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William V Padula, Joyce M Black, Patricia M Davidson, So Yeon Kang, Peter J Pronovost
OBJECTIVE: Health systems are grappling with improving the quality and safety of health care. By setting clear expectations, there is an opportunity to configure care models to decrease the risk of adverse events and promote the quality of care. The US Centers for Medicare and Medicaid Services have used Patient Safety Indicator 90 (PSI90), a composite rate of hospital-acquired conditions (HACs), to adjust payments and score hospitals on quality since 2015. However, PSI90 may be associated with adverse prioritization for preventing some conditions over others...
July 17, 2018: Journal of Patient Safety
Asim Waris, Imran Khan Niazi, Mohsin Jamil, Kevin Englehart, Winnie Jensen, Ernest Nlandu Kamavuako
Currently, most of the adopted myoelectric schemes for upper limb prostheses do not provide users with intuitive control. Higher accuracies have been reported using different classification algorithms but investigation on the reliability over time for these methods is very limited. In this study, we compared for the first time the longitudinal performance of selected state-of-the-art techniques for Electromyography (EMG) based classification of hand motions. Experiments were conducted on ten able-bodied and six transradial amputees for seven continuous days...
August 8, 2018: IEEE Journal of Biomedical and Health Informatics
Dongchang Zhao, Yeung-Hyen Kim, Seihwan Jeong, Joel K Greenson, Mohammed S Chaudhry, Matthias Hoepting, Erik R Anderson, Marcel Rm van den Brink, Jonathan U Peled, Antonio Lc Gomes, Ann E Slingerland, Michael J Donovan, Andrew C Harris, John E Levine, Umut Özbek, Lora V Hooper, Thaddeus S Stappenbeck, Aaron M Ver Heul, Ta-Chiang Liu, Pavan Reddy, James Lm Ferrara
Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract remains the major cause of morbidity and non-relapse mortality after bone marrow transplantation (BMT). The Paneth cell protein, regenerating islet-derived 3-alpha (REG3α), is a biomarker specific for GI GVHD. REG3α serum levels rose in the systematic circulation as GVHD progressively destroyed Paneth cells and reduced GI epithelial barrier function. Paradoxically, GVHD suppressed intestinal REG3γ (the mouse homologue of human REG3α), and the absence of REG3γ in BMT recipients intensified GVHD but did not change the composition of the microbiome...
August 14, 2018: Journal of Clinical Investigation
Kiyotaka Uchiyama, Naoki Washida, Nobuyuki Yube, Takahiro Kasai, Keisuke Shinozuka, Kohkichi Morimoto, Akihito Hishikawa, Hiroyuki Inoue, Hidenori Urai, Aika Hagiwara, Kentaro Fujii, Shu Wakino, Souzana Deenitchina, Hiroshi Itoh
AIMS: Remote monitoring (RM) can improve management of chronic diseases. We evaluated the impact of RM in automated peritoneal dialysis (APD) in a simulation study. MATERIALS AND METHODS: We simulated 12 patient scenarios with common clinical problems and estimated the likely healthcare resource consumption with and without the availability of RM (RM+ and RM- groups, respectively). Scenarios were evaluated 4 times by randomly allocated nephrologist-nurse teams or nephrologist-alone assessors...
August 14, 2018: Clinical Nephrology
Jiaoyan Zhou, Mingzhang Xie, Anyang Cui, Bin Zhou, Kai Jiang, Liyan Shang, Zhigao Hu, Jun-Hao Chu
Vanadium dioxide (VO$_{2}$) with a metal-insulator transition (MIT) has been supposed as a candidate in the optoelectronic devices. However, the MIT temperature ($T_{\rm MIT}$) above room temperature limits its application scope. Here, high-quality V$_{1-x}$W$_{x}$O$_{2}$ films have been prepared by pulsed laser deposition. Based on temperature dependent transmittance and Raman spectra, it was found that the $T_{\rm MIT}$ increases from 241 to 279 K, when increasing doping concentration in the range of $0.16 \leqslant x \leqslant 0...
August 14, 2018: ACS Applied Materials & Interfaces
Wenlong Ma, Yanfeng Liu, Yue Wang, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu
Glucosamine-6-phosphate N-acetyltransferase (GNA1) that catalyzes acetyl transfer from acetyl-coenzyme A to glucosamine-6-phosphate (GlcN-6P), and glutamine-fructose-6- phosphate aminotransferase (GlmS) that catalyzes the formation of GlcN-6P from fructose-6-phosphate (Fru-6P), are two key enzymes in Bacillus subtilis for the bioproduction of N-acetylglucosamine (GlcNAc), a nutraceutical that has various applications in the healthcare. In this study, we fine-tuned the expression of GNA1 and GlmS by 5'-terminus fusion engineering to improve GlcNAc production...
August 14, 2018: Biotechnology Journal
Shin-Ichiro Hiraga, Chandre Monerawela, Yuki Katou, Sophie Shaw, Kate Rm Clark, Katsuhiko Shirahige, Anne D Donaldson
Despite its evolutionarily conserved function in controlling DNA replication, the chromosomal binding sites of the budding yeast Rif1 protein are not well understood. Here, we analyse genome-wide binding of budding yeast Rif1 by chromatin immunoprecipitation, during G1 phase and in S phase with replication progressing normally or blocked by hydroxyurea. Rif1 associates strongly with telomeres through interaction with Rap1. By comparing genomic binding of wild-type Rif1 and truncated Rif1 lacking the Rap1-interaction domain, we identify hundreds of Rap1-dependent and Rap1-independent chromosome interaction sites...
August 13, 2018: EMBO Reports
Hanyeong Park, Minhee Lee, Kee-Tae Kim, Eunju Park, Hyun-Dong Paik
The purpose of this study was to evaluate the antioxidant and antigenotoxic effect of dairy products milk (M) and yogurt (Y) after the addition of 2% red ginseng extract to milk (RM) and to yogurt (RY). Total phenolic content, total flavonoid content, 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity, oxygen radical absorbance capacity, and total radical trapping antioxidant potential were determined in the samples. Furthermore, antigenotoxic effect of samples was measured, using comet assay in human leukocytes...
August 9, 2018: Journal of Dairy Science
Niko S Wasenius, Mika Simonen, Liisa Penttinen, Minna K Salonen, Samuel Sandboge, Johan G Eriksson
PURPOSE: Maternal obesity can unfavorably influence offspring body composition, muscle strength, and possibly muscle's adaptability to training, but the human studies are scarce. Therefore, we aimed to investigate the effect of maternal obesity on offspring muscle strength responses to resistance training intervention in elderly frail women. MATERIALS/METHODS: Recruited participants were elderly frail women offspring of lean/normal weight mothers (n = 19, mean body mass index (BMI): 22...
August 9, 2018: Advances in Medical Sciences
Allah Rakha, Yu Na Oh, Hwan Young Lee, Safdar Hussain, Ali Muhammad Waryah, Atif Adnan, Kyoung-Jin Shin
Rapidly mutating Y-STRs (RM Y-STRs) have been paid much attention in recent years. The 13 RM Y-STRs (DYF387S1, DYF399S1, DYF403S1a/b, DYF404S1, DYS449, DYS518, DYS526I/II, DYS547, DYS570, DYS576, DYS612, DYS626, and DYS627) have been proved to have substantially higher haplotype diversity and discrimination capacity than conventionally used Y-STRs indicating the considerable power in paternal lineage differentiation in endogamous populations, separation of which is usually impossible with standard Y-STRs. In current study, we analyzed the RM Y-STRs and PowerPlex® Y23 System in 216 male relatives from 18 deep rooted endogamous Sindhi families from Pakistan...
August 4, 2018: Legal Medicine
Julian Smazynski, John R Webb
Resident memory T cells (TRM ) are a recently identified subset of long-lived memory T cells that are characterized in terms of their unique surface phenotype combined with a non-recirculating pattern of localization to non-lymphoid, peripheral tissues. TRM have quickly become a key area of focus in understanding immune responses to microbial infection in so-called "barrier" tissues, and appear to be particularly critical for protection against repeat exposure at the same site. More recently, tumor-infiltrating T cells with canonical TRM features are being identified in human cancers, in particular cancers of epithelial origin, and their presence is broadly found to be associated with favorable long-term prognosis...
2018: Frontiers in Immunology
Caterina Di Bella, Luca Lacitignola, Salvatore Grasso, Paola Centonze, Antonella Greco, Rossella Ostuni, Antonio Crovace, Francesco Staffieri
OBJECTIVE: To evaluate the effects of an alveolar recruitment maneuver (ARM) followed by 5 cmH2 O positive end-expiratory pressure (PEEP) in dogs undergoing laparoscopy. STUDY DESIGN: Prospective, randomized clinical study. ANIMALS: A group of 20 dogs undergoing laparoscopic ovariectomy. METHODS: Dogs were sedated with acepromazine and methadone intramuscularly; anesthesia was induced with propofol intravenously and maintained with inhaled isoflurane...
April 16, 2018: Veterinary Anaesthesia and Analgesia
Jong-Chi Oh, Jae-Sung Kwon
OBJECTIVE: The effect of a resistive jaw-opening exercise using an elastic band on suprahyoid muscle activity and tongue strength was examined in healthy volunteers. METHODS: Twenty-one adults wore an elastic loop around their head and mandible. To prescribe the appropriate elastic band resistance, the 10-repetition maximum (10 RM) was measured among 4 bands at baseline. Band loops, starting with the highest resistance value band, were sequentially applied to determine the suitability for 10 RM...
August 8, 2018: Folia Phoniatrica et Logopaedica
Biljana Ilievska-Poposka, Maja Zakoska, Karolina Pilovska-Spasovska, Ljiljana Simonovska, Vladimir Mitreski
BACKGROUND: Tuberculosis (TB) is a major health problem in penitentiary institutions (prisons), and its prevalence was reported to be multiple times higher compared to that of the general population. Conditions such as overcrowding, malnutrition and limited access to medical care which often exist in prisons increase the risk of reactivation, transmission and poor prognosis of tuberculosis disease among inmates. AIM: The main objective of this study was to present the epidemiological situation of TB in the prisons from 2008 till 2017 in the Republic of Macedonia (RM)...
July 20, 2018: Open Access Macedonian Journal of Medical Sciences
Jesús Vera, Raimundo Jiménez, Beatríz Redondo, Alejandro Torrejón, Carlos Gustavo De Moraes, Amador García-Ramos
BACKGROUND: We aimed to evaluate the influence of the level of effort during four basic resistance exercises leading to muscular failure on intraocular pressure (IOP) and ocular perfusion (OPP), as well as the role of exercise type and sex. METHODS: Twenty-five young adults (12 women) performed 10 repetitions against their 10-RM (repetition maximum) load in the squat, military press, biceps curl and calf raise exercises. IOP was measured before, during and after exercise, whereas OPP was indirectly assessed before and after each exercise...
August 7, 2018: European Journal of Sport Science
Haim Shmuely, Baruch Brenner, David Groshar, Nir Hadari, Ofer Purim, Meital Nidam, Merab Eligalashvili, Jacob Yahav, Hanna Bernstine
BACKGROUND: Evidence has been emerging that Helicobacter pylori may also impact colorectal cancer (CRC). Positron emission tomography/computed tomography (PET/CT) imaging can predict overall survival in CRC patients. OBJECTIVES: To determine a possible association between H. pylori seropositivity and all-cause mortality among CRC patients evaluated by PET/CT scans. METHODS: This prospective cohort study was comprised of 110 consecutive CRC patients who had undergone a PET/CT evaluation in a tertiary academic medical center...
August 2018: Israel Medical Association Journal: IMAJ
Claudia S López-Reyes, Lilia N Baca-Velázquez, Miguel A Villasis-Keever, Jessie N Zurita-Cruz
Introducción: La sepsis en pediatría es la principal causa de muerte hospitalaria. Se han intentado crear herramientas que faciliten su identificación, como el índice de choque (IC), definido como el cociente entre frecuencia cardíaca y tensión arterial sistólica. El objetivo de este trabajo fue identificar el mejor momento del IC para predecir la mortalidad en pacientes pediátricos con sepsis grave y choque séptico. Métodos: Cohorte retrospectiva con 165 pacientes pediátricos que desarrollaron sepsis grave y choque séptico en la Unidad de Terapia Intensiva Pediatrica...
2018: Boletín Médico del Hospital Infantil de México
Juan C Lona-Reyes, Ana L Valdez-Núñez, Araceli Cordero-Zamora, Alejandro Rea-Rosas, Elba P Ascencio-Esparza, Luis G Orozco-Alatorre
Introducción: Las causas de meningoencefalitis, meningitis o encefalitis pueden ser infecciosas o no infecciosas. Para el diagnóstico microbiológico se requieren cultivos y pruebas moleculares. El objetivo del estudio fue describir las causas infecciosas de meningoencefalitis y su presentación clínica. Métodos: Estudio transversal realizado en el Hospital Civil de Guadalajara Dr. Juan I. Menchaca. Se incluyeron pacientes mayores de 28 días de vida con síndrome de meningitis, encefalitis o meningoencefalitis...
2018: Boletín Médico del Hospital Infantil de México
Fei Wan
The analysis of covariance (ANCOVA) or repeated measures (RM) models are often used to compare the treatment effect between different arms in pre-post randomized studies. ANCOVA adjusts the baseline score as a covariate in regression models. RM treats both the baseline and post-randomization scores as outcome variables. We aim to establish the underlying connections between ANCOVA and a constrained RM ("cRM"). We start with the interrelated concepts in a pre-post randomized designs: homogeneous vs...
August 7, 2018: Statistical Methods in Medical Research
Mohammad Hossein Nekoofar, Fariba Motevasselian, Mansoreh Mirzaei, Esmaeil Yassini, Hoda Pouyanfar, Paul Mh Dummer
Introduction: The type of materials and application time of veneering restorations on calcium silicate cements are important factors which influence the interfacial properties. The aim of this study was to measure the micro-shear bond strength of a resin composite (RC) using several adhesive systems and a resin-modified glass ionomer cement (RM-GIC) to different aged Biodentine specimens. Methods and Materials: A total of 15 Biodentine blocks were prepared and assigned to three aging periods: 12 min, one week and one month...
2018: Iranian Endodontic Journal
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