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Manual diagnosis

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Objective: To obtain baseline data of pediatricians' clinical use of antibacterial agents in children in China, and provide evidence for the follow-up of guidelines for the diagnosis and treatment of children's clinical medications and the development of rational drug management measures and norms. Methods: A multi-center cross-sectional study was designed to conduct a network electronic questionnaire survey of doctors with child prescription rights in hospitals of all provinces, municipalities and autonomous regions across the country through cluster sampling to understand the current status of antibacterial drugs use in 2016...
December 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Birgit Bremer, Olympia E Anastasiou, Sandra Ciesek, Heiner Wedemeyer
BACKGROUND: Hepatitis D virus (HDV) infection is a cause of severe liver disease. Diagnosis and monitoring of HDV RNA are important to patient management. Since 2012 a WHO standard for HDV RNA quantification is available, however, the impact of RNA extraction methods on HDV viral load quantification has never been evaluated. METHODS: Aim of this study was to compare four commonly used automated nucleic acid (NA) extraction methods (AmpliPrep, MagNA Pure, QIAcube QBK and QIAcube VRK) to a manual RNA extraction method (Instant Virus RNA/DNA kit) and evaluate the possible effect of each method on HDV RNA yield with subsequent amplification with the Robogene HDV assay...
December 5, 2018: Antiviral Therapy
Cicilia Marcella, Rui Hua Shi, Shakeel Sarwar
Aims: To review the clinical presentation, diagnosis, assessment of risk of malignancy, and recent advances in management (mainly focusing on the role of endoscopic resection) of gastrointestinal stromal tumors (GISTs) in upper GI. Method: We searched Embase, Web of science, and PubMed databases from 1993 to 2018 by using the following keywords: "gastrointestinal stromal tumors," "GIST," "treatment," and "diagnosis." Additional papers were searched manually from references of the related articles...
2018: Gastroenterology Research and Practice
Cole A Deisseroth, Johannes Birgmeier, Ethan E Bodle, Jennefer N Kohler, Dena R Matalon, Yelena Nazarenko, Casie A Genetti, Catherine A Brownstein, Klaus Schmitz-Abe, Kelly Schoch, Heidi Cope, Rebecca Signer, Julian A Martinez-Agosto, Vandana Shashi, Alan H Beggs, Matthew T Wheeler, Jonathan A Bernstein, Gill Bejerano
PURPOSE: Diagnosing monogenic diseases facilitates optimal care, but can involve the manual evaluation of hundreds of genetic variants per case. Computational tools like Phrank expedite this process by ranking all candidate genes by their ability to explain the patient's phenotypes. To use these tools, busy clinicians must manually encode patient phenotypes from lengthy clinical notes. With 100 million human genomes estimated to be sequenced by 2025, a fast alternative to manual phenotype extraction from clinical notes will become necessary...
December 5, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Céline Guien, Gaëlle Blandin, Pauline Lahaut, Benoît Sanson, Katia Nehal, Sitraka Rabarimeriarijaona, Rafaëlle Bernard, Nicolas Lévy, Sabrina Sacconi, Christophe Béroud
BACKGROUND: Facioscapulohumeral muscular dystrophy is a rare inherited neuromuscular disease with an estimated prevalence of 1/20,000 and France therefore harbors about 3000 FSHD patients. With research progress and the development of targeted therapies, patients' identification through registries can facilitate and improve recruitment in clinical trials and studies. RESULTS: The French National Registry of FSHD patients was designed as a mixed model registry involving both patients and physicians, through self-report and clinical evaluation questionnaires respectively, to collect molecular and clinical data...
December 4, 2018: Orphanet Journal of Rare Diseases
Xuhao Du, Gary Allwood, Katherine Mary Webberley, Adam Osseiran, Barry J Marshall
Interpretation of bowel sounds (BS) provides a convenient and non-invasive technique to aid in the diagnosis of gastrointestinal (GI) conditions. However, the approach's potential is limited by variation between BS and their irregular occurrence. A short, manual auscultation is sufficient to aid in diagnosis of only a few conditions. A longer recording has the potential to unlock additional understanding of GI physiology and clinical utility. In this paper, a low-cost and straightforward piezoelectric acoustic sensing device was designed and used for long BS recordings...
December 3, 2018: Sensors
Ling Li, Min Li, Jianping Lu, Xiaohu Ge, Weiguo Xie, Zichen Wang, Xiaoling Li, Chao Li, Xiaoyan Wang, Yan Han, Yifei Wang, Liyan Zhong, Wei Xiang, Xiaodong Huang, Haijia Chen, Paul Yao
We have previously reported that prenatal progestin exposure induces autism-like behavior in offspring through ERβ (estrogen receptor β) suppression in the brain, indicating that progestin may induce autism spectrum disorders (ASD). In this study, we aim to investigate whether prenatal progestin exposure is associated with ASD. A population-based case-control epidemiology study was conducted in Hainan province of China. The ASD children were first screened with the Autism Behavior Checklist (ABC) questionnaire, and then diagnosed by clinical professionals using the ASD diagnosis criteria found in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V)...
2018: Frontiers in Psychiatry
Chien-Wei Chen, Li-Sheng Hsu, Jun-Cheng Weng, Hsu-Huei Weng, Yu-Ling Ye, Sheng-Lung Hsu, Wei-Ming Lin
To explore the role of quantitative digital subtraction angiography (QDSA) in the diagnosis of small hepatocellular carcinoma (HCC).Between November 2015 and November 2017, all patients who underwent chemoembolization for HCC were retrospectively reviewed. Patients with tumors measuring more than 5 cm or evident post-processing imaging artifacts were excluded. Images were post-processed using the QDSA technique. Regions of interest were manually drawn on proper hepatic artery (as a reference), target HCC and peritumoral liver...
November 2018: Medicine (Baltimore)
Bruno Schivinski, Magdalena Brzozowska-Woś, Erin M Buchanan, Mark D Griffiths, Halley M Pontes
Internet Gaming Disorder (IGD) has been recognized by the American Psychiatric Association (APA) as a tentative disorder in the latest fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). In order to advance research on IGD, the APA has suggested that further research on the nine IGD criteria to investigate its clinical and empirical feasibility is necessary. The aim of the present study was to develop the Polish the Internet Gaming Disorder Scale-Short-Form (IGDS9-SF) and scrutinize the nine IGD criteria empirically...
December 2018: Addictive Behaviors Reports
Jason K Wang, Jason Hom, Santhosh Balasubramanian, Jonathan H Chen
In this data article, we learn clinical order patterns from inpatient electronic health record (EHR) data at a tertiary academic center from three different cohorts of providers: (1) Clinicians with lower-than-expected patient mortality rates, (2) clinicians with higher-than-expected patient mortality rates, and (3) an unfiltered population of clinicians. We extract and make public these order patterns learned from each clinician cohort associated with six common admission diagnoses (e.g. pneumonia, chest pain, etc...
December 2018: Data in Brief
He Guowei, Liao Yuan, Li Ma, Liu Zhongyang, Song Zhixing, Li Lin, Luo Minqi
OBJECTIVE: To evaluate the reliability and accuracy of Cytokeratin-19-fragment (CYFRA21-1) in the diagnosis of intrahepatic cholangiocarcinoma (ICC) based on literature meta-analysis and the diagnostic efficacy and clinical application of CYFRA21-1 in ICC. METHODS: MEDLINE, China National Knowledge Infrastructure Library and other databases were used to base the inclusion and exclusion criteria. In addition, relevant data from studies on CYFRA21-1 were used to diagnose ICC individually or in combination was retrieved for meta-analysis...
November 28, 2018: Clinics and Research in Hepatology and Gastroenterology
Mei Ishiguro, Hajime Baba, Hitoshi Maeshima, Takahisa Shimano, Megumi Inoue, Tomoya Ichikawa, Seita Yasuda, Hiroko Shukuzawa, Toshihito Suzuki, Heii Arai
OBJECTIVE: Epidemiologic studies have demonstrated that depression is a risk factor for dementia. In particular, dementia with Lewy bodies (DLB) has been noted to be highly relevant to depression. It has been suggested that α-synuclein (α-syn), a major component of Lewy bodies, is related to the onset and progression of DLB. To investigate the relationship between depression and DLB, we compared serum α-syn levels of patients with depression to those of healthy subjects. METHODS: The subjects were 103 inpatients with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), or DSM-5 major depressive disorder (MDD) and 132 healthy comparisons...
November 2, 2018: American Journal of Geriatric Psychiatry
Irene Cabrera-Martos, Araceli Ortiz-Rubio, Irene Torres-Sánchez, Janet Rodríguez-Torres, Laura López-López, Marie Carmen Valenza
OBJECTIVE: To evaluate the effects of an intervention based on a specific set of goals on goal attainment, manual dexterity, hand grip strength and finger prehension force compared to a standardized approach in patients with Parkinson's disease. DESIGN: Randomized controlled trial. SETTING: Home-based. PARTICIPANTS: Fifty patients with a clinical diagnosis of Parkinson's disease acknowledging impaired manual ability were randomized into two groups...
December 3, 2018: Clinical Rehabilitation
César Fernández-de-Las-Peñas, Ricardo Ortega-Santiago, Homid Fahandezh-Saddi Díaz, Jaime Salom-Moreno, Joshua A Cleland, Juan A Pareja, José L Arias-Buría
STUDY DESIGN: A randomized clinical trial. BACKGROUND: Carpal tunnel syndrome (CTS) results in substantial costs for the society and can be treated by either nonsurgical or surgical approaches. OBJECTIVE: To evaluate cost-effectiveness differences of manual physical therapy versus surgery in women with CTS. METHODS: One hundred and twenty women with clinical and electromyographic diagnosis of CTS were randomized through concealed allocation to either manual physical therapy or surgery...
November 30, 2018: Journal of Orthopaedic and Sports Physical Therapy
Khalida Douibi, Nesma Settouti, Mohammed Amine Chikh, Jesse Read, Mohamed Malik Benabid
Ambulatory blood pressure monitoring (ABPM) involves measuring blood pressure by means of a tensiometer carried by the patient for a duration of 24 h, it currently occupies a central place in the diagnosis and follow-up of hypertensive patients, it provides crucial information which allows to make a specific diagnosis and adapt therapeutic attitude accordingly. The traditional analysis process suffers from different problems: it requires a lot of time and expertise, and several calculations should be performed manually by the expert, who is generally very busy...
November 29, 2018: Australasian Physical & Engineering Sciences in Medicine
Hwan-Ho Cho, Seung-Hak Lee, Jonghoon Kim, Hyunjin Park
Background: Grading of gliomas is critical information related to prognosis and survival. We aimed to apply a radiomics approach using various machine learning classifiers to determine the glioma grading. Methods: We considered 285 (high grade n  = 210, low grade n  = 75) cases obtained from the Brain Tumor Segmentation 2017 Challenge. Manual annotations of enhancing tumors, non-enhancing tumors, necrosis, and edema were provided by the database. Each case was multi-modal with T1-weighted, T1-contrast enhanced, T2-weighted, and FLAIR images...
2018: PeerJ
Josette Jones, Meeta Pradhan, Masoud Hosseini, Anand Kulanthaivel, Mahmood Hosseini
BACKGROUND: The increasing use of social media and mHealth apps has generated new opportunities for health care consumers to share information about their health and well-being. Information shared through social media contains not only medical information but also valuable information about how the survivors manage disease and recovery in the context of daily life. OBJECTIVE: The objective of this study was to determine the feasibility of acquiring and modeling the topics of a major online breast cancer support forum...
November 29, 2018: JMIR Medical Informatics
Rita Brito, Louis-Paulin Mondouagne, Carine Stettler, Christophe Combescure, Haran Burri
BACKGROUND: Handheld ECG recorders may have algorithms which automatically inform the user of presence of arrhythmia. The main objectives of this study were to evaluate the accuracy of the arrhythmia diagnosis algorithm of Beurer ME90 recorder to diagnose atrial fibrillation (AF)/flutter, and to evaluate whether recording technique (finger versus precordial) affects diagnostic performance. METHODS: Consecutive patients admitted at the cardiology ward of a tertiary care hospital were enrolled...
November 2018: Journal of Electrocardiology
Ishanka Ayeshwari Talagala, Carukshi Arambepola
BACKGROUND: Oesophageal carcinoma is one of the leading cancers in Sri Lanka. Recent advances in treatment modalities have drastically improved the survival of these patients. However, the quality of life (QoL) among the survivors needs to be reviewed in order to recognise the need for advocating more focussed rehabilitation for oesophageal carcinoma in Sri Lanka. METHODS: A prospective cohort study was conducted among 51 incident cases of oesophageal carcinoma recruited consecutively from the National Cancer Institute, Maharagama...
November 29, 2018: BMC Cancer
Pegah Mahmoodi, Mona Fani, Majid Rezayi, Amir Avan, Zahra Pasdar, Ehsan Karimi, Iraj S Amiri, Majid Ghayour-Mobarhan
Human papillomavirus type (HPV) is a common cause of sexually transmitted disease (STD) in humans. HPV types 16 and 18 as the highest risk types are related with gynecologic malignancy and cervical cancer (CC) among women worldwide. Recently, considerable development of genosensors, which allows dynamic monitoring of hybridization events for HPV-16 and 18, has been a topic of focus by many researchers. In this systematic review, we highlight the route of development of DNA-based genosensory detection methods for diagnosis of high risk of HPV precancer...
November 29, 2018: BioFactors
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