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Said El-Ashker, Helmi Chaabene, Yassine Negra, Olaf Prieske, Urs Granacher
This study aimed at examining physiological responses (i.e., oxygen uptake [VO₂] and heart rate [HR]) to a semi-contact 3 × 3-min format, amateur boxing combat simulation in elite level male boxers. Eleven boxers aged 21.4 ± 2.1 years (body height 173.4 ± 3.7, body mass 74.9 ± 8.6 kg, body fat 12.1 ± 1.9, training experience 5.7 ± 1.3 years) volunteered to participate in this study. They performed a maximal graded aerobic test on a motor-driven treadmill to determine maximum oxygen uptake (VO2max ), oxygen uptake (VO2AT ) and heart rate (HRAT ) at the anaerobic threshold, and maximal heart rate (HRmax )...
October 15, 2018: Sports
Rik Ossenkoppele, Gil D Rabinovici, Ruben Smith, Hanna Cho, Michael Schöll, Olof Strandberg, Sebastian Palmqvist, Niklas Mattsson, Shorena Janelidze, Alexander Santillo, Tomas Ohlsson, Jonas Jögi, Richard Tsai, Renaud La Joie, Joel Kramer, Adam L Boxer, Maria L Gorno-Tempini, Bruce L Miller, Jae Y Choi, Young H Ryu, Chul H Lyoo, Oskar Hansson
Importance: The positron emission tomography (PET) tracer [18F]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of Alzheimer disease (AD), but its diagnostic utility is unclear. Objective: To examine the discriminative accuracy of [18F]flortaucipir for AD vs non-AD neurodegenerative disorders. Design, Setting, and Participants: In this cross-sectional study, 719 participants were recruited from 3 dementia centers in South Korea, Sweden, and the United States between June 2014 and November 2017 (160 cognitively normal controls, 126 patients with mild cognitive impairment [MCI], of whom 65...
September 18, 2018: JAMA: the Journal of the American Medical Association
Sally Bromley, Michael Drew, Scott Talpey, Andrew McIntosh, Caroline Finch
BACKGROUND: Electronic methods are increasingly being used to manage health-related data among sporting populations. Collection of such data permits the analysis of injury and illness trends, improves early detection of injuries and illnesses, collectively referred to as health problems, and provides evidence to inform prevention strategies. The Athlete Management System (AMS) has been employed across a range of sports to monitor health. Australian combat athletes train across the country without dedicated national medical or sports science teams to monitor and advocate for their health...
October 9, 2018: JMIR Human Factors
Maria Luisa Mandelli, Ariane E Welch, Eduard Vilaplana, Christa Watson, Giovanni Battistella, Jesse A Brown, Katherine L Possin, Honey I Hubbard, Zachary A Miller, Maya L Henry, Gabe A Marx, Miguel A Santos-Santos, Lynn P Bajorek, Juan Fortea, Adam Boxer, Gil Rabinovici, Suzee Lee, Jessica Deleon, Howard J Rosen, Bruce L Miller, William W Seeley, Maria Luisa Gorno-Tempini
Non-fluent/agrammatic primary progressive aphasia (nfvPPA) is caused by neurodegeneration within the left fronto-insular speech and language production network (SPN). Graph theory is a branch of mathematics that studies network architecture (topology) by quantifying features based on its elements (nodes and connections). This approach has been recently applied to neuroimaging data to explore the complex architecture of the brain connectome, though few studies have exploited this technique in PPA. Here, we used graph theory on functional MRI resting state data from a group of 20 nfvPPA patients and 20 matched controls to investigate topological changes in response to focal neurodegeneration...
August 11, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Elizabeth Finger, Scott Berry, Jeffrey Cummings, Kristy Coleman, Robin Hsiung, Howard H Feldman, Adam Boxer
BACKGROUND: There are currently no treatments for empathy deficits in neuropsychiatric disorders. Acute administration of the hormone oxytocin has been associated with symptomatic improvements across animal models and several neuropsychiatric disorders, but results of the majority of oxytocin randomised controlled trials (RCTs) of longer duration have been negative or inconclusive. This lack of efficacy of may be due to rapid habituation to oxytocin with chronic dosing. The objective of the present study is to describe the design of a phase 2 adaptive randomised controlled crossover trial of intranasal oxytocin in frontotemporal dementia (FOXY) as an efficient model for future investigations of symptomatic treatments in neuropsychiatric and neurodegenerative disorders...
September 27, 2018: Alzheimer's Research & Therapy
Ingemar Björkhem, Kalicharan Patra, Adam L Boxer, Per Svenningsson
24S-hydroxycholesterol (24OHC) and Tau are produced in neuronal cells and neurodegeneration leads to increased flux of both of them into cerebrospinal fluid (CSF). In the present study, CSF levels of 24OHC and 27S-hydroxycholesterol (27OHC) along with those of Tau, P-Thr181 -Tau and Aβ42 were measured in patients with early Parkinson's disease (PD), Corticobasal syndrome (CBS), Corticobasal Degeneration (CBD), and controls. Using mouse models with increased or no formation of Tau protein and increased production of 24OHC, we have also tested the hypothesis that there is a direct association between neuronal turnover of 24OHC and Tau...
2018: Frontiers in Neurology
Diptendu Chatterjee, Meena Fatah, Deniz Akdis, Danna A Spears, Tamara T Koopmann, Kirti Mittal, Muhammad A Rafiq, Bruce M Cattanach, Qili Zhao, Jeff S Healey, Michael J Ackerman, Johan Martijn Bos, Yu Sun, Jason T Maynes, Corinna Brunckhorst, Argelia Medeiros-Domingo, Firat Duru, Ardan M Saguner, Robert M Hamilton
Aims: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by right ventricular myocardial replacement and life-threatening ventricular arrhythmias. Desmosomal gene mutations are sometimes identified, but clinical and genetic diagnosis remains challenging. Desmosomal skin disorders can be caused by desmosomal gene mutations or autoantibodies. We sought to determine if anti-desmosome antibodies are present in subjects with ARVC. Methods and results: We evaluated ARVC subjects and controls for antibodies to cardiac desmosomal cadherin proteins...
September 17, 2018: European Heart Journal
Paige S Nemec, Alexander Kapatos, Jennifer C Holmes, Paul R Hess
Development of effective immunotherapy for chemoresistant malignancies can be advanced by studies in spontaneous cancer models, such as the dog. A crucial first step, T-cell epitope discovery, can be assisted by determination of binding motifs of common Dog Leukocyte Antigen (DLA) class Ia allotypes. Boxers are popular, inbred dogs with increased risks of relevant target cancers and restricted MHC diversity. We sought to identify the motif of DLA-88*034:01, a breed-dominant allotype, to assist peptide prediction from tumor antigens...
September 21, 2018: HLA
Irineu Loturco, Chris Bishop, Rodrigo Ramirez-Campillo, Felipe Romano, Mateus Alves, Lucas A Pereira, Michael McGuigan
The purpose of this case study was to examine the effects of a resistance-training program based on the optimum power loads (OPL) method on neuromuscular performance of Olympic boxing athletes during preparation for the Rio-2016 Olympic Games. Twelve elite amateur boxers from the Brazilian National Olympic Team participated in this study. Athletes were assessed at four time-points, over two consecutive competitive seasons. In the first season (considered as "control period"), the athletes executed a non-controlled strength-power training program for 10 weeks...
September 13, 2018: Sports
Christopher Randolph
There was a long-lasting debate during the first half of the 1900s about whether boxers suffered from a condition called "dementia pugilistica". This included arguments as to whether there was such a distinct clinical condition, whether it was static or progressive, and whether boxers were actually at any increased risk of any neurological issues at all. The debate was never resolved, but was resuscitated in 2005 with the speculation that a similar condition, dubbed "chronic traumatic encephalopathy (CTE)" existed in retired National Football League (NFL) players...
August 1, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
Frank R Moss, Steven R Shuken, Jaron A M Mercer, Carolyn M Cohen, Thomas M Weiss, Steven G Boxer, Noah Z Burns
Ladderane lipids are unique to anaerobic ammonium-oxidizing (anammox) bacteria and are enriched in the membrane of the anammoxosome, an organelle thought to compartmentalize the anammox process, which involves the toxic intermediate hydrazine (N2 H4 ). Due to the slow growth rate of anammox bacteria and difficulty of isolating pure ladderane lipids, experimental evidence of the biological function of ladderanes is lacking. We have synthesized two natural and one unnatural ladderane phosphatidylcholine lipids and compared their thermotropic properties in self-assembled bilayers to distinguish between [3]- and [5]-ladderane function...
September 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
Ingmar Kiefer, Nicole Glowienka, Stephan Pfleghaar, Claudia Köhler, Christian Niesterok, Michaele Alef
An intact female 2-year-old boxer presented with polydipsia, polyuria, and decreased feed intake. Palpation of the abdomen was painful. Sonography revealed an abdominal mass of the left kidney causing displacement of the organs located in the cranial and mid-abdomen. Dimen sion and invasiveness of the process were evaluated both by contrast enhanced ultrasound (CEUS) and contrast-enhanced computed tomography. Histopathological examination of a biopsy sample revealed a nephroblastoma. The case report describes the clinical, sonographic, and computed tomographic results and the outcome in the untreated dog over a period of 5 months...
August 2018: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
S M Cunningham, B D Aona, K Antoon, J E Rush, B A Barton
OBJECTIVES: To determine whether there are differences in measures of longitudinal right ventricular (RV) systolic function among Boxers with arrhythmogenic right ventricular cardiomyopathy (ARVC) compared with healthy control Boxer dogs. To explore relationships between markers of RV systolic function and age, body weight, gender, arrhythmia frequency, and markers of left ventricular (LV) systolic function in Boxer dogs. ANIMALS: The study included 50 client-owned Boxer dogs...
October 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
Ramona Graf, Andreas Pospischil, Franco Guscetti, Daniela Meier, Monika Welle, Martina Dettwiler
Data collected in animal cancer registries comprise extensive and valuable information, even more so when evaluated in context with precise population data. The authors evaluated 11 740 canine skin tumors collected in the Swiss Canine Cancer Registry from 2008-2013, considering data on breed, sex, age, and anatomic locations. Their incidence rate (IR) per 100 000 dogs/year in the Swiss dog population was calculated based on data from the official and mandatory Swiss dog registration database ANIS. The most common tumor types were mast cell tumors (16...
August 21, 2018: Veterinary Pathology
Lidia Mínguez-Alarcón, Audrey J Gaskins, Yu-Han Chiu, Carmen Messerlian, Paige L Williams, Jennifer B Ford, Irene Souter, Russ Hauser, Jorge E Chavarro
STUDY QUESTION: Is self-reported type of underwear worn associated with markers of testicular function among men at a fertility center? SUMMARY ANSWER: Men who reported most frequently wearing boxers had higher sperm concentration and total count, and lower FSH levels, compared to men who did not. WHAT IS KNOWN ALREADY: Elevated scrotal temperatures are known to adversely affect testicular function. However, the epidemiologic literature on type of underwear, as a proxy of scrotal temperature, and male testicular function is inconsistent...
September 1, 2018: Human Reproduction
Peter C Douris, Zachary S Cogen, Helen T Fields, Lauren C Greco, Matthew R Hasley, Christina M Machado, Peter M Romagnuolo, George Stamboulis, Joanne DiFrancisco-Donoghue
Background: Blood flow restriction (BFR) applied during low intensity exercise produces hypertrophy and strength gains equivalent to traditional training. Previous research has shown the positive effects of BFR on younger and older adults. However, the effectiveness of BFR on subjects with Parkinson Disease (PD) has not been investigated. Hypotheses/Purpose: The purpose of the study was to determine the effects of BFR on a recreationally active person with PD in regards to functional improvements and safety...
April 2018: International Journal of Sports Physical Therapy
Jason A Chen, Zhongbo Chen, Hyejung Won, Alden Y Huang, Jennifer K Lowe, Kevin Wojta, Jennifer S Yokoyama, Gilbert Bensimon, P Nigel Leigh, Christine Payan, Aleksey Shatunov, Ashley R Jones, Cathryn M Lewis, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean-Francois Dartigues, Albert Ludolph, Adam L Boxer, Jeff M Bronstein, Ammar Al-Chalabi, Daniel H Geschwind, Giovanni Coppola
BACKGROUND: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease for which the genetic contribution is incompletely understood. METHODS: We conducted a joint analysis of 5,523,934 imputed SNPs in two newly-genotyped progressive supranuclear palsy cohorts, primarily derived from two clinical trials (Allon davunetide and NNIPPS riluzole trials in PSP) and a previously published genome-wide association study (GWAS), in total comprising 1646 cases and 10,662 controls of European ancestry...
August 8, 2018: Molecular Neurodegeneration
Stefano Comazzi, Stefano Marelli, Marzia Cozzi, Rita Rizzi, Riccardo Finotello, Joaquim Henriques, Josep Pastor, Frederique Ponce, Carla Rohrer-Bley, Barbara C Rütgen, Erik Teske
BACKGROUND: Canine breeds may be considered good animal models for the study of genetic predisposition to cancer, as they represent genetic clusters. From epidemiologic and case collection studies it emerges that some breeds are more likely to develop lymphoma or specific subtypes of lymphoma but available data are variable and geographically inconsistent. This study was born in the context of the European Canine Lymphoma Network with the aim of investigating the breed prevalence of canine lymphoma in different European countries and of investigating possible breed risk of lymphoma overall and/or different lymphoma subtypes...
August 6, 2018: BMC Veterinary Research
Kirsten J Duggan, Jennifer Wiltshire, Rebecca Strutt, Miriam M Boxer, Angela Berthelsen, Joseph Descallar, Shalini K Vinod
BACKGROUND: Palliative care (PC) and psychosocial care (PSC) are essential services, which can positively impact on quality of life in patients with metastatic lung cancer, when advanced disease and poor prognosis preclude the use of curative therapies. The aims of this study were to describe patterns of PC and PSC and identify factors associated with service utilisation and overall patient survival. METHOD: A retrospective Australian cohort of South Western Sydney residents with newly diagnosed stage IV non-small cell lung cancer (NSCLC) in 2006-2012 was identified from the Local Health District Clinical Cancer Registry...
July 31, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Yung-Cheng Chiu, Ming-Tzu Tsai, Cheng-En Hsu, Horng-Chaung Hsu, Heng-Li Huang, Jui-Ting Hsu
BACKGROUND: Fifth metacarpal neck fracture, also known as boxer's fracture, is the most common metacarpal fracture. Percutaneous Kirschner-wire (K-wire) pinning has been shown to produce favorable clinical results. However, the fixation power of K-wires is a major concern. Plate fixation is also a surgical option, but it has the disadvantages of tendon adhesion, requirement of secondary surgery for removal of the implant, and postoperative joint stiffness. A fixation method that causes little soft tissue damage and provides high biomechanical stability is required for patients with fifth metacarpal neck fracture for whom surgical intervention is indicated...
July 25, 2018: Journal of Orthopaedic Surgery and Research
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