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https://www.readbyqxmd.com/read/28726115/the-impact-of-coronary-calcification-on-angiographic-and-3-year-clinical-outcomes-of-everolimus-eluting-stents-results-of-a-xience-v-promus-post-marketing-surveillance-study
#1
Nobuo Shiode, Ken Kozuma, Jiro Aoki, Masaki Awata, Mamoru Nanasato, Kengo Tanabe, Junichi Yamaguchi, Hajime Kusano, Hong Nie, Takeshi Kimura
Coronary calcification (CCA) is one of the independent predictors for major adverse cardiac events (MACEs) in coronary intervention. Post-marketing surveillance study Japan is a prospective registry designed to evaluate the safety and efficacy of the everolimus-eluting stent (EES, XIENCE V/PROMUS Stent) in routine clinical practice at 47 centers. In this study, 1848 lesions (1546 patients) were assessed using quantitative coronary angiography. In these 1546 patients, renal function data were unknown in 26 patients...
July 19, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28721493/modelling-of-lesions-associated-with-functional-mitral-regurgitation-in-an-ex-vivo-platform
#2
Michal Jaworek, Federico Lucherini, Claudia Romagnoni, Guido Gelpi, Monica Contino, Paolo Romitelli, Carlo Antona, Gianfranco B Fiore, Riccardo Vismara
Functional mitral regurgitation (FMR) is a complex pathology involving valvular and subvalvular structures reconfiguration, and its treatment is considered challenging. There is a lack of experimental models allowing for reliable preclinical FMR treatments' evaluation in a realistic setting. A novel approach to simulate FMR was developed and incorporated into an ex vivo passive beating heart platform. FMR was obtained by dilating the mitral annulus (MA) mainly in the antero-posterior direction and displacing the papillary muscles (PMs) apically and laterally by ad hoc designed and 3D printed dilation and displacing devices...
July 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28720535/effect-of-polymer-type-on-the-surface-energy-of-acetaminophen-solid-dispersions-prepared-by-melt-method
#3
Tereza Školáková, Jan Patera, Petr Zámostný
Many newly developed active pharmaceutical ingredients (APIs) have very low solubility in aqueous media. The preparation of solid dispersions (SDs) is one way of avoiding this problem. However, compound wettability and thus solubility are influenced by surface energy. In this study, we used inverse gas chromatography (IGC) to evaluate the surface energies of prepared SDs, and compared them with those obtained for physical mixtures (PMs). SDs containing different weight ratios of crystalline acetaminophen and one of three polymers (Kollidon(®) 12 PF, Kollidon(®) VA 64 or Soluplus(®)) were prepared by the melt-quenching of corresponding PMs...
July 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28704664/a-primary-estimation-of-pcdd-fs-release-reduction-from-non-wood-pulp-and-paper-industry-in-china-based-on-the-investigation-of-pulp-bleaching-with-chlorine-converting-to-chlorine-dioxide
#4
Qingcong Xiao, Xiaoqian Song, Wenchao Li, Yuanna Zhang, Hongchen Wang
Chlorine bleaching technology (C process, CEH process, H process and theirs combination), which was identified as a primary formation source of PCDD/Fs, is still widely used by the vast majority of Chinese non-wood pulp and paper mills (non-wood PMs). The purpose of this study was to provide information and data support for further eliminating dioxin for non-wood PMs in China, and especially to evaluate the PCDD/Fs release reduction for those mills converting their pulp bleaching processes from CEH to ECF. The PCDD/Fs concentrations of the bleached pulp and bleaching wastewater with ECF bleaching were in the ranges of 0...
June 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/28698067/glycyrrhetinic-acid-modified-tpgs-polymeric-micelles-for-hepatocellular-carcinoma-targeted-therapy
#5
Xiumei Zhu, Altansukh Tsend-Ayush, Zhongyue Yuan, Jing Wen, Jiaxin Cai, Shifu Luo, Jianxu Yao, Junxing Bian, Linfang Yin, Jianping Zhou, Jing Yao
In this study, glycyrrhetinic acid (GA)-modified D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) polymeric micelles (TGA PMs) were developed for the delivery of etoposide (ETO) to hepatoma cells. GA was incorporated as a ligand because of its high affinity to the hepatocytes, while TPGS functioned as a P-gp inhibitor to reverse multidrug resistance. ETO-loaded TGA PMs (ETO-TGA PMs) displayed a mean particle size of 133.6±1.2nm with a low poly-dispersity index (0.224±0.013) and negative zeta potential (-16...
July 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28686910/polar-transport-in-plants-mediated-by-membrane-transporters-focus-on-mechanisms-of-polar-auxin-transport
#6
REVIEW
Satoshi Naramoto
Directional cell-to-cell transport of functional molecules, called polar transport, enables plants to sense and respond to developmental and environmental signals. Transporters that localize to plasma membranes (PMs) in a polar manner are key components of these systems. PIN-FORMED (PIN) auxin efflux carriers, which are the most studied polar-localized PM proteins, are implicated in the polar transport of auxin that in turn regulates plant development and tropic growth. In this review, the regulatory mechanisms underlying polar localization of PINs, control of auxin efflux activity, and PIN abundance at PMs are considered...
July 4, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28682101/premenstrual-symptoms-and-factors-implicated-in-smoking-cessation-among-woman-smokers
#7
Raina D Pang, Nafeesa Andrabi, Adam M Leventhal
Premenstrual symptoms (PMS) may reduce smoking cessation success. Yet, little is known about the factors that may impact smoking cessation among women with elevated PMS, leaving little data to guide smoking cessation science and practice for this population. This cross-sectional study is a secondary analysis of data from laboratory studies focused on menstrual cycle effects and smoking. Premenopausal woman daily smokers (n = 157) completed self-report measures of tobacco dependence and other cessation-relevant factors (i...
July 6, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28681740/cognition-in-advanced-normal-pressure-hydrocephalus-a-pilot-study-from-south-india
#8
Robert Mathew, Sauda Pavithran
BACKGROUND: Literature on cognition in normal pressure hydrocephalus (NPH) is sparse and more so on cognition in advanced NPH. OBJECTIVE: To study the cognitive profile in a hospital-based cohort of cognitively-advanced NPH. SETTINGS AND DESIGN: This was a prospective cross-sectional study. The patients included those availing dementia care service from three different tertiary care centres during a period of 5 years from 2010 to 2014. Patients were considered to have cognitively-advanced NPH if the Addenbrooke's Cognitive Examination(ACE) score was 50 or less...
July 2017: Neurology India
https://www.readbyqxmd.com/read/28681293/ferrous-activated-peroxymonosulfate-oxidation-of-antimicrobial-agent-sulfaquinoxaline-and-structurally-related-compounds-in-aqueous-solution-kinetics-products-and-transformation-pathways
#9
Yuefei Ji, Lu Wang, Mengdi Jiang, Yan Yang, Peizeng Yang, Junhe Lu, Corinne Ferronato, Jean-Marc Chovelon
Sulfaquinoxaline (SQX) is a coccidiostatic drug widely used in poultry and swine production and has been frequently detected in various environmental compartments such as surface water, groundwater, soils, and sediments. In the present study, degradation of SQX by ferrous ion-activated peroxymonosulfate oxidation process (Fe(II)/PMS), a promising in situ chemical oxidation (ISCO) technique, was systematically investigated. Experimental results showed that Fe(II)/PMS process appeared to be more efficient for SQX removal relative to Fe(II)/persulfate process (Fe(II)/PS)...
July 5, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28681290/physicochemical-properties-in-vitro-cytotoxic-and-genotoxic-effects-of-pm1-0-and-pm2-5-from-shanghai-china
#10
Yajuan Zou, Yizhao Wu, Yali Wang, Yinsheng Li, Chengyu Jin
Exposure to ambient particulate matter (PM) links with a variety of respiratory diseases. However, compared with coarse particles (PM10) and fine particles (PM2.5), submicrometer particles (PM1.0) may be a more important indicator of human health risks. In this study, the cytotoxic and genotoxic effects of PM1.0 samples from Shanghai were examined using A549 cells, and compared with the effects of PM2.5, to better understand the health effects of PM1.0 in this area. The PM1.0 and PM2.5 samples were characterized for morphology, water-soluble inorganic ions, organic and elemental carbon, and metal elements...
July 5, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28679477/bromate-inhibition-by-reduced-graphene-oxide-in-thermal-pms-process
#11
Xin Huang, Xujie Zhou, Jizhi Zhou, Zhifeng Huang, Shuang Liu, Guangren Qian, Naiyun Gao
Bromate (BrO3(-)), as a contaminant producing from bromide (Br(-)) oxidation, has been revealed for generation in sulfate radical involved processes. In this work, reduced graphene oxide (rGO) was firstly applied to inhibit the formation of BrO3(-) in thermally activated peroxymonosulfate (thermal/PMS) treatment. In the presence of 5-35 mg/L rGO, the decomposition rate of PMS was slightly increased from 0.0162 ± 0.0013 min(-1) to 0.0200 ± 0.0010 min(-1), corresponding to removal rate of target pollutant increasing from 0...
June 15, 2017: Water Research
https://www.readbyqxmd.com/read/28679023/notable-drug-drug-interaction-between-etizolam-and-itraconazole-in-poor-metabolizers-of-cytochrome-p450-2c19
#12
Takehito Yamamoto, Kenichi Furihata, Akihiro Hisaka, Takashi Moritoyo, Kazuaki Ogoe, Shizuko Kusayama, Keiju Motohashi, Akiko Mori, Takeshi Iwatsubo, Hiroshi Suzuki
In this study, impact of a polymorphism of CYP2C19 on drug-drug interaction (DDI) was examined for etizolam. The effect of itraconazole (a strong CYP3A inhibitor) on the pharmacokinetics of etizolam (a substrate of CYP2C19 and CYP3A) was assessed in both extensive metabolizers (EMs) and poor metabolizers (PMs) of CYP2C19. Sixteen participants (8 EMs and 8 PMs) received a single oral dose of etizolam (0.25 mg) on day 1. The participants ingested itraconazole (200 mg twice a day) on days 2-5. On day 5, participants received an oral dose of etizolam (0...
July 5, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28677887/inferior-lead-discordance-in-ventricular-arrhythmias-a-specific-marker-for-certain-arrhythmia-locations
#13
Andres Enriquez, Rajeev K Pathak, Pasquale Santangeli, Jackson Jeikai Liang, Mohammed Al Rawahi, Tatsuya Hayashi, Danielle Muser, David S Frankel, Gregory Supple, Robert Schaller, David Lin, Saman Nazarian, Erica Zado, Francis E Marchlinski, Fermin C Garcia
BACKGROUND: Most idiopathic ventricular arrhythmias (VAs) originate from the outflow tracts and are characterized by an inferior axis on the 12-lead ECG. A group of patients will exhibit inferior lead discordance (ILD), demonstrating a positive QRS in lead II with negative QRS in III or the opposite finding. METHODS AND RESULTS: We identified patients undergoing ablation of idiopathic premature ventricular contractions (PVCs) or ventricular tachycardia (VT) between 2013 and 2015...
July 5, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28670129/stress-reactivity-and-emotion-in-premenstrual-syndrome
#14
Qing Liu, Yongshun Wang, Cornelis Hermanus van Heck, Wei Qiao
BACKGROUND: Hormone level fluctuation across the menstrual cycle causes women to experience negative emotions and also affects their mood regulation and stress sensitivity. However, the stress reactivity and emotional variations in women with premenstrual syndrome (PMS), who are especially sensitive to the variations in hormone cycles, have not been explained. METHODS: The present study used an electroencephalogram (EEG) stress evaluation test, a physiology stress evaluation test, and the positive affect and negative affect scale (PANAS) to evaluate the stress reactivity pattern and emotional state of women with PMS...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28666132/neuropsychological-function-in-relation-to-dysmenorrhea-in-adolescents
#15
Afsane Bahrami, Hamidreza Sadeghnia, Amir Avan, Seyed Jamal Mirmousavi, Alireza Moslem, Saeed Eslami, Masoud Heshmati, Hamidreza Bahrami-Taghanaki, Gordon A Ferns, Majid Ghayour-Mobarhan
OBJECTIVE: Hormonal variations during the menstrual cycle may affect emotional regulation. We aimed to investigate the association between dysmenorrhea (the severe abdominal pain and cramps associated with menstruation) and cognitive abilities, emotional function and sleep patterns in adolescent girls. Moreover, we evaluated the frequency of premenstrual syndrome (PMS) in our population and then divided them into 4 groups: subjects with only PMS; subjects with only dysmenorrhea; individuals with both PMS and dysmenorrhea and normal subjects...
June 21, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28666081/mhc-class-ii-alleles-influence-induction-of-pathogenic-antiphospholipid-antibodies-in-a-thrombosis-mouse-model
#16
Elizabeth Papalardo, Zurina Romay-Penabad, Rohan Willis, Premkumar Christadoss, Ana Laura Carrera-Marin, Elba Reyes-Maldonado, Rajani Rudrangi, Silvana Alfieri-Papalardo, Ethel Garcia-Latorre, Miri Blank, Silvia Pierangeli, Allan R Brasier, Emilio B Gonzalez
OBJECTIVE: Both environmental and genetic factors are important in antiphospholipid antibody(aPL) development in antiphospholipid syndrome(APS). Currently, the only available data on predisposing genetic factors have been obtained from epidemiological studies without mechanistic evidence. Therefore, we studied the influence of Major Histocompatibility Complex Class II(MHC-II) alleles on the production of aPL in an APS mouse model. METHODS: Three groups of mice: MHC-II deficient (MHC-II(-/-) ) mice, MHC-II(-/-) mice transgenic for human DQ6, DQ8 or DR4 alleles and their corresponding wild-type(WT) strains were each immunized, half with human β2 glycoprotein-I(β2 GPI) and the other half with control ovalbumin(OA) protein...
June 30, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28663788/using-spectral-decomposition-of-the-signals-from-laurdan-derived-probes-to-evaluate-the-physical-state-of-membranes-in-live-cells
#17
Serge Mazeres, Farzad Fereidouni, Etienne Joly
Background: We wanted to investigate the physical state of biological membranes in live cells under the most physiological conditions possible. Methods: For this we have been using laurdan, C-laurdan or M-laurdan to label a variety of cells, and a biphoton microscope equipped with both a thermostatic chamber and a spectral analyser. We also used a flow cytometer to quantify the 450/530 nm ratio of fluorescence emissions by whole cells. Results: We find that using all the information provided by spectral analysis to perform spectral decomposition dramatically improves the imaging resolution compared to using just two channels, as commonly used to calculate generalized polarisation (GP)...
2017: F1000Research
https://www.readbyqxmd.com/read/28662843/environmental-impacts-and-benefits-of-state-of-the-art-technologies-for-e-waste-management
#18
Mahdi Ikhlayel
This study aims to evaluate the environmental impacts and benefits of state-of-the-art technologies for proper e-waste handling using Jordan as a case study. Life Cycle Assessment (LCA) was employed to evaluate five advanced management systems represent state-of-the-art treatment technologies, including sanitary landfilling; proper recycling of metals, materials, and precious metals (PMs); and incineration of plastic and the hazardous portion of printed circuit boards (PCBs). Six e-waste products that contribute the most to the e-waste in Jordan were included in the assessment of each scenario, which resulted in 30 total cases of e-waste management...
June 26, 2017: Waste Management
https://www.readbyqxmd.com/read/28661785/effect-of-pulsed-magnetic-stimulation-on-sexual-function-in-couples-with-female-stress-urinary-incontinence-partners
#19
Renly Lim, Men Long Liong, Yong Khee Lau, Wing Seng Leong, Nurzalina Abdul Karim Khan, Kah Hay Yuen
We prospectively evaluated the effects of pulsed magnetic stimulation (PMS) on sexual function of couples with stress urinary incontinence (SUI) partners. Female SUI subjects received 16 or 32 biweekly PMS sessions depending on treatment response. Prior to, immediately after and at 6-months post-treatment, couples completed the Golombok Rust Inventory of Sexual Satisfaction (GRISS) questionnaire. Fifty-three (80.3%) of 66 couples completed reassessments. Based on the overall GRISS score, there were significant improvements in sexual function in both female subjects (Mdiff -5...
June 29, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/28655694/total-glucosides-of-curculigo-rhizome-to-perimenopausal-period-mice-model
#20
Mingsan Miao, Shuo Tian, Ming Bai, Xin Weiyun
To investigate the effects of total glucosides of Curculigo rhizome (TGC) to perimenopausal period (PMS) mice model. After removed the bilateral ovaries induced the PMS mice model, high, medium and low doses of TGC group were partly given TGC solution 400,200,100mg•kg-1, administered once a day, continuously 21 days. Compared with the model group (MG) mices, each dose of TGC group could significantly improve the activities of mice, increase thymus, uterus, spleen index(TI, UI, SI), the levels of testosterone(T), estradiol (E2), reduce the level of luteinizing hormone (LH), the high dose of TGC group(HD-C) group has the best effects...
May 2017: Pakistan Journal of Pharmaceutical Sciences
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