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F F Argenta, S O de Souza, L S Meirelles, G G M Snel, C De Lorenzo, J Ienes-Lima, F Horn, D Driemeier, S P Pavarini
A 9-year-old female American Staffordshire terrier was presented to a veterinary hospital with diarrhoea, severe prostration, hypothermia, dehydration and anaemia. The dog died 6 days after the first consultation. At necropsy examination the serosa of the large intestine showed a granular appearance and the mucosa was thickened, ulcerated and red, with prominent folding. Histological examination revealed marked inflammatory infiltration of macrophages into the mucosa and submucosa of the large intestine. These cells stained positively by the periodic acid-Schiff reaction...
November 2018: Journal of Comparative Pathology
Ioannis Tasiopoulos, Pantelis T Nikolaidis, Alexandra Tripolitsioti, Apostolos Stergioulas, Thomas Rosemann, Beat Knechtle
Aim: The kinetic chain of the punch of boxers is characterized by the contribution of the shoulder; however, the isokinetic muscle strength of shoulder's rotators muscles has not been well studied so far, especially with regards to performance. Therefore, the aim of the present study was (a) to profile the isokinetic muscle strength of rotators of the glenohumeral joint, bilateral (BL), unilateral (UL) and functional ratios in amateur boxers, and (b) to examine the variation of these muscle strength characteristics by performance level...
2018: Frontiers in Physiology
Henrik Zetterberg, Kaj Blennow
Chronic traumatic encephalopathy (CTE) is a neuropathologic condition that has been described in individuals who have been exposed to repetitive head impacts, including concussions and subconcussive trauma. CTE cannot currently be diagnosed during life. Clinical symptoms of CTE (including changes in mood, behavior, and cognition) are nonspecific and may develop after a latency phase following the injuries. Differential diagnosis based solely on clinical features is, therefore, difficult. For example, some younger patients who do not experience the latency phase (i...
2018: Handbook of Clinical Neurology
Ann C Mckee, Bobak Abdolmohammadi, Thor D Stein
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head trauma, including concussion and subconcussion. CTE was first recognized in boxers nearly a century ago as "dementia pugilistica" or "punch drunk," but has been recently identified in contact sports athletes (including American football, ice hockey, soccer, baseball, rugby, boxing, and wrestling) and military veterans exposed to blast. Similar to many other neurodegenerative diseases, CTE is diagnosed conclusively only by neuropathologic examination of brain tissue...
2018: Handbook of Clinical Neurology
Philip Davis, Andrew J Connorton, Sonny Driver, Sean Anderson, Robert Waldock
Davis, P, Connorton, AJ, Driver, S, Anderson, S, and Waldock, R. The activity profile of elite male amateur boxing after the 2013 rule changes. J Strength Cond Res 32(12): 3450-3455, 2018-An activity profile of competitive elite amateur boxing after the rule changes in 2013 was created from video footage to allow identification of the technical and tactical demands as well as differences between winners and losers. The study analyzed 50 World Championship bouts involving 60 male boxers (mean ± SD) of age: 23...
December 2018: Journal of Strength and Conditioning Research
Jerome Montnach, Esperanza Agullo-Pascual, Rafik Tadros, Connie R Bezzina, Mario Delmar
Aims: Previous studies in murine hearts and in cell systems have shown that modifications in the expression or sequence integrity of the desmosomal molecule plakophilin-2 (PKP2) can alter the downstream expression of transcripts necessary for the electrical and mechanical function of the heart. These findings have provided support to mechanistic hypotheses that seek to explain arrhythmogenic right ventricular cardiomyopathy (ARVC) in humans. However, the relation between PKP2 expression and the transcriptome of the human heart remains poorly explored...
November 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
William Renthal, Lisa D Boxer, Sinisa Hrvatin, Emmy Li, Andrew Silberfeld, M Aurel Nagy, Eric C Griffith, Thomas Vierbuchen, Michael E Greenberg
In females with X-linked genetic disorders, wild-type and mutant cells coexist within brain tissue because of X-chromosome inactivation, posing challenges for interpreting the effects of X-linked mutant alleles on gene expression. We present a single-nucleus RNA sequencing approach that resolves mosaicism by using single-nucleotide polymorphisms in genes expressed in cis with the X-linked mutation to determine which nuclei express the mutant allele even when the mutant gene is not detected. This approach enables gene expression comparisons between mutant and wild-type cells within the same individual, eliminating variability introduced by comparisons to controls with different genetic backgrounds...
December 2018: Nature Neuroscience
David C Dale, Audrey Anna Bolyard, Tracy Marrero, Merideth L Kelley, Vahagn Makaryan, Emily Tran, Jamie Leung, Laurence A Boxer, Priya S Kishnani, Stephanie Austin, Corbinian Wanner, Iris A Ferrecchia, Dina Khalaf, Dawn Maze, Joanne Kurtzberg, Cornelia Zeidler, Karl Welte, David A Weinstein
PURPOSE OF REVIEW: Glycogen storage disease Ib (GSD Ib) is characterized by hepatomegaly, hypoglycemia, neutropenia, enterocolitis and recurrent bacterial infections. It is attributable to mutations in G6PT1, the gene for the glucose-6-phosphate transporter responsible for transport of glucose into the endoplasmic reticulum. Neutropenia in GSD Ib is now frequently treated with granulocyte colony-stimulating factor (G-CSF). We formed a cooperative group to review outcomes of the long-term treatment of GSD Ib patients treated with G-CSF...
November 16, 2018: Current Opinion in Hematology
Emerson Franchini, Stuart Cormack, Monica Y Takito
Franchini, E, Cormack, S, and Takito, MY. Effects of high-intensity interval training on Olympic combat sports athletes' performance and physiological adaptation: A systematic review. J Strength Cond Res XX(X): 000-000, 2018-Combat sports represent around 25% of all Olympic medals disputed, and the success in these sports are determined by technical-tactical excellence and supported by physiological and psychological development. Although the training in combat sports is intermittent training by nature, some researchers have started to focus their attention on the effects of complementary high-intensity interval training (HIIT)-coupled standard combat sports-specific training on morphological, physiological, and performance adaptations...
November 13, 2018: Journal of Strength and Conditioning Research
Anna Śmiech, Brygida Ślaska, Wojciech Łopuszyński, Agnieszka Jasik, Diana Bochyńska, Roman Dąbrowski
BACKGROUND: The degree of differentiation of mast cell tumours (MCTs) is the most important feature and reflects the morphological characteristics and metastatic potential of the tumour and its likely response to treatment and the prognosis. The aim of this study was to epidemiologically analyse the risk of MCT development in dogs according to breed, age, sex, size and anatomical location of the tumour using the Kiupel grading system. The analysis involved 492 dogs selected based on a histopathological assessment of 2763 canine skin tumours...
November 3, 2018: Acta Veterinaria Scandinavica
J L Hall, L Owen, A Riddell, D B Church, D C Brodbelt, D G O'Neill
OBJECTIVE: To estimate prevalence and identify demographic risk factors for urinary incontinence in male dogs. METHODS AND METHODS: The study population included all dogs within (the VetCompass database) from September 1, 2009 to July 7, 2013. Electronic patient records were searched for urinary incontinence cases; demographic and clinical information were extracted and analysed. RESULTS: Of 109,428 male dogs attending 119 clinics in England, there were an estimated 1027 dogs diagnosed with urinary incontinence, giving a prevalence of 0...
November 1, 2018: Journal of Small Animal Practice
Philippe Desmarais, Jonathan D Rohrer, Quoc Dinh Nguyen, Nathan Herrmann, Donald T Stuss, Anthony E Lang, Adam L Boxer, Bradford C Dickerson, Howie Rosen, John Cornelis van Swieten, Lieke H Meeter, Barbara Borroni, Maria Carmela Tartaglia, Howard H Feldman, Sandra E Black, Mario Masellis
The frontotemporal dementia (FTD) spectrum is a heterogeneous group of neurodegenerative syndromes with overlapping clinical, molecular and pathological features, all of which challenge the design of clinical trials in these conditions. To date, no pharmacological interventions have been proven effective in significantly modifying the course of these disorders. This study critically reviews the construct and methodology of previously published randomised controlled trials (RCTs) in FTD spectrum disorders in order to identify limitations and potential reasons for negative results...
October 25, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Mitchell J Finlay, Matt Greig, Jake McCarthy, Richard M Page
Finlay, MJ, Greig, M, McCarthy, J, and Page, RM. Physical response to pad- and bag-based boxing-specific training modalities. J Strength Cond Res XX(X): 000-000, 2018-This study examined the differences in the physical response elicited from a contemporary Boxing-Specific Exercise Protocol (BSEP) performed using a punch bag and a pad routine. Fourteen male elite amateur boxers (age = 22 ± 2 years; height = 176.9 ± 7.3 cm; body mass = 78.8 ± 8.7 kg; and V[Combining Dot Above]O2max = 55.94 ± 5.96 ml·kg·min) were recruited...
October 24, 2018: Journal of Strength and Conditioning Research
Yiming Ma, Zhicheng Guo, Xiaohui Wang
Purpose: To investigate the effects of Tribulus terrestris (TT) extracts on muscle mass, muscle damage, and anaerobic performances of trained male boxers and its mechanisms: roles of plasma androgen, insulin growth factor 1 (IGF-1), and IGF-1 binding protein-3 (IGFBP-3). Methods: Fifteen male boxers were divided into exercise group (E, n  = 7) and exercise plus TT group (E + TT, n  = 8). The 2 groups both undertook 3-week high-intensity and 3-week high-volume trainings separated by a 4-week rest...
December 2017: Journal of Sport and Health Science
Peter A Ljubenkov, Adam M Staffaroni, Julio C Rojas, Isabel E Allen, Ping Wang, Hilary Heuer, Anna Karydas, John Kornak, Yann Cobigo, William W Seeley, Lea T Grinberg, Salvatore Spina, Anne M Fagan, Gina Jerome, David Knopman, Brad F Boeve, Bradford C Dickerson, Joel Kramer, Bruce Miller, Adam L Boxer, Howard J Rosen
Objective: The prognostic value of cerebrospinal fluid neurofilament light chain, total tau, phosphorylated tau181 , and amyloid beta1-42 was examined in frontotemporal dementia subtypes. Methods: We compared baseline biomarkers between 49 controls, 40 patients with behavioral variant frontotemporal dementia, 24 with semantic variant primary progressive aphasia, and 26 with nonfluent variant primary progressive aphasia. Linear mixed effect models were used to assess the value of baseline biomarkers in predicting clinical and radiographic change in patient cohorts over multiple yearly follow up visits...
October 2018: Annals of Clinical and Translational Neurology
Renaud La Joie, Nagehan Ayakta, William W Seeley, Ewa Borys, Adam L Boxer, Charles DeCarli, Vincent Doré, Lea T Grinberg, Eric Huang, Ji-Hye Hwang, Milos D Ikonomovic, Clifford Jack, William J Jagust, Lee-Way Jin, William E Klunk, Julia Kofler, Orit H Lesman-Segev, Samuel N Lockhart, Val J Lowe, Colin L Masters, Chester A Mathis, Catriona L McLean, Bruce L Miller, Daniel Mungas, James P O'Neil, John M Olichney, Joseph E Parisi, Ronald C Petersen, Howard J Rosen, Christopher C Rowe, Salvatore Spina, Prashanthi Vemuri, Victor L Villemagne, Melissa E Murray, Gil D Rabinovici
INTRODUCTION: We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [11 C]PIB-positron emission tomography ([11 C]PIB-PET) analyzed with the Centiloid (CL) method, a standardized scale for Aβ-PET quantification. METHODS: Four centers contributed 179 participants encompassing a broad range of clinical diagnoses, PET data, and autopsy findings. RESULTS: CL values increased with each CERAD neuritic plaque score increment (median -3 CL for no plaques and 92 CL for frequent plaques) and nonlinearly with Thal Aβ phases (increases were detected starting at phase 2) with overlap between scores/phases...
October 19, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Said El-Ashker, Helmi Chaabene, Yassine Negra, Olaf Prieske, Urs Granacher
This study aimed at examining physiological responses (i.e., oxygen uptake [VO₂] and heart rate [HR]) to a semi-contact 3 × 3-min format, amateur boxing combat simulation in elite level male boxers. Eleven boxers aged 21.4 ± 2.1 years (body height 173.4 ± 3.7, body mass 74.9 ± 8.6 kg, body fat 12.1 ± 1.9, training experience 5.7 ± 1.3 years) volunteered to participate in this study. They performed a maximal graded aerobic test on a motor-driven treadmill to determine maximum oxygen uptake (VO2max ), oxygen uptake (VO2AT ) and heart rate (HRAT ) at the anaerobic threshold, and maximal heart rate (HRmax )...
October 15, 2018: Sports
Rik Ossenkoppele, Gil D Rabinovici, Ruben Smith, Hanna Cho, Michael Schöll, Olof Strandberg, Sebastian Palmqvist, Niklas Mattsson, Shorena Janelidze, Alexander Santillo, Tomas Ohlsson, Jonas Jögi, Richard Tsai, Renaud La Joie, Joel Kramer, Adam L Boxer, Maria L Gorno-Tempini, Bruce L Miller, Jae Y Choi, Young H Ryu, Chul H Lyoo, Oskar Hansson
Importance: The positron emission tomography (PET) tracer [18F]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of Alzheimer disease (AD), but its diagnostic utility is unclear. Objective: To examine the discriminative accuracy of [18F]flortaucipir for AD vs non-AD neurodegenerative disorders. Design, Setting, and Participants: In this cross-sectional study, 719 participants were recruited from 3 dementia centers in South Korea, Sweden, and the United States between June 2014 and November 2017 (160 cognitively normal controls, 126 patients with mild cognitive impairment [MCI], of whom 65...
September 18, 2018: JAMA: the Journal of the American Medical Association
Sally Bromley, Michael Drew, Scott Talpey, Andrew McIntosh, Caroline Finch
BACKGROUND: Electronic methods are increasingly being used to manage health-related data among sporting populations. Collection of such data permits the analysis of injury and illness trends, improves early detection of injuries and illnesses, collectively referred to as health problems, and provides evidence to inform prevention strategies. The Athlete Management System (AMS) has been employed across a range of sports to monitor health. Australian combat athletes train across the country without dedicated national medical or sports science teams to monitor and advocate for their health...
October 9, 2018: JMIR Human Factors
Maria Luisa Mandelli, Ariane E Welch, Eduard Vilaplana, Christa Watson, Giovanni Battistella, Jesse A Brown, Katherine L Possin, Honey I Hubbard, Zachary A Miller, Maya L Henry, Gabe A Marx, Miguel A Santos-Santos, Lynn P Bajorek, Juan Fortea, Adam Boxer, Gil Rabinovici, Suzee Lee, Jessica Deleon, Howard J Rosen, Bruce L Miller, William W Seeley, Maria Luisa Gorno-Tempini
Non-fluent/agrammatic primary progressive aphasia (nfvPPA) is caused by neurodegeneration within the left fronto-insular speech and language production network (SPN). Graph theory is a branch of mathematics that studies network architecture (topology) by quantifying features based on its elements (nodes and connections). This approach has been recently applied to neuroimaging data to explore the complex architecture of the brain connectome, though few studies have exploited this technique in PPA. Here, we used graph theory on functional MRI resting state data from a group of 20 nfvPPA patients and 20 matched controls to investigate topological changes in response to focal neurodegeneration...
November 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
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