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bipolar AND disorder

Joannes W Renes, Eline J Regeer, Adriaan W Hoogendoorn, Willem A Nolen, Ralph W Kupka
BACKGROUND: Most previous studies on concordance with treatment guidelines for bipolar disorder focused on pharmacotherapy. Few studies have included other treatment modalities. AIMS: To study concordance with the Dutch guideline of various treatment modalities in outpatient treatment settings for patients with bipolar disorder and to identity factors associated with concordance. METHODS: A nationwide non-interventional study using psychiatrists' and patients' surveys...
October 20, 2018: International Journal of Bipolar Disorders
Siri Ranlund, Maria Joao Rosa, Simone de Jong, James H Cole, Marinos Kyriakopoulos, Cynthia H Y Fu, Mitul A Mehta, Danai Dima
Psychiatric illnesses are complex and polygenic. They are associated with widespread alterations in the brain, which are partly influenced by genetic factors. There have been some attempts to relate polygenic risk scores (PRS) - a measure of the overall genetic risk an individual carries for a disorder - to brain structure using univariate methods. However, PRS are likely associated with distributed and covarying effects across the brain. We therefore used multivariate machine learning in this proof-of-principle study to investigate associations between brain structure and PRS for four psychiatric disorders; attention deficit-hyperactivity disorder (ADHD), autism, bipolar disorder and schizophrenia...
October 9, 2018: NeuroImage: Clinical
Jaimee L Heffner, Kristin E Mull, Noreen L Watson, Jennifer B McClure, Jonathan B Bricker
BACKGROUND: The extent to which smokers with bipolar disorder (BD) differ from other smokers on cessation-related characteristics and outcomes is unknown and could improve knowledge of treatment needs for this group. These analyses compared smokers with BD versus smokers with other affective disorders (ADs; anxiety and unipolar depression) and smokers with no mental health conditions (MHCs). METHOD: Participants (n = 2570) were a subsample of those enrolled in a smoking cessation trial comparing two web-delivered intervention approaches: acceptance and commitment therapy (ACT) and cognitive behavioral therapy...
October 10, 2018: Drug and Alcohol Dependence
Ivy Lee, Kathryn Nielsen, Mei-Hua Hall, Dost Öngür, Matcheri Keshavan, Jr Roscoe Brady
BACKGROUND: Neuroimaging of psychiatric disease is challenged by the difficulty of establishing the causal role of neuroimaging abnormalities. Lesions that cause mania present a unique opportunity to understand how brain network disruption may cause mania in both lesions and in bipolar disorder. METHODS: A literature search revealed 23 case reports with imaged lesions that caused mania in patients without history of bipolar disorder. We traced these lesions and examined resting-state functional Magnetic Resonance Imaging (rsfMRI) connectivity to these lesions and control lesions to find networks that would be disrupted specifically by mania-causing lesions...
October 10, 2018: Journal of Affective Disorders
Alexandre Paim Diaz, Connie Svob, Ruixin Zhao, Baxter DiFabrizio, Virginia Warner, Marc J Gameroff, Jamie Skipper, Jay Gingrich, Jonathan Posner, Priya J Wickramaratne, Myrna M Weissman, Ardesheer Talati
BACKGROUND: Longitudinal studies of children with disruptive disorders (DDs) have shown high rates of antisocial personality disorder (ASPD) and substance use in adulthood, but few have examined the contribution of parental disorders. We examine child-/adulthood outcomes of DDs in offspring, whose biological parents did not have a history of ASPD, bipolar disorder, or substance use disorders. METHOD: Offspring (N = 267) of parents with or without major depression (MDD), but no ASPD or bipolar disorders were followed longitudinally over 33 years, and associations between DDs and psychiatric and functional outcomes were tested...
October 10, 2018: Journal of Affective Disorders
Yan Zhao, Xiao Liang, Feng Zhu, Yan Wen, Jiawen Xu, Jian Yang, Miao Ding, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Xiong Guo, Feng Zhang
Attention deficit hyperactivity disorder (ADHD), bipolar disorder (BP) and schizophrenia (SCZ) are complex psychiatric disorders. We conducted a large-scale integrative analysis of genome-wide association studies (GWAS) and life course consistent methylation quantitative trait loci (meQTLs) datasets. The GWAS data of ADHD (including 20,183 cases and 35,191 controls), BP (including 7,481 cases and 9,250 controls) and SCZ (including 36,989 cases and 113,075 controls) were derived from published GWAS. Life course consistent meQTLs dataset was obtained from a longitudinal meQTLs analysis of 1,018 mother-child pairs...
October 16, 2018: Neuroscience and Biobehavioral Reviews
Tanya Wright, Suzanne Stevens, Trecia A Wouldes
Research on Mother-Baby Units (MBUs) has mainly focused on maternal psychiatric outcomes, not the well-being of infants. This study investigated infant development and mental health along with maternal characteristics and the mother-infant relationship in 45 dyads (60% New Zealand European, 20% Māori, 11% Pacific) admitted to a new MBU. Maternal psychopathology was measured with the Health of the Nations Outcome Scale (HoNOS, J.K Wing et al., ) and Global Assessment of Functioning (GAF; I.M. Aas, ). The Parent-Infant Relationship Global Assessment Scale (PIR-GAS, Zero to Three, ) measured the mother-infant relationship...
October 19, 2018: Infant Mental Health Journal
Jan Scott, Greg Murray
The DSM-5 definition of bipolar disorder elevates increased activity or energy as a cardinal symptom (alongside mood changes) for mania and hypomania ('hypo/mania'). The ICD-10 likewise requires increases in activity and energy (alongside mood) for hypo/mania, as well as decreases for bipolar depression. Using bipolar disorder as an example, we propose that, when diagnostic criteria are revised, instruments used to measure clinical course and treatment response may need revisiting. Here, we highlight that the 'gold-standard' symptom rating scales for hypo/mania and depression were developed in an era when abnormalities of mood were viewed as the cardinal symptom of bipolar disorder...
November 2018: British Journal of Psychiatry: the Journal of Mental Science
Francisco J Zamora-Rodríguez, María R Sánchez-Waisen-Hernández, Juan A Guisado-Macías, Francisco J Vaz-Leal
INTRODUCTION: Patients with bipolar disorder (BD) have a comorbid substance use with high frequency. Our study aims to establish a relationship between substance use and BD, in terms of greater diagnostic difficulty, a worse prognosis and changes in pharmacological prescription. METHODS: The sample consisted of 394 subjects over twenty years were hospitalized with a diagnosis of BD in acute psychiatry unit of a general hospital (10.6% of total of 3,704 patients)...
September 2018: Actas Españolas de Psiquiatría
S Rafiq, C Campodonico, F Varese
OBJECTIVE: Several studies have observed that dissociative experiences are frequently reported by individuals with severe mental illness (SMI), especially amongst patients that report a history of adverse/traumatic life experiences. This review examined the magnitude and consistency of the relationship between childhood adversity (sexual abuse, physical abuse, emotional abuse, neglect, bullying, natural disasters and mass violence) and dissociation across three SMI diagnostic groups: schizophrenia, bipolar disorder and personality disorders...
October 18, 2018: Acta Psychiatrica Scandinavica
Simona Scheggi, Teresa Pelliccia, Alessandro Cuomo, Maria Graziella De Montis, Carla Gambarana
Background: The antiepileptic lamotrigine is approved for maintenance treatment of bipolar disorder and augmentation therapy in treatment-resistant depression. Previous preclinical investigations showed lamotrigine antidepressant-like effects without addressing its possible activity on motivational aspects of anhedonia, a symptom clinically associated with poor treatment response and with blunted mesolimbic dopaminergic responsiveness to salient stimuli in preclinical models. Thus, in rats expressing a depressive-like phenotype we studied whether repeated lamotrigine administration restored behavioral responses to aversive and positive stimuli and the dopaminergic response to sucrose in the nucleus accumbens shell (NAcS), all disrupted by stress exposure...
October 2018: Heliyon
Ester Lopez-Fernandez, Brisa Sole, Esther Jimenez, Estela Salagre, Anna Gimenez, Andrea Murru, Caterina Del Mar Bonnín, Benedikt Lorenz Amann, Iria Grande, Eduard Vieta, Anabel Martínez-Aran
Background: Patients with schizoaffective disorder (SAD) suffer from cognitive impairment, which negatively influences their functionality. Cognitive remediation (CR) interventions have been shown to be effective in patients with schizophrenia (SZ) and bipolar disorder (BD), but evidence in SAD is limited so far. The aim of this study is to systematically review the published data on CR interventions, either in neurocognition or social cognition, in patients with SAD. Methods: We conducted a comprehensive, computerized literature search using terms related to CR interventions in psychotic and affective disorders, and particularly in SAD...
2018: Frontiers in Psychiatry
Eun Jin Kim, Yong-Chun Bahk, Hyeonju Oh, Won-Hye Lee, Jong-Sun Lee, Kee-Hong Choi
Cognition is an important factor that affects daily functioning and quality of life. Impairment in cognitive function is a common symptom present in various psychological disorders, which hinders patients from functioning normally. Given that cognitive impairment has devastating effects, enhancing this in patients should lead to improvements in compromised quality of life and functioning, including vocational functioning. Over the past 50 years, several attempts have been made to improve impaired cognition, and empirical evidence for cognitive remediation (CR) has accumulated that supports its efficacy for treating schizophrenia...
2018: Frontiers in Psychiatry
Ewa Ferensztajn-Rochowiak, Mariusz Kaczmarek, Marlena Wójcicka, Elzbieta Kaufman-Szukalska, Sebastian Dziuda, Agnieszka Remlinger-Molenda, Agnieszka Szeliga-Neymann, Jacek Losy, Janusz K Rybakowski
AIMS: The aim of this study was to evaluate serum levels of the antineuronal antibodies anti-N-methyl-D-aspartate receptor (NMDAR) and anti-glutamic acid decarboxylase (GAD), and insulin-like growth factor 1 (IGF-1), in patients with bipolar disorder (BD), during manic and depressive episodes and in remission compared to euthymic patients receiving long-term lithium therapy. METHODS: Serum levels of anti-NMDAR and anti-GAD 450/620 antibodies, as well as IGF-1, were measured using the ELISA method in 19 manic and 17 depressed patients both in an acute episode and in remission after the episode...
October 18, 2018: Neuropsychobiology
Hélène Richard-Lepouriel, Anne-Lise Kung, Roland Hasler, Frank Bellivier, Paco Prada, Sébastien Gard, Stefano Ardu, Jean-Pierre Kahn, Alexandre Dayer, Chantal Henry, Jean-Michel Aubry, Marion Leboyer, Nader Perroud, Bruno Etain
BACKGROUND: Impulsivity is a core feature of the attention-deficit/hyperactivity disorder (ADHD) and is one of the DSM-V diagnostic criteria for borderline personality disorder (BPD). Impulsivity is also present in bipolar disorder (BD). Impulsivity has been linked to adverse behavior (suicidality,…) and to traumatic childhood experiences. Our study explored impulsivity in BPD, BD, ADHD and healthy controls (CTRL) and investigated the impact of early trauma on impulsivity. METHODS: 744 patients with BD (n = 276), BPD (n = 168), ADHD (n = 173) or a combination (BPD_BD, n = 29; BPD_ADHD, n = 94, BD_BPD_ADHD n = 13) and 47 controls were included...
August 6, 2018: Journal of Affective Disorders
Zhen Liu, Rui Li, Cheng Jiang, Sha Zhao, Weishan Li, Xiaobo Tang
To the clinical cognitive impairment following intracerebral hemorrhage, comprehensive neuropsychological assessments and efficacious interventions have rarely been conducted. Lithium chloride, a classical treatment for bipolar disorder, has shown neuroprotective effects through glycogen synthase kinase-3β inhibition in a variety of central nervous system diseases, including stroke. Since neurons that contain glutamate play crucial roles in psychological functions, such as learning and memory, the glutamate-mediated excitotoxicity and consequent neuronal death and cognitive impairment in hippocampus may co-determine the clinical course of intracerebral hemorrhage...
October 15, 2018: European Journal of Pharmacology
Femke Lamers, Joel Swendsen, Lihong Cui, Mathilde Husky, Jordan Johns, Vadim Zipunnikov, Kathleen R Merikangas
The application of ecological momentary assessment (EMA) in community settings provides a powerful opportunity to obtain measures of emotional reactivity to daily life events, as well as emotional dynamics in real time. This investigation examines the association between emotional reactivity to daily events and emotional experience in mood and anxiety disorders in a large community-based sample. Two-hundred and 87 participants with a lifetime history of bipolar I disorder (BPI; n = 33), bipolar II disorder (BPII; n = 37), major depression (MDD; n = 116), anxiety disorders without a mood disorder (ANX; n = 36), and controls without a lifetime history of mood, anxiety, or substance use disorder (n = 65) completed a 2-week EMA evaluation period concerning mood states and daily events...
October 2018: Journal of Abnormal Psychology
Matthew K Nock, Georges Han, Alexander J Millner, Peter M Gutierrez, Thomas E Joiner, Irving Hwang, Andrew King, James A Naifeh, Nancy A Sampson, Alan M Zaslavsky, Murray B Stein, Robert J Ursano, Ronald C Kessler
Persistent suicide ideation (SI) is known to be a risk factor for subsequent suicidal behaviors. Reducing SI persistence among people with a history of SI consequently might be a useful target for preventive intervention; however, basic information is lacking about patterns and predictors of SI persistence. We report preliminary retrospective data on annual SI persistence in a representative sample of 3,501 U.S. Army soldiers with lifetime SI from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)...
October 2018: Journal of Abnormal Psychology
E Pettersson, P Lichtenstein, H Larsson, J Song, A Agrawal, A D Børglum, C M Bulik, M J Daly, L K Davis, D Demontis, H J Edenberg, J Grove, J Gelernter, B M Neale, A F Pardiñas, E Stahl, J T R Walters, R Walters, P F Sullivan, D Posthuma, T J C Polderman
No abstract text is available yet for this article.
October 18, 2018: Psychological Medicine
Janusz K Rybakowski
The use of lithium for the prevention of recurrences in mood disorders has a 55-year history. Nowadays, lithium is universally accepted as the first-choice mood-stabilizer (MS) for maintenance treatment of bipolar disorder. In addition to its mood-stabilizing properties, lithium exerts anti-suicidal, immunomodulatory and neuroprotective action which may further substantiate its clinical usefulness. Despite these facts, the use of lithium in mood disorders has been greatly underutilized. The reasons include the introduction and promoting other MS as well as a perception of lithium as a "toxic drug" due to its side effects, mainly thyroid, renal and cognitive disturbances...
2018: Frontiers in Molecular Neuroscience
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