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Brain srs

Kathleen Connery, Marie Tippett, Leanna M Delhey, Shannon Rose, John C Slattery, Stephen G Kahler, Juergen Hahn, Uwe Kruger, Madeleine W Cunningham, Craig Shimasaki, Richard E Frye
The identification of brain-targeted autoantibodies in children with autism spectrum disorder (ASD) raises the possibility of autoimmune encephalopathy (AIE). Intravenous immunoglobulin (IVIG) is effective for AIE and for some children with ASD. Here, we present the largest case series of children with ASD treated with IVIG. Through an ASD clinic, we screened 82 children for AIE, 80 of them with ASD. IVIG was recommended for 49 (60%) with 31 (38%) receiving the treatment under our care team. The majority of parents (90%) reported some improvement with 71% reporting improvements in two or more symptoms...
August 10, 2018: Translational Psychiatry
John A Vargo, Kristie M Sparks, Rahul Singh, Geraldine M Jacobson, Joshua D Hack, Christopher P Cifarelli
BACKGROUND AND PURPOSE: Post-operative SRS (stereotactic radiosurgery) for large brain metastases is challenged by risks of radiation necrosis that limit SRS dose. Intraoperative radiotherapy (IORT) is a potential alternative, however standard dose recommendations are lacking. METHODS AND MATERIALS: Twenty consecutive brain metastases treated with post-operative SRS were retrospectively compared to IORT plans generated for 10-30 Gy in 1 fraction to 0-5 mm by estimating the applicator size and distance from critical organs using pre-operative and post-operative MRI...
August 9, 2018: Journal of Neuro-oncology
Rajal A Patel, Derrick Lock, Irene B Helenowski, James P Chandler, Matthew C Tate, Orin Bloch, Sean Sachdev, Tim J Kruser
PURPOSE: Postoperative stereotactic radiosurgery (SRS) is increasingly utilized following resection of brain metastases (BM); however, there are no volumetric data guiding dose selection. We performed a volumetric analysis to guide cavity SRS dosing for resected BM. METHODS: 83 consecutive patients with gross total resection who underwent postoperative SRS to 90 cavities were identified. The 12 Gy isodose lines (V12total ) along with the volume of brain parenchyma receiving 12 Gy excluding cavity fluid, ventricular fluid, and calvarium (V12parenchyma ) were contoured...
August 6, 2018: Journal of Neuro-oncology
L Brun, G Dupic, V Chassin, P Verrelle, M Lapeyre, J Biau
Stereotactic radiotherapy is a major issue in the management of brain metastases. Radionecrosis is a major concern, especially for large lesions. Optimizing dosimetric parameters is essential to allow optimal local control rate while minimizing potential toxicity. We report the case of a 30-mm brain metastases treated with stereotactic radiotherapy after initial whole brain radiotherapy, complicated with symptomatic radionecrosis. A dose of 24Gy in three fractions on the 80% isodose were delivered using a dynamic conformal arc technique (Novalis TX® )...
August 2, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Assaf Berger, Ido Strauss, Shlomit Ben Moshe, Benjamin W Corn, Dror Limon, Nathan Shtraus, Tal Shahar, Andrew A Kanner
PURPOSE: Post-operative radiation therapy for brain metastases (BM) has become standard treatment. Concerns regarding the deleterious cognitive effects of Whole Brain Radiation Therapy spurred a trend to use focal therapies such as stereotactic radiosurgery (SRS). The purpose of this study was to prospectively evaluate the neuropsychological effects following post-resection SRS treatment since limited data exist in this context. METHODS: We conducted a prospective single arm cohort study of patients with 1-2 BM, who underwent resection of a single BM between May 2015 to December 2016...
August 4, 2018: Journal of Neuro-oncology
In-Young Kim, Shin Jung, Tae-Young Jung, Kyung-Sub Moon, Woo-Youl Jang, Jae-Young Park, Tae-Wook Song, Sa-Hoe Lim
Objective: We investigated the outcomes of repeat stereotactic radiosurgery (SRS) for metastatic brain tumors that locally recurred despite previous SRS, focusing on the tumor control. Methods: A total of 114 patients with 176 locally recurring metastatic brain tumors underwent repeat SRS after previous SRS. The mean age was 59.4 years (range, 33 to 85), and there were 68 male and 46 female patients. The primary cancer types were non-small cell lung cancer (n=67), small cell lung cancer (n=12), gastrointestinal tract cancer (n=15), breast cancer (n=10), and others (n=10)...
August 1, 2018: Journal of Korean Neurosurgical Society
Paul Lesueur, Justine Lequesne, Victor Barraux, William Kao, Julien Geffrelot, Jean-Michel Grellard, Jean-Louis Habrand, Evelyne Emery, Brigitte Marie, Juliette Thariat, Dinu Stefan
BACKGROUND: Until 50% of patients with renal cancer or melanoma, develop brain metastases during the course of their disease. Stereotactic radiotherapy has become a standard of care for patients with a limited number of brain metastases. Given the radioresistant nature of melanoma and renal cancer, optimization of the fractionation of stereotactic radiotherapy is needed. The purpose of this retrospective study was to elucidate if hypofractionated stereotactic radiotherapy (HFSRT) impacts local control of brain metastases from radioresistant tumors such as melanoma and renal cancer, in comparison with radiosurgery (SRS)...
July 28, 2018: Radiation Oncology
Martin J Higgins, Orlaidh Burke, David Fitzpatrick, Killian G Nugent, Christina Skourou, Mary Dunne, Mohsen Javadpour, Clare Faul
INTRODUCTION: We reviewed local control (LC) and overall survival (OS) post intracranial SRS to cavity post resection of brain metastases at one institution, and factors affecting LC. METHODS: A retrospective review was conducted of adjuvant SRS at one institution from 2013 to 2016. Patient records, treatment plans and diagnostic images were reviewed. Local failure was MRI defined. Categorical variables were analysed using chi-square and Fisher's exact tests. Continuous variables were analysed using Mann-Whitney tests...
July 25, 2018: Journal of Medical Imaging and Radiation Oncology
Chengcheng Gui, Joseph Moore, Jimm Grimm, Lawrence Kleinberg, Todd McNutt, Colette Shen, Linda Chen, Chetan Bettegowda, Michael Lim, Kristin J Redmond
PURPOSE: In the treatment of resected metastatic brain disease, a recent phase 3 trial by the North Central Cancer Treatment Group (N107C/CEC.3) surprisingly found that the local control rate for whole-brain radiation therapy was better than that of stereotactic radiation surgery (SRS). To optimize target delineation, we performed a quantitative analysis of local failure patterns after postoperative SRS. METHODS AND MATERIALS: Patients with brain metastases who were treated with surgery and SRS to the cavity were evaluated...
April 26, 2018: Practical Radiation Oncology
Ahilan Kailaya-Vasan, Thiti Samuthrat, Daniel C Walsh
Treatment of brain arteriovenous malformations (AVM) with stereotactic radiosurgery is rarely complicated by severe adverse radiation effects (ARE). The treatment of these sequelae is varied and often ineffectual. We present three cases of brain AVMs treated with SRS, all complicated by severe AREs. All three cases failed to respond to what is currently considered the standard treatment - corticosteroids - and indeed one patient died as a result of the side effects of their extended use. Two cases were successfully treated with surgical excision of the necrotic lesion resulting in immediate clinical improvement...
July 18, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Hiromi Furuta, Tatsuya Yoshida, Atsushi Natsume, Toyoaki Hida, Yasushi Yatabe
No abstract text is available yet for this article.
July 11, 2018: Journal of Thoracic Oncology
François Lucia, Stéphane Key, Gurvan Dissaux, Gaëlle Goasduff, Anne-Sophie Lucia, Luc Ollivier, Olivier Pradier, Ulrike Schick
INTRODUCTION: The aim of this study was to analyze the impact of inhomogeneous versus homogeneous dose distribution on local control (LC) and radionecrosis (RN) in patients treated with fractionated stereotactic radiotherapy (SRT) for newly-diagnosed brain metastases (BM). PATIENTS AND METHODS: From 2014 to 2017, 134 patients (median age 61 years) underwent SRT for BM (n = 114 with ≤2, n = 20 with 3-6 BM) at our institution. Treatment was delivered using volumetric modulated arc therapy on a linear accelerator...
July 14, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Yoshinori Higuchi, Masaaki Yamamoto, Toru Serizawa, Hitoshi Aiyama, Yasunori Sato, Bierta E Barfod
Historically, whole brain radiotherapy was administered to most patients with brain metastases. However, over the past three decades, stereotactic radiosurgery (SRS), targeted at individual cranial lesions, has been accepted widely. In this study, based on the authors' experiences along with published data, recent trends in SRS for brain metastases are discussed. This article focuses on the following issues: 1) How many tumors can or should be treated with SRS? 2) Two-/three-staged SRS for relatively large tumors, 3) post- or preoperative SRS, and 4) repeat SRS...
2018: Cancer Management and Research
Denise Bernhardt, Adriane Hommertgen, Daniela Schmitt, Rami El Shafie, Angela Paul, Laila König, Johanna Mair-Walther, Johannes Krisam, Christina Klose, Thomas Welzel, Juliane Hörner-Rieber, Jutta Kappes, Michael Thomas, Claus Peter Heußel, Martin Steins, Meinhard Kieser, Jürgen Debus, Stefan Rieken
BACKGROUND: Conventional whole brain radiotherapy (WBRT) has been established as the treatment standard in patients with cerebral metastases from small-cell lung cancer (SCLC), however, it has only modest efficacy and limited prospective data is available for WBRT as well as local treatments such as stereotactic radiosurgery (SRS). METHODS/DESIGN: The present single-center prospective randomized study, conducted at Heidelberg University Hospital, compares neurocognitive function, as objectively measured by significant deterioration in Hopkins Verbal Learning Test - Revised total recall at 3 months...
July 16, 2018: Trials
Marco Possanzini, Carlo Greco
The treatment of metastatic breast cancer is largely focused on systemic therapy. However, over the past decades, there has been growing interest in the use of metastasis-directed therapy in selected cases presenting with an oligometastatic phenotype, i.e. low disease burden with a more indolent biology. Identification of the oligometastatic breast cancer population has, so far, proven elusive. Stereotactic radiotherapy offers an effective, non-invasive approach to ablate metastatic disease both in the brain and in extra-cranial settings...
June 28, 2018: Breast: Official Journal of the European Society of Mastology
Chao Li, Mengyu Tian, Lu Zhang, Qiang Fu, Lin Song, Fei Chen, Ning Yang
Scavenger receptors (SRs) are a group of membrane-bound receptors that could bind to a variety of ligands including endogenous proteins and pathogens. SRs have been recognized to play vital roles in innate immune response against pathogen infection in both vertebrates and invertebrates. In this regard, one SmSCARA5 gene was captured in turbot (Scophthalmus maximus). The full-length SmSCARA5 transcript contains an open reading frame (ORF) of 1494 bp. SmSCARA55 showed both the highest identity and similarity to half-smooth tongue sole (Cynoglossus semilaevis), and a high degree of conservation of genomic structure to the teleost species...
July 11, 2018: Fish & Shellfish Immunology
Ching-Jen Chen, Dale Ding, Hideyuki Kano, David Mathieu, Douglas Kondziolka, Caleb Feliciano, Rafael Rodriguez-Mercado, Inga S Grills, Gene Barnett, L Dade Lunsford, Jason P Sheehan
BACKGROUND AND PURPOSE: The aim of this international, multicenter, retrospective matched cohort study is to directly compare the outcomes after stereotactic radiosurgery (SRS) for brain arteriovenous malformations (AVM) in pediatric versus adult patients. METHODS: We performed a retrospective review of patients with AVM who underwent SRS at 8 institutions participating in the International Gamma Knife Research Foundation from 1987 to 2014. Patients were categorized into pediatric (<18 years of age) and adult (≥18 years of age) cohorts and matched in a 1:1 ratio using propensity scores...
July 12, 2018: Stroke; a Journal of Cerebral Circulation
Ayako Horiba, Motohiro Hayashi, Noriko Tamura, Kentaro Chiba, Yasuo Aihara, Takakazu Kawamata
Stereotactic radiosurgery (SRS) is a treatment option, which is capable of pinpoint irradiation and thus, reduce the potential late complications. However, any type of radiation therapy is not recommended for brain tumor patients under the age of 3 years. SRS is not routinely recommended for patients than 2 years of age in consideration of infant skull brittleness for frame fixation, and lack of treatment evidence for the safety and effects of stereotactic radiosurgery in infants. We experienced the case of Gamma Knife treatment upon an infantile pineoblastoma where repeated tumor excision had already been perfromed and chemotherapy resistance was apparent...
2018: Journal of Radiosurgery and SBRT
Majed Alghamdi, Yaser Hasan, Mark Ruschin, Eshetu G Atenafu, Sten Myrehaug, Chia-Lin Tseng, Julian Spears, Todd Mainprize, Arjun Sahgal, Hany Soliman
Objective: To determine changes in post-surgical cavity volume for metastases based on time from surgery, pre-operative tumor dimensions and other predictors, in patients planned for post-operative stereotactic radiosurgery (SRS). Methods: Patients with resected brain metastases from a primary solid tumor, treated with post-operative surgical cavity SRS from 2008 to 2014 were identified from an institutional prospective database. The segmented three-dimensional (3D) volume of the pre-operative tumor and post-operative surgical cavity were determined based on MRI and percent volume change was calculated...
2018: Journal of Radiosurgery and SBRT
Chunhao Wang, Wenzheng Sun, John Kirkpatrick, Zheng Chang, Fang-Fang Yin
Purpose: To assess the response and predict the overall survival (OS) of recurrent malignant gliomas (MG) patients treated with concurrent BVZ/SRS using multi-modality MRI imaging and radiomics analysis.Methods and materials: SRS was delivered in a single fraction (18/24Gy) or 25Gy in 5 fractions. BVZ was administered immediately before SRS and 2 weeks after. MRI scans were performed before SRS, 1 week and 2 months after SRS. The MR protocol included 2 anatomical (T1w and T2w) and 2 functional (dynamic contrast-enhanced DCE-MRI and diffusion weighted DW-MRI) modalities...
2018: Journal of Radiosurgery and SBRT
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