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Rachel de A Câmara, Cristiano A Köhler, Benicio N Frey, Thomas N Hyphantis, André F Carvalho
Objective: To develop and validate a Brazilian Portuguese version of the Premenstrual Symptoms Screening Tool (PSST), a questionnaire used for the screening of premenstrual syndrome (PMS) and of the most severe form of PMS, premenstrual dysphoric disorder (PMDD). The PSST also rates the impact of premenstrual symptoms on daily activities. Methods: A consecutive sample of 801 women aged ≥ 18 years completed the study protocol. The internal consistency, test-retest reliability, and content validity of the Brazilian PSST were determined...
November 24, 2016: Revista Brasileira de Psiquiatria
Koichi Shinoda, Shogo Hayashi, Daisuke Fukuoka, Ryo Torii, Tsuneo Watanabe, Takashi Nakano
The three-dimensional (3D) structures of the right atrial appendage (RAA) and left atrial appendage (LAA) were compared to clarify why thrombus formation less frequently occurs in RAA than in LAA. Morphological differences between RAA and LAA of 34 formalin-preserved cadaver hearts were investigated. Molds of RAA and LAA specimens were made and the neck areas, volumes of the atrial appendages (AA), and amount of pectinate muscles (PMs) were analyzed using multidetector computed tomography. In RAA, most PMs were connected to one another and formed a "dendritic" appearance and the inner surface area was smaller than in LAA...
2016: BioMed Research International
Nematollah Jaafarzadeh, Farshid Ghanbari, Mehdi Ahmadi
2,4-Dichlorophenoxyacetic acid (2,4-D) is one of the most applicable herbicides in the world. Therefore, its residue in aquatic environment threatens the human health and ecosystems. In this study, Fe2O3 (hematite) nanoparticles (HNPs) were synthesized, and the characteristics of the obtained HNPs were determined using X-ray powder diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET) technique, and particle size analyzer (PSA)...
November 26, 2016: Chemosphere
Yoichi Ohtaki, Kimihiro Shimizu, Keiju Aokage, Masayuki Nakao, Junji Yoshida, Mitsuhiro Kamiyoshihara, Masayuki Sugano, Yusuke Takahashi, Seshiru Nakazawa, Toshiteru Nagashima, Kai Obayashi, Tomoyuki Hishida, Masahiro Tsuboi, Shohei Mori, Mingyon Mun, Sakae Okumura, Hitoshi Igai, Noriyuki Matsutani, Akira Mogi, Hiroyuki Kuwano
OBJECTIVES: There are only a few detailed reports concerning the prognosticators following surgical resection of pulmonary metastases (PMs) from renal cell carcinoma (RCC). We investigated the prognosis of patients with RCC PMs undergoing pulmonary metastasectomy and identified prognostic factors in a multi-institutional retrospective study. METHODS: We retrospectively evaluated 84 patients who underwent resection of PMs from RCC between 1993 and 2014. We assessed the clinicopathological characteristics, focusing on the histological findings of PMs...
November 28, 2016: World Journal of Surgery
Priyanka Kumari, Cheolwoon Woo, Naomichi Yamamoto, Hong-Lim Choi
We examined the abundance, diversity and community composition of airborne fungi in swine houses during winter and summer seasons by using quantitative PCR and Illumina HiSeq sequencing of ITS1 region. The abundance of airborne fungi varied significantly only between seasons, while fungal diversity varied significantly both within and between seasons, with both abundance and diversity peaked in winter. The fungal OTU composition was largely structured by the swine house unit and season as well as by their interactions...
November 28, 2016: Scientific Reports
Yue Qu, Ines Hahn, Stephen Webb, Simon P Pearce, Andreas Prokop
Axons are the cable-like neuronal processes wiring the nervous system. They contain parallel bundles of microtubules as structural backbones, surrounded by regularly-spaced actin rings termed the periodic membrane skeleton (PMS). Despite being an evolutionarily-conserved, ubiquitous, highly-ordered feature of axons, the function of PMS is unknown. Here we studied PMS abundance, organisation and function, combining versatile Drosophila genetics with super-resolution microscopy and various functional readouts...
November 23, 2016: Molecular Biology of the Cell
Zhu-Jun Yi, Yun Zhou, Wen-Feng Zhang, Hao Chen, Wei Zhao, Zuo-Jin Liu, Jian-Ping Gong
OBJECTIVE: To investigate the role of receptor-interacting protein 140 (RIP140) in tumor-associated macrophages (TAMs) in the invasion and proliferation of hepatoma cells in vitro. METHODS: Western blotting, qRT-PCR and flow cytometry were performed to examine the effects of lentivirus-mediated RIP140 over-expression in mouse peritoneal macrophages (PMs). Western blotting, qRT-PCR and immunofluorescence staining were used to detect the expression of RIP140 in TAMs following stimulation of the PMs with hepatocellular carcinoma conditioned medium (HCM) for 24 h...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Yoon Jee Lee, Jae Hee Cheon, Jae Hyun Kim, Sunho Yoo, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim
PURPOSE: Our aim was to evaluate the efficacy and safety of oral beclomethasone dipropionate (BDP) in Korean patients with ulcerative colitis (UC). MATERIALS AND METHODS: The medical records of patients with active UC who were treated with BDP were retrospectively reviewed. Partial Mayo Clinic score (pMS) was calculated to determine disease activity. After 4 weeks of therapy, clinical remission, clinical response, and response failure rates were evaluated. Clinical remission was defined as a post-treatment pMS of 0 or 1, clinical response as a decrease of two of three points in pMS and >30% from baseline, and response failure as a lack of clinical response...
January 2017: Yonsei Medical Journal
Renly Lim, Men Long Liong, Wing Seng Leong, Nurzalina Abdul Karim Khan, Kah Hay Yuen
PURPOSE: Despite significant differences in success rates between surgical and non-surgical treatments for female stress urinary incontinence (SUI), a few cross-sectional surveys reviewed that most patients still prefer the latter. We evaluated the efficacy of the under-studied non-surgical treatment using pulsed magnetic stimulation (PMS) in female SUI. MATERIALS AND METHODS: This randomized, double-blind, sham-controlled study involved 120 female SUI subjects aged at least 21 years old...
November 18, 2016: Journal of Urology
Ronit Peled, Avi Porath, Rachel Wilf-Miron
BACKGROUND: Primary Care Health organizations, operating under universal coverage and a regulated package of benefits, compete mainly over quality of care. Monitoring, primary care clinical performance, has been repeatedly proven effective in improving the quality of care. In 2004, Maccabi Healthcare Services (MHS), the second largest Israeli HMO, launched its Performance Measurement System (PMS) based on clinical quality indicators. A unique module was built in the PMS to adjust for case mix while tailoring targets to the local units...
November 21, 2016: BMC Health Services Research
Jinling Wang, Ying Li, Wenzhuan Ma, Xiaohui Wang, Pengfei Tu
A specific and sensitive LC-MS/MS with protein precipitation- ultrasonic breaking method has been developed and validated for simultaneously determination of doxorubicin (DOX) and curcumin (Cur) in DOX and Cur co-loaded hyaluronic acid- vitamin E succinate (HA-VES) micelles ((DOX + Cur)-PMs) in subcellular compartments of resistant MCF-7/Adr cells. Sequential extraction of four subcellular protein fractions (cytosolic, membrane/organelle, nucleic and cytoskeleton) was performed directly from MCF-7/Adr cells after incubation with (DOX + Cur)-PMs...
November 11, 2016: Biomedical Chromatography: BMC
Huanli Xu, Qunying Chen, Hong Wang, Pingxiang Xu, Ru Yuan, Xiaorong Li, Lu Bai, Ming Xue
BACKGROUND: Lapachol is a natural naphthoquinone compound that possesses extensive biological activities. The aim of this study is to investigate the inhibitory effects of lapachol on rat C6 glioma both in vitro and in vivo, as well as the potential mechanisms. METHODS: The antitumor effect of lapachol was firstly evaluated in the C6 glioma model in Wistar rats. The effects of lapachol on C6 cell proliferation, apoptosis and DNA damage were detected by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS)/ phenazinemethosulfate (PMS) assay, hoechst 33358 staining, annexin V-FITC/PI staining, and comet assay...
November 16, 2016: Journal of Experimental & Clinical Cancer Research: CR
Jiaquan Liu, Jeungphill Hanne, Brooke M Britton, Jared Bennett, Daehyung Kim, Jong-Bong Lee, Richard Fishel
Mismatched nucleotides arise from polymerase misincorporation errors, recombination between heteroallelic parents and chemical or physical DNA damage. Highly conserved MutS (MSH) and MutL (MLH/PMS) homologues initiate mismatch repair and, in higher eukaryotes, act as DNA damage sensors that can trigger apoptosis. Defects in human mismatch repair genes cause Lynch syndrome or hereditary non-polyposis colorectal cancer and 10-40% of related sporadic tumours. However, the collaborative mechanics of MSH and MLH/PMS proteins have not been resolved in any organism...
November 16, 2016: Nature
Yue Gu, Jing Li, Yang Li, Lei Song, Dan Li, Liping Peng, Ying Wan, Shucheng Hua
PURPOSE: A new type of polymeric micelle (PM) was assembled using a polyethylene glycol (PEG)-linked (PEGylated) amphiphilic copolymer and d-tocopheryl PEG1000 succinate (TPGS1000). The micelles were used to deliver doxorubicin (DOX) and curcumin (CUR) for alleviating multidrug resistance (MDR) in lung cancer cells while enhancing the therapeutic efficacy of DOX. METHODS: Micelles loaded with DOX and CUR were assembled using a film-forming technique. Micelles were used to treat A549/Adr cells to find out whether micelles had the ability to reverse the MDR of A549/Adr cells...
2016: International Journal of Nanomedicine
Hajar Rezaee, Maryam Amidi Mazaheri, Fatemeh Sadrhashemi
Premenstrual Syndrome (PMS) is one of the most common disorders in women known to cause impairment of daily function and relationships with others. This study was down to investigate the premenstrual syndrome, physical activity and spousal social support status among women in Isfahan city. This descriptive-analytical study was down in health centers of Isfahan city in Iran 2015. The study populations were 190 couples in reproductive age; symptoms of premenstrual syndrome and spousal social support information were collected by self-report questionnaires...
August 26, 2016: Global Journal of Health Science
Ameneh Safarzadeh, Gholamreza Ghoreishinia, Marzieh Rakhshkhorshid, Sadegh Zare, Saeedeh Rigi Yousefabadi
INTRODUCTION: Premenstrual syndrome (PMS) is the advent of physical and psychological symptoms related to the menstrual cycle, the symptoms of this syndrome start in luteal phase and ends at the end of menstrual period. During the last decades, the patterns of PMS (PMS) have studied in a wide range. But those researches had had different methodologies and definitions and the results were not well comparable. Hence, the researchers decided to conduct a study with the aim of investigation of the prevalent of PMS among the students of the Zahedan University of Medical Sciences...
July 21, 2016: Global Journal of Health Science
Li-Qing Chen, Wei Huang, Zhong-Gao Gao, Wei-Shuo Fang, Ming-Ji Jin
Lx2-32c is a novel taxane derivative with a strong antitumor activity. In this study, we developed Lx2-32c-loaded polymeric micelles (Lx2-32c-PMs) with small size and investigated their antitumor efficacy against tumor growth and metastasis on 4T1 murine breast cancer cell line with Cremophor EL-based Lx2-32c solution as the control. In this study, copolymer monomethoxy polyethylene glycol2000-polylactide1300 was used to prepare Lx2-32c-PMs by film hydration method, and their physicochemical properties were characterized as well, according to morphology, particle size, zeta potential, in vitro drug release, and reconstitution stability...
2016: International Journal of Nanomedicine
Takashi Takeda, Yoko Imoto, Hiroyo Nagasawa, Atsuko Takeshita, Masami Shiina
OBJECTIVES: To investigate the relationship between the occurrence of stress fracture and premenstrual syndrome (PMS)/premenstrual dysphoric disorder (PMDD) in Japanese adolescent athletes. DESIGN: Cross-sectional study. SETTING: Osaka, Japan. PARTICIPANTS: A school-based survey on menstruation and school life was conducted using a sample of 1818 Japanese female students who belonged to two public high schools in Japan...
October 18, 2016: BMJ Open
Ru Yuan, Huanli Xu, Xiaohui Liu, Ye Tian, Cong Li, Xiaoliang Chen, Shuonan Su, Ilana Perelshtein, Aharon Gedanken, Xiukun Lin
PURPOSE: Zinc-doped copper oxide nanocomposites (nZn-CuO NPs) are novel nanoparticles synthesized by our group. In this study, the antitumor effects and the underlying molecular mechanisms of the nZn-CuO NPs were investigated. METHODS AND RESULTS: The cytotoxicity of nZn-CuO NPs against several cancer cell lines was studied using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2- (4-sulfophenyl)-2H-tetrazolium (MTS)/phenazinemethosulfate (PMS) assay. Results showed that nZn-CuO NPs exerted obvious anti-proliferation effects on cancer cells and relatively weak anti-proliferation effects on normal cells...
October 28, 2016: ACS Applied Materials & Interfaces
Peng Zhou, Bei Liu, Jing Zhang, Yongli Zhang, Gucheng Zhang, Chenmo Wei, Juan Liang, Ya Liu, Wei Zhang
A highly efficient advanced oxidation process for the degradation of benzoic acid (BA) during activation of peroxomonosulfate (PMS) by nanoscale zero-valent copper (nZVC) in acidic solution is reported. BA degradation was almost completely achieved after 10 min in the nZVC/PMS process at initial pH 3.0. PMS could accelerate the corrosion of nZVC in acidic to release Cu(+) which can further activate PMS to produce reactive radicals. Both sulfate radical (SO4(-)•) and hydroxyl radical (•OH) were considered as the primary reactive oxidant in the nZVC/PMS process with the experiments of methyl (MA) and tert-butyl alcohol quenching...
October 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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