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Oana A Tatucu-Babet, Emma J Ridley
Outpatients who receive hyperbaric oxygen treatment (HBOT) may represent a group at significant risk of malnutrition owing to the underlying conditions that are often treated with HBOT (e.g., non-healing diabetic wounds and radiation-induced skin injury). In this issue, See and colleagues provide new, preliminary evidence of the prevalence of malnutrition in a small group of HBOT outpatients treated in an Australian hospital, reporting that approximately one-third of patients receiving HBOT were at risk of malnutrition...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Zhimeng Lv, Ming Guo, Chenghua Li, Yina Shao, Xuelin Zhao, Weiwei Zhang
Vascular endothelial growth factor (VEGF) is a key conservative regulator of inflammation response by promoting cell proliferation, migration, and vascular permeability. It also induces the release of inflammatory factors in vertebrates. We previously characterized NLR family pyrin domain containing 3 and HMGB3 homology in Apostichopus japonicus, providing the occurrence of inflammation in this species. However, to our knowledge, other inflammation-related molecules, such as VEGF, have rarely been investigated...
December 2, 2018: Developmental and Comparative Immunology
Alejandra L Collopy, Shiqian Ding, Yewei Wu, Ian A Finneran, Loïc Anderegg, Benjamin L Augenbraun, John M Doyle, Jun Ye
We report three-dimensional trapping of an oxide molecule (YO), using a radio-frequency magneto-optical trap (MOT). The total number of molecules trapped is ∼1.5×10^{4}, with a temperature of 4.1(5) mK. This diversifies the frontier of molecules that are laser coolable and paves the way for the second-stage narrow-line cooling in this molecule to the microkelvin regime. Futhermore, the new challenges of creating a 3D MOT of YO resolved here indicate that MOTs of more complex nonlinear molecules should be feasible as well...
November 23, 2018: Physical Review Letters
Rebekah L Rogers, Long Zhou, Chong Chu, Roberto Márquez, Ammon Corl, Tyler Linderoth, Layla Freeborn, Matthew D MacManes, Zijun Xiong, Jiao Zheng, Chunxue Guo, Xu Xun, Marcus R Kronforst, Kyle Summers, Yufeng Wu, Huanming Yang, Corinne L Richards-Zawacki, Guojie Zhang, Rasmus Nielsen
We sequenced the genome of the strawberry poison frog, Oophaga pumilio, at a depth of 127.5× using variable insert size libraries. The total genome size is estimated to be 6.76 Gb, of which 4.76 Gb are from high copy number repetitive elements with low differentiation across copies. These repeats encompass DNA transposons, RNA transposons, and LTR retrotransposons, including at least 0.4 and 1.0 Gb of Mariner/Tc1 and Gypsy elements, respectively. Expression data indicate high levels of gypsy and Mariner/Tc1 expression in ova of O...
December 1, 2018: Molecular Biology and Evolution
Jun Xiong, Tian-Tian Ye, Cheng-Jie Ma, Qing-Yun Cheng, Bi-Feng Yuan, Yu-Qi Feng
In addition to DNA cytosine methylation (5-methyl-2'-deoxycytidine, m5dC), DNA adenine methylation (N6-methyl-2'-deoxyadenosine, m6dA) is another DNA modification that has been discovered in eukaryotes. Recent studies demonstrated that the content and distribution of m6dA in genomic DNA of vertebrates and mammals exhibit dynamic regulation, indicating m6dA may function as a potential epigenetic mark in DNA of eukaryotes besides m5dC. Whether m6dA undergoes the further oxidation in a similar way to m5dC remains elusive...
December 4, 2018: Nucleic Acids Research
Laura C Coates, Proton Rahman, Eliofotisti Psaradellis, Emmanouil Rampakakis, Brendan Osborne, Allen J Lehman, Francois Nantel
Objectives: Treat to target recommendations for PsA state that the target of treatment should be remission or, at the very least, low disease activity. Different clinical indexes have been proposed to define these disease states including the minimal disease activity criteria and the Disease Activity Index for PsA (DAPSA) scores, which have 7 and 4-5 domains, respectively. Using a Canadian cohort, the objectives were to calculate the proportion of patients achieving these criteria, their prognostic value and the overall patient impact of these disease states...
December 4, 2018: Rheumatology
Kelly L Wyres, Jane Hawkey, Marit A K Hetland, Aasmund Fostervold, Ryan R Wick, Louise M Judd, Mohammad Hamidian, Benjamin P Howden, Iren H Löhr, Kathryn E Holt
Objectives: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. Methods: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). Results: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants...
December 4, 2018: Journal of Antimicrobial Chemotherapy
Xiaoning Zhang, Peng Zhang, Dandan Song, Suping Xiong, Hongyan Zhang, Jianbo Fu, Fengxin Gao, Houyang Chen, Xuhui Zeng
Increasing studies have shown that specific mRNAs and miRNAs expressed in mature sperm may be related to sperm motility. However, the expression profiles and roles of lncRNAs in sperm remain unknown. In the present study, numerous lncRNAs were identified in human sperm, and some lncRNAs were expressed exclusively in sperm and testis. Compared with normal sperm, the lncRNA expression profiles in asthenozoospermia (AZS) sperm showed significant differences. Gene ontology and pathway analyses showed that function of differentially expressed lncRNA targets and mRNAs between AZS and normal sperm were closely-linked with many processes involved in spermatogenesis and sperm function...
December 4, 2018: Biology of Reproduction
Rafaela Azevedo Abrantes de Oliveira, Márcia Maria Fontão Zago
PURPOSE: to describe the meanings that patients attribute to the term cancer survivor and to analyze the identities assumed by them according to their experience with the disease. METHODS: qualitative study with a narrative method, theoretical framework of the medical anthropology and identity concept. The study included 14 participants, men and women, diagnosed with urologic cancer. The semi-structured interviews were performed at the individual's home, after confirming participation...
November 29, 2018: Revista Latino-americana de Enfermagem
Antônio Rafael da Silva, Pedro Martins Lima Neto, Leonardo Hunaldo Dos Santos, Raina Jansen Cutrim Propp Lima, Pedro Luiz Tauil, Eloísa da Graça do Rosário Gonçalves
INTRODUCTION: The Integrated Program of Leprosy Control was initiated in the municipality of Buriticupu, Maranhão, Brazil, an area considered hyperendemic for leprosy in 2003. It aims at assessing the clinical and epidemiological characteristics of the disease to reduce the detection rate of new cases until 2015. Here, we present the evolution of the indicators of leprosy within the period from 2003 to 2015. METHODS: We conducted a descriptive analytical study based on the active search for and voluntary referral of cases of leprosy...
November 2018: Revista da Sociedade Brasileira de Medicina Tropical
Lisset Garcia-Fernandez, Rommy Novoa, Byelca Huaman, Carlos Benites
In 2013, the Joint United Nations Programme on HIV/AIDS (UNAIDS) proposed, in terms of public health, to end the HIV epidemic by 2030 by achieving the so-called 90-90-90 targets by 2020. This goal will only be possible if coverage in the HIV care continuum indicators is increased. With the methodology proposed by PAHO/WHO, this paper estimates the indicators of the continuum of care in Peru for 2014, consisting of diagnostic coverage, antiretroviral treatment (ART), and viral suppression in people living with HIV (PLHIV)...
July 2018: Revista Peruana de Medicina Experimental y Salud Pública
Luciano Antonacci Condessa, Carlos Alex Soares, Gregore Iven Mielke, Deborah Carvalho Malta, Waleska Teixeira Caiaffa
OBJECTIVE: To compare the prevalence of physically active adolescents living in Brazilian capitals, using 2012 and 2015 National Adolescent School-based Health Survey. METHOD: The sample consisted of 61,145 (2012) and 51,192 (2015) adolescents who were residents in 27 Brazilian capitals and were attending the 9th year of elementary school. The globally estimated physical activity indicator with the cutoff point of 300 minutes or more per week was used to determine the prevalence of physically active adolescents in both surveys...
November 29, 2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Thiago Ferreira de Souza, Eduardo Grecco, Luiz Gustavo de Quadros, Yael Duarte de Albuquerque, Fernanda Oliveira Azôr, Manoel Galvão Neto
BACKGROUND: New endoscopic treatments for gastroesophageal reflux (GERD) are developed every year and are indicated in cases that are refractory to conventional therapies as well as after surgical treatment failure. OBJECTIVE: To present the first cases of endoscopic therapy for GERD performed in Brazil. METHODS: Use of radiofrequency with the Stretta procedure in symptomatic volunteers diagnosed with GERD. RESULTS: The technique was performed in three patients after they were included in the study protocol...
November 2018: Arquivos de Gastroenterologia
Carlos Dornels Freire de Souza, Franklin Gerônimo Bispo Santos, Caroline de Sales Marques, Thiago Cavalcanti Leal, João Paulo Silva de Paiva, Emmylly Maria Correia Ferro de Araújo
OBJECTIVE: to compare the temporal evolution and spatial distribution of epidemiological indicators of leprosy, both crude and also corrected using the empirical Bayesian model, Bahia, Brazil, 2001-2012. METHODS: this was an ecological study using data from the Notifiable Diseases Information System; all 417 municipalities in Bahia were included and the following indicators per 100,000 inhabitants were analyzed - detection rate of new cases in the general population, in those <15 years old, and in those with grade 2 physical disability -; the local empirical Bayesian model was used to smoothen the indicators, and Student's t-test was used to compare means...
November 29, 2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
Thaís Jeronimo Vidal, Tatiana Aragão Figueiredo, Vera Lúcia Edais Pepe
Monoclonal antibodies (mABs) have been indicated as an innovative technology for the treatment of some types of cancer, since they are capable of targeting and selectively killing tumor cells. However, the high costs of these therapies raise questions as to the sustainability of access. This study aimed to identify the principal characteristics of monoclonal antibodies used in cancer treatment with active marketing authorization in Brazil as of 2016. This was a descriptive retrospective analysis based on consultation of the Brazilian Health Regulatory Agency (Anvisa) website, in which these mABs were characterized according to the target antigen, type of antibody, year of registration, therapeutic indications, and applicant...
November 29, 2018: Cadernos de Saúde Pública
Maria Clara Ponce, Alessandro Rozim Zorzi, João Batista de Miranda, Eliane Maria Ingrid Amstalden
OBJECTIVE: This study aimed to develop a new histological scoring system for use in a partial-thickness cartilage repair animal model. Although previous papers have investigated the regeneration of articular cartilage, the good results achieved in small animals have not been replicated in large animal models or humans, possibly because of the frequent use of models with perforation of the subchondral bone plates. Partial-thickness lesions spare the subchondral bone, and this pattern is the most frequent in humans; therefore, new therapies should be tested using this model...
November 29, 2018: Clinics
Joviane Bagolin Bonini, Márcia Keske-Soares
The pseudowords are a resource rarely used in clinical practice, but may be an excellent option for phonological therapy. This study aimed to verify the therapeutic progress of children with phonological disorder, treated from a new therapeutic approach, considering the favorable linguistic environment in pseudowords and words. The sample consisted of three children, aged between 4 and 8 years old, who submitted to a new therapeutic approach to phonological basis. The children were treated with different targets involving pseudowords and real words in favorable and neutral linguistic environments...
November 29, 2018: CoDAS
Ying Yao, Asima Zia, Łukasz Wyrożemski, Ida Lindeman, Geir Kjetil Sandve, Shuo-Wang Qiao
By offering high sequencing speed and ultra-high-throughput at a low price, Illumina next-generation sequencing platforms have been widely adopted in recent years. However, an experiment with multiplexed library could be at risk of molecular recombination, known as "index switching", which causes a proportion of the reads to be assigned to an incorrect sample. It is reported that a new advance, exclusion amplification (ExAmp) in conjunction with the patterned flow cell technology introduced on HiSeq 3000/HiSeq 4000/HiSeq X sequencing systems, potentially suffers from a higher rate of index switching than conventional bridge amplification...
2018: PloS One
Luca Francaviglia, Gözde Tütüncüoglu, Federico Matteini, Anna Fontcuberta I Morral
Nanoscale variations in the composition of an Al x Ga1-x As shell around a GaAs nanowire affect the nanowire functionality and can lead to the formation of localized quantum emitters. These composition fluctuations can be the consequence of variations of crystal phase and/or nanoscale adatom mobility. By applying electron-microscopy-related techniques we correlate the optical, compositional and structural properties at the nanoscale on the same object. The results indicate a clear correlation between the twin density in the nanowire and the quantum-emitter density as well as a significant redshift in the emission...
February 1, 2019: Nanotechnology
Alex Sheremet, Jack P Kennedy, Yu Qin, Yuchen Zhou, Sarah D Lovett, Sarah N Burke, Andrew Porter Maurer
Oscillations in the hippocampal LFP at theta and gamma frequencies are prominent during awake-behavior and have demonstrated several behavioral correlates. Both oscillations have been observed to increase in amplitude and frequency as a function of running speed. Previous investigations, however, have examined the relationship between speed and each of these oscillation bands separately. Based on energy cascade models where "... perturbations of slow frequencies cause a cascade of energy dissipation at all frequency scales" (Buzsaki 2006), we hypothesized that cross-frequency interactions between theta and gamma should increase as a function of speed...
December 5, 2018: Journal of Neurophysiology
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