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Manual diagnosis

Yafei Tan, Dan Zhang, Hui Mei, Hong Mei, Zhengmin Qian, Katherine A Stamatakis, Savannah S Jordan, Yan Yang, Shaoping Yang, Bin Zhang
OBJECTIVE: The aim of this study was to determine whether specific perinatal factors are associated with obstructive sleep apnea syndrome (OSAS) in children. METHODS: A retrospective case-control study was conducted. All cases of OSAS were obtained from a tertiary pediatric hospital between April 2013 and April 2016. A total of 823 children who had been diagnosed with OSAS were designated as the case group, and 823 children without OSAS were selected with strict criteria to match with the case group by age, gender and body mass index...
September 17, 2018: Sleep Medicine
Isabel Pino Peña, Veronika Cheplygina, Sofia Paschaloudi, Morten Vuust, Jesper Carl, Ulla Møller Weinreich, Lasse Riis Østergaard, Marleen de Bruijne
PURPOSE: A method for automatically quantifying emphysema regions using High-Resolution Computed Tomography (HRCT) scans of patients with chronic obstructive pulmonary disease (COPD) that does not require manually annotated scans for training is presented. METHODS: HRCT scans of controls and of COPD patients with diverse disease severity are acquired at two different centers. Textural features from co-occurrence matrices and Gaussian filter banks are used to characterize the lung parenchyma in the scans...
2018: PloS One
Kees H Woldendorp, Antoine W de Schipper, Anne M Boonstra, Corry K van der Sluis, J Hans Arendzen, Michiel F Reneman
STUDY DESIGN: Psychometric study with 2-week interval. INTRODUCTION: Musculoskeletal hand complaints are common among manual workers. Mismatch between anthropometric hand features and tasks can affect the ability to perform hand activities, with an increased risk of complaints. Although screening of these features may improve diagnosis and treatment, no validated screening tool is available. The Practical Hand Evaluation (PHE) screening tool might fill this gap, but its psychometric properties are unknown...
October 11, 2018: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
Atul Goel, Arjun Dhar, Abhidha Shah, Dikpal Jadhav, Nilesh Bakale, Tejas Vaja, Neha Jadhav
AIM: The implications of diagnosis and treatment of central or axial atlantoaxial dislocation (CAAD) as a cause of symptoms of cervical myelopathy is evaluated. MATERIAL AND METHODS: This is a report of a series of 5 patients who presented with the primary symptoms of spasticity and motor weakness and paresthesiae in all the limbs. There was no evidence of any significant compression of the dural tube or neural structures at the craniovertebral junction. There was no craniovertebral junction instability when assessed by classically described radiological parameters...
October 10, 2018: World Neurosurgery
Ahmed Mokhtar, Thomas Arnason, Daniel Gaston, Weei-Yuarn Huang, Heather MacKenzie, Rayan Al-Hazmi, Nadine Vaninetti, Barna Tugwell, Daniel Rayson
BACKGROUND: Approximately 30% of neuroendocrine tumors (NETs) present with secretory syndromes or develop one during the course of the disease. Cushing syndrome caused by a gastrointestinal tract NET is rare, with limited published information. We describe a patient with florid Cushing syndrome due to ectopic adrenocorticotropic hormone (ACTH) from a NET of colonic origin. A literature review was conducted to describe the spectrum of this clinical and pathologic entity as reported in the scientific literature...
August 11, 2018: Clinical Colorectal Cancer
Khadijeh Abbasi, Sara Beigrezai, Reza Ghiasvand, Makan Pourmasoumi, Behzad Mahaki
OBJECTIVE: Associations between nutritional/dietary factors and mental disorders have been suggested. This study was conducted to assess the relation of major dietary patterns determined by factor analysis with attention-deficit/hyperactivity disorder (ADHD) in a group of Iranian preschool- and school-aged children. METHODS: This case-control study was conducted with 500 preschool- and school-aged children (4-12 years old) matched by age and sex, in Isfahan, Iran...
October 11, 2018: Journal of the American College of Nutrition
Saisha M Muñiz Alers, Kristin Page, Ryan Simmons, Barbara Waters-Pick, Lynn Cheatham, Jesse D Troy, Joanne Kurtzberg
BACKGROUND: The cell dose infused for cord blood transplantation strongly correlates with outcomes following transplantation. Post thaw recoveries can be improved by washing cord blood units (CBUs) in dextran/albumin. Early methods used a labor-intensive manual process. We have recently developed and validated an automated washing method. We now report our results of a study comparing cellular recoveries achieved after manual and automated wash, as well as the impact on engraftment following allogeneic transplantation...
October 11, 2018: Transfusion
Gesine F C Weckmann, Sylvia Stracke, Annekathrin Haase, Jacob Spallek, Fabian Ludwig, Aniela Angelow, Jetske M Emmelkamp, Maria Mahner, Jean-François Chenot
BACKGROUND: Chronic kidney disease (CKD) is age-dependent and has a high prevalence in the general population. Most patients are managed in ambulatory care. This systematic review provides an updated overview of quality and content of international clinical practice guidelines for diagnosis and management of non-dialysis CKD relevant to patients in ambulatory care. METHODS: We identified guidelines published from 2012-to March 2018 in guideline portals, databases and by manual search...
October 11, 2018: BMC Nephrology
Matthieu Hein, Jean-Pol Lanquart, Gwenolé Loas, Philippe Hubain, Paul Linkowski
BACKGROUND: Since few studies have investigated the risk of high blood pressure associated with objective insomnia and self-reported insomnia complaints in major depression, the aim of this study was to examine this risk in a large sample of individuals with major depression. METHODS: Data from 703 individuals with major depression recruited from the research database of the sleep laboratory of the Erasme Hospital were analysed. High blood pressure status was defined by the presence of one of the following: self-reports at interview of either a physician-diagnosis or taking antihypertensive medication; or an average systolic blood pressure ≥140 mmHg or an average diastolic blood pressure ≥90 mmHg during at least two medical examinations...
October 10, 2018: Clinical and Experimental Hypertension: CHE
Eva Burkhardt, Andrea Pfennig, Gwendolin Breitling, Steffi Pfeiffer, Cathrin Sauer, Andreas Bechdolf, Christoph U Correll, Michael Bauer, Karolina Leopold
AIM: The association between bipolar disorder and creativity may be related to symptoms of the disorder itself or personality traits present before the onset. To further explore the relationship between creativity and clinical risk for bipolar disorder, creativity among individuals with a history of depressive disorder and varying risk for future (hypo-)manic episodes was assessed and compared. METHODS: Thirty-eight participants completed the diagnostic process, including Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) Diagnosis, Hamilton Depression Scale and Young Mania Rating Scale...
October 10, 2018: Early Intervention in Psychiatry
Stacy M Fischer, Sung-Joon Min, Adam Atherly, Danielle M Kline, Wendolyn S Gozansky, John Himberger, Joseph Lopez, Kathleen Lester, Regina M Fink
Latinos are more likely to experience uncontrolled pain, and institutional death, and are less likely to engage in advance care planning. Efforts to increase access to palliative care must maximize primary palliative care and community based models to meet the ever-growing need in a culturally sensitive and congruent manner. Patient navigator interventions are community-based, culturally tailored models of care that have been successfully implemented to improve disease prevention, early diagnosis, and treatment...
October 10, 2018: Research in Nursing & Health
Charley Gros, Benjamin De Leener, Atef Badji, Josefina Maranzano, Dominique Eden, Sara M Dupont, Jason Talbott, Ren Zhuoquiong, Yaou Liu, Tobias Granberg, Russell Ouellette, Yasuhiko Tachibana, Masaaki Hori, Kouhei Kamiya, Lydia Chougar, Leszek Stawiarz, Jan Hillert, Elise Bannier, Anne Kerbrat, Gilles Edan, Pierre Labauge, Virginie Callot, Jean Pelletier, Bertrand Audoin, Henitsoa Rasoanandrianina, Jean-Christophe Brisset, Paola Valsasina, Maria A Rocca, Massimo Filippi, Rohit Bakshi, Shahamat Tauhid, Ferran Prados, Marios Yiannakas, Hugh Kearney, Olga Ciccarelli, Seth Smith, Constantina Andrada Treaba, Caterina Mainero, Jennifer Lefeuvre, Daniel S Reich, Govind Nair, Vincent Auclair, Donald G McLaren, Allan R Martin, Michael G Fehlings, Shahabeddin Vahdat, Ali Khatibi, Julien Doyon, Timothy Shepherd, Erik Charlson, Sridar Narayanan, Julien Cohen-Adad
The spinal cord is frequently affected by atrophy and/or lesions in multiple sclerosis (MS) patients. Segmentation of the spinal cord and lesions from MRI data provides measures of damage, which are key criteria for the diagnosis, prognosis, and longitudinal monitoring in MS. Automating this operation eliminates inter-rater variability and increases the efficiency of large-throughput analysis pipelines. Robust and reliable segmentation across multi-site spinal cord data is challenging because of the large variability related to acquisition parameters and image artifacts...
October 6, 2018: NeuroImage
R Jiang, M S Kelly, J C Routh
OBJECTIVE: Bowel and bladder dysfunction (BBD) is a clinical syndrome defined by the coexistence of constipation and lower urinary tract symptoms. Although BBD is a common condition in pediatric urology and can cause significant stress to patients/parents, clinical diagnosis of BBD has not been standardized. Bowel and bladder dysfunction instruments have gained popularity over the past decade to aid in diagnosis. In this review, the currently published BBD symptom questionnaires were summarized and an analysis on their psychometric validation process was provided...
August 28, 2018: Journal of Pediatric Urology
Imran Razzak, Muhammad Imran, Guandong Xu
Manual segmentation of the brain tumors for cancer diagnosis from MRI images is a difficult, tedious and time-consuming task. The accuracy and the robustness of brain tumor segmentation, therefore, are crucial for the diagnosis, treatment planning, and treatment outcome evaluation. Mostly, the automatic brain tumor segmentation methods use hand designed features. Similarly, traditional methods of Deep learning such as Convolutional Neural Networks require a large amount of annotated data to learn from, which is often difficult to obtain in the medical domain...
October 4, 2018: IEEE Journal of Biomedical and Health Informatics
Virginia A Pujol Lereis, Mario O Melcon, Maximiliano A Hawkes, Maia M Gomez Schneider, Daiana E Dossi, Matías J Alet, Guillermo P Povedano, Claudio D Gonzalez, Sebastián F Ameriso
BACKGROUND: Epidemiological data on stroke is scarce in Latin America. Estudio Epidemiológico Poblacional sobre Accidente Cerebrovascular (EstEPA) is a population-based program planned to assess prevalence, incidence, mortality, and burden of disease for stroke in the Department of General Villegas, province of Buenos Aires, Argentina. METHODS AND DESIGN: Prevalence study will consist of a two-phase survey approach in the urban area of General Villegas. First, trained social workers with a structured questionnaire will collect data in 2000 randomly selected housing units...
October 3, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Emma Finch, Anna F Rumbach, Stacie Park
PURPOSE: The purpose of this study is to conduct a systematic review of interventions for the treatment of non-progressive dysarthria in adults. MATERIALS AND METHODS: Five electronic databases (PubMed, Embase, CINAHL, PSYCINFO, Cochrane Collaboration) were searched for all studies that described and evaluated treatment used for non-progressive dysarthria in adults. Studies were included if (1) participants were adults (18+ years) with a confirmed diagnosis of non-progressive dysarthria, (2) participants received intervention with pre-post outcome data, and (3) the article was published between 2006 and 2017 (including early online publications)...
October 4, 2018: Disability and Rehabilitation
Shawn R Criswell, Richard Sherman, Stanley Krippner
OBJECTIVE: To test the effectiveness of a mental health therapy designed to reduce noncombat-related persistent posttraumatic stress disorder (PTSD) symptoms in 30 adult outpatients with a diagnosis of PTSD. The individual treatment offered modules to address PTSD nightmare distress, dissociation, general core skills, alterations in arousal and reactivity, avoidance, intrusion, and negative alternations in cognitions and mood. The therapeutic approach centered on cognitive behavioral therapy and heart rate variability biofeedback...
September 27, 2018: Permanente Journal
John W Longshore, Kelli DeMartin, Karen Yu, Partha Das, Guili Zhang, Taraneh Tamaddon Rehage, Deepa Jethwaney, Sylwia Karwowska
Laboratory testing for thrombophilia is complicated but essential for diagnosis. In 2017, the cobas® Factor II and Factor V Test (cobas F2F5 test) was launched for use with the cobas z 480 analyzer. This qualitative polymerase chain reaction test enables multiplex Factor II and Factor V testing with flexible reporting and workflow efficiency. Here, we report the results from studies investigating the performance of the cobas F2F5 test. Technical performance verification, clinical validation, external laboratory performance, and workflow comparison studies were performed...
October 3, 2018: Journal of Thrombosis and Thrombolysis
Fabian Balsiger, Carolin Steindel, Mirjam Arn, Benedikt Wagner, Lorenz Grunder, Marwan El-Koussy, Waldo Valenzuela, Mauricio Reyes, Olivier Scheidegger
Diagnosis of peripheral neuropathies relies on neurological examinations, electrodiagnostic studies, and since recently magnetic resonance neurography (MRN). The aim of this study was to develop and evaluate a fully-automatic segmentation method of peripheral nerves of the thigh. T2-weighted sequences without fat suppression acquired on a 3 T MR scanner were retrospectively analyzed in 10 healthy volunteers and 42 patients suffering from clinically and electrophysiologically diagnosed sciatic neuropathy. A fully-convolutional neural network was developed to segment the MRN images into peripheral nerve and background tissues...
2018: Frontiers in Neurology
Tülin Aktürk, Nermin Tanık, Halil İbrahim Serin, Hikmet Saçmacı, Levent Ertuğrul İnan
OBJECTIVE: Osmophobia and headache triggered by odors are commonly seen in migraine, and these are symptoms that differentiate migraine from other primary headaches. Since these odor-related symptoms are disease-specific, we aimed to measure the volume of olfactory bulb and depth of olfactory sulcus in migraine patients. PATIENTS AND METHOD: A total of 93 subjects, consisting of 62 episodic migraine (32 with osmophobia, 30 without osmophobia) patients and 31 healthy controls, were included in this study...
October 2, 2018: Neurological Sciences
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