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https://www.readbyqxmd.com/read/30062349/cancer-cell-nucleus-targeting-nanocomposites-for-advanced-tumor-therapeutics
#1
Limin Pan, Jianan Liu, Jianlin Shi
Tumor therapeutic efficacy is determined, to a great extent, by the delivery efficiency of therapeutic drugs to their final targets. The cell nucleus has been proven to be the main interaction site for most therapeutic agents such as anticancer drugs, genes, free radicals, and heat. Therefore, it is highly expected that cell nucleus-targeting or nuclear membrane-penetrating nanotherapeutics would provide a more effective strategy than ordinary cell membrane-targeting ones for benefiting precise nanomedicine in humans' battles against cancer...
July 31, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/30053487/prussian-blue-nanoparticles-synthesis-surface-modification-and-application-in-cancer-treatment
#2
REVIEW
Milan Gautam, Kishwor Poudel, Chul Soon Yong, Jong Oh Kim
This review outlines recently developed Prussian blue nanoparticle (PB NPs)-based multimodal imaging-guided chemo-photothermal strategies for cancer diagnosis and treatment in order to provide insight into the future of the field. The primary limitation of existing therapeutics is the lack of selectivity in drug delivery: they target healthy and cancerous cells alike. In this paper, we provide a thorough review of diverse synthetic and surface engineering techniques for PB NP fabrication. We have elucidated the various targeting approaches employed to deliver the therapeutic and imaging ligands into the tumor area, and outlined methods for enhancement of the tumor ablative ability of the NPS, including several important combinatorial approaches...
July 24, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30041150/functionalization-of-graphene-family-nanomaterials-for-application-in-cancer-therapy
#3
REVIEW
Duarte de Melo-Diogo, Rita Lima-Sousa, Cátia G Alves, Elisabete C Costa, Ricardo O Louro, Ilídio J Correia
Graphene family nanomaterials' (GFN) ability to interact with near-infrared light has propelled their application in cancer photothermal therapy. Furthermore, the graphitic lattice of GFN can adsorb different types of molecules, which has motivated their use in cancer drug delivery. However, the direct application of GFN in cancer therapy is severely hindered by their poor colloidal stability, sub-optimal safety, inefficient tumor uptake and non-selectivity towards cancer cells. To overcome these limitations, GFN have been functionalized with different types of materials...
July 17, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30024579/catalytic-chemistry-of-glucose-oxidase-in-cancer-diagnosis-and-treatment
#4
Lian-Hua Fu, Chao Qi, Jing Lin, Peng Huang
Glucose oxidase (GOx) is an endogenous oxido-reductase that is widely distributed in living organisms. Over recent years, GOx has attracted increasing interest in the biomedical field due to its inherent biocompatibility, non-toxicity, and unique catalysis against β-d-glucose. GOx efficiently catalyzes the oxidization of glucose into gluconic acid and hydrogen peroxide (H2O2), which can be employed by various biosensors for the detection of cancer biomarkers. Various cancer therapeutic strategies have also been developed based on the catalytic chemistry of GOx: (1) the consumption of glucose provides an alternative strategy for cancer-starvation therapy; (2) the consumption of oxygen increases tumor hypoxia, which can be harnessed for hypoxia-activated therapy; (3) the generation of gluconic acid enhances the acidity of the tumor microenvironment, which can trigger pH-responsive drug release; (4) the generation of H2O2 increases the levels of tumor oxidative stress, and the H2O2 can be converted into toxic hydroxyl radicals that can kill cancer cells upon exposure to light irradiation or via the Fenton reaction...
July 19, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29986450/gold-nanoparticles-in-diagnostics-and-therapeutics-for-human-cancer
#5
REVIEW
Priyanka Singh, Santosh Pandit, V R S S Mokkapati, Abhroop Garg, Vaishnavi Ravikumar, Ivan Mijakovic
The application of nanotechnology for the treatment of cancer is mostly based on early tumor detection and diagnosis by nanodevices capable of selective targeting and delivery of chemotherapeutic drugs to the specific tumor site. Due to the remarkable properties of gold nanoparticles, they have long been considered as a potential tool for diagnosis of various cancers and for drug delivery applications. These properties include high surface area to volume ratio, surface plasmon resonance, surface chemistry and multi-functionalization, facile synthesis, and stable nature...
July 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29981170/nanoparticle-based-photothermal-and-photodynamic-immunotherapy-for-tumor-treatment
#6
REVIEW
Xiaoyang Hou, Yingkai Tao, Yanyu Pang, Xinxin Li, Yanqun Liu, Guan Jiang
Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion, and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly killing tumor cells through heat and reactive oxygen species, PTT and PDT can also induce various anti-tumor effects. In particular, the resultant massive tumor cell death after PTT and PDT triggers immune responses, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines, and the transformation of memory T lymphocytes...
July 7, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29974662/progress-in-applications-of-prussian-blue-nanoparticles-in-biomedicine
#7
REVIEW
Zhiguo Qin, Yan Li, Ning Gu
Prussian blue nanoparticles (PBNPs) with favorable biocompatibility and unique properties have captured the attention of extensive biomedical researchers. A great progress is made in the application of PBNPs as therapy and diagnostics agents in biomedicine. This review begins with the recent synthetic strategies of PBNPs and the regulatory approaches for their size, shape, and uniformity. Then, according to the different properties of PBNPs, their application in biomedicine is summarized in detail. With modifiable features, PBNPs can be used as drug carriers to improve the therapeutic efficacy...
July 4, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29927583/two-dimensional-metal-nanomaterials-synthesis-properties-and-applications
#8
Ye Chen, Zhanxi Fan, Zhicheng Zhang, Wenxin Niu, Cuiling Li, Nailiang Yang, Bo Chen, Hua Zhang
As one unique group of two-dimensional (2D) nanomaterials, 2D metal nanomaterials have drawn increasing attention owing to their intriguing physiochemical properties and broad range of promising applications. In this Review, we briefly introduce the general synthetic strategies applied to 2D metal nanomaterials, followed by describing in detail the various synthetic methods classified in two categories, i.e. bottom-up methods and top-down methods. After introducing the unique physical and chemical properties of 2D metal nanomaterials, the potential applications of 2D metal nanomaterials in catalysis, surface enhanced Raman scattering, sensing, bioimaging, solar cells, and photothermal therapy are discussed in detail...
July 11, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29896881/polymer-dots-as-effective-phototheranostic-agents
#9
REVIEW
Liang Guo, Jiechao Ge, Pengfei Wang
Conjugated polymer dots (Pdots, also named polymer nanoparticles, PNPs), which consist of π-conjugated organic polymers, are novel organic nanomaterials with size in the range of 1-100 nm. Compared with traditional organic small molecules, semiconductor quantum dots and inorganic nanomaterials, the Pdots exhibit significant potential applications in biological imaging, sensing and detection, drug delivery and theranostics, due to their advantages of special optical properties, diverse structure, easy surface modification and good biocompatibility...
June 13, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29890034/photothermal-heating-and-cooling-of-nanostructures
#10
Matthew Joseph Crane, Xuezhe Zhou, E James Davis, Peter Pauzauskie
A vast range of insulating, semiconducting, and metallic nanomaterials have been studied over the past several decades with the aim of understanding how continuous-wave or pulsed laser radiation can influence their chemical functionality and local environment. Many fascinating observations have been made during laser irradiation including, but not limited to, the superheating of solvents, mass-transport-mediated morphology evolution, photodynamic therapy, morphology dependent resonances, and a range of phase transformations...
June 11, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29882569/omnipotent-phosphorene-a-next-generation-two-dimensional-nanoplatform-for-multidisciplinary-biomedical-applications
#11
Meng Qiu, Wen Xiu Ren, Taeho Jeong, Miae Won, Geun Young Park, David Kipkemoi Sang, Li-Ping Liu, Han Zhang, Jong Seung Kim
Phosphorene, also known as single- or few-layer black phosphorus (FLBP), is a new member of the two-dimensional (2D) material family and has attracted significant attention in recent years for applications in optoelectronics, energy storage and biomedicine due to its unique physicochemical properties and excellent biocompatibility. FLBP is regarded as a potential biological imaging agent for cancer diagnosis due to its intrinsic fluorescence (FL) and photoacoustic (PA) properties and negligible cytotoxicity...
June 8, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29881657/recent-advances-and-future-prospects-of-iron-oxide-nanoparticles-in-biomedicine-and-diagnostics
#12
REVIEW
N V Srikanth Vallabani, Sanjay Singh
Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as chemically inert materials and, therefore, being extensively applied in the areas of imaging, targeting, drug delivery and biosensors. Their unique properties such as low toxicity, biocompatibility, potent magnetic and catalytic behavior and superior role in multifunctional modalities have epitomized them as an appropriate candidate for biomedical applications. Recent developments in the area of materials science have enabled the facile synthesis of Iron oxide nanoparticles (IONPs) offering easy tuning of surface properties and surface functionalization with desired biomolecules...
June 2018: 3 Biotech
https://www.readbyqxmd.com/read/29869424/recent-progress-in-macromolecule-anchored-hybrid-gold-nanomaterials-for-biomedical-applications
#13
REVIEW
Zheng Luo, Yang Xu, Enyi Ye, Zibiao Li, Yun-Long Wu
Gold nanoparticles (AuNPs), with elegant thermal, optical, or chemical properties due to quantum size effects, may serve as unique species for therapeutic or diagnostic applications. It is worth mentioning that their small size also results in high surface activity, leading to significantly impaired stability, which greatly hinders their biomedical utilizations. To overcome this problem, various types of macromolecular materials are utilized to anchor AuNPs so as to achieve advanced synergistic effect by dispersing, protecting, and stabilizing the AuNPs in polymeric-Au hybrid self-assemblies...
June 4, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29865999/theranostics-of-gold-nanoparticles-with-an-emphasis-on-photoacoustic-imaging-and-photothermal-therapy
#14
Yi Liu, Wenhui Ma, Jing Wang
Gold nanoparticles (AuNPs) are promising biomedical agents in terms of both imaging and therapy, exhibiting excellent physical and chemical characteristics. The actions of AuNPs can be remotely controlled using strong near-infrared (NIR) light, associated with minimal lateral invasion. Employing the photoacoustic (PA) principle, AuNPs integrate imaging and temperature control, affording both diagnosis and treatment mediated by NIR light. We here review recent progress in the theranostic field employing AuNPs to both PA and photothermal ends...
June 3, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29844672/recent-advances-in-functional-nanostructures-as-cancer-photothermal-therapy
#15
REVIEW
Essraa A Hussein, Moustafa M Zagho, Gheyath K Nasrallah, Ahmed A Elzatahry
Being a non-invasive and relatively safe technique, photothermal therapy has attracted a lot of interest in the cancer treatment field. Recently, nanostructure technology has entered the forefront of cancer therapy owing to its ability to absorb near-infrared radiation as well as efficient light to heat conversion. In this study, key nanostructures for cancer therapy including gold nanoparticles, magnetite iron oxide nanoparticles, organic nanomaterials, and novel two-dimensional nanoagents such as MXenes are discussed...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29795017/detection-of-intracellular-gold-nanoparticles-an-overview
#16
REVIEW
Mario D'Acunto
Photothermal therapy (PTT) takes advantage of unique properties of gold nanoparticles (AuNPs) (nanospheres, nanoshells (AuNSs), nanorods (AuNRs)) to destroy cancer cells or tumor tissues. This is made possible thanks principally to both to the so-called near-infrared biological transparency window, characterized by wavelengths falling in the range 700⁻1100 nm, where light has its maximum depth of penetration in tissue, and to the efficiency of cellular uptake mechanisms of AuNPs. Consequently, the possible identification of intracellular AuNPs plays a key role for estimating the effectiveness of PTT treatments...
May 24, 2018: Materials
https://www.readbyqxmd.com/read/29791151/recent-advances-and-progress-on-melanin-like-materials-and-their-biomedical-applications
#17
Long Huang, Meiying Liu, Hongye Huang, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Melanins are well-known biopolymers that are ubiquitous in nature, distributed widely in microorganisms, plants, and animals, and play significant physiological roles. They are mostly biopolymers formed from phenolic compounds by polymerization via quinones. Poly(dopamine) (PDA), a melanin-like material, is similar in structure and properties to eumelanin and has attracted considerable interest for various types of biological applications. This review outlines the recent advances in the structure and synthesis of PDA and discusses applications of PDA in many biological fields, such as biological imaging, photothermal therapy, and drug delivery systems...
June 11, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29766541/gold-nanoparticles-in-ophthalmology
#18
REVIEW
Florence Masse, Mathieu Ouellette, Guillaume Lamoureux, Elodie Boisselier
Many research projects are underway to improve the diagnosis and therapy in ophthalmology. Indeed, visual acuity deficits affect 285 million people worldwide and different strategies are being developed to strengthen patient care. One of these strategies is the use of gold nanoparticles (GNP) for their multiple properties and their ability to be used as both diagnosis and therapy tools. This review exhaustively details research developing GNPs for use in ophthalmology. The toxicity of GNPs and their distribution in the eye are described through in vitro and in vivo studies...
May 16, 2018: Medicinal Research Reviews
https://www.readbyqxmd.com/read/29734008/biochemistry-and-biomedicine-of-quantum-dots-from-biodetection-to-bioimaging-drug-discovery-diagnostics-and-therapy
#19
REVIEW
Jun Yao, Pingfan Li, Lin Li, Mei Yang
According to recent research, nanotechnology based on quantum dots (QDs) has been widely applied in the field of bioimaging, drug delivery, and drug analysis. Therefore, it has become one of the major forces driving basic and applied research. The application of nanotechnology in bioimaging has been of concern. Through in vitro labeling, it was found that luminescent QDs possess many properties such as narrow emission, broad UV excitation, bright fluorescence, and high photostability. The QDs also show great potential in whole-body imaging...
July 1, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29725670/crucial-breakthrough-of-second-near-infrared-biological-window-fluorophores-design-and-synthesis-toward-multimodal-imaging-and-theranostics
#20
REVIEW
Shuqing He, Jun Song, Junle Qu, Zhen Cheng
The development of fluorophores and molecular probes for the second near-infrared biological window (NIR-II, 1000-1700 nm) represents an important, newly emerging and dynamic field in molecular imaging, chemical biology and materials chemistry. Because of reduced scattering, minimal absorption and negligible autofluorescence, NIR-II imaging provides high resolution, a high signal-to-noise ratio, and deep tissue penetration capability. Among various state-of-the-art bioimaging modalities, one of the greatest challenges in developing novel probes is to achieve both high resolution and sensitivity...
June 18, 2018: Chemical Society Reviews
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