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Lidia Mínguez-Alarcón, Audrey J Gaskins, Yu-Han Chiu, Carmen Messerlian, Paige L Williams, Jennifer B Ford, Irene Souter, Russ Hauser, Jorge E Chavarro
STUDY QUESTION: Is self-reported type of underwear worn associated with markers of testicular function among men at a fertility center? SUMMARY ANSWER: Men who reported most frequently wearing boxers had higher sperm concentration and total count, and lower FSH levels, compared to men who did not. WHAT IS KNOWN ALREADY: Elevated scrotal temperatures are known to adversely affect testicular function. However, the epidemiologic literature on type of underwear, as a proxy of scrotal temperature, and male testicular function is inconsistent...
August 8, 2018: Human Reproduction
Peter C Douris, Zachary S Cogen, Helen T Fields, Lauren C Greco, Matthew R Hasley, Christina M Machado, Peter M Romagnuolo, George Stamboulis, Joanne DiFrancisco-Donoghue
Background: Blood flow restriction (BFR) applied during low intensity exercise produces hypertrophy and strength gains equivalent to traditional training. Previous research has shown the positive effects of BFR on younger and older adults. However, the effectiveness of BFR on subjects with Parkinson Disease (PD) has not been investigated. Hypotheses/Purpose: The purpose of the study was to determine the effects of BFR on a recreationally active person with PD in regards to functional improvements and safety...
April 2018: International Journal of Sports Physical Therapy
Jason A Chen, Zhongbo Chen, Hyejung Won, Alden Y Huang, Jennifer K Lowe, Kevin Wojta, Jennifer S Yokoyama, Gilbert Bensimon, P Nigel Leigh, Christine Payan, Aleksey Shatunov, Ashley R Jones, Cathryn M Lewis, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean-Francois Dartigues, Albert Ludolph, Adam L Boxer, Jeff M Bronstein, Ammar Al-Chalabi, Daniel H Geschwind, Giovanni Coppola
BACKGROUND: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease for which the genetic contribution is incompletely understood. METHODS: We conducted a joint analysis of 5,523,934 imputed SNPs in two newly-genotyped progressive supranuclear palsy cohorts, primarily derived from two clinical trials (Allon davunetide and NNIPPS riluzole trials in PSP) and a previously published genome-wide association study (GWAS), in total comprising 1646 cases and 10,662 controls of European ancestry...
August 8, 2018: Molecular Neurodegeneration
Stefano Comazzi, Stefano Marelli, Marzia Cozzi, Rita Rizzi, Riccardo Finotello, Joaquim Henriques, Josep Pastor, Frederique Ponce, Carla Rohrer-Bley, Barbara C Rütgen, Erik Teske
BACKGROUND: Canine breeds may be considered good animal models for the study of genetic predisposition to cancer, as they represent genetic clusters. From epidemiologic and case collection studies it emerges that some breeds are more likely to develop lymphoma or specific subtypes of lymphoma but available data are variable and geographically inconsistent. This study was born in the context of the European Canine Lymphoma Network with the aim of investigating the breed prevalence of canine lymphoma in different European countries and of investigating possible breed risk of lymphoma overall and/or different lymphoma subtypes...
August 6, 2018: BMC Veterinary Research
Kirsten J Duggan, Jennifer Wiltshire, Rebecca Strutt, Miriam M Boxer, Angela Berthelsen, Joseph Descallar, Shalini K Vinod
BACKGROUND: Palliative care (PC) and psychosocial care (PSC) are essential services, which can positively impact on quality of life in patients with metastatic lung cancer, when advanced disease and poor prognosis preclude the use of curative therapies. The aims of this study were to describe patterns of PC and PSC and identify factors associated with service utilisation and overall patient survival. METHOD: A retrospective Australian cohort of South Western Sydney residents with newly diagnosed stage IV non-small cell lung cancer (NSCLC) in 2006-2012 was identified from the Local Health District Clinical Cancer Registry...
July 31, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Yung-Cheng Chiu, Ming-Tzu Tsai, Cheng-En Hsu, Horng-Chaung Hsu, Heng-Li Huang, Jui-Ting Hsu
BACKGROUND: Fifth metacarpal neck fracture, also known as boxer's fracture, is the most common metacarpal fracture. Percutaneous Kirschner-wire (K-wire) pinning has been shown to produce favorable clinical results. However, the fixation power of K-wires is a major concern. Plate fixation is also a surgical option, but it has the disadvantages of tendon adhesion, requirement of secondary surgery for removal of the implant, and postoperative joint stiffness. A fixation method that causes little soft tissue damage and provides high biomechanical stability is required for patients with fifth metacarpal neck fracture for whom surgical intervention is indicated...
July 25, 2018: Journal of Orthopaedic Surgery and Research
Constantin Mayer, Falk Hilsmann, Gerald Julius Wiechmann, Christoph Zilkens, Rüdiger Krauspe, Christoph Schleich
OBJECTIVE: Mixed martial arts (MMA) is a combination of multiple combat sports. Acute injuries in MMA are well known and have been broadly described. However, there is little knowledge about degenerative changes in the musculoskeletal system. The aim of this study was to investigate the impact of techniques used in MMA on the occurrence of degenerative changes in the hand and wrist in comparison to classical boxing. METHODS: 11 MMA fighters and 10 boxers with chronic wrist pain were clinically examined...
June 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Lindsay A Holden, Meharji Arumilli, Marjo K Hytönen, Sruthi Hundi, Jarkko Salojärvi, Kim H Brown, Hannes Lohi
Dogs are excellent animal models for human disease. They have extensive veterinary histories, pedigrees, and a unique genetic system due to breeding practices. Despite these advantages, one factor limiting their usefulness is the canine genome reference (CGR) which was assembled using a single purebred Boxer. Although a common practice, this results in many high-quality reads remaining unmapped. To address this whole-genome sequence data from three breeds, Border Collie (n = 26), Bearded Collie (n = 7), and Entlebucher Sennenhund (n = 8), were analyzed to identify novel, non-CGR genomic contigs using the previously validated pseudo-de novo assembly pipeline...
July 18, 2018: Scientific Reports
Hiroyuki Sagayama, Eiichi Yoshimura, Yosuke Yamada, Hiroaki Tanaka
BACKGROUND: Boxers need to consider energy metabolism during rapid weight loss (RWL) followed by rapid weight regain. We examined the effects of RWL and a 3-h acute weight recovery on energy expenditure, carbohydrate oxidation, and fat oxidation in boxing athletes. METHODS: The analysis was based on the data of seven healthy young male athletes who underwent rapid weight loss followed by acute weight recovery. Energy expenditure was evaluated at three time points: one week prior to the acute weight loss (baseline); after the 1- week weight loss period; after a 3-h acute weight recovery period...
July 9, 2018: Journal of Sports Medicine and Physical Fitness
Piotr Lesiakowski, Wojciech Lubiński, Teresa Zwierko
OBJECTIVE: Injuries with varying degrees of temporary or permanent visual dysfunction are common in boxing. This study presents clinical diagnostic information regarding the functional integrity of the visual system in elite amateur boxers. The objective of this study was to assess the presence of normal or abnormal pattern visual evoked potentials (VEP). VEP in boxers were analyzed in relation to the nonathletic group and years of boxing activity. METHODS: Clinical examination involved 31 boxers (21 male and 10 female) and 31 controls homogeneous in terms of age and gender...
July 18, 2018: Physician and Sportsmedicine
Tharmegan Tharmaratnam, Mina A Iskandar, Tyler C Tabobondung, Iqdam Tobbia, Prasaanthan Gopee-Ramanan, Taylor A Tabobondung
Repetitive head trauma provides a favorable milieu for the onset of inflammatory and neurodegenerative processes. The result of long-lasting head trauma is chronic traumatic encephalopathy (CTE), a disease process well-recognized in boxers, military personnel, and more recently, in American football players. CTE is a chronic neurodegenerative disease with hallmarks of hyperphosphorylated tau (p-tau) aggregates and intercellular lesions of neurofibrillary tangles. The criteria for CTE diagnosis requires at least 1-2 focal perivascular lesions of p-tau in the cerebral cortex, at the depth of the sulci...
2018: Frontiers in Neurology
George A Heckman, Alyana Karim Shamji, Raisa Ladha, Jackie Stapleton, Veronique Boscart, Rebecca S Boxer, Lora Bruyn Martin, Lauren Crutchlow, Robert S McKelvie
Heart failure (HF) affects 20% of nursing home (NH) residents, causing high morbidity and mortality. The optimal approach to HF management in NHs remains elusive. We conducted a scoping review of published guidelines and HF management interventions in NHs. A search for English publications since 1990 was conducted using PubMed, EMBASE, CINAHL, and Scopus, for scientific statements, guidelines, recommendations, or intervention studies that addressed at least 1 principle of HF management. Of 2545 records retrieved, 19 articles were retained after screening, and 2 additional articles identified through reference list manual searches...
July 2018: Canadian Journal of Cardiology
Theresa Conze, Isabelle Ritz, Rainer Hospes, Axel Wehrend
Cleft palate in dogs is a congenital defect that mostly leads to euthanasia of the affected puppy. If an attempt is made to raise the puppy, it is generally fed via an orogastric tube. Here, we describe the management of cleft palate in three puppies (two Boxers, one Collie) using a customised temporary prosthesis, which allowed the puppies to be bottle-fed and successfully raised by their owners (Cases 2 and 3) and the author (Case 1). The temporary palatal prosthesis was manufactured from a mouthguard intended for human children, which is made of thermoplastic silicone...
June 24, 2018: Veterinary Sciences
Brad J Bushman, Sarah M Coyne, Craig A Anderson, Kaj Björkqvist, Paul Boxer, Kenneth A Dodge, Eric F Dubow, David P Farrington, Douglas A Gentile, L Rowell Huesmann, Jennifer E Lansford, Raymond W Novaco, Jamie M Ostrov, Marion K Underwood, Wayne A Warburton, Michele L Ybarra
No abstract text is available yet for this article.
July 2018: Aggressive Behavior
K B Casaletto, F E Elahi, R Fitch, S Walters, E Fox, A M Staffaroni, B Bettcher, H Zetterberg, A Karydas, J C Rojas, A L Boxer, J H Kramer
BACKGROUND: Quantification of biofluid cytokines is a rapidly growing area of translational research. However, comparability across the expanding number of available assay platforms for detection of the same proteins remains to be determined. We aimed to directly compare a panel of commonly measured cytokines in plasma of typically aging adults across two high sensitivity quantification platforms, Meso Scale Discovery high performance electrochemiluminiscence (HPE) and single-molecule immunosorbent assays (Simoa) by Quanterix...
June 13, 2018: Cytokine
Y Y Jiang
In February 1906, Union Medical College (UMC, Peking) held the opening ceremony. The establishment and operation of the College was mostly attributed to Thomas Cochrane (1866-1953) from London Missionary Society. As a medical missionary in China, Cochrane lived through the dramatic political and social changes in the modern history of China and the world.As an English medical missionary, he witnessed and experienced the extreme poverty and severe shortage of medicine of the Chinese people when he was in Chaoyang, Liaoning Province, most inhabited by the Mongolian ethnic group...
January 28, 2018: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
W Zheng, Y C Li
The Mogan Mt.Sanatorium for Pulmonary Tuberculosis, founded in 1927, was the first tuberculosis sanatorium in modern China, with an initial intention of "treating and caring the diseased, not seeking profits" , and its name was then changed to Mogan Mountain Sanatorium in 1931. During the early period of Anti-Japanese War, it became an asylum for refugees and carrying out charitable rehabilitation activity.In May 1939, the Sanatorium was compelled to close because of the bombardment of Japanese aircraft, andonly formally opened in 1948 until today...
September 28, 2017: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
Israel Halperin, Dale W Chapman, Kevin G Thompson, Chris Abbiss
Prior research indicates that providing participants with positive augmented feedback tends to enhance motor learning and performance, whereas the opposite occurs with negative feedback. However, the majority of studies were conducted with untrained participants performing unfamiliar motor tasks and so it remains unclear if elite athletes completing familiar tasks respond in a similar fashion. Thus, this study investigated the effects of three different versions of false-performance feedback on punching force (N), pacing (force over time) and ratings of perceived exertion (RPE) in 15 elite amateur male boxers...
June 4, 2018: Journal of Sports Sciences
Annina S Vischer, David J Connolly, Caroline J Coats, Virginia Luis Fuentes, William J McKenna, Silvia Castelletti, Antonios A Pantazis
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a myocardial disease with an increased risk for ventricular arrhythmias. The condition, which occurs in Boxer dogs, shares phenotypic features with the human disease arrhythmogenic cardiomyopathy (ACM) suggesting its potential as a natural animal model. However, there are currently no universally accepted clinical criteria to diagnose ARVC in Boxer dogs. We aimed to identify diagnostic criteria for ARVC in Boxer dogs defining a more uniform and consistent phenotype...
September 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
Zhuoming Liu, Rudell Screven, Lynne Boxer, Michael J Myers, Lax R Devireddy
In this article, we report on the development of a defined serum-free medium capable of supporting the culture expansion of mesenchymal stromal/stem cells (MSCs) from canine adipose tissue (canine Ad-MSCs). The potential benefits of serum-free media can only be utilized if cells cultured in serum-free media maintain the same functional characteristics as cells cultured in serum-containing media. Therefore, we analyze the characteristics of canine Ad-MSCs cultured in this serum-free medium or in serum-containing medium through evaluation of growth kinetics, clonogenic capacity, senescence, and differentiation capacity...
July 2018: Tissue Engineering. Part C, Methods
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