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https://www.readbyqxmd.com/read/28925877/4-aryl-heteroaryl-4h-fused-pyrans-as-anti-proliferative-agents-design-synthesis-and-biological-evaluation
#1
Dinesh Kumar, Gurpreet Singh, Pooja Sharma, Arem Quayum, Girish Mahajan, M J Mintoo, Shashank Kumar Singh, Dilip Manikrao Mondhe, Pms Bedi, Subheet K Jain, Girish Kumar Gupta
The current study is focused on the design and synthesis of 4-aryl/heteroaryl-4H-fused pyrans as anti-proliferative agents. All the synthesized molecules were screened against a panel of human carcinoma cell lines. Significant inhibition was exhibited by the compounds against HCT-116 (Colon) and PC-3 (Prostate) cell lines while A-549 (Lung) cell lines, MiaPaCa-2 (Pancreatic) cell lines and HL-60 (Leukemia Cancer) cell lines were almost resistant to the exposure of the test compounds. Compound FP-(v)n displayed noteworthy cytotoxicity towards HCT-116 malignant cells with IC50 value of 0...
September 18, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28923748/controllable-mullite-bismuth-ferrite-micro-nanostructures-with-multifarious-catalytic-activities-for-switchable-hybrid-catalytic-degradation-processes
#2
Zhong-Ting Hu, Wen-Da Oh, Yiquan Liu, En-Hua Yang, Teik-Thye Lim
In this work, controllable preparation of micro/nanostructured bismuth ferrites (BFOs) were used to investigate multifarious heterogeneous catalyses, including Fenton/Fenton-like reaction, photocatalysis, photo-Fenton oxidation, and peroxymonosulfate (PMS) activation. Results showed that BFO can be used asa novel catalyst to activate switchable catalytic degradation of organic matters. Additionally, a novel catalytic system for degradation of organic pollutants, which integrating all-above heterogeneous catalyses is denoted as BFO/H2O2/PMS hybrid reaction, is introduced for the first time...
September 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28922881/intraoperative-flow-800-analysis-for-intramedullary-cystic-lesion-a-technical-case-report
#3
Masahiro Sawada, Toshihiro Munemitsu, Masato Hojo
BACKGROUND AND IMPORTANCE: During intramedullary lesion surgery, the lesion site and the posterior median sulcus (PMS) should be accurately identified prior to myelotomy to avoid severe injury of the posterior funiculus. However, intramedullary lesions are fundamentally invisible until the myelotomy is performed. Furthermore, the PMS location is frequently unclear due to lesion-induced swelling or distortion of the spinal cord. Intraoperative indocyanine green videoangiography (ICG-VA) followed by FLOW 800 analysis, which shows vascularization of the spinal parenchyma, may provide a solution for these problems in specific cases...
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28898954/degradation-of-2-4-6-trichlorophenol-with-peroxymonosulfate-catalyzed-by-soluble-and-supported-iron-porphyrins
#4
Tuğçe Günay, Yasemin Çimen
Degradation of 2,4,6-trichloropenol (TCP) with peroxymonosulfate (PMS) catalyzed by iron porphyrin tetrasulfonate ([FePTS)] was investigated in an 8-to-1 (v/v) CH3OH-H2O mixture. Typical reaction medium contained a 4.00 mL methanol solution of TCP (0.100 mmol), a 0.50 mL aqueous solution of catalyst (5.0 × 10(-4) mmol), and 0.100 mmol PMS (as 0.031 g of Oxone). The reaction was performed at ambient temperature. The conversion of TCP was 74% in 30 min and 80% in 6 h when the catalyst was [FePTS]. Amberlite IRA-900 supported [FePTS] catalyst was also prepared...
September 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28894350/short-term-regulation-of-fc%C3%AE-r-mediated-phagocytosis-by-tlrs-in-macrophages-participation-of-5-lipoxygenase-products
#5
Carla da S Pinheiro, Ana Paula T Monteiro, Fabiano F Dutra, Marcelo T Bozza, Marc Peters-Golden, Claudia F Benjamim, Claudio Canetti
TLRs recognize a broad spectrum of microorganism molecules, triggering a variety of cellular responses. Among them, phagocytosis is a critical process for host defense. Leukotrienes (LTs), lipid mediators produced from 5-lipoxygenase (5-LO) enzyme, increase FcγR-mediated phagocytosis. Here, we evaluated the participation of TLR2, TLR3, TLR4, and TLR9 in FcγR-mediated phagocytosis and whether this process is modulated by LTs. Rat alveolar macrophages (AMs), murine bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PMs) treated with TLR2, TLR3, and TLR4 agonists, but not TLR9, enhanced IgG-opsonized sheep red blood cell (IgG-sRBC) phagocytosis...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28892119/prophylactic-chemotherapy-for-hydatidiform-mole-to-prevent-gestational-trophoblastic-neoplasia
#6
REVIEW
Qiuyi Wang, Jing Fu, Lina Hu, Fang Fang, Lingxia Xie, Hengxi Chen, Fan He, Taixiang Wu, Theresa A Lawrie
BACKGROUND: This is an update of the original Cochrane Review published in Cochrane Library, Issue 10, 2012.Hydatidiform mole (HM), also called a molar pregnancy, is characterised by an overgrowth of foetal chorionic tissue within the uterus. HMs may be partial (PM) or complete (CM) depending on their gross appearance, histopathology and karyotype. PMs usually have a triploid karyotype, derived from maternal and paternal origins, whereas CMs are diploid and have paternal origins only...
September 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28884872/the-tip-of-the-muscle-is-a-dominant-location-of-ventricular-ectopy-originating-from-papillary-muscles-in-the-left-ventricle
#7
Petr Peichl, Jakub Baran, Dan Wichterle, Robert Čihák, Tomáš Skála, Bashar Aldhoon, Matevž Jan, Bor Antolič, Josef Kautzner
INTRODUCTION: Frequent ventricular premature complexes (VPCs) may cause symptoms and/or lead to deterioration of LV systolic function. Although frequent VPCs may be abolished by catheter ablation, it may be challenging in case of their origin from the LV papillary muscles (PMs). Our collaborative study aimed to analyze in detail the site of origin and the outcome of ablation. METHODS: Consecutive 34 patients (males: 68%; aged 62±12 years; LV ejection fraction: 50±9%) undergoing catheter ablation of VPCs originating from PMs were included...
September 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28881241/degradation-of-acid-orange-7-using-peroxymonosulfate-catalyzed-by-granulated-activated-carbon-and-enhanced-by-electrolysis
#8
Jing Li, Heng Lin, Kangmeng Zhu, Hui Zhang
Electrochemistry coupled with granulated activated carbon catalysis of peroxymonosulfate (electro/GAC/PMS) as a novel wastewater treatment process was performed for the degradation of Acid Orange 7 (AO7) in aqueous solution. The decolorization of AO7 was compared under different permutations and combinations of electro-oxidation, GAC and PMS. It showed that the electro/GAC/PMS process was the most effective and the decolorization of AO7 followed pseudo-first order kinetics. The surface chemistry of GAC samples was analyzed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy...
August 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28879768/supramolecular-copolymerization-of-short-peptides-and-polyoxometalates-toward-the-fabrication-of-underwater-adhesives
#9
Jing Xu, Xiangyi Li, Xiaodong Li, Bao Li, Lixin Wu, Wen Li, Xiaoming Xie, Rong Xue
Peptide assembly has reached exquisite levels of efficiency in the creation of bioactive materials. However, we have not yet been able to take what we have learned from peptide assembly to develop a general strategy for the fabrication of biomimetic underwater adhesives, which retain significant advantages as medical glue for clinical treatment. Herein we report a simple approach to prepare peptide-based adhesives through the supramolecular polymerization of cationic peptides drove by polyoxometalates (PMs)...
September 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28877350/oxidative-stress-increases-erythrocyte-sensitivity-to-shear-mediated-damage
#10
Antony P McNamee, Jarod T Horobin, Geoff D Tansley, Michael J Simmonds
Patients receiving mechanical circulatory support often present with heightened inflammation and free radical production associated with pre-existing conditions in addition to that which is due to blood interactions with nonbiological surfaces. The aim of this experimental laboratory study was to assess the deformability of red blood cells (RBC) previously exposed to oxygen free radicals and determine the susceptibility of these cells to mechanical forces. In the present study, RBC from 15 healthy donors were washed and incubated for 60 min at 37°C with 50 µM phenazine methosulfate (PMS; an agent that generates superoxide within RBC)...
September 6, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28875498/comparative-study-of-effects-of-vonoprazan-and-esomeprazole-on-anti-platelet-function-of-clopidogrel-or-prasugrel-in-relation-to-cyp2c19-genotype
#11
Takuma Kagami, Mihoko Yamade, Takahiro Suzuki, Takahiro Uotani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Kazuo Umemura, Hiroaki Miyajima, Takahisa Furuta
Drug-drug interaction between anti-acid and anti-platelet agents has not been fully elucidated. Vonoprazan, a new potassium competitive acid blocker, has been available in Japan. CYP2C19 and CYP3A4 are involved in the metabolism of clopidogrel, prasugrel, esomeprazole and vonoprazan. Using P2Y12 assay, we compared the effects of vonoprazan and esomeprazole on the anti-platelet functions of clopidogrel or prasugrel in 31 healthy Japanese volunteers [14 CYP2C19 homo-extensive (homo-EMs), 9 hetero-extensive (hetero-EMs), and 8 poor metabolizers (PMs)]...
September 5, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28871564/redefining-the-positive-margin-in-pancreatic-cancer-impact-on-patterns-of-failure-long-term-survival-and-adjuvant-therapy
#12
Arsen Osipov, Nicholas Nissen, Joanne Rutgers, Deepti Dhall, Jason Naziri, Shefali Chopra, Quanlin Li, Andrew Eugene Hendifar, Richard Tuli
PURPOSE: There is debate regarding the definition and clinical significance of margin clearance in pancreatic ductal adenocarcinoma (PDA). A comprehensive archival analysis of surgical resection margins was performed to determine the effect on locoregional recurrence and survival, and the impact of adjuvant therapy in PDA. METHODS: We identified 105 patients with resected PDA. Pancreatic, anterior, bile duct, and posterior surgical resection margins (PM; posterior surface, uncinate and vascular groove) were identified...
September 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28863343/activation-of-peroxymonosulfate-by-phenols-important-role-of-quinone-intermediates-and-involvement-of-singlet-oxygen
#13
Yang Zhou, Jin Jiang, Yuan Gao, Su-Yan Pang, Yi Yang, Jun Ma, Jia Gu, Juan Li, Zhen Wang, Li-Hong Wang, Li-Peng Yuan, Yue Yang
In this study, the kinetics of reactions of peroxymonosulfate (PMS) with ten model phenols (including phenol, methylphenols, methoxyphenols, and dihydroxybenzenes) were examined. The oxidation kinetics of these phenols by PMS except for catechol and resorcinol showed autocatalysis in alkaline conditions (pH 8.5 and 10), due to the contribution of singlet oxygen ((1)O2) produced from PMS activation by quinone intermediates formed from their phenolic parents. The oxidation rates of ortho- and meta-substituted methylphenols and methoxyphenols by PMS were much higher than their para-substituted counterparts under similar conditions...
August 23, 2017: Water Research
https://www.readbyqxmd.com/read/28862395/phelan-mcdermid-syndrome-data-network-integrating-patient-reported-outcomes-with-clinical-notes-and-curated-genetic-reports
#14
Cartik Kothari, Maxime Wack, Claire Hassen-Khodja, Sean Finan, Guergana Savova, Megan O'Boyle, Geraldine Bliss, Andria Cornell, Elizabeth J Horn, Rebecca Davis, Jacquelyn Jacobs, Isaac Kohane, Paul Avillach
The heterogeneity of patient phenotype data are an impediment to the research into the origins and progression of neuropsychiatric disorders. This difficulty is compounded in the case of rare disorders such as Phelan-McDermid Syndrome (PMS) by the paucity of patient clinical data. PMS is a rare syndromic genetic cause of autism and intellectual deficiency. In this paper, we describe the Phelan-McDermid Syndrome Data Network (PMS_DN), a platform that facilitates research into phenotype-genotype correlation and progression of PMS by: a) integrating knowledge of patient phenotypes extracted from Patient Reported Outcomes (PRO) data and clinical notes-two heterogeneous, underutilized sources of knowledge about patient phenotypes-with curated genetic information from the same patient cohort and b) making this integrated knowledge, along with a suite of statistical tools, available free of charge to authorized investigators on a Web portal https://pmsdn...
September 1, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28860863/premenstrual-syndrome-pms-among-high-school-students
#15
Nattapong Buddhabunyakan, Srinaree Kaewrudee, Chompilas Chongsomchai, Sukree Soontrapa, Woraluk Somboonporn, Jen Sothornwit
BACKGROUND: Premenstrual syndrome (PMS) is a common health problem among adolescents. OBJECTIVE: To assess the prevalence of PMS in Thai high school students. MATERIALS AND METHODS: This was a prospective study conducted among menstruating high school students in Khon Kaen, Thailand, from September to December, 2015. Participants were asked to prospectively complete an anonymous questionnaire, which included information about demographic data, menstrual patterns, and symptoms to be recorded on a daily calendar of premenstrual experiences according to the diagnostic criteria proposed by the American College of Obstetricians and Gynecologists...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28859878/the-adaptiveness-of-a-queuing-strategy-shaped-by-social-experiences-during-adolescence
#16
Tobias D Zimmermann, Sylvia Kaiser, Norbert Sachser
Social experiences during adolescence profoundly influence behavioural and endocrine phenotypes. A key question is whether these environmentally induced changes can adjust the individual to prevailing environmental conditions. Previous work shows that male guinea pigs living in pairs from early adolescence are more aggressive and exhibit distinctly higher cortisol responses than males living in large mixed-sex colonies. In environments with limited numbers of competitors, the high-aggressive phenotype of pair-housed males (PMs) leads to more dominant positions and higher reproductive success compared with colony-housed males (CMs) and thus represents an adaptation to this situation...
August 30, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28859013/the-efficacy-of-compression-garments-on-recovery-from-a-simulated-rugby-protocol
#17
Corrinn M Upton, Freddy Cw Brown, Jessica A Hill
The aim of this study was to examine the efficacy of lower limb compression garments on recovery in club level rugby players. Nineteen participants (age, 20.3 ± 1.7 years, height, 184.2 ± 7.5 cm and body mass, 89.5 ± 9.9 kg) completed a rugby specific, muscle damaging protocol before being assigned to a compression garment group (n = 10) or a SHAM ("recovery" drink) treatment (n = 9). The compression group wore the garments for 48 h post-exercise, while SHAM consumed a sweetened, low energy drink within an hour of protocol completion...
August 29, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28858715/effects-of-chloride-on-pms-based-pollutant-degradation-a-substantial-discrepancy-between-dyes-and-their-common-decomposition-intermediate-phthalic-acid
#18
Ying Huang, Zhaohui Wang, Qingze Liu, Xiaoxiao Wang, Zhijun Yuan, Jianshe Liu
A considerable effort has been devoted to elucidating the roles of chloride in oxidative degradation and chlorination of dyes. However, few investigations are available on kinetic analysis and transformation pathways of secondary degradation byproducts of dyes in saline wastewater treatment. Here the impact of chlorine on the degradation rate of phthalic acid, a typical dye degradation intermediate, by the Co(2+)/peroxymonosulfate (PMS) process was examined. Degradation efficiency, intermediate products, AOX (adsorbable organic halogen) formation and mineralization were considered...
August 24, 2017: Chemosphere
https://www.readbyqxmd.com/read/28858502/selective-degradation-of-organic-pollutants-using-an-efficient-metal-free-catalyst-derived-from-carbonized-polypyrrole-via-peroxymonosulfate-activation
#19
Peidong Hu, Hanrui Su, Zhenyu Chen, Chunyang Yu, Qilin Li, Baoxue Zhou, Pedro J J Alvarez, Mingce Long
Metal-free carbonaceous materials, including nitrogen-doped graphene and carbon nanotubes, are emerging as alternative catalysts for peroxymonosulfate (PMS) activation to avoid drawbacks of conventional transition metal-containing catalysts, such as leaching of toxic metal ions. However, these novel carbocatalysts face relatively high cost and complex syntheses, and their activation mechanisms have not been well understood. Herein, we developed a novel nitrogen-doped carbonaceous nanosphere catalyst by carbonization of polypyrrole, which was prepared through a scalable chemical oxidative polymerization...
August 31, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28848621/comparison-between-the-lifestyles-of-university-students-with-and-without-premenstrual-syndromes
#20
Maryam Mohebbi, Sedigheh Amir Ali Akbari, Zohre Mahmodi, Malihe Nasiri
INTRODUCTION: Premenstrual syndrome is a common disorder in reproductive age and it is associated with decreased quality of life in women. In view of various factors contributing to outbreak of PMS (premenstrual syndrome) among women, the present study intended to compare lifestyles of university students with and without premenstrual syndromes living in dormitories of Qazvin University of Medical Sciences in 2015. METHODS: The descriptive cross-sectional study recruited 200 university students with and without PMS from students living in dormitories...
June 2017: Electronic Physician
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