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https://www.readbyqxmd.com/read/30061288/-in-vitro-activity-of-isavuconazole-against-opportunistic-fungal-pathogens-from-two-mycology-reference-laboratories
#1
Michael A Pfaller, Paul R Rhomberg, Nathan P Wiederhold, Connie Gibas, Carmita Sanders, Hongxin Fan, James Mele, Laura L Kovanda, Mariana Castanheira
Monitoring antifungal susceptibility patterns for new and established antifungal agents seems prudent given the increasing prevalence of uncommon species associated with higher antifungal resistance. We evaluated the activity of isavuconazole against 4,856 invasive yeasts and molds collected worldwide. The 4,856 clinical fungal isolates, including 2,351 Candida species isolates, 97 non- Candida yeasts, 1,972 Aspergillus species isolates, and 361 non- Aspergillus molds, including 292 Mucorales isolates collected in 2015 to 2016, were tested using CLSI methods...
October 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29960631/ejaculatory-disorders-in-men-with-urethral-stricture-and-impact-of-urethroplasty-on-the-ejaculatory-function-a-systematic-review
#2
Adam Kaluzny, Artur Gibas, Marcin Matuszewski
BACKGROUND: Urethral stricture may disturb both micturition and semen emission. Urethroplasty, despite the restoration of a proper urethral patency, may not eliminate the accompanying ejaculatory dysfunction (EjD). AIM: To investigate the relationship among urethral stricture, urethroplasty, and ejaculatory function. METHODS: For the systematic review, the authors followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement...
July 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29934879/invasive-rhinosinusitis-caused-by-lasiodiplodia-theobromae-in-an-allogeneic-hematopoietic-cell-transplant-recipient-case-report-and-review-of-literature
#3
Anamaria Rodriguez, Shweta Anjan, Octavio V Martinez, Lazaros J Lekakis, Amer Beitinjaneh, Jose F Camargo, Connie F C Gibas, Carmita J Sanders, Nathan P Wiederhold, Lilian M Abbo
Lasiodiplodia theobromae is a known plant pathogen in tropical and subtropical areas. Few cases have been reported in humans (usually keratitis and endophthalmitis) with only two cases of fungal sinusitis in immunocompromised and immunocompetent patients published to date. We report a case of invasive sinusitis secondary to L. theobromae in an allogeneic hematopoietic cell transplant recipient successfully treated with surgical debridement and triazole antifungals with a review of available literature.
June 22, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29786448/serum-rbp4-positively-correlates-with-triglyceride-level-but-not-with-bmi-fat-mass-and-insulin-resistance-in-healthy-obese-and-non-obese-individuals
#4
Emilia Korek, Magdalena Gibas-Dorna, Zuzanna Chęcińska-Maciejewska, Hanna Krauss, Małgorzata Łagiedo-Żelazowska, Barbara Kołodziejczak, Paweł Bogdański
PURPOSE: Retinol binding protein 4 (RBP4) has recently been identified as an adipokine possibly involved in the development of impaired glucose metabolism. We aimed to test serum RBP4 in healthy non-obese individuals and in patients with well-characterized phenotype: obesity without confounding effects of diabetes, metabolic syndrome or dyslipidaemia. Additionally, we examined whether serum RBP4 is associated with anthropometric parameters, insulin resistance and blood lipid parameters...
June 20, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29748034/ampk-induced-memory-improvements-in-the-diabetic-population-a-case-study
#5
Alicia Halikas, Kelly J Gibas
Diabetics in mid-life carry a 1.5 times higher risk of developing Alzheimer's disease than those diagnosed with diabetes (T2D) later in life [1]. Recent research points to accelerated cognitive decline within a range of 20%-50% for middle-aged diabetics as compared to non-diabetic populations [2,3]. Metabolic syndrome (MetS), a type 2 diabetes (T2D) precursor, is also linked to MCI and AD pathologies via hypo-metabolic brain circuitry that inhibits glucose metabolism and attenuates cognitive function [4]. Dysregulation of intracellular and extracellular signaling as mediated by the mTOR and AMPK pathways is the result...
November 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29706312/metabolic-syndrome-marks-early-risk-for-cognitive-decline-with-apoe4-gene-variation-a-case-study
#6
Dawson Brown, Kelly J Gibas
A vast amount of research has been done on the APOE4 genetic marker for Alzheimer's disease (AD), but its connection to metabolic processes associated with peripheral insulin resistance and cerebral glucose metabolism is still relatively unknown. The APOE4 allele is the strongest genetic risk factor for developing late-onset Alzheimer's disease, particularly in individuals who have inherited two copies of the gene (Zhao et al., 2017). In this case study, a 38 year old male with metabolic syndrome (MetS), the APOE4 gene, early stage memory problems and a family history of Alzheimer's Disease (AD) was placed on a ketogenic diet combined with high intensity interval training (HIIT) for 10 weeks...
September 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678606/ketogenic-diet-high-intensity-interval-training-hiit-and-memory-training-in-the-treatment-of-mild-cognitive-impairment-a-case-study
#7
Kaitlyn Dahlgren, Kelly J Gibas
Alzheimer's disease (AD) deaths have increased by 89% since 2000. This alarming trajectory of neurological disease highlights the failure of current best practice. Deteriorating brain fuel supply is the nemesis of intact neurological health. Cerebral hypo-metabolism associated with AD occurs years before onset. Both the ketogenic diet and calorie restriction (fasting) lead to a compensatory rise in ketones to improve energy deficits in the brain derived from cerebral insulin resistance. Two forms of ketone bodies, β-hydroxybutyrate and acetoacetate, fuel the brain during starvation, fasting and strenuous exercise...
September 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29550801/gender-related-effect-of-cold-water-swimming-on-the-seasonal-changes-in-lipid-profile-apob-apoa-i-ratio-and-homocysteine-concentration-in-cold-water-swimmers
#8
Z Checinska-Maciejewska, E Miller-Kasprzak, A Checinska, E Korek, M Gibas-Dorna, A Adamczak-Ratajczak, P Bogdanski, H Krauss
It has been proposed that regular cold swimming is associated with health benefits. However, the effect of cold adaptation on particular cardiovascular risk factors, within a single swimming season, remains unknown. Our aim was to evaluate the impact of cold water swimming on the seasonal changes in lipid profile and on apolipoprotein and homocysteine concentration in 34 cold water swimmers (CWS) aged 48 - 68 years. Blood samples were collected at the beginning (October), the middle (January), and the end (April) of the swimming season...
December 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29384171/cyclic-trimers-of-phosphinic-acids-in-polar-aprotic-solvent-symmetry-chirality-and-h-d-isotope-effects-on-nmr-chemical-shifts
#9
V V Mulloyarova, I S Giba, M A Kostin, G S Denisov, I G Shenderovich, P M Tolstoy
The hydrogen-bonded self-associates of dimethylphosphinic (1), diphenylphosphoric (2), phenylphosphinic (3), and bis(2,4,4-trimethylpentyl)phosphinic (4) acids have been studied by using liquid-state NMR down to 100 K in a low-freezing polar solvent, CDF3 /CDClF2 . The H/D isotope effects on 1 H NMR chemical shifts caused by partial deuteration of hydroxyl groups unambiguously reveal the stoichiometry of the self-associates and the cooperativity of their hydrogen bonds. In all cases, cyclic trimers are the dominant form, while cyclic dimers are present as a minor form for 1 and 2...
February 14, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29372393/approach-to-the-diagnostic-workup-and-management-of-small-bowel-lesions-at-a-tertiary-care-center
#10
Jonathan Green, Christopher R Schlieve, Ann K Friedrich, Kevin Baratta, David H Ma, May Min, Krunal Patel, David Stein, David R Cave, Demetrius E Litwin, Mitchell A Cahan
BACKGROUND: Small bowel lesions (SBL) are rare, representing diagnostic and management challenges. The purpose of this cross-sectional study was to evaluate diagnostic modalities used and management practices of patients with SBL at an advanced endoscopic referral center. METHODS: We analyzed patients undergoing surgical management for SBL from 2005 to 2015 at a single tertiary care center. Patients were stratified into gastrointestinal bleed/anemia (GIBA) or obstruction/pain (OP)...
June 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29182524/long-term-proton-pump-inhibitor-therapy-leads-to-small-bowel-bacterial-overgrowth-as-determined-by-breath-hydrogen-and-methane-excretion
#11
Agnieszka Sieczkowska, Piotr Landowski, Artur Gibas, Barbara Kamińska, Carlos Lifschitz
OBJECTIVES: Prolonged suppression of gastric acid secretion by proton pump inhibitors (PPIs) may alter the bacterial microbiota of the upper gastrointestinal tract and lead to small bowel bacterial overgrowth (SBBO). Published reports have shown conflicting results on the association between PPI therapy and risk of SBBO development. We evaluated whether long-term PPI treatment is associated with presence of SBBO as determined by breath hydrogen (H2 ) and methane (CH4 ) excretion. We also assessed the differences in H2 /CH4 excretion patterns in patients taking PPI compared with those not taking the medication and searched for the potential predictors of a positive breath test result...
March 12, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29151070/circadian-rhythms-of-melatonin-and-cortisol-in-manifest-huntington-s-disease-and-in-acute-cortical-ischemic-stroke
#12
A Adamczak-Ratajczak, J Kupsz, M Owecki, D Zielonka, A Sowinska, Z Checinska-Maciejewska, H Krauss, S Michalak, M Gibas-Dorna
Recent studies indicate disruptions to the circadian system in brain injury and neurodegeneration. The results, however, are often not consistent and limited by measurement of only one circadian marker and by infrequent sampling rates. In this study, we examined diurnal rhythmicity in different stages of Huntington (HD) disease and in patients with acute moderate ischemic stroke (AIS) outside the retinohypothalamic pathway by evaluating serum concentrations of melatonin and cortisol at twelve timepoints. All study participants were subjected to the same study protocol of 12-hour light/dark cycle and controlled room conditions...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29142047/multicenter-evaluation-of-the-vitek-ms-v3-0-system-for-the-identification-of-filamentous-fungi
#13
Jenna Rychert, E Sue Slechta, Adam P Barker, Edwin Miranda, N Esther Babady, Yi-Wei Tang, Connie Gibas, Nathan Wiederhold, DeAnna Sutton, Kimberly E Hanson
Invasive fungal infections are an important cause of morbidity and mortality affecting primarily immunocompromised patients. While fungal identification to the species level is critical to providing appropriate therapy, it can be slow and laborious and often relies on subjective morphological criteria. The use of matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry has the potential to speed up and improve the accuracy of identification. In this multicenter study, we evaluated the accuracy of the Vitek MS v3...
February 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29077568/current-therapeutic-strategies-in-treating-obesity-in-children-and-adolescents-review-of-the-literature
#14
Agnieszka Zachurzok, Anna Springwald, Piotr Gibała, Paweł Matusik
The present paper is a review of current knowledge concerning the most appropriate strategy in the conservative therapy of obese children and adolescents. It presents an account of the combined mode of therapy consisting of behavioral and dietary counseling with appropriate physical activity (also using the support of modern media and devices). The rise in obesity is usually a long-lasting process involving genetic predispositions but also environmental factors which can be modified. The treatment of obesity should be focused on these modified factors and be a lifelong treatment, not merely a short period of exercise or a diet program...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28899812/the-starving-brain-overfed-meets-undernourished-in-the-pathology-of-mild-cognitive-impairment-mci-and-alzheimer-s-disease-ad
#15
REVIEW
Kelly J Gibas
Type II Diabetes affects 400 million people worldwide (IDF, 2013). The pathology is paradoxical: internal starvation activated by overfeeding. Hyperinsulinemic impairments of glucose homeostasis are treated with anti-hyperglycemics exacerbating cell starvation, inducing hypoglycemia and raising respiratory quotient. Reductions in hyperglycemia are achieved at the expense of glucose dependency and metabolic inflexibility (Gibas & Gibas, 2017). The brain is not immune from these cycles of starvation. The bioenergetic model characterizes propagation of late-onset, sporadic Alzheimer's disease as loss of molecular fidelity and compromised energy originating in brain networks with highest metabolic demand...
November 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28820536/atp7a-and-atp7b-regulate-copper-homeostasis-in-developing-male-germ-cells-in-mice
#16
Mateusz Ogórek, Małgorzata Lenartowicz, Rafał Starzyński, Aneta Jończy, Robert Staroń, Andrzej Doniec, Wojciech Krzeptowski, Aleksandra Bednarz, Olga Pierzchała, Paweł Lipiński, Zenon Rajfur, Zbigniew Baster, Patrycja Gibas-Tybur, Paweł Grzmil
The maintenance of copper homeostasis is critical for all cells. As learned from mice with disturbed copper metabolism, this trace element is also important for spermatogenesis. The experiments conducted in yeasts have demonstrated that appropriate copper level must be preserved to enable meiosis progression; however, increased copper level is toxic for cells. This study aims to analyze the expression profile of Atp7a and Atp7b and other genes encoding copper-related proteins during spermatogenesis in mice...
September 20, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28793740/prediction-of-the-chloride-resistance-of-concrete-modified-with-high-calcium-fly-ash-using-machine-learning
#17
Michał Marks, Michał A Glinicki, Karolina Gibas
The aim of the study was to generate rules for the prediction of the chloride resistance of concrete modified with high calcium fly ash using machine learning methods. The rapid chloride permeability test, according to the Nordtest Method Build 492, was used for determining the chloride ions' penetration in concrete containing high calcium fly ash (HCFA) for partial replacement of Portland cement. The results of the performed tests were used as the training set to generate rules describing the relation between material composition and the chloride resistance...
December 11, 2015: Materials
https://www.readbyqxmd.com/read/28788224/new-methods-of-enhancing-the-thermal-durability-of-silica-optical-fibers
#18
Karol Wysokiński, Tomasz Stańczyk, Katarzyna Gibała, Tadeusz Tenderenda, Anna Ziołowicz, Mateusz Słowikowski, Małgorzata Broczkowska, Tomasz Nasiłowski
Microstructured optical fibers can be precisely tailored for many different applications, out of which sensing has been found to be particularly interesting. However, placing silica optical fiber sensors in harsh environments results in their quick destruction as a result of the hydrolysis process. In this paper, the degradation mechanism of bare and metal-coated optical fibers at high temperatures under longitudinal strain has been determined by detailed analysis of the thermal behavior of silica and metals, like copper and nickel...
October 13, 2014: Materials
https://www.readbyqxmd.com/read/28787821/influence-of-blended-cements-with-calcareous-fly-ash-on-chloride-ion-migration-and-carbonation-resistance-of-concrete-for-durable-structures
#19
Michał A Glinicki, Daria Jóźwiak-Niedźwiedzka, Karolina Gibas, Mariusz Dąbrowski
The objective of this paper is to examine the possible use of new blended cements containing calcareous fly ash in structural concrete, potentially adequate for structural elements of nuclear power plants. The investigation included five new cements made with different contents of non-clinker constituents: calcareous fly ash, siliceous fly ash, ground granulated blastfurnace slag, and a reference cement-ordinary Portland cement. The influence of innovative cements on the resistance of concrete to chloride and carbonation exposure was studied...
January 2, 2016: Materials
https://www.readbyqxmd.com/read/28766404/drug-eluting-biopsy-needle-as-a-novel-strategy-for-antimicrobial-prophylaxis-in-transrectal-prostate-biopsy
#20
Marcin Sieczkowski, Artur Gibas, Andrzej Wasik, Agata Kot-Wasik, Lidia Piechowicz, Jacek Namieśnik, Marcin Matuszewski
OBJECTIVES: To preclinically evaluate drug-eluting biopsy needles (patent pending WO2016118026) as a new potential way of antimicrobial prophylaxis for transrectal prostate biopsy. METHODS: Twenty steel biopsy needles have been coated with polyvinyl alcohol, ciprofloxacin, and amikacin. Modified biopsy needles have been randomly divided into 3 groups (1:2:1 ratio). Needles from group I were immersed for 30 minutes in dedicated test tubes containing saline. Needles from group II were immersed (one by one) for 5 seconds in a set of 12 test tubes containing saline...
January 1, 2017: Technology in Cancer Research & Treatment
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