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Benign liver diseases

Vijay Gayam, Mazin Khalid, Sumit Dahal, Pavani Garlapati, Arshpal Gill
Fluconazole is a triazole antifungal medication used in the treatment of various fungal infections. It is available in both oral and parenteral formulations. Liver damage has been reported with fluconazole use, but most commonly it is benign elevated liver transaminases. Acute liver failure (ALF) in fluconazole use is rare, with cases being reported sporadically in literature and large cohorts describing incidence rates of acute liver injury ranging from 0.0 to 31.6/10,000 patients. We present a case of a 45-year-old African-American male with no history of liver disease who presented with superficial candidiasis and superimposed bacterial cellulitis...
March 2018: Journal of Family Medicine and Primary Care
Sarah G K Engel, Sonal Bhatia
Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder characterized by dermatologic manifestations and growth of multiple benign tumors often involving the brain, skin, kidneys, heart, lungs, and liver. It exhibits wide phenotypic variation, ranging from the most severe cases with intellectual disability and intractable epilepsy to the mildest, clinically silent forms of the disease. The incidence of TSC is reported to be 1/6000; however, this does not account for those with milder forms of the disease, of which forme fruste is the mildest...
April 2018: Journal of Pediatric Neurosciences
Ihab Hassanieh, Lara Hilal, Karine A Al Feghali, Ibrahim Khalifeh, Bassem Youssef
Background: Carcinoma Ex-pleomorphic adenoma is a malignant transformation of the common benign neoplasm of the salivary glands, "pleomorphic adenoma." Only two cases were ever reported with brain metastases, with absence of good evidence guiding management of such cases. Case Presentation: A 61-year-old woman presenting with facial paralysis was found to have carcinoma ex-pleomorphic adenoma of the parotid gland. Twenty months after local treatment, she developed brain metastases, treated with whole brain radiation therapy...
2018: Frontiers in Oncology
Luis Cano, Juan Pablo Cerapio, Eloy Ruiz, Agnès Marchio, Bruno Turlin, Sandro Casavilca, Luis Taxa, Guillaume Marti, Eric Deharo, Pascal Pineau, Stéphane Bertani
We previously described a divergent clinical and molecular presentation of hepatocellular carcinoma (HCC) in Peru. The present study aimed to further characterize the tissue features associated with this singular nosological form of HCC in order to gain insight into the natural history of the disease. We performed an exploratory analysis of the histology of both tumor and non-tumor liver (NTL) tissues from 50 Peruvian HCC patients, and compared with that of 75 individuals with non-HCC liver tumor or benign liver lesions as a baseline for NTL features...
July 30, 2018: Scientific Reports
Michał Wójciak, Jolanta Gozdowska, Marek Pacholczyk, Wojciech Lisik, Maciej Kosieradzki, Andrzej Cichocki, Olga Tronina, Magdalena Durlik
d_abstr_CB Solid-pseudopapillary neoplasms (SPN) of the pancreas, first described by Frantz in 1959, are a very rare entity and account for 0.13-2.7% of all pancreatic neoplasms. They are seen predominantly in young women in their second and third decade of life. d_abstr_CCR We report a case of a 51-year-old female first diagnosed with a pancreatic tumor in 2010 following a computed tomography (CT) scan of the abdomen. The lesion was originally thought to be a neuroendocrine tumor subsequently treated with chemotherapy, which delayed the appropriate treatment...
July 31, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Sarah Poetter-Lang, Katharina Staufer, Pascal Baltzer, Dietmar Tamandl, Dina Muin, Nina Bastati, Emina Halilbasic, Jacqueline C Hodge, Michael Trauner, Lili Kazemi-Shirazi, Ahmed Ba-Ssalamah
PURPOSE: To identify independent imaging features and establish a diagnostic algorithm for diagnosis of cystic fibrosis (CF)-associated liver disease (CFLD) in CF patients compared to controls using gadoxetic acid-enhanced MRI. METHODS: A total of 90 adult patients were enrolled: 50 with CF, 40 controls. The CF group was composed of two subgroups: a retrospective test subgroup (n = 33) and a prospective validation subgroup (n = 17). Controls (patients with normal liver enzymes and only benign focal liver lesions) were divided accordingly (27:13)...
July 27, 2018: European Radiology
Mansour S Aljabry, Shuaa Asiri, Tayseer Elsafi, Ghaleb Elyamany
Extramedullary hematopoiesis (EMH) is a presence of hematopoietic activity in the extramedullary sites. EMH can occur in both benign and malignant hematologic diseases. The liver and spleen are the most common sites, but may also occur infrequently at other sites. EMH often occurs in more than one site and quite rare in an isolated organ. In this study we describe an unusual case of generalized lymphadenopathy secondary to isolated extramedullary hematopoiesis as an initial manifestation of primary myelofibrosis...
May 14, 2018: Hematology Reports
Zijun Xie, Fangyuan Zhou, Yidong Yang, Leijia Li, Yiming Lei, Xianyi Lin, Haijiao Li, Xuemei Pan, Jianning Chen, Genshu Wang, Huiling Liu, Jie Jiang, Bin Wu
BACKGROUND: Long non-coding RNAs (lncRNAs) show great potential as diagnostic tools in many diseases. We aimed to develop sensitive and noninvasive biomarkers in saliva for detecting early hepatocellular carcinoma (HCC). METHODS: Candidate lncRNA biomarkers identified by Agilent microarray were subjected to validation using qPCR for the quantification of their expression levels in independent tissue, plasma and saliva sample sets, including healthy controls, HBsAg carriers, patients with chronic Hepatitis B, liver cirrhosis, early HCC, and advanced HCC...
July 2018: EBioMedicine
Yan-Lan Fang, Hong Chen, Chun-Lin Wang, Li Liang
Nonalcoholic fatty liver disease (NAFLD) has become the dominant form of chronic liver disease in children and adolescents with the increasing prevalence of obesity worldwide. NAFLD represents a wide spectrum of conditions, ranging from fatty liver - which generally follows a benign, non-progressive clinical course - to non-alcoholic steatohepatitis, a subset of NAFLD that may progress to cirrhosis and end-stage liver disease or liver carcinoma. The underlying pathophysiological mechanism of "pediatric" NAFLD remains unclear, although it is strongly associated with obesity and insulin resistance...
July 21, 2018: World Journal of Gastroenterology: WJG
Aashray K Gupta, Harsh A Kanhere, Guy J Maddern, Markus I Trochsler
BACKGROUND: Australian life expectancy is high by world standards, largely because of advanced health care. It is therefore important to determine safety and oncological benefits of major surgical procedures in the elderly. This retrospective review examines outcomes of liver resection in octogenarians. METHODS: Data on all liver resections performed at The Queen Elizabeth Hospital were collected in a prospective database. The primary aim was to determine overall and disease-free survival, and secondary aim to assess perioperative quality of life (QoL) and functionality outcomes using surrogate markers...
July 22, 2018: ANZ Journal of Surgery
Layanne C C Araujo, Karla B Feitosa, Gilson M Murata, Isadora C Furigo, Simone A Teixeira, Camila F Lucena, Luciene M Ribeiro, Marcelo N Muscará, Soraia K P Costa, José Donato, Silvana Bordin, Rui Curi, Carla R O Carvalho
We investigated the effect of the crude herbal extract from Uncaria tomentosa (UT) on non-alcoholic fatty liver disease (NAFLD) in two models of obesity: high fat diet (HFD) and genetically obese (ob/ob) mice. Both obese mouse models were insulin resistant and exhibited an abundance of lipid droplets in the hepatocytes and inflammatory cell infiltration in the liver, while only the HFD group had collagen deposition in the perivascular space of the liver. UT treatment significantly reduced liver steatosis and inflammation in both obese mouse models...
July 20, 2018: Scientific Reports
Sabrina Rüschenbaum, Katharina Schwarzkopf, Mireen Friedrich-Rust, Florian Seeger, Fabian Schoelzel, Yolanda Martinez, Stefan Zeuzem, Jörg Bojunga, Christian M Lange
Single nucleotide polymorphism (SNP) rs738409 C>G in the patatin-like phospholipase domain containing 3 ( PNPLA3 ) gene results in an amino acid exchange from isoleucin to methionine at position I148M of PNPLA3. The expression of this loss-of-function mutation leads to impaired hepatocellular triglyceride hydrolysis and is associated with the development of liver steatosis, fibrosis, and hepatocellular carcinoma. In contrast to these well-established associations, the relationship of the PNPLA3 rs738409 variant with other metabolic traits is incompletely understood...
July 2018: Hepatology Communications
Naim Alkhouri, Fred Poordad, Eric Lawitz
Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of insulin resistance, which is the hallmark of type 2 diabetes (T2D). NAFLD is a known risk factor for developing T2D and has a very high prevalence in those with existing T2D. The diabetes spectrum includes several conditions from prediabetes to T2D to insulin-dependent diabetes leading to macrovascular and microvascular complications. Similarly, NAFLD has a histologic spectrum that ranges from the relatively benign nonalcoholic fatty liver to the aggressive form of nonalcoholic steatohepatitis with or without liver fibrosis to nonalcoholic steatohepatitis-cirrhosis leading to end-stage liver disease...
July 2018: Hepatology communications
Stefano Fiorucci, Michele Biagioli, Eleonora Distrutti
With an estimated prevalence of ≈25% in Western and Asian countries, non alcoholic fatty liver disease (NAFLD), caused by chronic excessive caloric intake, is the emerging as the most prevalent liver disorder worldwide. NAFLD exists in two clinical entities, non-alcoholic fatty liver disease (NAFL), a relative benign disease that carry on minimal risk of liver-related morbidity but significant risk of cardiovascular complications, and non-alcoholic steatohepatitis (NASH), a progressive liver disorder with a significant risk for development of liver-related morbidities and mortality...
August 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Jaclyn LoPiccolo, Michael I Brener, Kiyoko Oshima, Evan J Lipson, James P Hamilton
Nodular regenerative hyperplasia (NRH) is a rare condition characterized by diffuse, benign transformation of hepatic parenchyma into regenerative nodules, and is an under-recognized cause of portal hypertension. We present a case of NRH associated with the anti-PD1 agent pembrolizumab, a previously unrecognized complication of immune checkpoint blockade.A 35 year-old male with no history of liver disease was diagnosed with localized B-Raf mutant axillary melanoma, initially treated with anti-PD1 agent pembrolizumab...
July 16, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Xiang-Fei Meng, Ying-Wei Pan, Zhan-Bo Wang, Wei-Dong Duan
Primary hepatic neuroendocrine tumor (PHNET) is an extremely rare liver tumor. Patients often have no clinical symptoms or have only non-specific symptoms, such as abdominal pain and abdominal mass. The clinical manifestations, disease development, treatment methods, and treatment outcomes of PHNET vary greatly among cases. Here we report a case of PHNET with a confirmed 26-year survival before surgery. The patient was a 56-year-old female. A large right hepatic mass was detected when the patient was 30 years old...
June 28, 2018: World Journal of Gastroenterology: WJG
Marianna G Mavilia, Tina Pakala, Marco Molina, George Y Wu
Hepatic cysts (HCs) are frequently discovered incidentally on abdominal imaging. The prevalence of HCs has been reported as high as 15-18% in the United States. Although most cysts are benign, some are malignant or premalignant. It is important to diagnose cystic lesions in order to properly manage them. Imaging with conventional ultrasound, computed tomography, magnetic resonance imaging, or contrast-enhanced ultrasound can be used to further characterize and diagnose HCs. Ultrasound is typically the first-line imaging modality, whereas more advanced imaging can help narrow down the specific lesion...
June 28, 2018: Journal of Clinical and Translational Hepatology
Y Shen, Z-B Zhang, S-D Wu, X-B Wu, J Li
OBJECTIVE: To investigate the values of growth differentiation factor-15 (GDF-15) level in the diagnosis of primary liver cancer and evaluation of chemotherapeutic effect. PATIENTS AND METHODS: 92 patients with liver cancer treated from June 2015 to May 2016 were selected as liver cancer group; 53 patients with benign liver lesion were selected as benign liver disease group, and 40 healthy subjects receiving physical examination were selected as healthy control group...
June 2018: European Review for Medical and Pharmacological Sciences
Vladimir Neychev, Vesela Ivanova, Tihomir Dikov, Georgi Todorov
A 67-year-old woman presented with clinical symptoms, radiological findings, and preoperative work-up highly suggestive of advanced stage IV carcinoma of the gallbladder (CG). An extended cholecystectomy with the excision of adjacent liver segments and loco-regional lymphadenectomy was performed. Final pathology results revealed diffuse xanthogranulomatous cholecystitis (XG) with ruptured Rokitansky-Aschoff sinuses with tumor-resembling adenomyosis without atypical or malignant cells. There was a reactive inflammatory and fatty degeneration of the adjacent hepatic tissue and a nonspecific inflammatory reaction of the enlarged periportal lymph nodes...
April 17, 2018: Curēus
Cheng-Gang Jiang, Qun Chen, Lina Wu, Guang Wang, Jianzhong Ma
Purpose: This study was performed to examine the regularity and role of p16 methylation in hepatocellular carcinoma (HCC) blood. Methods: Big data of the case-control studies due to blood p16 methylation detection were collected in English and Chinese Journals. The risk of HCC's histologic process was investigated using both Meta-analysis and the quantitative correlation analysis. Results: p16 methylation frequencies in blood were gradually increased from 0 % in normal to 10 % in benign disease, and to 60 % in HCC development...
2018: Journal of Cancer
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