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Teresa M S A Böhm, Christoph J Klinger, Natalie Gedon, Laura Udraite, Katja Hiltenkamp, Ralf S Mueller
OBJECTIVE: Edible insects (like mealworms, locusts and crickets) contain energy, protein, fatty acids, minerals and trace elements and have been found to be high quality food sources. They could provide a new food source for patients with adverse food reactions, as well as being of ecological and ethical interest. The aim of this study was to evaluate the effect of a new commercially available, insect protein-based diet on the clinical signs in those dogs via Canine Atopic Dermatitis Lesion Index (CADLI), Pruritus Visual Analogue Scale (PVAS) and coat quality score...
October 2018: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Marietta Iacucci, Kenneth McQuaid, X Sean Gui, Yasushi Iwao, Brendan C Lethebe, Mark Lowerison, Takayuki Matsumoto, Uday N Shivaji, Samuel C L Smith, Venkataraman Subramanian, Toshio Uraoka, Silvia Sanduleanu, Subrata Ghosh, Ralf Kiesslich
BACKGROUND:  Characterization of colonic lesions in inflammatory bowel disease (IBD) remains challenging. We developed an endoscopic classification of visual characteristics to identify colitis-associated neoplasia using multimodal advanced endoscopic imaging (Frankfurt Advanced Chromoendoscopic IBD LEsions [FACILE] classification). METHODS:  The study was conducted in three phases: 1) development - an expert panel defined endoscopic signs and predictors of dysplasia in IBD and, using multivariable logistic regression created the FACILE classification; 2) validation - using 60 IBD lesions from an image library, two assessments of diagnostic accuracy for neoplasia were performed and interobserver agreement between experts using FACILE was determined; 3) reproducibility - the reproducibility of the FACILE classification was tested in gastroenterologists, trainees, and junior doctors after completion of a training module...
December 12, 2018: Endoscopy
Yasuko Kaneko, Farhana Sharmin, Nayeema Bulbul, Kimie Atsuzawa
High-pressure frozen soybean root nodules were fractured and backscattered electron images were obtained from uncoated samples in a low vacuum scanning electron microscope equipped with a cryo-transfer system. Structures of infected cells were well preserved: numerous symbiosomes, as well as nuclei, plastids and mitochondria were observed without ice crystal damage. After appropriate sublimation of water, bacteria included in symbiosomes were visualized. Membrane accumulation near nuclei, and vesicles and tubular membranes, which possibly contribute to symbiosome membrane formation, could be observed in a near native state...
December 12, 2018: Microscopy
Tomica Milosavljevic, Dusan Popovic, Simon Zec, Miodrag Krstic, Dragana Mijac
Superficial neoplastic lesions of the digestive tract are usually asymptomatic, and often represent incidental findings on endoscopy. The Paris Classification was developed for the systematic evaluation of superficial lesions of the oesophagus, stomach and colon. The significance of this classification in clinical practice is that it allows the depth of invasion to be estimated. Chromoendoscopy is used to improve the visualization of gastrointestinal lesions. There are 2 types of chromoendoscopy: dye and virtual chromoendoscopy...
December 12, 2018: Digestive Diseases
Richard Heyes, Courtney M Tomblinson, David G Lott
Post-transplant lymphoproliferative disorder (PTLD) is a unifying term for a spectrum of lymphoid expansion entities brought about by immunosuppression. It can present throughout the head and neck, and tonsillar involvement is not limited to children. We report the case of a 67-year-old woman who developed odynophagia associated with putrid halitosis 4 months after she had undergone renal transplantation. Direct visualization of the oropharynx revealed multiple sites of severe ulceration and erythema, with erosion of both the anterior and posterior right tonsillar pillars and a necrotic ulceration fistulating deeply...
December 2018: Ear, Nose, & Throat Journal
Julia E Noel, Hamed Sajjadi
Endoscopic technology is widely used in rhinology and anterior skull base surgery, but it has been less quickly incorporated into otologic practice. The design of the instrumentation forces surgeons to work one-handed and limits depth perception. Nevertheless, endoscopy also offers wide fields of view and access to spaces that are typically difficult to visualize. Its advantages have broadened the type and extent of operations that can be performed via the ear canal. We describe a method of endoscopic resection of glomus tympanicum tumors in 5 adults who had undergone endoscopic or endoscopy- assisted resection...
December 2018: Ear, Nose, & Throat Journal
Ying-Cheng Huang, Chun-Yu Chen, Kai-Cheng Lin, Shang-Wei Yang, Yih-Wen Tarng, Wei-Ning Chang
Wide-awake local anesthesia no tourniquet (WALANT) is used for various hand surgeries, but there are no reports of its use for distal radius fractures. The authors compared perioperative variables and clinical outcomes for volar plating for distal radius fractures with WALANT vs general anesthesia with tourniquet. This retrospective study included 47 patients who presented with distal radius fractures between January 2015 and February 2017. Twenty-one underwent surgical volar plating with WALANT, and 26 underwent surgical volar plating with general anesthesia with tourniquet...
December 11, 2018: Orthopedics
Young-Hoo Kim, Jang-Won Park, Jun-Shik Kim
No study has compared the prevalence of fretting and corrosion at the trunnion of cobalt-chrome (Co-Cr) and zirconia ceramic heads in the same patients. The authors sought to compare the prevalence of fretting and corrosion at the trunnion after total hip arthroplasty with a 32-mm Co-Cr or a 32-mm zirconia ceramic head-on-polyethylene bearing. Isolated revision of the ace-tabular components was performed in 78 patients (156 hips) for polyethylene wear and osteolysis of the acetabulum. Seventy-eight Co-Cr head-titanium alloy stem pairs were compared with 78 zirconia ceramic head-titanium alloy stem pairs in the same patients...
December 11, 2018: Orthopedics
Pieter C Geervliet, Mike Houtveen, Inger N Sierevelt, Cornelis P J Visser, Arthur van Noort
Shoulder arthroplasty is a valuable option for treating glenohumeral osteoarthritis. Revision surgery for a failed shoulder arthroplasty is associated with difficult procedures, complications, and worse outcomes. Compared with a total joint arthroplasty, a resurfacing prosthesis has the supposed advantages of limited perioperative complications and little bone loss during revision. The aim of this study was to describe patient-reported outcome measures of revision surgery from failed uncemented Global CAP (DePuy, Warsaw, Indiana) resurfacing hemiarthroplasty to total shoulder or reverse shoulder arthroplasty...
December 11, 2018: Orthopedics
Edward Hollingdale, Francisco Javier Pérez-Barbería, David McPetrie Walker
Interactions between domestic and wild species has become a global problem of growing interest. Global Position Systems (GPS) allow collection of vast records of time series of animal spatial movement, but there is need for developing analytical methods to efficiently use this information to unravel species interactions. This study assesses different methods to infer interactions and their symmetry between individual animals, social groups or species. We used two data sets, (i) a simulated one of the movement of two grazing species under different interaction scenarios by-species and by-individual, and (ii) a real time series of GPS data on the movements of sheep and deer grazing a large moorland plot...
2018: PloS One
Emily J Wilkins, Holly M Miller, Elizabeth Tilak, Rudy M Schuster
How information is communicated influences the public's environmental perceptions and behaviors. Information channels and sources both play an important role in the dissemination of information. Trust in a source is often used as a proxy for whether a particular piece of information is credible. To determine preferences for information channels and trust in various sources for information on nature-related topics, a mail-out survey was sent to randomly selected U.S. addresses (n = 1,030). Diverse groups of people may have differing communication preferences...
2018: PloS One
Paul Hömke, Judith Holler, Stephen C Levinson
In face-to-face communication, recurring intervals of mutual gaze allow listeners to provide speakers with visual feedback (e.g. nodding). Here, we investigate the potential feedback function of one of the subtlest of human movements-eye blinking. While blinking tends to be subliminal, the significance of mutual gaze in human interaction raises the question whether the interruption of mutual gaze through blinking may also be communicative. To answer this question, we developed a novel, virtual reality-based experimental paradigm, which enabled us to selectively manipulate blinking in a virtual listener, creating small differences in blink duration resulting in 'short' (208 ms) and 'long' (607 ms) blinks...
2018: PloS One
Rita Chen, Nora M Bello, Mark W Becker, Laura Bix
BACKGROUND: Unintentional exposure to medications is a noted problem in pediatric populations despite the prevalent use of child-resistant (CR) packaging and educational campaigns informing consumers about appropriate storage. OBJECTIVE: Conduct a proof-of concept study that evaluates how package designs that engage the attention of children in meaningless ways affect opening time and number of openings. STUDY DESIGN: Non-CR vials with or without distracters were provided to 108 children (24-51 months) in pairs...
2018: PloS One
Elizabeth K Brauer, George V Popescu, Dharmendra K Singh, Mauricio Calviño, Kamala Gupta, Bhaskar Gupta, Suma Chakravarthy, Sorina C Popescu
Plant protein kinases form redundant signaling pathways to perceive microbial pathogens and activate immunity. Bacterial pathogens repress cellular immune responses by secreting effectors, some of which bind and inhibit multiple host kinases. To understand how broadly bacterial effectors may bind protein kinases and the function of these kinase interactors, we first tested kinase-effector (K-E) interactions using the Pseudomonas syringae pv. tomato-tomato pathosystem. We tested interactions between five individual effectors (HopAI1, AvrPto, HopA1, HopM1, and HopAF1) and 279 tomato kinases in tomato cells...
December 12, 2018: PLoS Biology
Graham Seow-Hng Goh, Ming Han Lincoln Liow, William Yeo, Zhixing Marcus Ling, Guo Chang Ming, Wai Mun Yue, Seang Beng Tan, Li Tat John Chen
STUDY DESIGN: Retrospective study using prospectively collected registry data. OBJECTIVES: The authors examine the influence of preoperative mental health on outcomes after anterior cervical discectomy and fusion (ACDF) and determine the impact of ACDF on postoperative mental health. SUMMARY OF BACKGROUND DATA: While studies have reported a negative correlation between preoperative mental health and outcomes following lumbar spine surgery, the influence on outcomes following cervical spine surgery remains relatively understudied...
December 11, 2018: Spine
Katarina Berling Holm, Anna Bornefalk-Hermansson, Johan Knutsson, Magnus von Unge
OBJECTIVES: Patients with otosclerosis more often complain about postoperative taste disturbance than patients with chronic otitis media, which seems paradoxical. We aim to investigate if and potentially why this seems to be the case, since the chorda tympani nerve (CTN) is thought to be severely traumatized less frequently during surgery in the former than in the latter. STUDY DESIGN: Prospective cohort study. SETTING: Department of Otorhinolaryngology at Hospital of Vastmanland, Vasteras, Sweden...
January 2019: Otology & Neurotology
Danuta Raj-Koziak, Elżbieta Gos, Weronika Świerniak, Lucyna Karpiesz, Iwona Niedziałek, Elżbieta Włodarczyk, Henryk Skarżyński, Piotr H Skarżyński
OBJECTIVE: The aim of the study was to assess the relationship between psychoacoustic matches of tinnitus loudness and tinnitus loudness measured with a visual analogue scale (VAS) in patients with normal hearing and patients with hearing loss. STUDY DESIGN: Cross-sectional study. PATIENTS: A clinical group of 140 adult patients (46.4% women, 53.6% men) aged from 19 to 81 years old who had had tinnitus for at least 6 months were included in the study...
January 2019: Otology & Neurotology
Margot Putukian, Kaitlin Riegler, Stephanie Amalfe, Jared Bruce, Ruben Echemendia
OBJECTIVES: To evaluate the relationship between preinjury risk factors (RFs) and subsequent occurrence of concussion and examine whether preinjury RFs or postinjury assessments predict clinical recovery in collegiate athletes. METHODS: Risk factors (sex, sport, and self-report history of concussion, migraine, attention-deficit disorder, learning disability, depression, and anxiety) and Sport Concussion Assessment Tool (SCAT), depression/anxiety screenings, and neuropsychological testing were obtained before the season...
December 6, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Jacek Hermann, Tomasz Banasiewicz, Barbara Kołodziejczak
BACKGROUND: Patients with Crohn disease-related anal fistulas are treated with debridement of fistulous tracts and the placement of noncutting setons (NCSs). However, to reduce the high recurrence rate, there is still a need to develop more effective treatment methods. OBJECTIVE: To compare NCS with vacuum-assisted closure (VAC) treatment. METHODS: Medical records of 47 patients with Crohn anal fistulas were retrospectively evaluated. They were divided into two groups (I, VAC; II, NCS), consisting of 24 and 23 patients, respectively...
December 12, 2018: Advances in Skin & Wound Care
Fabrice Bonneville, Louis-David Rivière, Stephan Petersenn, Js Bevan, Aude Houchard, Caroline Sert, Philippe Jean Caron
Objective Pituitary adenoma MRI T2 signal intensity associates with tumor characteristics including responsiveness to somatostatin analogs (SSAs). These analyses determined whether baseline T2 signal intensity predicts response to primary medical treatment with long-acting SSA. Design Post-hoc analyses of the prospective multicenter, open-label, single-arm PRIMARYS study in which patients with treatment-naïve GH-secreting pituitary macroadenomas received fixed-dose lanreotide autogel (120mg) every 4-weeks for 48-weeks...
December 1, 2018: European Journal of Endocrinology
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