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panic AND disorder

Bianca Besteher, Letizia Squarcina, Robert Spalthoff, Marcella Bellani, Christian Gaser, Igor Nenadić, Paolo Brambilla
Background: Symptoms of anxiety are present not only in panic disorder or other anxiety disorders, but are highly prevalent in the general population. Despite increasing biological research on anxiety disorders, there is little research on understanding subclinical or sub-threshold symptoms relating to anxiety in non-clinical community samples, which could give clues to factors relating to resilience or compensatory changes. Aims: This study focused on brain structural correlates of subclinical anxiety/agoraphobia symptoms from a multi-center imaging study...
2018: Frontiers in Psychiatry
C M Vicario, M A Salehinejad, K Felmingham, G Martino, M A Nitsche
The interest in the use of non-invasive brain stimulation for enhancing neural functions and reducing symptoms in anxiety disorders is growing. Based on the DSM-V classification for anxiety disorders, we examined all available research using repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) for the treatment of specific phobias, social anxiety disorder, panic disorder, agoraphobia, and generalized anxiety disorder. A systematic literature search conducted in PubMed and Google Scholar databases provided 26 results: 12 sham-controlled studies and 15 not sham-controlled studies...
December 10, 2018: Neuroscience and Biobehavioral Reviews
Erika Kropf, Sabrina K Syan, Luciano Minuzzi, Benicio N Frey
Since the pioneering work of Penfield and his colleagues in the 1930s, the somatosensory cortex, which is located on the postcentral gyrus, has been known for its central role in processing sensory information from various parts of the body. More recently, a converging body of literature has shown that the somatosensory cortex also plays an important role in each stage of emotional processing, including identification of emotional significance in a stimulus, generation of emotional states, and regulation of emotion...
December 6, 2018: Revista Brasileira de Psiquiatria
Carolyn D Davies, Patrick B McGrath, Lisa R Hale, Daniel N Weiner, David F Tolin
Capnometry guided respiratory interventions have shown promising results in the treatment of panic disorder, but mechanisms of change are not yet well-understood. The current study examined changes in end-tidal carbon dioxide (ETCO2 ), anxiety sensitivity, and perceived control as mediators of panic symptom change. Sixty-nine adults with panic disorder received 4 weeks of respiratory training, and panic symptom severity and potential mediators were assessed at Pre-treatment, Mid-treatment, Post-treatment, 2-month follow-up, and 12-month follow-up...
December 11, 2018: Applied Psychophysiology and Biofeedback
Vlasios Brakoulias
No abstract text is available yet for this article.
December 4, 2018: Australian and New Zealand Journal of Psychiatry
Maurizio Bussotti, Marinella Sommaruga
Background: Anxiety and depression are frequent disorders in patients with pulmonary arterial hypertension (PAH), but despite this only less than one-fourth of them is treated. Our aim was to review the studies regarding the prevalence and the impact of anxiety and depression and to propose management challenges. Methods: A literature review regarding 1) anxiety and depression studies in PAH patients and caregivers, 2) psychological interventions, 3) slow breathing approach, and 4) pharmacological approach was performed, based on evidence of effectiveness through a search of the most well-known databases (Cochrane Library, Medline, PsychINFO [2004-2018])...
2018: Vascular Health and Risk Management
Piroska Balog
With regard to cardiovascular health, the role of negative emotions, particularly that of depression, anxiety, vital exhaustion and hostility has been studied the most widely. Mainly the somatic symptoms of depression and, out of anxiety disorders, generalised anxiety and panic disorder have been linked to cardiovascular diseases. Based on an analysis of interviews of patients having suffered myocardial infarction, it was found that vital exhaustion (a combination of loss of energy, increased irritability, and general demoralization) is a precursor of infarction...
December 2018: Orvosi Hetilap
H Schwarzmeier, N I Kleint, H U Wittchen, A Ströhle, A O Hamm, U Lueken
Emotional-associative learning represents a translational model for the development, maintenance and treatment of anxiety disorders such as panic disorder (PD). The exact nature of the underlying fear learning and extinction deficits however, remains under debate. Using a three-day paradigm to separate the distinct learning and consolidation processes, we aimed to gain insights into the neurofunctional substrates of altered fear conditioning, extinction training and recall in PD. In contrast to studies employing one-session fear conditioning paradigms, a differential fear conditioning and delayed extinction task was conducted for the purpose of disentangling neural networks involved in fear acquisition, extinction training and recall of extinction memories...
November 26, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Christian Valt, Dorothea Huber, Ingrid Erhardt, Birgit Stürmer
Self-absorption describes a pathological tendency towards the internal mental world (internalization) that often conflicts with the accurate monitoring of the external world. In performance monitoring, an augmented electrophysiological response evoked by internal signals in patients with anxiety or depressive disorder seems to reflect this tendency. Specifically, the error-related negativity (Ne/ERN), an index of error processing based on internal signals, is larger in patients compared to controls. In the present experiment, we investigated whether the preferential processing of internal signals in patients is linked to diminished and inflexible external signal processing...
2018: PloS One
P U Prakash Saxena, Vaman Kulkarni, Rekha Thapar, Keshva Pai, Ayushi Gupta, Himani Kotian
Context: Cancer is one of the leading causes of disability worldwide. The psychological factors that significantly affect the functioning of the cancer patients are anxiety, depressive disorders, and somatization. Aims: To find out the spectrum of psychological disorders in cancer patients, also to find the association between sociodemographic variables and stage of tumor, treatment modality with the various psychological problems among cancer patients. Settings and Design: This cross-sectional study was carried out among cancer patients undergoing treatment in our institution...
October 2018: Journal of Cancer Research and Therapeutics
Evgenia Stefanopoulou, David Lewis, Matthew Taylor, James Broscombe, Jan Larkin
Digital interventions for anxiety disorders have been well-researched over the past two decades. However, reviews to date have focused on internet-based cognitive behavioural therapy (iCBT), whereas other psychological interventions have received less attention. The aim of this review was therefore to evaluate the effectiveness of digitally delivered psychological therapies (CBT, Attention Bias Modification, Exposure Therapy, Applied Relaxation, Bibliotherapy, Psychodynamic Therapy, Mindfulness, Behavioural Stress Management, Counselling) compared with control conditions and/or other psychological interventions for anxiety disorders (Social Anxiety Disorder (SAD), Health Anxiety, Obsessive-Compulsive Disorder (OCD), Post-traumatic Stress Disorder (PTSD), Specific Phobias, Panic Disorder (PD), Generalised Anxiety Disorder (GAD)]...
November 28, 2018: Psychiatric Quarterly
Lauren M Federici, Izabela F Caliman, Stephanie D Fitz, Anantha Shekhar, Philip L Johnson
Panic attacks (PAs) are episodes of intense fear or discomfort that are accompanied by a variety of both psychological and somatic symptoms. Panic induction in preclinical models (e.g. rats) has largely been assayed through flight and avoidance behavioral tests and cardiorespiratory activity. Yet, the literature pertaining to PAs shows that thermal sensations (hot flushes/heat sensations and chills) are also a common symptom during PAs in humans. Considering that temperature alterations are objectively measurable in rodents, we hypothesized that select panicogenic drugs and stimuli induce consistent changes in thermoregulation related to hot flushes and chills...
November 21, 2018: Behavioural Pharmacology
J Angst, W Rössler, V Ajdacic-Gross, F Angst, H-U Wittchen, R Lieb, K Beesdo-Baum, E Asselmann, K R Merikangas, L Cui, L H Andrade, M C Viana, F Lamers, B W J H Penninx, T de Azevedo Cardoso, K Jansen, L Dias de Mattos Souza, R Azevedo da Silva, F Kapczinski, C Grobler, M Gholam-Rezaee, M Preisig, C L Vandeleur
OBJECTIVES: Although clinical evidence suggests important differences between unipolar mania and bipolar-I disorder (BP-I), epidemiological data are limited. Combining data from 9 population-based studies, we compared subjects with mania (M) or mania with mild depression (Md) to those with BP-I with both manic and depressive episodes with respect to demographic and clinical characteristics in order to highlight differences. METHODS: Participants were compared for gender, age, age at onset of mania, psychiatric comorbidity, temperament and family history of mental disorders...
November 26, 2018: Bipolar Disorders
Alexander Richards, John Horwood, Joseph Boden, Martin Kennedy, Ruth Sellers, Lucy Riglin, Sumit Mistry, Hannah Jones, Daniel J Smith, Stanley Zammit, Michael Owen, Michael C O'Donovan, Gordon T Harold
BACKGROUND: Studies involving clinically recruited samples show that genetic liability to schizophrenia overlaps with that for several psychiatric disorders including bipolar disorder, major depression and, in a population study, anxiety disorder and negative symptoms in adolescence.AimsWe examined whether, at a population level, association between schizophrenia liability and anxiety disorders continues into adulthood, for specific anxiety disorders and as a group. We explored in an epidemiologically based cohort the nature of adult psychopathology sharing liability to schizophrenia...
November 26, 2018: British Journal of Psychiatry: the Journal of Mental Science
Vasilios G Masdrakis, Charalambos Papageorgiou, Manolis Markianos
The probable implication of testosterone in the neurobiology of anxiety disorders, and particularly panic disorder (PD), is poorly studied. We explored for potential differences concerning testosterone (T) plasma levels and the ratio testosterone/cortisol (T/C) between medication-free, consecutively-referred patients with acute exacerbation of PD comorbid with agoraphobia (PDA) (N = 40; females = 24; age = 31.4 ± 7.1 years) and healthy controls (N = 80; females = 48; matched for age)...
November 15, 2018: Psychoneuroendocrinology
J Bitzer, A Rapkin, C N Soares
INTRODUCTION: Lack of awareness of reproductive hormone-related mood changes in the general population or limited acknowledgement of their existence by health care providers regularly contribute to fears or misconceptions about the link between hormonal contraception and potential mood changes. Recent media discussion linked the levonorgestrel intrauterine system (LNG-IUS 20 µg/d) to elevated cortisol levels and the possibility of panic attacks, anxiety, mood changes, sleep disturbance and restlessness...
November 23, 2018: European Journal of Contraception & Reproductive Health Care
Domenico De Berardis, Michele Fornaro, Laura Orsolini, Luigi Olivieri, Francesco Nappi, Gabriella Rapini, Federica Vellante, Cosimo Napoletano, Nicola Serroni, Massimo Di Giannantonio
Clozapine may be associated with cardiovascular adverse effects including QTc prolongation and, more rarely, with myocarditis and pericarditis. Although rare, these latter cardiovascular adverse effects may be life-threatening and must be immediately recognized and treated. Several cases of clozapine related-pericarditis have been described and often it has a subtle and insidious onset with symptoms that may be often misdiagnosed with psychiatric manifestations (e.g. anxiety, panic or somatization) leading to a delayed correct diagnosis with potential fatal consequences...
November 30, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Zheng Ruihong, Wang Lu, Liu Xiaoli
Terbutaline aerosol and budesonide suspension are commonly used in the treatment of bronchial asthma, and budesonide suspension has local high efficiency and anti-inflammatory effects. In this paper, we selected 240 patients with bronchial asthma and randomly divided them into two groups. The experimental group was treated with atomization inhalation of terbutaline, after 5 minutes interval, nebulized inhalation of budesonide was performed. The control group was treated with atomized inhalation of mixed liquid as terbutaline and budesonide...
September 2018: Pakistan Journal of Pharmaceutical Sciences
Lisa Vork, Zlatan Mujagic, Marjan Drukker, Daniel Keszthelyi, José M Conchillo, Martine A M Hesselink, Jim van Os, Ad A M Masclee, Carsten Leue, Joanna W Kruimel
BACKGROUND: Confirming treatment response in clinical trials for irritable bowel syndrome (IBS) is challenging, due to the lack of biomarkers and limitations of the currently available symptom assessment tools. The Experience Sampling Method (ESM) might overcome these limitations by collecting digital assessments randomly and repeatedly during daily life. This study evaluated differences in change in abdominal pain between real-time (ie, ESM) and retrospective (ie, Gastrointestinal Symptom Rating Scale [GSRS] and an end-of-day symptom diary) measurements, using data of an RCT on escitalopram vs placebo in patients with IBS and comorbid panic disorder...
November 20, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Nicole K Leibold, Koen R Schruers
Panic disorder (PD) is one of the most common psychiatric disorders. Recurrent, unexpected panic attacks (PAs) are the primary symptom and strongly impact patients' quality of life. Clinical manifestations are very heterogeneous between patients, emphasizing the need for a dimensional classification integrating various aspects of neurobiological and psychological circuits in line with the Research Domain Criteria (RDoC) proposed by the US National Institute of Mental Health. To go beyond data that can be collected in the daily clinical situation, experimental panic provocation is widely used, which has led to important insights into involved brain regions and systems...
2018: Frontiers in Neuroscience
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