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https://www.readbyqxmd.com/read/29768411/cytoskeleton-structure-and-total-methylation-of-mouse-cardiac-and-lung-tissue-during-space-flight
#1
Irina V Ogneva, Sergey S Loktev, Vladimir N Sychev
The purpose of this work was to evaluate the protein and mRNA expression levels of multiple cytoskeletal proteins in the cardiac and lung tissue of mice that were euthanized onboard the United States Orbital Segment of the International Space Station 37 days after the start of the SpaceX-4 mission (September 2014, USA). The results showed no changes in the cytoskeletal protein content in the cardiac and lung tissue of the mice, but there were significant changes in the mRNA expression levels of the associated genes, which may be due to an increase in total genome methylation...
2018: PloS One
https://www.readbyqxmd.com/read/29753413/development-of-a-step-down-method-for-altering-male-c57bl-6-mouse-housing-density-and-hierarchical-structure-preparations-for-spaceflight-studies
#2
David C Scofield, Jeffrey D Rytlewski, Paul Childress, Kishan Shah, Aamir Tucker, Faisal Khan, Jessica Peveler, Ding Li, Todd O McKinley, Tien-Min G Chu, Debra L Hickman, Melissa A Kacena
This study was initiated as a component of a larger undertaking designed to study bone healing in microgravity aboard the International Space Station (ISS). Spaceflight experimentation introduces multiple challenges not seen in ground studies, especially with regard to physical space, limited resources, and inability to easily reproduce results. Together, these can lead to diminished statistical power and increased risk of failure. It is because of the limited space, and need for improved statistical power by increasing sample size over historical numbers, NASA studies involving mice require housing mice at densities higher than recommended in the Guide for the Care and Use of Laboratory Animals (National Research Council, 2011)...
May 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29475520/forces-associated-with-launch-into-space-do-not-impact-bone-fracture-healing
#3
Paul Childress, Alexander Brinker, Cynthia-May S Gong, Jonathan Harris, David J Olivos, Jeffrey D Rytlewski, David C Scofield, Sungshin Y Choi, Yasaman Shirazi-Fard, Todd O McKinley, Tien-Min G Chu, Carolynn L Conley, Nabarun Chakraborty, Rasha Hammamieh, Melissa A Kacena
Segmental bone defects (SBDs) secondary to trauma invariably result in a prolonged recovery with an extended period of limited weight bearing on the affected limb. Soldiers sustaining blast injuries and civilians sustaining high energy trauma typify such a clinical scenario. These patients frequently sustain composite injuries with SBDs in concert with extensive soft tissue damage. For soft tissue injury resolution and skeletal reconstruction a patient may experience limited weight bearing for upwards of 6 months...
February 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29446407/spacex-ignites-big-dreams
#4
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
February 15, 2018: Nature
https://www.readbyqxmd.com/read/28932101/a-new-upper-bound-of-geometric-constant-formula-see-text
#5
Jin Huan Li, Bo Ling, San Yang Liu
A new constant [Formula: see text] is introduced into any real [Formula: see text]-dimensional symmetric normed space X. By virtue of this constant, an upper bound of the geometric constant [Formula: see text], which is used to measure the difference between Birkhoff orthogonality and isosceles orthogonality, is obtained and further extended to an arbitrary m-dimensional symmetric normed linear space ([Formula: see text]). As an application, the result is used to prove a special case for the reverse Hölder inequality...
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/28199884/three-dimensional-growth-of-human-endothelial-cells-in-an-automated-cell-culture-experiment-container-during-the-spacex-crs-8-iss-space-mission-the-spheroids-project
#6
Jessica Pietsch, Samuel Gass, Stefano Nebuloni, David Echegoyen, Stefan Riwaldt, Christin Baake, Johann Bauer, Thomas J Corydon, Marcel Egli, Manfred Infanger, Daniela Grimm
Human endothelial cells (ECs) were sent to the International Space Station (ISS) to determine the impact of microgravity on the formation of three-dimensional structures. For this project, an automatic experiment unit (EU) was designed allowing cell culture in space. In order to enable a safe cell culture, cell nourishment and fixation after a pre-programmed timeframe, the materials used for construction of the EUs were tested in regard to their biocompatibility. These tests revealed a high biocompatibility for all parts of the EUs, which were in contact with the cells or the medium used...
April 2017: Biomaterials
https://www.readbyqxmd.com/read/27724831/an-astronaut-s-guide-to-life-on-earth-by-chris-hadfield-elon-musk-tesla-spacex-and-the-quest-for-a-fantastic-future-by-ashlee-vancenew-york-ny-back-bay-books-2015-320-pp-isbn-13-978-0-316-25303-1-17-00-paperback-new-york-ny-harpercollins-2015-400-pages-isbn
#7
https://www.readbyqxmd.com/read/27642199/an-efficient-approach-for-mars-sample-return-using-emerging-commercial-capabilities
#8
Andrew A Gonzales, Carol R Stoker
Mars Sample Return is the highest priority science mission for the next decade as recommended by the 2011 Decadal Survey of Planetary Science [1]. This article presents the results of a feasibility study for a Mars Sample Return mission that efficiently uses emerging commercial capabilities expected to be available in the near future. The motivation of our study was the recognition that emerging commercial capabilities might be used to perform Mars Sample Return with an Earth-direct architecture, and that this may offer a desirable simpler and lower cost approach...
June 2016: Acta Astronautica
https://www.readbyqxmd.com/read/27446039/cultivation-of-staphylococcus-epidermidis-in-the-human-spaceflight-environment-leads-to-alterations-in-the-frequency-and-spectrum-of-spontaneous-rifampicin-resistance-mutations-in-the-rpob-gene
#9
Patricia Fajardo-Cavazos, Wayne L Nicholson
Bacteria of the genus Staphylococcus are persistent inhabitants of human spaceflight habitats and represent potential opportunistic pathogens. The effect of the human spaceflight environment on the growth and the frequency of mutations to antibiotic resistance in the model organism Staphylococcus epidermidis strain ATCC12228 was investigated. Six cultures of the test organism were cultivated in biological research in canisters-Petri dish fixation units for 122 h on orbit in the International Space Station (ISS) as part of the SpaceX-3 resupply mission...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27344934/interplanetary-regenerative-medicine-for-mission-mars-of-spacex-and-nasa
#10
EDITORIAL
Tsu Tshen Chuang
No abstract text is available yet for this article.
July 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/23794777/evaluation-of-the-fluids-mixing-enclosure-system-for-life-science-experiments-during-a-commercial-caenorhabditis-elegans-spaceflight-experiment
#11
Paul Warren, Andy Golden, John Hanover, Dona Love, Freya Shephard, Nathaniel J Szewczyk
The Student Spaceflight Experiments Program (SSEP) is a United States national science, technology, engineering, and mathematics initiative that aims to increase student interest in science by offering opportunities to perform spaceflight experiments. The experiment detailed here was selected and flown aboard the third SSEP mission and the first SSEP mission to the International Space Station (ISS). Caenorhabditis elegans is a small, transparent, self-fertilizing hermaphroditic roundworm that is commonly used in biological experiments both on Earth and in Low Earth Orbit...
June 1, 2013: Advances in Space Research: the Official Journal of the Committee on Space Research (COSPAR)
https://www.readbyqxmd.com/read/23560417/the-icebreaker-life-mission-to-mars-a-search-for-biomolecular-evidence-for-life
#12
Christopher P McKay, Carol R Stoker, Brian J Glass, Arwen I Davé, Alfonso F Davila, Jennifer L Heldmann, Margarita M Marinova, Alberto G Fairen, Richard C Quinn, Kris A Zacny, Gale Paulsen, Peter H Smith, Victor Parro, Dale T Andersen, Michael H Hecht, Denis Lacelle, Wayne H Pollard
The search for evidence of life on Mars is the primary motivation for the exploration of that planet. The results from previous missions, and the Phoenix mission in particular, indicate that the ice-cemented ground in the north polar plains is likely to be the most recently habitable place that is currently known on Mars. The near-surface ice likely provided adequate water activity during periods of high obliquity, ≈ 5 Myr ago. Carbon dioxide and nitrogen are present in the atmosphere, and nitrates may be present in the soil...
April 2013: Astrobiology
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