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https://www.readbyqxmd.com/read/28214545/potential-of-amphiphilic-graft-copolymer-%C3%AE-tocopherol-succinate-g-carboxymethyl-chitosan-in-modulating-the-permeability-and-anticancer-efficacy-of-tamoxifen
#1
Sunil K Jena, Sanjaya K Samal, Shamandeep Kaur, Mahesh Chand, Abhay T Sangamwar
Recent studies showed an enhanced oral bioavailability of tamoxifen (TMX) by hydrophobically modified α-tocopherol succinate-g-carboxymethyl chitosan (Cmc-TS) micelles. As a continued effort, here we evaluated TMX-loaded polymeric micelles (TMX-PMs) for its enhanced permeability with increased anticancer efficacy and decreased hepatotoxicity. We employed co-solvent evaporation technique to encapsulate TMX into Cmc-TS. Apparent permeability assay of TMX-PMs was performed on Caco-2 cell line. The absorptive transport of TMX increased significantly about 3...
February 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28210250/simultaneous-activation-of-iron-and-thiol-based-sensor-regulator-systems-by-redox-active-compounds
#2
Kang-Lok Lee, Ji-Sun Yoo, Gyeong-Seok Oh, Atul K Singh, Jung-Hye Roe
Bacteria in natural habitats are exposed to myriad redox-active compounds (RACs), which include producers of reactive oxygen species (ROS) and reactive electrophile species (RES) that alkylate or oxidize thiols. RACs can induce oxidative stress in cells and activate response pathways by modulating the activity of sensitive regulators. However, the effect of a certain compound on the cell has been investigated primarily with respect to a specific regulatory pathway. Since a single compound can exert multiple chemical effects in the cell, its effect can be better understood by time-course monitoring of multiple sensitive regulatory pathways that the compound induces...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28208759/acute-effects-of-particulate-air-pollution-on-ischemic-heart-disease-hospitalizations-in-shanghai-china
#3
Anyang Xu, Zhe Mu, Bo Jiang, Wei Wang, Han Yu, Lijuan Zhang, Jue Li
Background: Air pollution has been demonstrated to be a major risk factor for the development of cardiovascular and respiratory diseases worldwide. This study examines the relationship between the exposure to fine particulate matter (PM) and patient hospitalizations as a result of ischemic heart disease (IHD) during 2013-2014 in Shanghai, China. Methods: Daily IHD hospitalization data were acquired from the Shanghai Health Insurance Bureau (SHIB) from 1 January 2013 to 21 December 2014. Daily average concentrations of air pollution as well as meteorological data were obtained from the database of Shanghai Environmental Monitoring Center (SEMC) during the same time period, and all data were analyzed using standard epidemiological methodology...
February 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28208463/frequency-regulators-for-the-nonperturbative-renormalization-group-a-general-study-and-the-model-a-as-a-benchmark
#4
Charlie Duclut, Bertrand Delamotte
We derive the necessary conditions for implementing a regulator that depends on both momentum and frequency in the nonperturbative renormalization-group flow equations of out-of-equilibrium statistical systems. We consider model A as a benchmark and compute its dynamical critical exponent z. This allows us to show that frequency regulators compatible with causality and the fluctuation-dissipation theorem can be devised. We show that when the principle of minimal sensitivity (PMS) is employed to optimize the critical exponents η, ν, and z, the use of frequency regulators becomes necessary to make the PMS a self-consistent criterion...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28203655/co2sno4-nanoparticles-as-a-high-performance-catalyst-for-oxidative-degradation-of-rhodamine-b-dye-and-pentachlorophenol-by-activation-of-peroxymonosulfate
#5
Monaam Ben Ali, Alexandre Barras, Ahmed Addad, Brigitte Sieber, Habib Elhouichet, Mokhtar Férid, Sabine Szunerits, Rabah Boukherroub
Spinel Co2SnO4 nanoparticles are synthesized by a facile hydrothermal route in alkaline solution using SnCl4 and CoCl2 as precursors. The structure, morphology and chemical composition of the nanoparticles are characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), energy dispersive X-ray (EDX), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). The catalytic performance of the Co2SnO4 nanoparticles is thoroughly evaluated for peroxymonosulfate (PMS) activation for removal of rhodamine B (RhB) and pentachlorophenol (PCP) from water...
February 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28202817/adaptive-shaping-of-the-behavioural-and-neuroendocrine-phenotype-during-adolescence
#6
Tobias D Zimmermann, Sylvia Kaiser, Michael B Hennessy, Norbert Sachser
Environmental conditions during early life can adaptively shape the phenotype for the prevailing environment. Recently, it has been suggested that adolescence represents an additional temporal window for adaptive developmental plasticity, though supporting evidence is scarce. Previous work has shown that male guinea pigs living in large mixed-sex colonies develop a low-aggressive phenotype as part of a queuing strategy that is adaptive for integrating into large unfamiliar colonies. By contrast, males living in pairs during adolescence become highly aggressive towards strangers...
February 22, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28192539/optical-coherence-tomography-segmentation-analysis-in-relapsing-remitting-versus-progressive-multiple-sclerosis
#7
Raed Behbehani, Abdullah Abu Al-Hassan, Ali Al-Salahat, Devarajan Sriraman, J D Oakley, Raed Alroughani
INTRODUCTION: Optical coherence tomography (OCT) with retinal segmentation analysis is a valuable tool in assessing axonal loss and neuro-degeneration in multiple sclerosis (MS) by in-vivo imaging, delineation and quantification of retinal layers. There is evidence of deep retinal involvement in MS beyond the inner retinal layers. The ultra-structural retinal changes in MS in different MS phenotypes can reflect differences in the pathophysiologic mechanisms. There is limited data on the pattern of deeper retinal layer involvement in progressive MS (PMS) versus relapsing remitting MS (RRMS)...
2017: PloS One
https://www.readbyqxmd.com/read/28192122/plasmodium-berghei-plasmepsin-viii-is-essential-for-sporozoite-gliding-motility
#8
Babu S Mastan, Sunil Kumar Narwal, Sandeep Dey, Kota Arun Kumar, Satish Mishra
Plasmodium aspartic proteases, termed plasmepsins (PMs) play many critical roles such as haemoglobin degradation, cleavage of PEXEL proteins and sporozoite development in the parasite life cycle. Most of the plasmepsins are well characterized, however the role of PM VIII in Plasmodium remains unknown. Here, we elucidate the functions of PM VIII (PBANKA_132910) in the rodent malaria parasite Plasmodium berghei (Pb). By targeted gene deletion, we show that PbPM VIII is critical for sporozoite egress from an oocyst and gliding motility, which is a prerequisite for the invasion of salivary glands and subsequent transmission to the vertebrate host...
February 10, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28188965/effect-of-zinc-sulfate-supplementation-on-premenstrual-syndrome-and-health-related-quality-of-life-clinical-randomized-controlled-trial
#9
Shiva Siahbazi, Samira Behboudi-Gandevani, Lida Moghaddam-Banaem, Ali Montazeri
AIM: The purpose of study was to assess the effect of zinc sulfate (ZS) supplementation on premenstrual syndrome (PMS) and health-related quality of life (QoL). METHODS: This was a double-blind randomized and placebo-controlled trial using the parallel technique conducted between June 2013 and May 2014. A total of 142 women (age, 20-35 years) with PMS were allocated to either the ZS or placebo group. The women in the intervention group received ZS 220-mg capsules (containing 50 mg elemental zinc) from the 16th day of the menstrual cycle to the second day of the next cycle...
February 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28187348/ferrous-iron-peroxymonosulfate-oxidation-as-a-pretreatment-for-ceramic-ultrafiltration-membrane-control-of-natural-organic-matter-fouling-and-degradation-of-atrazine
#10
Xiaoxiang Cheng, Heng Liang, An Ding, Xiaobin Tang, Bin Liu, Xuewu Zhu, Zhendong Gan, Daoji Wu, Guibai Li
Ferrous iron/peroxymonosulfate (Fe(II)/PMS) oxidation was employed as a pretreatment method for ultrafiltration process to control membrane fouling caused by natural organic matter, including humic acid (HA), sodium alginate (SA), bovine serum albumin (BSA), and their mixture (HA-SA-BSA). To evaluate the mechanism of fouling mitigation, the effects of Fe(II)/PMS pretreatment on the characteristics of feed water were examined. The degradation of atrazine (ATZ) was also investigated and the species of generated radicals were preliminarily determined...
February 1, 2017: Water Research
https://www.readbyqxmd.com/read/28183015/synergistic-degradation-of-phenols-using-peroxymonosulfate-activated-by-cuo-co3o4-mno2-nanocatalyst
#11
Aimal Khan, Zhuwei Liao, Yong Liu, Ali Jawad, Jerosha Ifthikar, Zhuqi Chen
The development of transition metal based heterogeneous catalysts with efficient reactivity and intensive stability is of great demand in peroxymonosulfate based AOPs in water treatment. Herein, we present a novel approach of creating stable and effective nano-rod catalyst of CuCo@MnO2 with tetragonal structure. A remarkable synergetic effect was found between bi-metallic oxides of Cu and Co: 0.5%Cu-2%Co-MnO2 can efficiently degrade 100% of 30ppm phenol, while 0.5%Cu@MnO2 or 2%Co@MnO2 alone is apparently sluggish for the degradation of organic contaminants...
January 19, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28178271/tead-transcription-factors-are-required-for-normal-primary-myoblast-differentiation-in-vitro-and-muscle-regeneration-in-vivo
#12
Shilpy Joshi, Guillaume Davidson, Stéphanie Le Gras, Shuichi Watanabe, Thomas Braun, Gabrielle Mengus, Irwin Davidson
The TEAD family of transcription factors (TEAD1-4) bind the MCAT element in the regulatory elements of both growth promoting and myogenic differentiation genes. Defining TEAD transcription factor function in myogenesis has proved elusive due to overlapping expression of family members and their functional redundancy. We show that silencing of either Tead1, Tead2 or Tead4 did not effect primary myoblast (PM) differentiation, but that their simultaneous knockdown strongly impaired differentiation. In contrast, Tead1 or Tead4 silencing impaired C2C12 differentiation showing their different contributions in PMs and C2C12 cells...
February 8, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28168367/clinical-implications-of-nonspecific-pulmonary-nodules-identified-during-the-initial-evaluation-of-patients-with-head-and-neck-squamous-cell-carcinoma
#13
Minsu Kwon, Sang Hoon Lee, Yoon Se Lee, Choong Wook Lee, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
OBJECTIVE: We aimed to identify the clinical implications of nonspecific pulmonary nodules (NPNs) detected in the initial staging workup for patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Medical records of patients who had been diagnosed and treated in our hospital were retrospectively analysed. After definite treatment, changes of NPNs detected on initial evaluation were monitored via serial chest computed tomography. The associations between NPNs and the clinicopathological characteristics of primary HNSCC were evaluated...
February 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28165635/variance-of-the-pectoralis-major-in-relation-to-the-inframammary-fold-and-the-pectoralis-minor-and-its-application-to-breast-surgery
#14
Woo Yeol Baek, Il Hwan Byun, Young Seok Kim, Bok Ki Jung, In Sik Yun, Tai Suk Roh
INTRODUCTION: Understanding the anatomy of the muscles and other structures of the chest is of great importance in breast surgery. We have conducted the first analysis of the overall variations and relationships among the pectoralis major (PM), inframammary fold (IMF), and pectoralis minor (Pm). MATERIALS AND METHODS: We studied 30 patients and 10 cadavers, leading to a total of 50 breasts. Preoperatively, the breast width was measured, and the costal origin of the lowest IMF point was marked...
February 6, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28160258/effect-of-microneedles-on-transdermal-permeation-enhancement-of-amlodipine
#15
Buchi N Nalluri, Chandrateja Uppuluri, Jyothirmayee Devineni, Atul Nayak, Karthik J Nair, Benjamin R Whiteside, Diganta B Das
The present study aimed to investigate the effect of microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation enhancement of amlodipine (AMLO). Two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 1.2 and 1.5 mm lengths) and laboratory-fabricated polymeric MNs (PM) of 0.6 mm length were employed. In the case of PMs, arrays were applied thrice at different places within a 1.77-cm(2) skin area (PM-3) to maintain the MN density closer to 0.6 mm ADM. Scaling analyses were done using dimensionless parameters like concentration of AMLO (Ct/Cs), thickness (h/L) and surface area of the skin (Sa/L(2))...
February 3, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28157637/synthesis-of-oms-2-graphite-nanocomposites-with-enhanced-activity-for-pollutants-degradation-in-the-presence-of-peroxymonosulfate
#16
Jia Fang, Jun Li, Long Gao, Xiwang Jiang, Jingwen Zhang, Aihua Xu, Xiaoxia Li
The octahedral molecular sieve manganese oxide (OMS-2) and graphite (Gt) composites (OMS-2/Gt) were prepared by a facile refluxing approach. The structure and morphology of the obtained materials were systematically investigated. The results reveal that OMS-2 nanofibers are uniformly dispersed on the surface of Gt, and the ratio of Mn(3+) species in OMS-2 increases lineally with the increase of Gt dosage. The catalytic activity of OMS-2/Gt was evaluated by the degradation of Acid Orange 7 (AO7) in the presence of peroxymonosulfate (PMS)...
January 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28152919/asco-pro-workgroup-update-patient-reported-outcome-measures-as-a-quality-indicator
#17
Anne C Chiang, Ethan M Basch
: 276 Background: Although patient questionnaires are commonly used to assess healthcare experiences (e.g., satisfaction with care), patient-reported outcome (PRO) measures assessing symptoms and physical functioning have not conventionally been used for quality assessment. More typically, quality of care is measured with administrative data, such as hospital readmission rates. There is an opportunity to advance the science of quality measurement by integrating a patient-centered approach...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152471/subtle-persistent-working-memory-and-selective-attention-deficits-in-women-with-premenstrual-syndrome
#18
Anastasiya Slyepchenko, Sonali Lokuge, Brianne Nicholls, Meir Steiner, Geoffrey B C Hall, Claudio N Soares, Benicio N Frey
As a recurrent, cyclical phenomenon, premenstrual syndrome (PMS) affects a significant proportion of women of the reproductive age, and leads to regular monthly days of functional impairment. Symptoms of PMS include somatic and psychological symptoms, such as headaches, sleep disturbances, social withdrawal and mood changes, during the late luteal phase of the menstrual cycle, which alleviate during the follicular phase. This study investigated neurocognitive functioning in women with moderate to severe PMS symptoms (n=13) compared to women with mild/no PMS (n=27) through administration of a battery of neuropsychological tests during the asymptomatic follicular phase of the menstrual cycle...
January 15, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28152025/prevalence-of-g6pd-deficiency-in-selected-populations-from-two-previously-high-malaria-endemic-areas-of-sri-lanka
#19
Sharmini Gunawardena, G M G Kapilananda, Dilhani Samarakoon, Sashika Maddevithana, Sulochana Wijesundera, Lallindra V Goonaratne, Nadira D Karunaweera
Glucose-6-Phosphate Dehydrogenase (G6PD) enzyme deficiency is known to offer protection against malaria and an increased selection of mutant genes in malaria endemic regions is expected. However, anti-malarial drugs such as primaquine can cause haemolytic anaemia in persons with G6PD deficiency. We studied the extent of G6PD deficiency in selected persons attending Teaching Hospitals of Anuradhapura and Kurunegala, two previously high malaria endemic districts in Sri Lanka. A total of 2059 filter-paper blood spots collected between November 2013 and June 2014 were analysed for phenotypic G6PD deficiency using the modified WST-8/1-methoxy PMS method...
2017: PloS One
https://www.readbyqxmd.com/read/28143468/are-performance-measurement-systems-useful-perceptions-from-health-care
#20
Chiara Demartini, Sara Trucco
BACKGROUND: Prior literature identified the use of Performance Measurement Systems (PMS) as crucial in addressing improved processes of care. Moreover, a strategic use of PMS has been found to enhance quality, compared to non-strategic use, although a clear understanding of this linkage is still to be achieved. This paper deals with the test of direct and indirect models related to the link between the strategic use of PMS and the level of improved processes in health care organizations...
January 31, 2017: BMC Health Services Research
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