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panic AND disorder

James Reich, Alan Schatzberg, Kevin Delucchi
BACKGROUND: Treatment resistant disorders are a significant clinical problem. Impediments to good outcome need to be identified and addressed. Personality pathology has been hypothesized to be one such factor in panic disorder. There is no consensus as to the effects of personality pathology on the outcome of panic disorder. This study examined empirical evidence. The hypothesis was that personality pathology would cause poorer outcome of panic disorder. METHODS: A literature search was conducted that winnowed 2627 articles down to 27 based on 1) longitudinal design; 2) validated measures of personality; 3) validated outcome measures; and 4) the presence of effect size or data to calculate effect size...
October 5, 2018: Journal of Psychiatric Research
Mark Zimmerman, Jacob Martin, Patrick McGonigal, Lauren Harris, Sophie Kerr, Caroline Balling, Reina Kiefer, Kasey Stanton, Kristy Dalrymple
BACKGROUND: DSM-5 introduced the anxious distress specifier in recognition of the clinical significance of anxiety in depressed patients. Recent studies that supported the validity of the specifier did not use measures that were designed to assess the criteria of the specifier but instead approximated the DSM-5 criteria from scales that were part of an existing data base. In the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project, we examined the validity of the specifier diagnosed with a semistructured interview...
October 12, 2018: Depression and Anxiety
Sinem Ilgin, Volkan Kilic, Merve Baysal, Gozde Aydogan-Kilic, Seyda Ucarcan, Begum Dermenci, Ozlem Atli
Sertraline is an antidepressant that is frequently prescribed to treat depression, obsessive-compulsive disorder, panic disorder, and anxiety. This drug had a safe cardiotoxicity profile, until the reporting of cases of sertraline-associated cardiotoxicities in the early 2000s. Since then, there have been conflicting results on the cardiotoxicity of this drug. In the study reported here we aimed to identify the cardiotoxic effects of sertraline by evaluating serum cardiac biomarkers, such as serum aspartate aminotransferase (AST), creatinine phosphokinase-myoglobin band (CK-MB), lactate dehydrogenase (LDH), and cardiac troponin T (cTn-T) levels as well as electrocardiographic parameters, DNA damage in cardiomyocytes, and histological findings of heart tissue in rats that were administered oral doses of 5, 10, or 20 mg kg-1 of sertraline for 28 days...
September 1, 2018: Toxicology Research
Seon-Cheol Park, Yong-Ku Kim
To conceptualize a novel bio-psychosocial-behavioral treatment model of panic disorder (PD), it is necessary to completely integrate behavioral, psychophysiological, neurobiological, and genetic data. Molecular genetic research on PD is specifically focused on neurotransmitters, including serotonin, neuropeptides, glucocorticoids, and neurotrophins. Although pharmacological interventions for PD are currently available, the need for more effective, faster-acting, and more tolerable pharmacological interventions is unmet...
October 11, 2018: Psychiatry Investigation
Sahib S Khalsa, Mahlega S Hassanpour, Michael Strober, Michelle G Craske, Armen C Arevian, Jamie D Feusner
Individuals with anorexia nervosa (AN) typically display anxious traits prior to the onset of food avoidance and weight loss that characterize the disorder. Meal associated anxiety is an especially common clinical feature in these patients, and heightened sensitivity to sympathetically mediated interoceptive sensations has also been observed. However, it remains unclear how heightened interoceptive sensitivity relates to experiences of anxiety before and after meals. To investigate this relationship, we experimentally induced anxiety and panic symptoms with isoproterenol, a peripheral sympathetic agonist similar to adrenaline, across several different conditions: during panic provocation, during anticipation of a 1,000 Calorie meal, and after meal consumption...
2018: Frontiers in Psychiatry
Bethany L DiPrete, Brian W Pence, Angela M Bengtson, Richard D Moore, David J Grelotti, Conall O'Cleirigh, Riddhi Modi, Bradley N Gaynes
Little is known about disparities in depression prevalence, treatment, and remission by psychiatric comorbidities and substance use among persons living with HIV (PLWH). We conducted a cross-sectional analysis in a large cohort of PLWH in routine care and analyzed conditional probabilities of having an indication for depression treatment, receiving treatment, receiving indicated treatment adjustments, and achieving remission, stratified by alcohol use, illicit drug use, and panic symptoms. Overall, 34.7% (95% CI 33...
October 4, 2018: AIDS and Behavior
Susanne Neufang, Maximilian J Geiger, György A Homola, Marina Mahr, Miriam A Schiele, Andrea Gehrmann, Brigitte Schmidt, Agnieszka Gajewska, Johannes Nowak, Eva Meisenzahl-Lechner, Mirko Pham, Marcel Romanos, Atae Akhrif, Katharina Domschke
Given the particular relevance of arousal and alerting in panic disorder (PD), here the alerting network was investigated (1) contrasting patients with PD and healthy controls, (2) as a function of anxiety sensitivity constituting a dimensional measure of panic-related anxiety, and (3) as a possible correlate of treatment response. Using functional magnetic resonance imaging (fMRI), 45 out-patients with PD (f = 34) and 51 matched healthy controls were investigated for brain activation patterns and effective connectivity (Dynamic Causal Modeling, DCM) while performing the Attention Network Task (ANT)...
October 4, 2018: European Archives of Psychiatry and Clinical Neuroscience
Emily Carl, Aliza T Stein, Andrew Levihn-Coon, Jamie R Pogue, Barbara Rothbaum, Paul Emmelkamp, Gordon J G Asmundson, Per Carlbring, Mark B Powers
Trials of virtual reality exposure therapy (VRET) for anxiety-related disorders have proliferated in number and diversity since our previous meta-analysis that examined 13 total trials, most of which were for specific phobias (Powers & Emmelkamp, 2008). Since then, new trials have compared VRET to more diverse anxiety and related disorders including social anxiety disorder (SAD), posttraumatic stress disorder (PTSD), and panic disorder (PD) with and without agoraphobia. With the availability of this data, it is imperative to re-examine the efficacy of VRET for anxiety...
August 10, 2018: Journal of Anxiety Disorders
Pasquale Roberge, Martin D Provencher, Patrick Gosselin, Helen-Maria Vasiliadis, Isabelle Gaboury, Annie Benoit, Martin M Antony, Nils Chaillet, Janie Houle, Catherine Hudon, Peter J Norton
BACKGROUND: Anxiety disorders are the most common mental disorders in community settings, and they are associated with significant psychological distress, functional and social impairment. While cognitive behaviour therapy (CBT) is the most consistently efficacious psychological treatment for anxiety disorders, barriers preclude widespread implementation of CBT in primary care. Transdiagnostic group CBT (tCBT) focuses on cognitive and behavioural processes and intervention strategies common to different anxiety disorders, and could be a promising alternative to conventional CBT...
October 3, 2018: BMC Psychiatry
Andreas Ströhle, Jochen Gensichen, Katharina Domschke
BACKGROUND: Anxiety disorders are the most common type of mental illness in Europe, with a 12-month prevalence of 14% among persons aged 14 to 65. Their onset is usually in adolescence or early adulthood. The affected patients often develop further mental or somatic illnesses (sequential comorbidity). METHODS: This review is based on pertinent publications retrieved by a selective search in PubMed. RESULTS: The group of anxiety disorders includes generalized anxiety disorder (GAD), phobic disorders, panic disorders, and two disorders that are often restricted to childhood-separation anxiety and selective mutism...
September 14, 2018: Deutsches Ärzteblatt International
Zhili Zou, Jian Qiu, Yulan Huang, Jinyu Wang, Wenjiao Min, Bo Zhou
A large body of evidence indicates that patients with panic disorder(PD) report more obvious alexithymia, and previous studies suggest genetic factors may be play an important role in alexithymia. This study aims to examine the association between the Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and alexithymia, and then to evaluate the association of the BDNFVal66Met polymorphism with PD risk. 223 patients with PD and 218 healthy controls were enrolled in the study. The Toronto Alexithymia Scale (TAS-20), and Panic Disorder Severity Scale (PDSS) were administered to all subjects...
October 1, 2018: Psychology, Health & Medicine
André Wittmann, Florian Schlagenhauf, Anne Guhn, Ulrike Lueken, Manja Elle, Meline Stoy, Carolin Liebscher, Felix Bermpohl, Thomas Fydrich, Bettina Pfleiderer, Harald Bruhn, Alexander L Gerlach, Benjamin Straube, Hans-Ulrich Wittchen, Volker Arolt, Andreas Heinz, Tilo Kircher, Andreas Ströhle
BACKGROUND: Patients suffering from panic disorder and agoraphobia are significantly impaired in daily life due to anxiety about getting into a situation due to apprehension about experiencing a panic attack, especially if escape may be difficult. Dysfunctional beliefs and behavior can be changed with cognitive behavioral therapy; however, the neurobiological effects of such an intervention on the anticipation and observation of agoraphobia-specific stimuli are unknown. METHODS: We compared changes in neural activation by measuring the blood oxygen level-dependent signal of 51 patients and 51 healthy controls between scans before and those after treatment (group by time interaction) during anticipation and observation of agoraphobia-specific compared to neutral pictures using 3-T fMRI...
September 28, 2018: Psychotherapy and Psychosomatics
Hans-Peter Kapfhammer
Traumata, by definition, refer to exterior events that expose a person to experiences of overwhelming threat and catastrophe and elicit feelings of death anxiety, panic, horror, helplessness, loss of personal control, and intractability. Most affected persons respond with at least some distressing symptoms of trauma-related memory intrusions, autonomic hyperarousal, dissociation, and depression in the acute aftermath. Fortunately, the majority of traumatized individuals succeed in coping with this major stress quite well during the following weeks and months unless the process of recovery is hampered by additional adverse psychosocial circumstances, psychological disposition or biological vulnerability...
September 2018: Psychiatria Danubina
Meredith C Meacham, Amber L Bahorik, Martha Shumway, Carina Marquez, Elise D Riley
We sought to identify the prevalence and independent correlates of condomless sex within a cohort of community-recruited homeless and unstably housed cisgender adult women who were followed biannually for 3 years (N = 143 HIV+ , N = 139 HIV-). Nearly half (44%) of participants reported condomless sex in the 6 months before baseline, which increased to 65% throughout the study period. After adjusting for having a primary partner, longitudinal odds of condomless sex among women with HIV were significantly higher among those reporting < daily use of alcohol or cannabis (AOR = 2...
September 28, 2018: AIDS and Behavior
Carla Nel, Linda Augustyn, Nandie Bartman, Marizél Koen, Maggy Liebenberg, Jurgens Naudé, Gina Joubert
Background: Anxiety disorders are the most prevalent class of lifetime mental disorders according to South African research. However, little is known about the prevalence of factors that might complicate treatment among adults in a psychiatric outpatient setting. Aim: To explore the psychiatric comorbidities and psychosocial stressors among a population of adults treated for anxiety disorders at the outpatient unit of a tertiary psychiatric facility in Bloemfontein...
2018: South African Journal of Psychiatry: SAJP: the Journal of the Society of Psychiatrists of South Africa
Ayşe Selbes, Tonguç Demir Berkol, Sevilay Kunt, Can Uğurpala, Muhammed Mehtar, Pınar Gökçeimam
INTRODUCTION: The attachment processes give us a theoretical frame work to understand the psychopathological development. Unsafe attachment type is often associated with the emergence of psychopathology in the later periods of life. METHOD: This study includes 65 patients from psychiatry outpatient clinic with a diagnosis of panic disorder and 65 healthy volunteers as a control group. In order to determine clinical status and disease severity of patients with panic disorder according to SCID-I (Structured Clinical Interview for DSM Disorders-I) Panic-Agoraphobia Scale, Adults Separation Anxiety Scale, Relationship Scale Questionnaire were used...
2018: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
Kevin S McCarthy, Dianne L Chambless, Nili Solomonov, Barbara Milrod, Jacques P Barber
OBJECTIVE: Given the chronic, episodic nature of panic disorder, it is important to examine long-term outcomes of patients who respond well to various psychotherapies. METHOD: Out of 116 patients with DSM-IV panic disorder who evidenced a ≥ 40% reduction in panic and avoidance symptoms on the Panic Disorder Severity Scale (PDSS) after 12-14 weeks of panic-focused psychodynamic psychotherapy, cognitive-behavioral therapy, or applied relaxation training as part of a 2-site randomized controlled trial conducted between January 2007 and July 2012, 91 patients provided at least 1 PDSS datapoint during follow-up...
September 11, 2018: Journal of Clinical Psychiatry
C Reichhardt, J Thibault, S Papanikolaou, C J O Reichhardt
It is well known that a binary system of nonactive disks that experience driving in opposite directions exhibits jammed, phase separated, disordered, and laning states. In active matter systems, such as a crowd of pedestrians, driving in opposite directions is common and relevant, especially in conditions which are characterized by high pedestrian density and emergency. In such cases, the transition from laning to disordered states may be associated with the onset of a panic state. We simulate a laning system containing active disks that obey run-and-tumble dynamics, and we measure the drift mobility and structure as a function of run length, disk density, and drift force...
August 2018: Physical Review. E
Virginie Borgès Da Silva, Roxane Borgès Da Silva, Alexandre Prud'homme, Pierre Campan, Jean Michel Azorin, Raoul Belzeaux
BACKGROUND: Eating disorders could be an important factor in the development of obesity, but psychiatric comorbidities are very heterogeneous in patients with obesity. Moreover, relationship between binge eating disorder and other psychiatric comorbidities is not clear. Our objective was to identify psychiatric comorbidity profiles of bariatric surgery candidates and to analyze the association between these profiles and binge-eating disorder. METHODS: Our sample consisted of bariatric surgery candidates (n = 92) with mean Body Mass Index at 41...
September 18, 2018: Comprehensive Psychiatry
Tobias Teismann, Karoline Lukaschek, Thomas S Hiller, Jörg Breitbart, Christian Brettschneider, Ulrike Schumacher, Jürgen Margraf, Jochen Gensichen
BACKGROUND: Suicidal ideation is common in patients suffering from panic disorder. The present study investigated rates of suicidal ideation and risk factors for suicidal ideation in a sample of primary care patients suffering from panic disorder with or without agoraphobia. METHODS: A total of N = 296 patients [n = 215 (72.6%) women; age: M = 43.99, SD = 13.44] were investigated. Anxiety severity, anxiety symptoms, avoidance behavior, comorbid depression diagnosis, severity of depression, age, sex, employment status, living situation and frequency of visits at the general practitioner were considered as risk factors of suicidal ideation...
September 24, 2018: BMC Psychiatry
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