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Sayan Ghosh, Peng Shang, Hiroto Terasaki, Nadezda Stepicheva, Stacey Hose, Meysam Yazdankhah, Joseph Weiss, Taiji Sakamoto, Imran A Bhutto, Shuli Xia, J Samuel Zigler, Ram Kannan, Jiang Qian, James T Handa, Debasish Sinha
Purpose: The RPE cells have a major role in the development of dry age-related macular degeneration (AMD). We present novel evidence that βA3/A1-crystallin, encoded by the Cryba1 gene, a protein known to be important for lysosomal clearance in the RPE, also has a role in epithelial-to-mesenchymal transition (EMT) of RPE cells. Methods: RPE from dry AMD globes, genetically engineered mice lacking Cryba1 globally or specifically in the RPE, spontaneous mutant rats (Nuc1) with a loss-of-function mutation in Cryba1, and the melanoma OCM3 cell line were used...
March 20, 2018: Investigative Ophthalmology & Visual Science
Francesco Moccia, Roberto Berra-Romani, Vittorio Rosti
Endothelial progenitor cells (EPCs) are mobilized in peripheral blood to rescue blood perfusion in ischemic tissues. Several approaches were, therefore, designed to inject autologous EPCs and induce therapeutic angiogenesis in patients affected by cardiovascular disorders. Endothelial colony forming cells (ECFCs) represent the only truly endothelial precursor and are regarded as the most suitable substrate for cell based therapy of ischemic diseases. Intracellular Ca2+ signalling drives ECFC proliferation, migration, homing and neovessel formation...
August 8, 2018: Current Pharmaceutical Biotechnology
J Matthew Knight, Gerd Kautz
BACKGROUND: While skin aging is triggered by multiple factors and typically presents with multiple manifestations, conventional treatment regimens deploy a single treatment modality. Typical approaches exploit ablative techniques, which involve considerable patient discomfort and downtime and can induce adverse events. Non-ablative fractionated laser (NAFL) resurfacing promotes neocollagenesis, with significantly fewer complications and discomfort. At the same time, intense pulsed light (IPL) therapies have a marked impact on skin tone, with an effect on collagen deposition...
August 8, 2018: Lasers in Surgery and Medicine
Farshad Homayouni Moghadam, Mehrnaz Mesbah-Ardakani, Mohammad Hossein Nasr-Esfahani
Objectives: Based on data from Chinese and Indian traditional herbal medicines, gum resin of Ferula assa-foetida (sometimes referred to asafetida or asafoetida) has several therapeutic applications. The authors of various studies have claimed that asafetida has cytotoxic, antiulcer, anti-neoplasm, anti-cancer, and anti-oxidative effects. In present study, the anti-aging effect of asafetida on senescent human dermal fibroblasts was evaluated. Methods: Senescence was induced in in vitro cultured human dermal fibroblasts (HDFs) through exposure to H2 O2 , and the incidence of senescence was recognized by using cytochemical staining for the activity of β -galactosidase...
September 2017: Journal of Pharmacopuncture
Anna Di Cosmo, Valeria Maselli, Gianluca Polese
Octopus vulgaris underwent a radical modification to cope with the benthic lifestyle. It diverged from other cephalopods in terms of body plan, anatomy, behavior, and intelligence. It independently evolved the largest and most complex nervous system and sophisticated behaviors among invertebrates in a separate evolutionary lineage. It is equipped with unusual traits that confer it an incredible evolutionary success: arms capable of a wide range of movements with no skeletal support; developed eyes with a complex visual behavior; vestibular system; primitive "hearing" system; chemoreceptors located in epidermis, suckers, and mouth; and a discrete olfactory organ...
2018: Results and Problems in Cell Differentiation
Gary Bratchford, Gina Giotaki, Liz Wewiora
This paper describes a 9-month project commissioned by Halton Clinical Commissioning Group (CCG) and Liverpool photography organisation, Open Eye Gallery. Socially engaged photographers worked with local residents from the Windmill Hill estate in Runcorn to describe healthy and unhealthy aspects of the area. Six women were trained to use cameras to document everyday things that mattered to them. Through focus groups they discussed what these photographs revealed about the health and ill-health of the area. The resulting exhibition, As and When, told their story...
2018: London Journal of Primary Care
Michael Meyer-Hermann
Rejuvenation of stem cell activity might increase life expectancy by prolonging functionality of organs. Higher stem cell replication rates also bear the risk of cancer. The extent of this risk is not known. While it is difficult to evaluate this cancer risk in experiments, it can be estimated using a mathematical model for tissue homeostasis by stem cell replication and associated cancer risk. The model recapitulates the observation that treatments targeting stem cell replication can induce a substantial delay of organ failure...
August 6, 2018: Scientific Reports
Miki Ando, Hiromitsu Nakauchi, Norio Komatsu
Extranodal natural killer (NK) /T-cell lymphoma (ENKL), nasal-type, is an aggressive lymphoma that is relatively common in Asia and is resistant to anthracycline-based chemotherapy. Antigen-specific cytotoxic T-lymphocyte (CTL) therapy can induce durable remission in selected tumors, such as melanomas and virus-related tumors. ENKLs are commonly infected with the Epstein-Barr virus (EBV) ; therefore, CTL therapy can be effective for these lymphomas. However, CTLs that are continuously exposed to viral or tumor antigens usually get exhausted...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Mário Jorge Freire Dos Santos, Ricardo Carvalho, Luis G Arnaut
BACKGROUND: QueryHyaluronic acid (HA) is a large polymer increasingly used as dermal filler. HA does not permeate through healthy skin and is administered using various injection techniques. As HA procedures become more popular, the number of complications in facial rejuvenation procedures is likely to increase. Alternative methods may be necessary to satisfy the increasing demand for HA procedures. High-frequency high-intensity ultrasound is a painless and noninvasive method to deliver large molecules to the skin that is expected to deliver HA with visible results...
August 3, 2018: Aesthetic Plastic Surgery
Carolin Göbel, Roman Goetzke, Thomas Eggermann, Wolfgang Wagner
Replicative senescence hampers application of mesenchymal stromal cells (MSCs) because it limits culture expansion, impairs differentiation potential, and hinders reliable standardization of cell products. MSCs can be rejuvenated by reprogramming into induced pluripotent stem cells (iPSCs), which is associated with complete erasure of age- and senescence-associated DNA methylation (DNAm) patterns. However, this process is also associated with erasure of cell-type and tissue-specific epigenetic characteristics that are not recapitulated upon re-differentiation towards MSCs...
August 3, 2018: Scientific Reports
Florian G Mildenberger
Modern sexology was introduced by the Berlin-based Magnus Hirschfeld, who was born 150 years ago. He revolutionized the physician-patient relationship by introducing new terms of sexual behavior. His theory of "sexual in-betweens" paved the way for new concepts in sexual therapy, including hormonal pills in urological practice. Some of his colleagues developed the idea of a rejuvenation of male organism by sterilization. Many urologists had learned this operation in 1920s, which thus unintentionally enabled the National Socialists to quickly implement racial hygiene laws after 1933...
August 3, 2018: Der Urologe. Ausg. A
Na-Young Choi, Ji Young Kim, Mina Hwang, Eun-Hye Lee, Hojin Choi, Kyu-Yong Lee, Young Joo Lee, Seong-Ho Koh
Oxygen and glucose (OGD) deprivation is one of the most important pathogenic mechanisms in cerebral infarction and is widely used as an in vitro model for ischemic stroke. OGD also damages neural stem cells (NSCs), which are important in brain recovery after cerebral infarction. To enhance recovery, there have been many studies aimed at determining methods to protect NSCs after stroke. Because atorvastatin has diverse protective effects on neural cells, we studied whether it could rejuvenate NSCs injured by OGD...
August 3, 2018: Molecular Neurobiology
Dapeng Jiang, Bo Xu, Peng Gao
BACKGROUND: Age-related changes in the properties of tendon stem cells (TSCs) may play a role in the progressive degeneration and increased risk of injury to tendon tissue. Recent reports have demonstrated that a decellularized extracellular matrix (DECM) can provide an appropriate niche to maintain the proliferation and differentiation capacity of adult stem cells. OBJECTIVES: We investigated the biological effects of DECM obtained from young TSCs on the proliferation, stemness, senescence, and differentiation of the aged TSCs...
July 31, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Hui-Fang Song, Sheng He, Shu-Hong Li, Wen-Juan Yin, Jun Wu, Jian Guo, Zheng-Bo Shao, Xiao-Yan Zhai, Hui Gong, Li Lu, Fang Wei, Richard D Weisel, Jun Xie, Ren-Ke Li
Reduced regenerative capacity of aged stem cells hampers the benefits of autologous cell therapy for cardiac regeneration. This study investigated whether neuron-derived neurotrophic factor (NDNF) could rejuvenate aged human bone marrow (hBM)- multipotent mesenchymal stromal cells (MSCs) and whether the rejuvenated hBM-MSCs could improve cardiac repair after ischemic injury. Over-expression of NDNF in old hBM-MSCs decreased cell senescence and apoptosis. Engraftment of NDNF over-expressing old hBM-MSCs into the ischemic area of mouse hearts resulted in improved cardiac function after myocardial infarction, while promoting implanted stem cell survival...
December 2017: JACC. Basic to Translational Science
Sven Teurlincx, Michiel J J M Verhofstad, Elisabeth S Bakker, Steven A J Declerck
The presence of a high diversity of different successional stages in a landscape may help to conserve and promote landscape-wide biodiversity. A strategy to achieve this is using Cyclic Rejuvenation through Management (CRM), an approach employed in a variety of different ecosystems. CRM periodically resets the successional stages in a landscape. For aquatic systems this constitutes vegetation removal and dredging. For this approach to be useful (a) successional stages are required to be different in community composition and (b) these differences need to be caused by true replacement of species between stages...
2018: Frontiers in Plant Science
Lu Lu, Xiaofei Bai, Yongliang Cao, Haiyu Luo, Xing Yang, Lijing Kang, Mei-Juan Shi, Wenying Fan, Bing-Qiao Zhao
Background: Growth differentiation factor 11 (GDF11), a member of transforming growth factor-β (TGF-β) superfamily, was shown to rejuvenate cardiac and skeletal muscle function and to improve cerebral vasculature and neurogenesis in old mice. However, recent experimental data reported that raising GDF11 levels inhibited skeletal muscle regeneration and had no effect on cardiac hypertrophy. Our aim was to investigate the effects of GDF11 on brain repair during the recovery phase after stroke. Methods: Mice were subjected to distal middle cerebral artery occlusion, and recombinant GDF11 (rGDF11) was injected intraperitoneally once a day during days 7-13 after stroke...
2018: Frontiers in Cellular Neuroscience
Steven H Dayan, Jonathan T Bacos, Nimit D Gandhi, Thuy-Van T Ho, Arjun Kalbag
BACKGROUND: Small-particle hyaluronic acid filler is approved for lip augmentation and correction of perioral rhytides. Treatment with this product may improve facial aesthetics, projected first impression, and self-perception of mood. OBJECTIVE: To determine the effect of perioral rejuvenation with hyaluronic acid on patient perception of mood and projected first impression. MATERIALS AND METHODS: Seventeen subjects underwent perioral rejuvenation treatment with small-particle hyaluronic acid filler...
July 27, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Kim Baumann
No abstract text is available yet for this article.
July 27, 2018: Nature Reviews. Molecular Cell Biology
Conor M Sugrue, Jack L Kelly, Niall McInerney
Background: Platysma bands are characteristic of an aging neck. Resection and plication of the platysma muscle is the basis of treatment. Yet, unfavorable surgical outcomes and improved understanding of platysma band etiology has shifted treatment towards nonsurgical rejuvenation. Objective: Assesses efficacy, injection techniques, and complications associated with botulinum toxin injection for the treatment of platysma bands. Methods: A systematic literature search was performed to identify articles reporting botulinum toxin injections for platysma bands in neck rejuvenation...
July 25, 2018: Aesthetic Surgery Journal
Elena Fasola, David Bosoni
Background: The well-being of the vulva and a woman's quality of life are distinctly correlated. Recent years have seen an increasing flow of papers about nonsurgical vulvar rejuvenation techniques. Dynamic Quadripolar RadioFrequency (DQRFTM), one of the newest light- and energy-based vulvar rejuvenation technologies, has showed to be an effective option in aesthetic gynecology. Objective: This article utilized qualitative and semi-quantitative evaluations of the short-term vulvar aesthetics to illustrate the efficacy of an accelerated DQRFTM vulvar rejuvenation program in women with mild to moderate vulvar hypotrophy...
July 25, 2018: Aesthetic Surgery Journal
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