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https://www.readbyqxmd.com/read/30280066/netherton-syndrome-a-case-report-and-review-of-literature
#1
Hafiz M Kashif Saleem, Muhammad Faizan Shahid, Amir Shahbaz, Atif Sohail, Muhammad Arslan Shahid, Issac Sachmechi
Netherton syndrome (NS) is a rare autosomal recessive disorder characterized by a triad of congenital ichthyosiform erythroderma (CIE) or ichthyosis linearis circumflexa (ILC), hair shaft abnormalities, and atopic diathesis (elevated serum IgE ). We report a case of a two-year-old boy presented with intractable pruritus, scaling, dry skin and generalized eczematous lesions resistant to atopic dermatitis therapy. Netherton syndrome misdiagnosed as atopic dermatitis due to the presence of eczematous skin lesions and allergic problems...
July 30, 2018: Curēus
https://www.readbyqxmd.com/read/30251122/precision-personalized-medicine-in-allergic-diseases-and-asthma
#2
REVIEW
Umut Can Kucuksezer, Cevdet Ozdemir, Mubeccel Akdis, Cezmi A Akdis
Like many other chronic diseases, every allergic patient has different characteristics based on clinical course, treatment responsiveness and disease outcomes, which are associated with the genetic and epigenetic control of molecular mechanisms and environment. This variability necessitates the establishment of patient-tailored and precision approaches in handling allergic disorders. Better understanding of the underlying pathophysiological mechanisms for the development of allergic disorders will provide more rationale strategies based on individual cases in controlling and treating these disorders...
December 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30159849/possible-role-of-environmental-factors-in-the-development-of-food-allergies
#3
REVIEW
Jodi Shroba, Niharika Rath, Charles Barnes
The development of food allergies is thought to involve multiple factors, and it is unclear which conveys the most risk regarding this process. Since food allergy is a chronic disease without a cure at this time, understanding its development could provide an avenue for preventive practices and development of a curative treatment. Both historical and current data implicate maternal factors, genetics, and environmental exposures as major risk factors in the development of food allergy. An immature gut of the infant has been hypothesized as a possible route of sensitization...
August 29, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/30144497/the-phytochemistry-pharmacokinetics-pharmacology-and-toxicity-of-euphorbia-semen
#4
REVIEW
An Zhu, Tao Zhang, Qi Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Euphorbia semen, the dried and ripe seed of Euphorbia lathyris Linnaeus, is widely cultivated for traditional medicine use. This semen is used to expel water, help with phlegm retention, promote blood circulation, remove blood stasis, cure tinea and scabies, and treat amenorrhea, snakebites, terminal schistosomiasis, anuria and constipation. AIM OF THE REVIEW: This review provides updated, comprehensive and categorized information on the local and traditional uses, phytochemistry, pharmacokinetics, pharmacological activities and toxicity of Euphorbia semen...
December 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30040230/determining-food-allergens-by-skin-sensitization-in-mice
#5
Norimasa Tamehiro, Reiko Adachi, Yoshie Kimura, Shinobu Sakai, Reiko Teshima, Kazunari Kondo
A food allergy is a chronic inflammatory disease against dietary antigens with high prevalence in industrialized countries. Because there is currently no cure for food allergies, avoiding the allergen is crucial for the prevention of an allergic reaction. Therefore, a further understanding of the pathogenesis and risk factors that augment the sensitization to food allergens is required. We have previously developed a food allergy mouse model using transdermal sensitization, which influences the susceptibility to food allergies...
May 2018: Current Protocols in Toxicology
https://www.readbyqxmd.com/read/30033432/mini-review-a-mini-review-of-therapeutic-potential-of-mangifera-indica-l
#6
Nazima Batool, Noshin Ilyas, Sumera Shabir, Maimoona Saeed, Roomina Mazhar
Among known species of 69 Mangifera, Mangifera indica L. is a medicinal plant being used in tropical regions by indigenous people. It has been a main plant species being used in Ayurvedic as well as indigenous medical systems form 4000 years. Components of M. indica are recurrently used as a traditional medicine system to cure numerous ailments. Active constituents are present in stem bark, leaves, heartwood, roots and fruit and have antioxidant, anti-inflammatory, radioprotective, antitumor, immune-modulatory, anti-allergic, anti-diabetic, anti-bone resorption, mono-amine oxidase inhibiting, anti-viral, anti-fungal, anti-bacterial, anti-spasmodic, antidiarrheal, anti-malarial, antiparasitic as well as lipolytic properties...
July 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30024891/genistein-induces-macrophage-polarization-and-systemic-cytokine-to-ameliorate-experimental-colitis
#7
Jessicca D Abron, Narendra P Singh, Robert L Price, Mitzi Nagarkatti, Prakash S Nagarkatti, Udai P Singh
Mucosal changes in Crohn's disease (CD) and ulcerative colitis (UC), two major forms of inflammatory bowel disease (IBD), are characterized by a prominent infiltration of inflammatory cells including lymphocytes, macrophages, T cells and neutrophils. The precise etiology of IBD is unknown but it involves a complex interplay of factors associated with the immune system, environment, host genotype and enteric commensal bacteria. As there is no known safe cure for IBD, natural alternative therapeutic options without side effects are urgently needed...
2018: PloS One
https://www.readbyqxmd.com/read/29985741/non-glaucoma-periocular-allergic-atopic-and-irritant-dermatitis-at-an-academic-institution-a-retrospective-review
#8
Saagar A Pandit, Lora R Dagi Glass
PURPOSE: To better understand the nature of periocular dermatitis (PD) patient presentation, treatment, time-to-cure, and referral pattern for allergy testing in an ophthalmic academic center. METHODS: A retrospective chart review of 344 patients diagnosed with PD between January 1, 2000 and November 30, 2016 at the Edward S. Harkness Eye Institute was performed. Eighty patients were eligible for the study. The primary endpoint was the time-to-cure. Cox proportional hazards regression was performed to assess if there was a significant difference between time-to-cure in patients treated with: 1) combination topical steroid/antibiotic (n = 6) vs...
July 9, 2018: Orbit
https://www.readbyqxmd.com/read/29916581/-immunological-mechanisms-of-allergic-diseases
#9
Enrico Maggi
OBJECTIVES: In the last decades the knowledge on pathogenetic mechanisms of allergic diseases extraordinarily improved with relevant clinical outputs. From the '90yrs we know that Th2 cells are essential for allergic inflammation, since they produce type 2 cytokines, recognise allergens, induce IgE switch on B cells and recruit mastcells and eosinophils into tissues for maintaining the flogosis. METHODS: Recently a new subset of innate immunity (ILC2) have been shown to amplify the allergic inflammation...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29885882/activated-mast-cells-mediate-low-grade-inflammation-in-type-2-diabetes-interleukin-37-could-be-beneficial
#10
REVIEW
Pio Conti, Gianpaolo Ronconi, Spyridon K Kritas, Alessandro Caraffa, Theoharis C Theoharides
Mast cells (MCs) promote guest immune responses to parasites and play a critical role in allergic and inflammatory reactions. Once they have been activated, MCs release highly inflammatory compounds that can provoke serious pathologic signs that can lead to death. MCs generate a number of preformed, de novo synthesized compounds and inflammatory cytokine/chemokine synthesis in response to the high-affinity (Kd=10-10 M) immunoglobulin E receptor triggering. Circulating MC progenitors migrate into arterial intima and develop lesions, mediating inflammation...
October 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29873211/-value-discussion-of-radical-sinus-surgery-for-difficult-to-treat-rhinosinusitis
#11
J Y Li, F Chen, C J Yu, X F Ma, H Li, H D Wang
Objective: To investigate the efficacy of radical sinus surgery (RSS) on difficult-to-treat rhinosinusitis(DTRS) with nasal polyps. Method: We retrospectively analyzed the clinical data of 26 patients with DTRS that treated with RSS and patients who were not treated with RSS in our hospital from August 2013 to June 2017.The effect of RSS were evaluated by comparing the CT Lund-Kennery score,endoscope Lund-Kennery score,global VAS score and dysosmia VAS score before operation and 6 months after operation. Result: RSS group had more severe Lund-Kennery score,global VAS score and dysosmia VAS score than non-RSS group,and also had more previous surgeries,higher ratio of olfactory region polyps,and higher ratio of co-existing asthma and allergic rhinitis...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29802846/synthetic-analogues-of-the-parasitic-worm-product-es-62-reduce-disease-development-in-in-vivo-models-of-lung-fibrosis
#12
Colin J Suckling, Sambuddho Mukherjee, Abedawn I Khalaf, Ashwini Narayan, Fraser J Scott, Sonal Khare, Saravanakumar Dhakshinamoorthy, Margaret M Harnett, William Harnett
Parasitic worms are receiving much attention as a potential new therapeutic approach to treating autoimmune and allergic conditions but concerns remain regarding their safety. As an alternative strategy, we have focused on the use of defined parasitic worm products and recently taken this one step further by designing drug-like small molecule analogues of one such product, ES-62, which is anti-inflammatory by virtue of covalently attached phosphorylcholine moieties. Previously, we have shown that ES-62 mimics are efficacious in protecting against disease in mouse models of rheumatoid arthritis, systemic lupus erythematosus and skin and lung allergy...
September 2018: Acta Tropica
https://www.readbyqxmd.com/read/29798351/-analysis-of-related-factors-of-recurrent-otitis-media-with-effusion-in-children
#13
Z Zhu, G X Zheng, Q Li, Q L Shi, H G Zhou, R P Fang
Objective: To investigate the influencing factors of recurrent episodes of otitis media with effusion in children. Method: A retrospective summary of the clinical data of 210 cases of children with otitis media with effusion, 75 cases of recurrence after treatment, 135 cases were recovered, the recurrence of the related factors and after symptomatic treatment effect is analyzed. Result: Logistic regression analysis results found that adenoid hypertrophy (Ⅲ°, Ⅳ°), tonsil hypertrophy (Ⅳ°) and sinusitis (including choanal polyp), a positive allergens, upper respiratory tract infection, the stomach esophagus regurgitation, cleft palate, younger age has significant effect on recurrence of otitis media with effusion, have significant difference ( P < 0...
August 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29798246/-clinical-analysis-of-48-cases-of-non-invasive-fungal-sinusitis
#14
L N Fang, H J Luo, Y L Ouyang
Objective: To analyze the causes, imaging diagnosis, clinical characteristics and clinical effect of the endoscopic surgery of non-invasive fungal rhino-sinusitis. Method: A retrospective analysis of 48 patients diagnosed with fungal sinusitis by pathology. Result: Forty-eight cases of 40 cases are fungal sinusitis (40/48), the other 8 cases are allergic fungal rhinosinusitis. The two morphology, imaging, histopathology, treatment and outcome are not the same, more than half of the CT scan and endoscopic examination, have different degrees of anatomical abnormalities (26/28), 25 cases had a long-term frequent using of antibiotics...
July 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29798088/-clinical-analysis-of-combined-treatment-in-87-patients-with-recurrent-allergic-fungal-rhinosinusitis
#15
M H Zhou, Y L Zhao, Y J Zhang, S T Zhang
Objective: To evaluate the effects of combined treatment with FESS on postoperative recurrent allergic fungal rhinosinusitis treatment. Method: Eighty-seven patients with allergic fungal sinusitis under combined treatment were investigated. Result: All patients were followed up for more than one year.Clinical symptoms had greatly improved after treatment compared with before treatment.Postoperative VAS score and Lund-Mackay score were lower than preoperative ones.Out of 87 patients,42 patients were successfully cured, 37 patients showed improvement, but there was no change in other 8 patients...
April 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29761483/epithelial-barrier-dysfunctions-in-atopic-dermatitis-a-skin-gut-lung-model-linking-microbiome-alteration-and-immune-dysregulation
#16
REVIEW
T H Zhu, T R Zhu, K A Tran, R K Sivamani, V Y Shi
BACKGROUND: Atopic dermatitis is a systemic disorder characterized by abnormal barrier function across multiple organ sites. Causes of epidermal barrier breakdown are complex and driven by a combination of structural, genetic, environmental and immunological factors. In addition, alteration in microflora diversity can influence disease severity, duration, and response to treatment. Clinically, atopic dermatitis can progress from skin disease to food allergy, allergic rhinitis, and later asthma, a phenomenon commonly known as the atopic march...
September 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29713367/wentong-decoction-cures-allergic-bronchial-asthma-by-regulating-the-apoptosis-imbalance-of-eos
#17
Yue Yan, Hai-Peng Bao, Chun-Lei Li, Qi Shi, Yan-Hua Kong, Ting Yao, You-Lin Li
Background: Eosinophils (EOS) is one of the most important cells involved in the pathogenesis of chronic airway inflammation in asthma, and its apoptosis is part of the mechanisms of asthma. Therefore, this study aimed to observe the effect of Chinese medicine Wentong decoction (WTD) in EOS apoptosis in asthmatic rats. This work also explored the mechanism of WTD regulation in EOS apoptosis and provided a new target for clinical treatment of asthma. Methods: Asthmatic rats induced by ovalbumin were treated with WTD...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29701897/sirt1-attenuates-murine-allergic-rhinitis-by-downregulated-hmgb-1-tlr4-pathway
#18
Y Yuan, Q Liu, J Zhao, H Tang, J Sun
Conventional allergic rhinitis (AR) treatments have limitations due to the lack of safety and complete cure strategy. We evaluated the effects of silent information regulator 1 (SIRT1), a multifunctional molecule involved in a variety of inflammatory pathways, on murine AR model. Ovalbumin (OVA)-induced murine model was constructed, and recombinant SIRT1 was administered into the nostril continuously. The expression of SIRT1 was measured at mRNA and protein levels, and the allergic symptoms were evaluated. Protein levels of OVA-specific IgE, leukotriene C4 (LTC4), eosinophil cation protein (ECP), prostaglandin D2 (PGD2), as well as different inflammatory cytokine mediators in the serum and nasal lavage fluid (NLF), were assessed by ELISA...
June 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29696736/bismuth-improves-efficacy-of-proton-pump-inhibitor-clarithromycin-metronidazole-triple-helicobacter-pylori-therapy-despite-a-high-prevalence-of-antimicrobial-resistance
#19
Xiaohua Long, Qi Chen, Lou Yu, Xiao Liang, Wenzhong Liu, Hong Lu
BACKGROUND: Helicobacter pylori (H. pylori) eradication has become increasingly difficult especially for penicillin allergy patients. AIMS: To evaluate the efficacy of adding bismuth or high-dose metronidazole to an H. pylori eradication regimen containing a proton-pump inhibitor, clarithromycin, and metronidazole in patients allergic to penicillin. METHODS: Pilot study in which penicillin-allergic, treatment-naive subjects were randomized (1:1) to 14-day esomeprazole (20 mg q12h), clarithromycin (500 mg q12h), and high dose of metronidazole (400 mg q6h) with (BECM group) or without (ECM group) bismuth (600 mg q12h)...
June 2018: Helicobacter
https://www.readbyqxmd.com/read/29613858/the-medical-necessity-of-comprehensive-patch-testing
#20
REVIEW
Tian Hao Zhu, Raagini Suresh, Erin Warshaw, Pamela Scheinman, Christen Mowad, Nina Botto, Bruce Brod, James S Taylor, Amber Reck Atwater, Kalman Watsky, Peter C Schalock, Brian C Machler, Stephen Helms, Sharon E Jacob, Jenny E Murase
Allergic contact dermatitis is associated with significant disease and economic burden in the United States. To properly manage allergic contact dermatitis, it is important to accurately identify the substance(s) implicated in the dermatitis to prevent disease recurrence. The commercially available T.R.U.E Test (36 allergens) screening panel has been reported to have a conservative hypothetical allergen detection rate of 66.0%, at most. Importantly, these calculations are based on the 78% of patients who had clinically relevant reactions to allergens present on the North American Contact Dermatitis Group screening series (70 allergens), without the use of supplemental allergens...
May 2018: Dermatitis
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