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https://www.readbyqxmd.com/read/30536523/ethanol-normalizes-glutamate-induced-elevation-of-intracellular-sodium-in-olfactory-neuroepithelial-progenitors-from-subjects-with-bipolar-illness-but-not-non-bipolar-controls-biologic-evidence-for-the-self-medication-hypothesis
#1
Yonglin Gao, Kavita Lohano, Nicholas A Delamere, Zhenmin Lei, Rif S El-Mallakh
Alcohol use disorders are quite common in bipolar patients with a prevalence of comorbidity that exceeds all other primary psychiatric diagnoses other than other substance use disorders; over 60% of people with BD I have comorbid alcohol dependence at some point in their lives. This intimate relationship has served as the basis of the proposed idea of 'self-medication.' However, biological confirmation of 'self-medication,' specifically, the correction of an abnormal biologic marker with alcohol, has never been demonstrated...
December 9, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/30536496/meditation-for-treating-adults-with-bipolar-disorder-ii-a-multi-city-study
#2
Samta P Pandya
There is a need to generate evidence on whether meditationꞋs core aspect of building and nurturing calm and peace serves as a mood stabilizer for current and recurrent episodes of depression through the acute and maintenance phases of treating bipolar disorder II affected patients. A two-year longitudinal multi-city randomized controlled trial experiment was conducted comprising 311 bipolar disorder II affected patients in the intervention and control group respectively across eight African and Asian cities...
December 10, 2018: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/30536299/-the-syndrome-of-inappropriate-diuretic-hormone-secretion-siadh-ending-lethal-during-the-use-of-paliperidon-and-lamotrigine
#3
M A H Monden, L P van der Vorst, H J M Martens, A van der Wolk
Hyponatremia, as a result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH), is well known with the use of nearly all antipsychotics and mood stabilizers. The first symptoms are atypical and are not always mentioned by the patient. However, not recognising the syndrome in due time can be lethal. We describe a 35-year-old woman who died due to lack of recognition of SIADH. The patient, who had a bipolar disorder and was for a long time on a paliperidone depot, developed complaints of nausea, vomiting and thirst after lamotrigine was prescribed...
2018: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/30536114/population-pharmacokinetics-and-exposure-response-of-lithium-carbonate-in-patients-based-on-tubular-reabsorption-mechanisms
#4
Daichi Yamaguchi, Yasuhiro Tsuji, Miki Sonoda, Kenji Shin, Hiroko Kito, Chika Ogami, Hidefumi Kasai, Hideto To, Hidetoshi Kamimura
BACKGROUND AND OBJECTIVE: Lithium, which is used to treat bipolar disorder, has a narrow therapeutic blood concentration range and quickly reaches clinically toxic levels. We performed a population pharmacokinetic analysis with a lithium tubular reabsorption model including urinary pH and investigated the relationship between blood lithium concentration and tremor as a side effect. METHODS: Routine clinical data, including 389 serum concentrations, were collected from 214 patients orally administered an adjusted amount of lithium carbonate...
December 7, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/30535680/mitochondrial-involvement-in-mental-disorders-energy-metabolism-genetic-and-environmental-factors
#5
Keiko Iwata
Mental disorders such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ) are generally characterized by a combination of abnormal thoughts, perceptions, emotions, behavior, and relationships with others. Multiple risk factors incorporating genetic and environmental susceptibility are associated with development of these disorders. Mitochondria have a central role in the energy metabolism, and the literature suggests energy metabolism abnormalities are widespread in the brains of subjects with MDD, BD, and SZ...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30535659/combined-actions-of-blueberry-extract-and-lithium-on-neurochemical-changes-observed-in-an-experimental-model-of-mania-exploiting-possible-synergistic-effects
#6
Luiza Spohr, Mayara Sandrielly Pereira Soares, Pathise Souto Oliveira, Bruna da Silveira de Mattos, Natália Pontes Bona, Nathalia Stark Pedra, Fernanda Cardoso Teixeira, Carlus Augustu Tavares do Couto, Vitor Clasen Chaves, Flávio Henrique Reginatto, Meibel Teixeira Lisboa, Anderson Schwingel Ribeiro, Claiton Leoneti Lencina, Francieli Moro Stefanello, Roselia Maria Spanevello
Bipolar disorder is a psychiatric disease characterized by recurrent episodes of mania and depression. Blueberries contain bioactive compounds with important pharmacological effects such as neuroprotective and antioxidant actions. The aim of this study was to investigate the effects of blueberry extract and/or lithium on oxidative stress, and acetylcholinesterase (AChE) and Na+ , K+ -ATPase activity in an experimental ketamine-induced model of mania. Male Wistar rats were pretreated with vehicle, blueberry extract (200 mg/kg), and/or lithium (45 mg/kg or 22...
December 7, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/30535610/an-interesting-case-of-carbamazepine-induced-stevens-johnson-syndrome
#7
Josiah Tatenda Masuka, Garikai Muzopambwa, Star Khoza, Dixon Chibanda
A 29-year-old Black female patient was admitted to a psychiatric ward with symptoms of major depressive disorder with psychosis. The patient was started on amitriptyline 50 mg/day and haloperidol 10 mg/day. On day 4 post-admission, the preferred first-line antidepressant, fluoxetine, became available and the patient was switched from amitriptyline to fluoxetine 20 mg/day. On the same day, the dose of haloperidol was reduced to 5 mg/day. Thirteen days post-initiation of these medications the patient became talkative, associated with emotional lability, an expansive mood, irritability and restlessness...
December 10, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/30535007/transcriptomic-landscape-of-von-economo-neurons-in-human-anterior-cingulate-cortex-revealed-by-microdissected-cell-rna-sequencing
#8
Lixin Yang, Yandong Yang, Jiamiao Yuan, Yan Sun, Jiapei Dai, Bing Su
The von Economo neurons (VENs) are specialized large bipolar projection neurons with restricted distribution in the human brain, and they are far more abundant in humans than in non-human primates. However, VEN functions remain elusive due to the difficulty of isolating VENs and dissecting their connections in the brain. Here, we combined laser-capture-microdissection with RNA sequencing to describe the transcriptomic profile of VENs from human anterior cingulate cortex (ACC). Using pyramidal neurons as reference cells, we identified 344 genes with VEN-associated expression differences, including 215 higher and 129 lower expression genes...
December 7, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/30534198/use-of-electroconvulsive-therapy-in-adolescents-with-schizophrenia-in-china
#9
Shuai Wang, Chao Yang, Junpu Jia, Yuming Zhou, Yi Zheng
Background: Electroconvulsive therapy (ECT) is an effective treatment for psychiatric disorders such as schizophrenia, major depression and bipolar disorder. However, few studies have addressed the use of ECT in adolescents with schizophrenia. The aims of our study were to investigate the frequency of ECT, and its relationship with clinical and demographic correlates among adolescents with schizophrenia in China. Methods: The study was a retrospective study and conducted in the Child and Adolescent Psychiatry Department of Beijing Anding Hospital, and adolescents with schizophrenia over a period of 10 years (2007-2016) were enrolled...
2018: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/30533956/lithium-induced-thyroiditis-in-a-patient-having-bipolar-affective-disorder-a-rare-case-report
#10
Praveen Arathil, Kotchuthressia Mathew, Dinesh Narayanan
A 22-year-old female, previously diagnosed with bipolar affective disorder on lithium therapy, presented to us with manic symptoms. The blood investigations revealed elevated thyroxine and thyroid peroxidase antibodies and reduced thyroid-stimulating hormone with poor tapping function of thyroid on technetium thyroid scintigraphy indicating lithium-induced thyroiditis.
November 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/30533953/ect-in-the-postpartum-period-a-retrospective-case-series-from-a-tertiary-health-care-center-in-india
#11
Sandeep Grover, Swapnajeet Sahoo, Subho Chakrabarti, Debashish Basu, Shubh M Singh, Ajit Avasthi
Objective: To evaluate the clinical profile and effectiveness of ECT in females with postpartum onset psychiatric syndromes or worsening of psychiatric disorder during the postpartum period. Materials and Methods: A retrospective chart review was carried out to identify females who had received ECT during their postpartum period from January2004 to April 2017. Results: During the study period, 13 females in their postpartum period received ECT, which accounted for 2...
November 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/30531795/replicated-associations-of-fads1-mad1l1-and-a-rare-variant-at-10q26-13-with-bipolar-disorder-in-chinese-population
#12
Lijuan Zhao, Hong Chang, Dong-Sheng Zhou, Jun Cai, Weixing Fan, Wei Tang, Wenxin Tang, Xingxing Li, Weiqing Liu, Fang Liu, Yuanfang He, Yan Bai, Yan Sun, Jiapei Dai, Lingyi Li, Xiao Xiao, Chen Zhang, Ming Li
Genetic analyses of psychiatric illnesses, such as bipolar disorder (BPD), have revealed essential information regarding the underlying pathological mechanisms. While such studies in populations of European ancestry have achieved prominent success, understanding the genetic risk factors of these illnesses (especially BPD) in Chinese population remains an urgent task. Given the lack of genome-wide association study (GWAS) of BPD in Chinese population from Mainland China, replicating the previously reported GWAS hits in distinct populations will provide valuable information for future GWAS analysis in Han Chinese...
December 7, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/30530457/a-web-based-intervention-for-relatives-of-people-experiencing-psychosis-or-bipolar-disorder-design-study-using-a-user-centered-approach
#13
Mahsa Honary, Naomi Ruth Fisher, Roisin McNaney, Fiona Lobban
BACKGROUND: Relatives of people experiencing bipolar mood episodes or psychosis face a multitude of challenges (eg, social isolation, limited coping strategies, and issues with maintaining relationships). Despite this, there is limited informational and emotional support for people who find themselves in supporting or caring roles. Digital technologies provide us with an opportunity to offer accessible tools, which can be used flexibly to provide evidence-based information and support, allowing relatives to build their understanding of mental health problems and learn from others who have similar experiences...
December 7, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/30530134/brivaracetam-in-adults-with-drug-resistant-epilepsy-and-psychiatric-comorbidities
#14
Evangelia Theochari, Hannah Cock, Dora Lozsadi, Clare Galtrey, Jan Arevalo, Marco Mula
This is a case series of 25 patients with drug-resistant epilepsy and psychiatric comorbidities who started on brivaracetam (BRV) at St George's University Hospitals and Frimley Health in London. Median BRV dose was 150 mg for a median follow-up period of 8 months. Twenty had focal epilepsy, four had generalized epilepsies, and one had unclassified epilepsy; 76% had mood disorders (either depression or bipolar disorder), 12% intellectual disabilities with autism spectrum disorder and challenging behavior, and 12% psychoses...
December 7, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30529319/increased-prolidase-activity-and-high-blood-monocyte-counts-in-pediatric-bipolar-disorder
#15
Mehmet Fatih Ceylan, Selma Tural Hesapcioglu, Meryem Kasak, Almila Senat, Ozcan Erel
Various psychological, genetic, and biochemical factors are thought to be involved in the aetiology of pediatric bipolar disorder (PBD). However, few studies have evaluated the biochemical basis of PBD. The level of peripheral blood mononuclear cells and serum prolidase activity were determined in PBD and matched healthy comparison subjects. Blood from 38 (age range: 14-17) PBD-type I and 37 age- and gender-matched healthy comparison subjects was analyzed for numbers of neutrophils, lymphocytes, monocytes, lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR) and serum prolidase activity...
December 1, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30529318/early-maladaptive-schemas-and-suicidal-risk-in-inpatients-with-bipolar-disorder
#16
Vahid Khosravani, Ali Mohammadzadeh, Farangis Sharifi Bastan, Ali Amirinezhad, Marziyeh Amini
The present study aimed to assess the associations of early maladaptive schemas (EMSs) and clinical factors (hypomanic/manic and depressive symptoms) with suicidal risk (current suicidal ideation and lifetime suicide attempts) in inpatients with bipolar disorder (BD). One hundred inpatients with BD completed the Young Schema Questionnaire-Short Form (YSQ-SF), the Bipolar Depression Rating Scale (BDRS), the Young Mania Rating Scale (YMRS), and the Beck Scale for Suicide Ideation (BSSI). 59% of patients had lifetime suicide attempts and 59% showed high suicidal risk (BSSI ≥ 6)...
December 1, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30527356/neural-response-during-emotion-regulation-in-monozygotic-twins-at-high-familial-risk-of-affective-disorders
#17
Iselin Meluken, Ninja Meinhard Ottesen, K Luan Phan, Phillipe R Goldin, Martina Di Simplicio, Julian Macoveanu, Hartwig Roman Siebner, Lars Vedel Kessing, Maj Vinberg, Kamilla Woznica Miskowiak
PURPOSE: We investigated the neural correlates of emotion regulation and -reactivity in adult unaffected monozygotic twins with a co-twin history of unipolar or bipolar disorder (high-risk), remitted or partially remitted twins with a personal history of unipolar or bipolar disorder (affected) and twins with no personal or first-degree family history of unipolar or bipolar disorder (low-risk). METHODS: We assessed 37 high-risk, 56 affected and 28 low-risk participants...
November 13, 2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/30527274/safety-and-efficacy-of-accelerated-repetitive-transcranial-magnetic-stimulation-protocol-in-elderly-depressed-unipolar-and-bipolar-patients
#18
Véronique Desbeaumes Jodoin, Jean-Philippe Miron, Paul Lespérance
OBJECTIVE: Major depressive disorder (MDD) is a prevalent condition in older adults. Although antidepressant drugs are commonly prescribed, efficacy is variable, and older patients are more prone to side effects. Repetitive transcranial magnetic stimulation (rTMS) is an alternative therapy used increasingly in the treatment of MDD. Even though recent studies have shown efficacy of rTMS in elderly depressed patients, the safety and efficacy of accelerated rTMS has not been studied in this population...
November 2, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/30526344/metabolic-syndrome-at-an-outpatient-clinic-for-bipolar-disorders-a-case-for-systematic-somatic-monitoring
#19
Mirjam Simoons, Hans Mulder, Bennard Doornbos, Pascal C C Raats, Richard Bruggeman, Daniëlle C Cath, Robert A Schoevers, Henricus G Ruhé, Eric N van Roon
OBJECTIVES: The primary objective of the study was to determine whether the Monitoring Outcomes of Psychiatric Pharmacotherapy (MOPHAR) program improved somatic monitoring practices at an outpatient clinic for bipolar disorders in the Netherlands. The secondary objective was to determine in MOPHAR the frequency of metabolic syndrome (compared with its measurability before MOPHAR) and treatment thereof. METHODS: Frequencies of physical examinations and laboratory tests before (retrospectively) and after (prospectively) the active introduction of MOPHAR were compared among adult patients (N=155)...
December 10, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/30525908/the-emergent-course-of-bipolar-disorder-observations-over-two-decades-from-the-canadian-high-risk-offspring-cohort
#20
Anne Duffy, Sarah Goodday, Charles Keown-Stoneman, Paul Grof
OBJECTIVE: The authors sought to describe the emergent course of bipolar disorder in offspring of affected parents subgrouped by parental response to lithium prophylaxis. METHODS: Parent bipolar disorder was confirmed by the best-estimate procedure and lithium response by research protocol. High-risk offspring (N=279) and control subjects (N=87) were blindly assessed, annually on average, with the Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime version or the Schedule for Affective Disorders and Schizophrenia-Lifetime version...
December 11, 2018: American Journal of Psychiatry
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