keyword
https://read.qxmd.com/read/38547423/new-biologics-for-food-allergy
#1
JOURNAL ARTICLE
Jackson P Schuetz, Brent Anderson, Sayantani B Sindher
PURPOSE OF REVIEW: This review aims to explore role of emerging biologics, including ligelizumab, UB-221, dupilumab, and antialarmins, in food allergy management. With a focus on recent developments, we evaluate their promise in mitigating adverse events during oral immunotherapy (OIT), reducing allergic reactions, and addressing the limitations of current therapeutic options. RECENT FINDINGS: Antiimmunoglobulin E mAbs, exemplified by omalizumab, demonstrate efficacy in desensitization and safety improvement during multiallergen OIT...
March 29, 2024: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/38547331/circulating-factors-in-cancer-cachexia-recent-opportunities-for-translational-research
#2
JOURNAL ARTICLE
Marina de Castro Coêlho, Giovana Parreira de Aquino, Amanda Soares Santos, Marilia Seelaender
PURPOSE OF REVIEW: To discuss the recent discoveries and limitations of the available literature on emerging circulating biomarkers of cancer cachexia. RECENT FINDINGS: Studies on circulating factors in cancer cachexia show promising alternatives for diagnosing the syndrome in a minimally invasive manner in the clinic setting, as well as potential targets for cancer cachexia treatment. Factors secreted by the tumor and the adipose tissue, such as extracellular vesicles and soluble proteins, respectively, have been shown to either directly induce wasting in vitro and in vivo or to be altered in the cachectic phenotype...
March 27, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547259/design-of-a-sars-cov-2-papain-like-protease-inhibitor-with-antiviral-efficacy-in-a-mouse-model
#3
JOURNAL ARTICLE
Bin Tan, Xiaoming Zhang, Ahmadullah Ansari, Prakash Jadhav, Haozhou Tan, Kan Li, Ashima Chopra, Alexandra Ford, Xiang Chi, Francesc Xavier Ruiz, Eddy Arnold, Xufang Deng, Jun Wang
The emergence of SARS-CoV-2 variants and drug-resistant mutants calls for additional oral antivirals. The SARS-CoV-2 papain-like protease (PLpro ) is a promising but challenging drug target. We designed and synthesized 85 noncovalent PLpro inhibitors that bind to a recently discovered ubiquitin binding site and the known BL2 groove pocket near the S4 subsite. Leads inhibited PLpro with the inhibitory constant Ki values from 13.2 to 88.2 nanomolar. The co-crystal structures of PLpro with eight leads revealed their interaction modes...
March 29, 2024: Science
https://read.qxmd.com/read/38547045/value-driven-pediatric-supracondylar-humerus-fracture-care-implementing-evidence-based-practices
#4
JOURNAL ARTICLE
Sonia Chaudhry
Supracondylar humerus fractures are high-volume injuries in children; therefore, value-driven treatment has far-reaching implications for patients and families as well as healthcare systems. Children younger than 5 years can remodel posterior angulation. Most Type IIa fractures will maintain alignment after closed reduction. Many patients with surgical fractures can safely wait for nonemergent fixation. Outpatient surgery is associated with shorter surgical time, lower costs, and fewer return visits to the emergency department with no increase in adverse events...
April 1, 2024: Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews
https://read.qxmd.com/read/38546959/a-case-of-hypertensive-emergency-with-alveolar-hemorrhage-and-thrombotic-microangiopathy
#5
JOURNAL ARTICLE
Yoshifumi Ubara, Shigekazu Kurihara, Yoshiki Tsuchiya, Yuki Oba, Daisuke Ikuma, Hiroki Mizuno, Masayuki Yamanouchi, Tatsuya Suwabe, Atsuko Imase, Nobumitsu Shibata, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Kentaro Ogata, Naoki Sawa
A 28-year-old woman with a 5-year history of untreated hypertension was admitted for respiratory distress, hemoptysis, and retinopathy. Computed tomography showed diffuse plaques in both lung fields. Acute kidney injury, hemolytic anemia, and thrombocytopenia were noted. Kidney biopsy showed thrombosis with fibrinoid necrosis and edematous intimal thickening and luminal narrowing of the small renal artery, indicating thrombotic microangiopathy; the majority of glomeruli were collapsed. After 8 weeks of treatment with antihypertensive drugs, serum creatinine decreased to 1...
March 28, 2024: CEN Case Reports
https://read.qxmd.com/read/38546921/an-insight-into-the-role-of-experimental-parameters-in-advanced-oxidation-process-applied-for-pharmaceutical-degradation
#6
REVIEW
Mohammad Qutob, Sultan Alshehri, Faiyaz Shakeel, Prawez Alam, Mohd Rafatullah
The advanced oxidation process (AOP) is an efficient method to treat recalcitrance pollutants such as pharmaceutical compounds. The essential physicochemical factors in AOP experiments significantly influence the efficiency, speed, cost, and safety of byproducts of the treatment process. In this review, we collected recent articles that investigated the elimination of pharmaceutical compounds by various AOP systems in a water medium, and then we provide an overview of AOP systems, the formation mechanisms of active radicals or reactive oxygen species (ROS), and their detection methods...
March 28, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38546865/-therapeutic-healthcare-professional-staffing-requirements-in-intensive-care-units
#7
REVIEW
Silke Klarmann, Anke Hierundar, Teresa Deffner, Andreas Markewitz, Christian Waydhas
BACKGROUND: Therapeutic healthcare professionals in the multiprofessional intensive care unit (ICU) team are important for early mobilization, dysphagia therapy, and psychosocial care of critically ill patients. OBJECTIVE: Despite the high relevance of therapeutic healthcare professions for care in ICUs, there are no recommendations on the specific staffing of therapists in ICUs. RESULTS: Considering the main areas of activity of the individual professional groups and based on productivity time, a requirements analysis for staffing ICUs of different care levels with physiotherapists, occupational therapists, speech therapists, and psychologists was performed...
March 28, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://read.qxmd.com/read/38546863/-evaluation-of-the-role-of-an-advanced-practice-dietitian-in-the-intensive-care-unit
#8
JOURNAL ARTICLE
Gioia Vinci, Reto Stocker
BACKGROUND: In Swiss intensive care units (ICUs), nutritional management is hardly or not at all supported or supervised by dietitians. Nutritional management in the ICU is mainly performed by ICU nursing staff and intensive care specialists. In 2022, the role of an advanced practice dietitian (APD) was newly defined, created, and implemented in a Swiss ICU as part of a pilot project. In contrast to other countries, APDs are still scarce in Switzerland. Evaluation of the APD role is essential to further define the position and adapt it to needs...
March 28, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://read.qxmd.com/read/38546846/unveiling-cardiac-involvement-in-juvenile-dermatomyositis-through-speckle-tracking-echocardiography
#9
JOURNAL ARTICLE
Reyhan Dedeoglu, Nujin Ulug Murt, Aybüke Gunalp, Yusuf İskender Cosgun, Funda Oztunc, Savas Dedeoglu, Amra Adrovic, Sezgin Sahin, Mehmet Yıldız, Kenan Barut, Esma Aslan, Elif Kılıc Konte, Ümit Gul, Ozgur Kasapcopur
Early detection of cardiac involvement in Juvenile Dermatomyositis (JDM) is difficult due to the absence of clinical signs and symptoms, with systolic dysfunction often emerging in late stages and associated with a poor prognosis. This study aimed to employ two-dimensional speckle-tracking echocardiography (STE) for subclinical assessment of left ventricular (LV) systolic failure in JDM and explore potential associations between impaired LV systolic function (LV-GLS) and disease activity. A prospective study enrolled 20 healthy volunteers and 26 JDM patients (< 18 years old) without cardiac symptoms...
March 28, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38546829/long-term-safety-tolerability-and-efficacy-of-apomorphine-sublingual-film-in-patients-with-parkinson-s-disease-complicated-by-off-episodes-a-phase-3-open-label-study
#10
JOURNAL ARTICLE
Jan Kassubek, Stewart A Factor, Ernest Balaguer, Johannes Schwarz, K Ray Chaudhuri, Stuart H Isaacson, Stacy Wu, Carmen Denecke Muhr, Jaime Kulisevsky
BACKGROUND: Apomorphine sublingual film (SL-APO) is an on-demand treatment for OFF episodes in patients with Parkinson's disease (PD). OBJECTIVE: To assess the long-term (≥ 3 years) safety/tolerability and efficacy of SL-APO. METHODS: Study CTH-301 ( https://www. CLINICALTRIALS: gov NCT02542696; registered 2015-09-03) was a phase 3, multicentre, open-label study of SL-APO in PD patients with motor fluctuations, comprised of a dose-titration and long-term safety phase...
March 28, 2024: Journal of Neurology
https://read.qxmd.com/read/38546752/prevalence-of-pretreatment-hiv-resistance-to-integrase-inhibitors-in-west-african-and-southeast-asian-countries
#11
JOURNAL ARTICLE
Avelin F Aghokeng, Nicole Ngo-Giang-Huong, Thu H K Huynh, Anoumou Y Dagnra, Thomas D'Aquin Toni, Almoustapha I Maiga, Kania Dramane, Sabrina Eymard-Duvernay, Marie-Laure Chaix, Vincent Calvez, Diane Descamps
OBJECTIVES: Integrase strand transfer inhibitors (INSTIs) have been recently recommended as the preferred first-line option for antiretroviral treatment initiators in low- and middle-income countries (LMICs) in response to the growing circulation of resistant HIV to non-nucleoside reverse transcriptase inhibitors (NNRTIs). In this study, we estimated the frequency of pretreatment drug resistance (PDR) to INSTIs in West Africa and Southeast Asia. MATERIALS AND METHODS: Using samples collected from 2015 to 2016, and previously used to assessed PI, NRTI and NNRTI resistance, we generated HIV integrase sequences and identified relevant INSTI PDR mutations using the Stanford and ANRS algorithms...
March 28, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38546706/evaluation-of-telehealth-services-that-are-clinically-appropriate-for-reimbursement-in-the-us-medicaid-population-mixed-methods-study
#12
JOURNAL ARTICLE
Sanjeev Saravanakumar, Andrey Ostrovsky
BACKGROUND: When the US Department of Health and Human Services instituted a State of Public Health Emergency (PHE) during the COVID-19 pandemic, many telehealth flexibilities were fast-tracked to allow state Medicaid agencies to reimburse new specialty services, sites of care, and mediums such as FaceTime to communicate with patients.. This resulted in expanded access to care for financially vulnerable Medicaid patients, as evidenced by an uptick in telehealth use. Research has mostly focused on telehealth reimbursement for limited use cases such as rural primary care, without broader consideration for how telehealth can be appropriately mainstreamed and maintained...
March 28, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38546660/feasibility-of-utilizing-gamified-learning-as-a-motivational-strategy-for-promoting-physical-activity-participation-and-healthy-eating-among-college-students
#13
JOURNAL ARTICLE
Jihoon Kim, Anna Karrin Lindqvist, Darla M Castelli
Emerging adulthood is a developmental stage influenced by the regularity of healthy behaviors. Gamification is the motivational strategy using virtual rewards and social comparison. This study aimed to explore the feasibility and proof of concept of utilizing digital badges, leaderboards, and quests as gamified learning in a health course. All data were collected using a pre/posttest format from first-year college students ( n  = 159; female = 42%). Employing a quasi-experimental design with the students in gamified/non-gamified conditions, Fitbit monitored physical activity (PA), and healthy eating (survey and diet recall) pre/post treatment...
March 28, 2024: Journal of American College Health: J of ACH
https://read.qxmd.com/read/38546646/socioeconomic-deprivation-and-health-care-use-in-patients-enrolled-in-swog-cancer-clinical-trials
#14
JOURNAL ARTICLE
Dawn L Hershman, Riha Vaidya, Cathee Till, William Barlow, Mike LeBlanc, Scott Ramsey, Joseph M Unger
IMPORTANCE: Reducing acute care use is an important strategy for improving value. Patients with cancer are at risk for unplanned emergency department (ED) visits and hospital stays (HS). Clinical trial patients have homogeneous treatment; despite this, structural barriers to care may independently impact acute care use. OBJECTIVE: To examine whether ED visits and HS within 12 months of trial enrollment are more common among Medicare enrollees who live in areas of socioeconomic deprivation or have Medicaid insurance...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38546623/klf-transcription-factors-in-bone-diseases
#15
REVIEW
Haixia Wang, Juanjuan Han, Gorbachev Dmitrii, Ke Ning, Xin-An Zhang
Krüppel-like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for the development of human tissues. In recent years, the role of KLFs in bone physiology and pathology has received adequate attention...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38546622/session-level-effects-of-cognitive-processing-therapy-and-prolonged-exposure-on-individual-symptoms-of-posttraumatic-stress-disorder-among-u-s-veterans
#16
JOURNAL ARTICLE
Samantha J Moshier, Colin T Mahoney, Michelle J Bovin, Brian P Marx, Paula P Schnurr
OBJECTIVE: To compare the course of change in individual posttraumatic stress disorder (PTSD) symptoms during prolonged exposure therapy (PE) and cognitive processing therapy (CPT). METHOD: We analyzed data from a previously published randomized clinical trial comparing PE and CPT among male and female U.S. military veterans with PTSD (Schnurr et al., 2022). Using data from a self-rated PTSD symptom measure administered before each therapy session, we evaluated individual symptom change from pretreatment to final therapy session ( N = 802)...
March 28, 2024: Journal of Consulting and Clinical Psychology
https://read.qxmd.com/read/38546616/depressive-symptoms-systemic-inflammation-and-survival-among-patients-with-head-and-neck-cancer
#17
JOURNAL ARTICLE
Elizabeth Cash, Christy Albert, Iona Palmer, Baylee Polzin, Alyssa Kabithe, Devaughn Crawford, Jeffrey M Bumpous, Sandra E Sephton
IMPORTANCE: Patients with head and neck cancer experience high rates of depression. Depression and systemic inflammation have been found to be associated in numerous cancer types, often independently from disease status. Depression-related inflammation may elevate the risks for poor tumor response to treatment and early mortality, and comprises a mechanism by which depression is associated with survival in head and neck cancer. OBJECTIVE: To assess mediation pathways incorporating pretreatment depressive symptoms, pretreatment inflammation, and tumor response posttreatment on overall survival among patients with head and neck cancer...
March 28, 2024: JAMA Otolaryngology—Head & Neck Surgery
https://read.qxmd.com/read/38546554/positive-impacts-of-psychological-pain-treatments-supplementary-analyses-of-a-randomized-clinical-trial
#18
JOURNAL ARTICLE
Erica J Ho, Aaron P Turner, Mark P Jensen, Melissa A Day, Dawn M Ehde, Tracy M Anastas, Rhonda M Williams
OBJECTIVE: Clinical trials often focus on symptom reduction as a primary outcome, overlooking positive psychology factors of potential importance although many individuals can and do live well with pain. The Patient-Reported Outcomes Measurement Information System (PROMIS) Psychosocial Illness Impact-Positive (PIIP) scale assesses perceptions of adaptive psychosocial functioning (e.g., coping and meaning-making) after illness onset. This study evaluated the effects of hypnosis (HYP), mindfulness meditation (MM), and pain psychoeducation (ED) on PIIP scores, using data from a completed randomized clinical trial (RCT) of complementary and integrative chronic pain interventions...
March 28, 2024: Rehabilitation Psychology
https://read.qxmd.com/read/38546462/characteristics-of-injuries-related-to-traffic-crashes-in-israel-before-and-during-the-covid-19-pandemic
#19
JOURNAL ARTICLE
Yaniv Yonai, Merav Ben Natan, David Maman, Ofir Ezra, Yaron Berkovich
OBJECTIVES: This study explored differences in patient characteristics, injury characteristics, treatment modalities, and treatment outcomes among patients who presented to the Emergency Department (ED) following traffic crashes during the COVID-19 period (from March 15, 2020 to March 15, 2022) in comparison to the previous corresponding period between 2017 and 2019. METHODS: The study is a retrospective chart review study. The study included a random sample of 610 patients who presented to the ED of a major hospital located in northern-central Israel following traffic crashes: 305 patients who presented during the COVID-19 period (from March 15, 2020 to March 15, 2022) and 305 patients who presented during the previous corresponding period (from March 15, 2017 to March 15, 2019)...
March 28, 2024: Traffic Injury Prevention
https://read.qxmd.com/read/38546456/clinical-hypnosis-intervention-for-improving-sleep-quality-emerging-research-and-future-directions
#20
EDITORIAL
Gary Elkins
Research into clinical hypnosis for sleep disturbances is an expanding area with important implications for clinical practice and future research. This issue of the International Journal of Clinical and Experimental Hypnosis includes emerging research on clinical hypnosis to improve sleep quality and disturbances. While clinical hypnosis for sleep is very promising, the underlying mechanisms are largely unknown. To address this is an article that examines pre-sleep arousal and worry reduction as potential variables associated with the effects of clinical hypnosis in improving sleep quality...
2024: International Journal of Clinical and Experimental Hypnosis
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