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Ashwaq AlE'ed, Pinar Ozge Avar Aydin, Nora Al Mutairi, Alhanouf AlSaleem, Hafize Emine Sonmez, Michael Henrickson, Jennifer L Huggins, Seza Ozen, Sulaiman M Al-Mayouf, Hermine I Brunner
Objective: To determine the measurement properties of the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) and the paediatric adaptation of the Skindex29 (pSkindex27) when used in childhood-onset SLE (cSLE). Methods: Patients with mucocutaneous involvement of cSLE were evaluated at the study entry and 6 months later. Besides the CLASI and pSkindex27, the Pediatric Quality of Life Inventory Generic Core scale (PedsQL-GC), its Rheumatology Module (PedsQL-RM), the SLE Disease Activity Index (SLEDAI) and the SLE Damage Index (SDI) were completed...
2018: Lupus Science & Medicine
Maribel Portilla, Michael Grodowitz
Life fertility tables were constructed for Phymastichus coffea LaSalle, the only known endoparasitoid wasp that attacks the adult female of the coffee berry borer (CBB) Hypothenemus hampei Ferrari. No preoviposition period was observed, and the parasitoid female attacked the CBB females immediately after emergence. The reproductive period was 20.33 (±0.87 SE) h and the postreproductive period of 14.78 (±0.99 SE) h. Mean generation time was 37 d. Median longevity for female and male fed on honey-water solution (50:50) was 35...
November 1, 2018: Journal of Insect Science
Elena Villafranca, Paola Navarrete, Amaya Sola, Juan Carlos Muruzabal, Sara Aguirre, Santiago Ostiz, Carmen Sanchez, Rosa Guarch, Nuria Lainez, Marta Barrado
Purpose: To evaluate dosimetric and clinical findings of MRI-guided HDR brachytherapy (HDR-B) for cervical carcinoma. Material and methods: All patients had a CT, MRI and pelvic-paraaortic lymphadenectomy. Treatment: pelvic (+/-)para-aortic3D/IMRT radiotherapy (45 Gy), weekly cisplatin and HDR-B and pelvic node/parametrial boost 60 Gy until interstitial brachytherapy was done. Two implants: 2008-2011: 5 fractions of 6 Gy, 2011: 2016, 4 fractions of 7 Gy. MRI/TAC were done in each implant...
November 2018: Reports of Practical Oncology and Radiotherapy
Anne-Claire Groo, Nada Matougui, Anita Umerska, Patrick Saulnier
Introduction: Resistance to traditional antibiotics is an increasingly serious problem. Antimicrobial peptides (AMPs) have emerged as a new therapeutic class with great potential against infectious diseases, as they are less prone to induce resistance. Nanotechnology-based delivery strategies can improve the efficiency and stability of AMPs, particularly against proteolytic degradation. Lipid nanocapsules (LNCs) are a new generation of biomimetic nanocarriers and were used in this study to deliver peptides...
2018: International Journal of Nanomedicine
Sarah C Wattie, R S Bridger
INTRODUCTION: UK Ministry of Defence (MOD) policy and strategy recommend the use of a 'Defence MODified' version of the Health and Safety Executive Management Standards Indicator Tool to help managers identify risks of work-related stress among Defence personnel. The Defence MODified Tool ('Stress Indicator Survey') asks personnel to rate their perceptions of eight working conditions known to be significantly associated with work-related stress. MOD psychologists are developing a Defence norm group against which future survey scores can be compared...
December 7, 2018: Journal of the Royal Army Medical Corps
I Álvarez-Manzaneda, F Guerrero, A I Del Arco, A Funes, L Cruz-Pizarro, I de Vicente
Magnetic microparticles (MPs) have been recently proposed as innovative and promising dissolved inorganic phosphorus (DIP) adsorbents. However, before using them in a whole-lake restoration project, it is essential to assess their toxicological effects (direct and indirect) on aquatic biota. In the present study we hypothesized that zooplankton community is affected by MPs used for lake restoration. To test our hypothesis we designed a microcosms experiment (n = 15) containing lake water and surface sediment from a hypertrophic lake...
November 28, 2018: Science of the Total Environment
Linette Lawlor-Savage, Cameron M Clark, Vina M Goghari
Attempts to determine the cognitive benefits of adaptive working memory training in healthy adults has resulted in a polarized and stagnating field. Heterogeneous approaches and problematic methodological choices have contributed to the controversy. Structural neuroimaging has the potential to identify biological changes present after working memory training, which could go undetected by cognitive outcome tasks. In this study, 24 healthy community dwelling adults aged 18 - 40 years underwent structural magnetic resonance neuroimaging (MRI) before and after completing a 6-week n-back working memory training program...
December 6, 2018: Behavioural Brain Research
Mukesh Kumar Awasthi, Hongyu Chen, Yumin Duan, Tao Liu, Sanjeev Kumar Awasthi, Quan Wang, Ashok Pandey, Zengqiang Zhang
The aim was to evaluate pathogenic bacteria (PB) survival during the composting of chicken manure (CM) amended with five different dosages of clay compared to CM without clay-applied treatment. The results showed that 85-87% of PB relative abundances (RAs) were significantly reduced in lower dosages of applied clay (T2 and T3). However, the maximum survival of PB was noticed in the T6 and T5 treatments, but most of the PB belong to Firmicutes, Actinobacteria and Proteobacteria phylum and their derivative bacterial species...
November 30, 2018: Journal of Hazardous Materials
Héctor Morillas, Maite Maguregui, Euler Gallego-Cartagena, Gladys Huallparimachi, Iker Marcaida, Isabel Salcedo, Luis F O Silva, Fernando Astete
Machu Picchu Inca sanctuary (Cusco Region, Peru) was constructed on a granitic plateau, better known as Vilcabamba batholith. One of the most important carved granitic rocks from this archaeological site is the Sacred Rock, used by Inca citizens for religious rituals. Due to the location and climatic conditions, different rocks from this archaeological site are affected by biocolonizations. Concretely, the Sacred Rock shows flaking and delamination problems. In this work, a non-destructive multi analytical methodology has been applied to determine the possible role of the biodeteriogens, forming the biological patina on the Sacred Rock, in the previously mentioned conservation problems...
November 22, 2018: Science of the Total Environment
Rumit Singh Kakar, Hilary B Greenberger, Patrick O McKeon
CONTEXT: Anterior knee pain also known as patellofemoral pain syndrome (PFPS) is a frequently encountered musculoskeletal disorder that worsens with activity. The multifactorial etiology of PFPS alters lower extremity mechanics, increasing patellofemoral joint stresses during weight-bearing tasks. Kinesio (KT) and McConnell (MC) tapings are often incorporated into the treatment, but their efficacy is still unclear. OBJECTIVES: To test the efficacy of KT, MC and sham taping (ST) in improving knee mechanics and reducing pain during activity...
December 11, 2018: Journal of Sport Rehabilitation
Scott W Cheatham, Kyle R Stull
CONTEXT: Roller massage (RM) is a popular myofascial intervention. To date, no research has investigated the effects of RM on experienced and non-experienced individuals and if there are difference between a prescribed RM program and a self-preferred program. OBJECTIVE: The main objective was to measure the effects of a prescribed RM program with a foam roller on knee passive range of motion (PROM) and pressure pain threshold (PPT) among experienced and non-experienced individuals...
December 11, 2018: Journal of Sport Rehabilitation
K Jacob Blackshaw, Meredith G Varmecky, Joshua David Patterson
The interfacial properties of NO3- were investigated using reverse micelles (RMs) in solution as proxies for sea spray aerosol (SSA) particles. By tuning the size of Bis(2-ethylhexyl) sulfosuccinate sodium salt (AOT) RMs doped with NO3- we are able to isolate the vibrational signature of interfacial NO3- using infrared spectroscopy. The infrared spectrum of interfacial NO3- along the asymmetric-stretch coordinate (υ_3) is blue-shifted and possesses smaller peak splitting relative to NO3- in aqueous solution...
December 7, 2018: Journal of Physical Chemistry. A
Marcelo Conrado de Freitas, Fabricio Eduardo Rossi, Lucas Antônio Colognesi, João Vitor N S de Oliveira, Nelo Eidy Zanchi, Fabio Santos Lira, Jason M Cholewa, Luís Alberto Gobbo
Conrado de Freitas, M, Rossi, FE, Colognesi, LA, de Oliveira, JVNS, Zanchi, NE, Lira, FS, Cholewa, JM, and Gobbo, LA. Postactivation potentiation improves acute resistance exercise performance and muscular force in trained men. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to investigate the effects of heavy back squat (90% one repetition maximum [1RM]) postactivation potentiation (PAP) on acute resistance exercise performance and force production in recreationally trained men, and to verify the relationship between maximal strength and the PAP response...
November 29, 2018: Journal of Strength and Conditioning Research
João Pedro Nunes, Alex S Ribeiro, Analiza M Silva, Brad J Schoenfeld, Leandro Dos Santos, Paolo M Cunha, Matheus A Nascimento, Crisieli M Tomeleri, Hellen C G Nabuco, Melissa Antunes, Letícia T Cyrino, Edilson S Cyrino
The aim of this study was to analyze the association between muscle quality index (MQI) and phase angle (PhA) after a program of progressive resistance training (RT) in older women. Sixty-six older women with previous RT experience (68.8 ± 4.6 years, 156.6 ± 5.3 cm, 66.0 ± 13.0 kg, 26.7 ± 4.6 kg/m²) underwent 12 weeks of RT (3 x/week, 8 exercises, 10-15 RM). Anthropometry, muscular strength (1RM tests), and body composition (DXA and spectral bioimpedance) were measured pre- and post-training. There were observed significant increase was observed for PhA, MQI, muscular strength, muscle mass, and reactance whereas no significant changes in body fat and resistance were found...
December 3, 2018: Journal of Aging and Physical Activity
Pranav Lakshminarayanan, Wei Jiang, Scott P Robertson, Zhi Cheng, Peijin Han, Michael Bowers, Joseph A Moore, Ilya Shpitser, Sauleh A Siddiqui, Harry Quon, Russ Taylor, Todd McNutt
PURPOSE: In radiotherapy, it is necessary to characterize dose over the patient anatomy to target areas and organs at risk. Current tools provide methods to describe dose in terms of percentage of volume and magnitude of dose, but are limited by assumptions of anatomical homogeneity within a region of interest (ROI) and provide a non-spatially aware description of dose. A practice termed radio-morphology is proposed as a method to apply anatomical knowledge to parametrically derive new shapes and substructures from a normalized set of anatomy, ensuring consistently identifiable spatially-aware features of the dose across a patient set...
December 3, 2018: Medical Physics
Akinori Kaneguchi, Junya Ozawa, Kengo Minamimoto, Kaoru Yamaoka
We investigated whether the combination of exercise and anti-inflammatory/anti-fibrotic treatment using low-level laser therapy (LLLT) promotes recovery from joint contracture without arthrogenic contracture progression. Rat knees were immobilized for 3 weeks in a flexed position. After fixator removal, rats were divided into no intervention (RM), daily treadmill walking (WALK), and daily treadmill walking and LLLT (W + L) groups. Total and arthrogenic contractures were assessed by restrictions of passive range of motion (ROM) before (m-ROM) and after myotomy (a-ROM), respectively...
December 1, 2018: Inflammation
Philip O'Hagan, Juergen Dederichs, Boomi Viswanad, Matthias Gasser, Susann Walda
Background: Good compliance in chronic obstructive pulmonary disease (COPD) is of 'paramount importance' in reducing the occurrence of acute exacerbations, hospitalisation and mortality and in improving quality of life. However, a number of studies have confirmed that long-term compliance is low and often associated with difficulties in handling maintenance inhalers. Therefore, the easier an inhaler is to use, the more likely the patient will comply with handling instructions and so, optimise control of the condition...
October 2018: Journal of Thoracic Disease
Vincenzo Russo, Anna Rago, Vincenzo Tavoletta, Valter Bianchi, Cristina Carella, Giuseppe Ammirati, Aniello Viggiano, Stefano De Vivo, Antonio Rapacciuolo, Gerardo Nigro, Antonio D'Onofrio
Background: Remote Monitoring (RM) has been introduced for several years and nowadays most pacemakers are equipped with such a technology. RM can provide early detection of high atrial rate episodes (AHREs) onset and enable prompt medical intervention. However, there are still little data on the clinical reactions triggered by the AHRE detected by RM of pacemaker recipients and on their possible benefit on patients' outcome. Methods/Design: The RAPID study is a multicenter, prospective, non-interventional study designed to compare the time from onset to first physician's evaluation of AHRE episode with arrhythmic burden ≥5% (72 minutes) for pacemaker recipients without atrial fibrillation history, between patients followed with RM or conventionally with annual in-hospital visits...
August 2018: Journal of Atrial Fibrillation
Lianhua Dong, Shangjun Wang, Boqiang Fu, Jing Wang
KRAS gene mutations are predictive markers of non-response to anti-epidermal growth factor receptor. An increasing number of techniques are being developed to detect KRAS mutations. To obtain consistent and comparable results, a traceable reference material (RM) is necessary for validation the routinely used method. However, a lack of reference methods is a main impediment for deriving traceability and measurement comparability. In this study, droplet digital PCR (ddPCR) and next generation sequencing (NGS) were evaluated...
November 30, 2018: Scientific Reports
Liangke Gou, Joshua S Bloom, Leonid Kruglyak
Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis of these differences. Here we leveraged the power of the yeast Saccharomyces cerevisiae as a model system to uncover natural genetic variants that underlie variation in mutation rate. We developed a high-throughput fluctuation assay and used it to quantify mutation rates in 7 natural yeast isolates and in 1040 segregant progeny from a cross between BY, a lab strain, and RM, a wine strain...
November 30, 2018: Genetics
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