phototherapy is a non-invasive or minimally invasive therapeutic strategy. Immunotherapy uses different immunological approaches, such as antibodies, vaccines, immunoadjuvants, and cytokines to stimulate the host immune system to fight against diseases. In cancer treatment, phototherapy not only destroys tumor cells, but also induces immunogenic tumor cell death to initiate a systemic anti-tumor immune response. When combined with immunotherapy, the effectiveness of phototherapy can be enhanced. Because of their special physical, chemical, and sometimes immunological properties, nanomaterials have also been used to enhance phototherapy...
November 23, 2018: Cancer Letters
Yanhong Xu, Yuling Shan, Hailin Cong, Youqing Shen, Bing Yu
Anticancer treatment has become a research highlight in recent years. Despite several techniques have been developed and applied in the clinic, this area still meets great challenges in the construction of smart anticancer devices with accurate targeting, controlled release and microenvironment response properties. Most of carbon-based materials are biocompatible, possessing abundant and tunable pore structures and particularly large surface areas. These properties make them suitable materials as drug carriers...
November 20, 2018: Current Pharmaceutical Design
Hadi Ranji-Burachaloo, Paul A Gurr, Dave E Dunstan, Greg G Qiao
Currently, cancer is the second largest cause of death worldwide and has reached critical levels. In spite of all the efforts, common treatments including chemotherapy, photodynamic therapy, and photothermal therapy suffer from various problems which limit their efficiency and performance. For this reason, different strategies are being explored which improve the efficiency of these traditional therapeutic methods or treat the tumor cells directly. One such strategy utilizing the Fenton reaction has been investigated by many groups for the possible treatment of cancer cells...
November 28, 2018: ACS Nano
Xu Zhen, Penghui Cheng, Kanyi Pu
Phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), and has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional phototherapeutic agents include easy recognition by the immune system, rapid clearance from blood circulation, and low accumulation in target sites. Cell-membrane coating has emerged as a potential way to overcome these limitations, owing to the abundant proteins on the surface of cell membranes that can be inherited to the cell membrane-camouflaged nanoparticles...
November 20, 2018: Small
Derong Lu, Jiajing Zhou, Yonghao Chen, Jielin Ma, Hongwei Duan
Self-assembly of plasmonic nanocrystals (PNCs) and polymers provides access to a variety of functionalized metallic-polymer building blocks and higher-order hybrid plasmonic assemblies, and thus is of considerable fundamental and practical interest. The hybrid assemblies often not only inherit individual characteristics of polymers and PNCs but also exhibit distinct photophysical and catalytic properties compared to that of a single PNC building block. The tailorable plasmonic coupling between PNCs within assemblies enables the precise control over localized surface plasmon resonance, which subsequently affords a series of light-driven or photo-activated applications, such as surface-enhanced Raman scattering detection, photoacoustic imaging, photothermal therapy, and photodynamic therapy...
November 19, 2018: Macromolecular Rapid Communications
Dong Wang, Michelle Mei Suet Lee, Wenhan Xu, Ryan Tsz Kin Kwok, Jacky Wing Yip Lam, Ben Zhong Tang
The utilization of luminogens with aggregation-induced emission (AIE) characteristics has recently been developed at a tremendous pace in the area of theranostics, mainly because AIE luminogens (AIEgens) hold various distinct advantages, such as good biocompatibility, excellent fluorescence properties, simple preparation and modification, perfect size of nano-aggregation for enhanced permeability and retention effect, promoted efficiencies of photodynamic and photothermal therapies, efficient photoacoustic imaging, and ready constructions of multimodal imaging and therapy...
2018: Theranostics
Huan Zhao, Yuanqi Li, Dan Wei, Hongrong Luo
Tumor is the most serious threat to human beings. Although war against cancer has been launched over forty years, cancer treatment is still far away from being satisfactory. Immunotherapy, especially checkpoint blockade immunotherapy, is a rising star that shows a promising future. To fulfill the requirement of depleting primary tumor and inhibiting tumor metastasis and recurrence, many researchers combined checkpoint blockade immunotherapy with other treatment strategies to extend the treatment outcome. Photodynamic therapy could induce immunogenic cell death, and checkpoint blockade could further accelerate the immunity; therefore, combining these two strategies publishes many papers...
2018: Journal of Immunology Research
Jihwan Son, Gawon Yi, Jihye Yoo, Changhee Park, Heebeom Koo, Hak Soo Choi
Nanoparticles (NPs) play a key role in nanomedicine in multimodal imaging, drug delivery and targeted therapy of human diseases. Consequently, due to the attractive properties of NPs including high stability, high payload, multifunctionality, design flexibility, and efficient delivery to target tissues, nanomedicine employs various types of NPs to enhance targeting and treatment efficacy. In this review, we primarily focus on light-responsive materials, such as fluorophores, photosensitizers, semiconducting polymers, carbon structures, gold particles, quantum dots, and upconversion crystals, for their biomedical applications...
October 12, 2018: Advanced Drug Delivery Reviews
Julian Bejarano, Mario Navarro-Marquez, Francisco Morales-Zavala, Javier O Morales, Ivonne Garcia-Carvajal, Eyleen Araya-Fuentes, Yvo Flores, Hugo E Verdejo, Pablo F Castro, Sergio Lavandero, Marcelo J Kogan
Cardiovascular diseases are the leading cause of death worldwide. Despite preventive efforts, early detection of atherosclerosis, the common pathophysiological mechanism underlying cardiovascular diseases remains elusive, and overt coronary artery disease or myocardial infarction is often the first clinical manifestation. Nanoparticles represent a novel strategy for prevention, diagnosis, and treatment of atherosclerosis, and new multifunctional nanoparticles with combined diagnostic and therapeutic capacities hold the promise for theranostic approaches to this disease...
2018: Theranostics
Yijing Liu, Pravin Bhattarai, Zhifei Dai, Xiaoyuan Chen
The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound energy (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis of cancer, respectively. By taking advantage of nanocarriers, both imaging and therapeutic functions together with enhanced tumour accumulation have been thoroughly studied to improve the pre-clinical efficiency of PAI and PTT. In this review, we first summarize the development of inorganic and organic nano photothermal transduction agents (PTAs) and strategies for improving the PTT outcomes, including applying appropriate laser dosage, guiding the treatment via imaging techniques, developing PTAs with absorption in the second NIR window, increasing photothermal conversion efficiency (PCE), and also increasing the accumulation of PTAs in tumours...
September 27, 2018: Chemical Society Reviews
Nitin Gupta, Divya Bharti Rai, Ashok Kumar Jangid, Hitesh Kulhari
BACKGROUND: In last few years, the use of modified carbon nanomaterials (CNMs) for theranostics (therapeutic and diagnosis) applications is a new and rapidly growing area in pharmacy and medical fields. Owing to this, their unique physical and chemical properties like high stability, high drug loading with high surface to volume ratio, low toxicity are mainly responsible to be considered those as smart nanomaterials. OBJECTIVE: This review describes the different sizes, shapes, and dimensions of carbon-based nanocarriers including 0-D fullerene, 1-D CNTs, and 2-D graphene and graphene oxide and their surface modification with different biocompatible and biodegradable molecules via covalent or non-covalent functionalization...
September 24, 2018: Current Drug Metabolism
Ashtami Jayakumar, Anju Surendranath, Mohanan Pv
2 dimensional (2D) materials are budding new class of materials with exciting potential in optical, electrical, chemical and biomedical applications. Inspired by the attractive properties of graphene attributing to its 2D structure has stimulated researchers to hunt for new 2D materials. Unique characteristics like high surface-volume ratio, shape, surface charge, anisotropic nature and tunable functionalities of 2D structures opens up its application scope further. 2D materials have marked their impact on a wide range of area notably material science, optoelectronics, engineering and biomedical science...
November 15, 2018: International Journal of Pharmaceutics
Yang Liu, Bridget M Crawford, Tuan Vo-Dinh
Cancer has been a significant threat to human health with more than eight million deaths each year in the world. Therefore, there is a significant need for novel technologies to effectively treat cancer and ultimately reduce cancer recurrences, treatment costs, number of radical cystectomies and mortality. A promising therapeutic platform for cancer is offered by nanoparticle-mediated therapy. This review highlights the development and applications of various nanoparticle platforms for photo-induced hyperthermia and immunotherapy...
September 2018: Immunotherapy
Filippo Pierini, Paweł Nakielski, Olga Urbanek, Sylwia Pawłowska, Massimiliano Lanzi, Luciano De Sio, Tomasz Aleksander Kowalewski
Materials for the treatment of cancer have been studied comprehensively over the past few decades. Among the various kinds of biomaterials, polymer-based nanomaterials represent one of the most interesting research directions in nanomedicine because their controlled synthesis and tailored designs make it possible to obtain nanostructures with biomimetic features and outstanding biocompatibility. Understanding the chemical and physical mechanisms behind the cascading stimuli-responsiveness of smart polymers is fundamental for the design of multifunctional nanomaterials to be used as photothermal agents for targeted polytherapy...
October 5, 2018: Biomacromolecules
Wei Zhao, Aihua Li, Aitang Zhang, Yiwei Zheng, Jingquan Liu
In this review, we focus on recent advances in the synthesis of polymer-functionalized transition-metal-based nanomaterials and follow this up by discussing their applications in bioimaging diagnosis and cancer therapy. Transition-metal-based nanomaterials show great potential in cancer therapy owing to their intensive near-IR absorption, excellent photothermal conversion efficiency, strong X-ray attenuation, and magnetic properties. Functional polymers are usually introduced by a one-step or multistep method to further endow these nanomaterials with great biocompatibility and physiological stability...
August 28, 2018: ChemMedChem
Paula García Calavia, Gordon Bruce, Lluïsa Pérez-García, David A Russell
Gold nanoparticles (AuNPs) have been extensively studied within biomedicine due to their biocompatibility and low toxicity. In particular, AuNPs have been widely used to deliver photosensitiser agents for photodynamic therapy (PDT) of cancer. Here we review the state-of-the-art for the functionalisation of the gold nanoparticle surface with both photosensitisers and targeting ligands for the active targeting of cancer cell surface receptors. From the initial use of the AuNPs as a simple carrier of the photosensitiser for PDT, the field has significantly advanced to include: the use of PEGylated modification to provide aqueous compatibility and stealth properties for in vivo use; gold metal-surface enhanced singlet oxygen generation; functionalisation of the AuNP surface with biological ligands to specifically target over-expressed receptors on the surface of cancer cells and; the creation of nanorods and nanostars to enable combined PDT and photothermal therapies...
August 17, 2018: Photochemical & Photobiological Sciences
Limin Pan, Jianan Liu, Jianlin Shi
Tumor therapeutic efficacy is determined, to a great extent, by the delivery efficiency of therapeutic drugs to their final targets. The cell nucleus has been proven to be the main interaction site for most therapeutic agents such as anticancer drugs, genes, free radicals, and heat. Therefore, it is highly expected that cell nucleus-targeting or nuclear membrane-penetrating nanotherapeutics would provide a more effective strategy than ordinary cell membrane-targeting ones for benefiting precise nanomedicine in humans' battles against cancer...
September 17, 2018: Chemical Society Reviews
Milan Gautam, Kishwor Poudel, Chul Soon Yong, Jong Oh Kim
This review outlines recently developed Prussian blue nanoparticle (PB NPs)-based multimodal imaging-guided chemo-photothermal strategies for cancer diagnosis and treatment in order to provide insight into the future of the field. The primary limitation of existing therapeutics is the lack of selectivity in drug delivery: they target healthy and cancerous cells alike. In this paper, we provide a thorough review of diverse synthetic and surface engineering techniques for PB NP fabrication. We have elucidated the various targeting approaches employed to deliver the therapeutic and imaging ligands into the tumor area, and outlined methods for enhancement of the tumor ablative ability of the NPS, including several important combinatorial approaches...
October 5, 2018: International Journal of Pharmaceutics
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