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https://www.readbyqxmd.com/read/30342399/decontamination-of-radioactive-wastewater-state-of-the-art-and-challenges-forward
#1
REVIEW
Xiaoyuan Zhang, Ping Gu, Yu Liu
Radioactive substances have been widely used in many industrial sectors, e.g. nuclear power station, biomedical engineering, etc. With increasing applications of nuclear technology, more and more radioactive wastewater is being generated via different channels, which indeed is posing an emerging challenge and threat to the environment and human health. Given such a situation, this review attempts to offer a holistic view with regard to the state of the art of technology for decontamination of radioactive wastewater as well as shed lights on the challenges forward...
October 11, 2018: Chemosphere
https://www.readbyqxmd.com/read/30342348/occurrence-of-antibiotics-and-bacterial-resistance-in-wastewater-and-sea-water-from-the-antarctic
#2
F Hernández, N Calısto-Ulloa, C Gómez-Fuentes, M Gómez, J Ferrer, G González-Rocha, H Bello-Toledo, A M Botero-Coy, C Boıx, M Ibáñez, M Montory
The potential presence of introduced antibiotics in the aquatic environment is a hot topic of concern, particularly in the Antarctic, a highly vulnerable area protected under the Madrid protocol. The increasing presence of human population, especially during summer, might led to the appearance of pharmaceuticals in wastewater. The previous discovery of Escherichia coli strains resistant to antibiotics in sea water and wastewater collected in King George Island motivated our investigation on antibiotics occurrence in these samples...
October 17, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/30342242/triggered-palliative-care-for-late-stage-dementia-a-pilot-randomized-trial
#3
Laura C Hanson, Christine E Kistler, Kyle Lavin, Stacey L Gabriel, Natalie C Ernecoff, Feng-Chang Lin, Greg A Sachs, Susan L Mitchell
CONTEXT: Persons with late-stage dementia have limited access to palliative care. OBJECTIVE: To test dementia-specific specialty palliative care triggered by hospitalization. METHODS: This pilot randomized controlled trial enrolled 62 dyads of persons with late-stage dementia and family decision-makers on admission to hospital. Intervention dyads received dementia-specific specialty palliative care consultation plus post-acute transitional care...
October 17, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/30342213/infection-of-prosthetic-patches-after-femoral-endarterectomy-an-unreported-complication
#4
Paolo Sapienza, Filippo Napoli, Elvira Tartaglia, Luigi Venturini, Antonio V Sterpetti, Gioia Brachini, Sergio Gazzanelli, Andrea Mingoli
BACKGROUND: Femoral prosthetic patch is a surgical procedure frequently used to treat atherosclerotic lesions involving femoral artery bifurcation. Even though it is an easy to perform procedure, surgical management of complications, first of all graft infection, may be challenging, with a high morbidity and mortality risk for patients. We report our experience on surgical treatment of femoral patch infection. MATERIALS AND METHODS: Between April 2012 and April 2018, 26 patients (26 limbs) were referred to the Emergency Department at our Institution, for the treatment of femoral prosthetic patch infection...
October 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30342190/synergetic-effect-of-cold-atmospheric-plasma-and-iron-oxide-based-magnetic-nanoparticles-in-lung-cancer-treatment
#5
Wentong Li, Hongli Yu, Dejun Ding, Zhitong Chen, Yonghong Wang, Saisai Wang, Xujing Li, Michael Keidar, Weifen Zhang
Cold atmospheric plasma (CAP) is an emerging biomedical technique that shows great potential for cancer treatment. On the other hand, magnetic nanoparticles open up a wide field of possible applications in medicine. Here we seek to develop a novel dual cancer therapeutic method by integrating promising CAP and iron oxide-based magnetic nanoparticles (MNPs), and evaluate its underlying mechanism for targeted lung cancer treatment. For this purpose, the synergistic effects of CAP and iron oxide-based MNPs on cellular bioactivity, epidermal growth factor receptor (EGFR) expression, and EGFR downstream signaling pathways were investigated...
October 17, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30342173/combination-drug-therapy-via-nanocarriers-against-infectious-diseases
#6
REVIEW
Pavan Walvekar, Ramesh Gannimani, Thirumala Govender
Current drug therapy against infections is threatening to become obsolete due to the poor physical, chemical, biological and pharmacokinetic properties of drugs, followed by high risk of acquiring resistance. Taking into account the significant benefits of nanotechnology, nano-based delivery of anti-infectious agents is emerging as a potential approach to combat several lethal infections. Co-delivery of multiple anti-infectious agents in a single nano-based system is beginning to show significant advantages over mono-therapy, such as synergism, enhanced anti-microbial activity, broad anti-microbial spectrum, reduced resistance development, and improved and cost-effective treatment...
October 17, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30342088/3d-cell-laden-polymers-to-release-bioactive-products-in-the-eye
#7
REVIEW
Gorka Orive, Edorta Santos-Vizcaino, Jose Luis Pedraz, Rosa Maria Hernandez, Julia E Vela Ramirez, Alireza Dolatshahi-Pirouz, Ali Khademhosseini, Nicholas A Peppas, Dwaine F Emerich
Millions of people worldwide suffer from debilitating, progressive, and often permanent loss of vision without any viable treatment options. The complex physiological barriers of the eye contribute to the difficulty in developing novel therapies by limiting our ability to deliver therapeutics in a sustained and controlled manner; especially when attempting to deliver drugs to the posterior eye or trying to regenerate the diseased retina. Cell-based therapies offer a significant potential advancement in these situations...
October 17, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/30342072/blockade-of-il-6-signaling-in-neuromyelitis-optica
#8
REVIEW
Manabu Araki
Neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) are autoimmune diseases associated with a disease-specific autoantibody directed against the water channel protein aquaporin-4. Standard immunotherapy, immunosuppressive agents, and corticosteroids can prevent acute attacks and maintain remission in most patients with NMOSD. However, there is a strong need for additional options for patients who are refractory to standard treatments. Emerging therapies targeting specific molecules related to the pathogenicity of NMOSD are currently being developed...
October 17, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/30341933/accepting-the-avoidable-death-the-philosophy-of-limiting-intensive-care
#9
Marc Sørensen, Lars Willy Andersen
Limiting intensive care is paid increasing attention. In the echoing call for physicians' ethical self-restriction, it is easily overlooked, however, that ethics needs a critical epistemological analysis before it can suffice as an emergency brake to futile treatment. This analysis is provided by the present essay. The authors suggest that the difficulties of resolving moral dilemmas related to limiting intensive care may just be due to the unclarified epistemological status of moral claims. Even if normative ethics cannot prescribe right decisions, but only draw conclusions from defined premises, the premises may or may not be true...
October 20, 2018: Bioethics
https://www.readbyqxmd.com/read/30341882/hepatitis-e-virus-associated-acute-encephalitic-parkinsonism
#10
Shaik Afsar Pasha, Shaik Arif Pasha, T Suhasini, D Ankamma Rao
Hepatitis E virus (HEV) is a common infection worldwide and is an emerging infectious disease in the developed countries. The unique characteristics of HEV is that it displays different epidemiological and clinical characteristics between developing and developed countries. Neurological disorders are emerging extra hepatic manifestations of both acute and chronic Hepatitis E virus infection. We report a 17 year old sportsman presenting with acute encephalitic Parkinsonism concurrent with acute hepatitis. Serology was positive for Hepatitis E virus (HEV) and HEV RNA was confirmed...
March 2018: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/30341848/treatment-of-vitamin-d-deficiency-and-comorbidities-a-review
#11
Parminder Singh
Vitamin D is essential for the maintenance of calcium and phosphorus homeostasis, skeletal growth and various other metabolic processes. The prevalence of vitamin D deficiency in India is 50-90% in various studies. Factors such as low sunlight exposure, age-related decrease in cutaneous synthesis, and low dietary intake of vitamin D contribute to the high prevalence of vitamin D inadequacy which has emerged as a highly pervasive condition. Bone diseases such as rickets in children, osteomalacia and osteoporosis in adults are related with vitamin D insufficiency...
January 2018: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/30341774/the-developing-regorafenib-eye-drops-for-neovascular-age-related-macular-degeneration-dream-study-an-open-label-phase-ii-trial
#12
Antonia M Joussen, Sebastian Wolf, Peter K Kaiser, David Boyer, Thomas Schmelter, Rupert Sandbrink, Oliver Zeitz, Gesa Deeg, Annett Richter, Torsten Zimmermann, Joachim Hoechel, Ulf Buetehorn, Walter Schmitt, Brigitte Stemper, Michael K Boettger
AIMS: This program investigated topical regorafenib, a multikinase inhibitor, in patients with neovascular age-related macular degeneration (nAMD). METHODS: Topical regorafenib was investigated in an open-label, phase IIa/b study in which patients with choroidal neovascularization (CNV) secondary to nAMD received regorafenib (25 μL, 30 mg/mL TID) for 12 weeks. The primary endpoint of the phase II/a/b study was mean change in best-corrected visual acuity (BCVA) from baseline to weeks 4 and 12...
October 20, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/30341756/development-of-electrospun-lignin-nanofibers-for-the-adsorption-of-pharmaceutical-contaminants-in-wastewater
#13
Alexandre Camiré, Julie Espinasse, Bruno Chabot, André Lajeunesse
Emerging contaminants present a challenge for water preservation, threatening humans' health and all ecosystems. They consist of a variety of molecules ranging from pharmaceutical and personal care products to pesticides and endocrine disruptors detectable in wastewater, sewage effluent, surface water, drinking water, and ground waters at trace level concentrations (e.g., ng/L, μg/L). Conventional wastewater treatment plants (WWTPs) possess low efficiency to remove them. Therefore, new technologies capable of removing such residues are needed...
October 19, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30341747/hypofractionated-whole-breast-radiotherapy-with-or-without-hypofractionated-boost-in-early-stage-breast-cancer-patients-a-mono-institutional-analysis-of-skin-and-subcutaneous-toxicity
#14
Isabella Palumbo, Cristina Mariucci, Lorenzo Falcinelli, Elisabetta Perrucci, Valentina Lancellotta, Anna Maria Podlesko, Marta Marcantonini, Simonetta Saldi, Vittorio Bini, Cynthia Aristei
BACKGROUND: Our study evaluated skin and subcutaneous toxicity analyzing its correlation with patient- and treatment-related factors in a large mono-institutional series of women with early stage breast cancer treated with adjuvant hypofractionated whole breast radiotherapy (WBRT) with or without a sequential hypofractionated boost (HB). METHODS: Two hundred and nineteen patients, median age 62 years, received adjuvant hypofractionated WBRT in 16 fractions to a total dose of 42...
October 19, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30341741/the-shrinking-brain-cerebral-atrophy-following-traumatic-brain-injury
#15
Taylor C Harris, Rijk de Rooij, Ellen Kuhl
Cerebral atrophy in response to traumatic brain injury is a well-documented phenomenon in both primary investigations and review articles. Recent atrophy studies focus on exploring the region-specific patterns of cerebral atrophy; yet, there is no study that analyzes and synthesizes the emerging atrophy patterns in a single comprehensive review. Here we attempt to fill this gap in our current knowledge by integrating the current literature into a cohesive theory of preferential brain tissue loss and by identifying common risk factors for accelerated atrophy progression...
October 17, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/30341649/is-bridge-to-surgery-stenting-a-safe-alternative-to-emergency-surgery-in-malignant-colonic-obstruction-a-meta-analysis-of-randomized-control-trials
#16
Chi Chung Foo, Samuel Ho Ting Poon, Rosemaire Hon Yiu Chiu, Wai Yiu Lam, Lam Chi Cheung, Wai Lun Law
BACKGROUND: Despite studies showing superior results in terms of reduced stoma rate and higher primary anastomosis rate, the safety of bridge to surgery stenting (BTS stent) for left-sided malignant colonic obstruction, especially in oncological terms, remains a concern. AIM: The aim of this meta-analysis was to evaluate whether BTS stent is a safe alternative to emergency surgery (EmS). METHODS: Randomized control trials (RCTs) comparing BTS stent and EmS for left-sided colonic obstruction caused by primary cancer of the colon, up to Sep 2018, were retrieved from the Pubmed, Embase database, clinical trials registry of U...
October 19, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30341458/a-nationwide-study-on-concordance-with-multimodal-treatment-guidelines-in-bipolar-disorder
#17
Joannes W Renes, Eline J Regeer, Adriaan W Hoogendoorn, Willem A Nolen, Ralph W Kupka
BACKGROUND: Most previous studies on concordance with treatment guidelines for bipolar disorder focused on pharmacotherapy. Few studies have included other treatment modalities. AIMS: To study concordance with the Dutch guideline of various treatment modalities in outpatient treatment settings for patients with bipolar disorder and to identity factors associated with concordance. METHODS: A nationwide non-interventional study using psychiatrists' and patients' surveys...
October 20, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/30341445/-management-of-syncope-in-clinical-practice-what-has-changed-according-to-the-new-esc-guidelines-2018
#18
S Oebel, G Hindricks
Syncope is a common problem in clinical practice, which affects approximately 1% of patients admitted to European emergency departments. The clinical practice guidelines for the diagnosis and management of syncope published by the European Society of Cardiology (ESC) are based on the newest scientific data in the field and have provided clinical cardiologists with a structured therapeutic approach for affected patients over many years. The previous ESC guidelines on syncope were published in 2009 and are compared to the most recent edition, which was published in 2018...
October 19, 2018: Herz
https://www.readbyqxmd.com/read/30341444/mesenchymal-stem-cell-therapy-for-heart-failure-a-meta-analysis
#19
REVIEW
H Fu, Q Chen
BACKGROUND: Mesenchymal stem cell (MSC) treatment has emerged as an important adjunct therapy for heart failure. However, the use of MSC to treat heart failure has not been well established. We conducted a systematic review and meta-analysis to evaluate the efficacy of MSC treatment for heart failure. METHODS: PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched. Randomized controlled trials (RCTs) assessing the influence of MSC treatment on cardiac function in heart failure were included in this analysis...
October 19, 2018: Herz
https://www.readbyqxmd.com/read/30341424/comparing-the-effects-of-different-cell-death-programs-in-tumor-progression-and-immunotherapy
#20
Michelle N Messmer, Annelise G Snyder, Andrew Oberst
Our conception of programmed cell death has expanded beyond apoptosis to encompass additional forms of cell suicide, including necroptosis and pyroptosis; these cell death modalities are notable for their diverse and emerging roles in engaging the immune system. Concurrently, treatments that activate the immune system to combat cancer have achieved remarkable success in the clinic. These two scientific narratives converge to provide new perspectives on the role of programmed cell death in cancer therapy. This review focuses on our current understanding of the relationship between apoptosis and antitumor immune responses and the emerging evidence that induction of alternate death pathways such as necroptosis could improve therapeutic outcomes...
October 19, 2018: Cell Death and Differentiation
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