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Piedad Martin-Olmedo, Rebecca Hams, Michele Santoro, Andrea Ranzi, Gerard Hoek, Kees de Hoogh, Giovanni S Leonardi
BACKGROUND: this paper is based upon work from COST Action ICSHNet. Public health surveillance (PHS) of industrially contaminated sites (ICSs) is likely to play a role in supporting the monitoring of harmful aspects of ICSs and related interventions. Environmental public health tracking (EPHT) has been proposed and developed as an approach to PHS when environmental factors affecting health are involved. OBJECTIVES: to identify existing arrangements for continuous collection and analysis of environmental and health data to guide the development of an optimal EPHT approach which would support the characterization of the impact on health of ICS...
September 2018: Epidemiologia e Prevenzione
Giuseppe Floresta, Emanuele Amata, Carla Barbaraci, Davide Gentile, Rita Turnaturi, Agostino Marrazzo, Antonio Rescifina
Sigma receptors are a fascinating receptor protein class whose ligands are actually under clinical evaluation for the modulation of opioid analgesia and their use as positron emission tomography radiotracers. In particular, peculiar biological and therapeutic functions are associated with the sigma-2 (σ₂) receptor. The σ ₂ receptor ligands determine tumor cell death through apoptotic and non-apoptotic pathways, and the overexpression of σ ₂ receptors in several tumor cell lines has been well documented, with significantly higher levels in proliferating tumor cells compared to quiescent ones...
October 14, 2018: Marine Drugs
Bo Bae Choi, Jin Sun Lee, Kun Ho Kim
BACKGROUND: Triple-negative breast cancer (TNBC) is a breast cancer subgroup that lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Certain magnetic resonance imaging (MRI) features of TNBC might reflect the poor prognosis of TNBC. Standardized uptake value (SUV) of [18F]fluorodeoxyglucose positron emission tomography/computed tomography is 1 of predictive prognostic factors for breast cancer. The purpose of this study was to correlate MRI features of TNBC with SUVmax to determine whether MRI findings in TNBC could be helpful for predicting prognosis...
October 16, 2018: Oncology Research and Treatment
M R S Siddiqui, C Simillis, J Bhoday, N J Battersby, J Mok, S Rasheed, P Tekkis, A M Abulafi, G Brown
AIM: Although T3 tumour subclassifications have been linked to prognosis, its mandatory adoption in histopathological reports has not been incorporated. This article focusses on the survival outcomes in patients with T3 rectal cancer according to extramural spread beyond the muscularis propria. METHODS: A systematic review of all studies up to January 2016, without language restriction, was identified from MEDLINE, Cochrane Controlled Trials Register (1960-2016) and Embase (1991-2016)...
October 12, 2018: European Journal of Cancer
Joan Carles, Enrique Gallardo, Montserrat Doménech, Albert Font, Joaquim Bellmunt, Mariona Figols, Begoña Mellado, Ma Isabel Sáez, Cristina Suárez, Ma José Méndez, Pablo Maroto, Raquel Luque, Teresa de Portugal, Ramón Aldabo, Teresa Bonfill, Rafael Morales-Barrera, José García, Sonia Maciá, Xavier Maldonado, Palmira Foro
BACKGROUND: Docetaxel improves survival in patients with metastatic prostate cancer (PC). This randomized phase II trial aimed to assess the activity of weekly docetaxel with radiotherapy (RT) plus androgen deprivation in patients with high-risk localized PC, examining the benefit of nine weekly docetaxel administrations to RT plus 3 years of LHRH analogues. PATIENTS AND METHODS: A total of 132 patients were accrued. Patients characteristics included T3-T4 (81.1%), Gleason score (GS) ≥ 8 (77...
October 12, 2018: International Journal of Radiation Oncology, Biology, Physics
Syed Muhammad Adnan Ali, Yumna Mirza, Zubair Ahmad, Nida Zahid, Syed Ather Enam
OBJECTIVE: Glioblastoma (GBM) is the most common adult primary brain tumour. Human cytomegalovirus (HCMV) has been studied for the past decade and conflicting results have been reported with no conclusive role has yet been established. Human papillomavirus (HPV) is involved in the pathogenesis of many cancers and has high prevalence in cervical and oral cancer patients of Pakistan. The objective of our study was to identify the prevalence of HCMV and HPV in Pakistani primary GBM patients...
October 12, 2018: World Neurosurgery
Shuang G Zhao, Jonathan Lehrer, S Laura Chang, Rajdeep Das, Nicholas Erho, Yang Liu, Martin Sjöström, Robert B Den, Stephen J Freedland, Eric A Klein, R Jeffrey Karnes, Edward M Schaeffer, Melody Xu, Corey Speers, Paul L Nguyen, Ashley E Ross, June M Chan, Matthew R Cooperberg, Peter R Carroll, Elai Davicioni, Lawrence Fong, Daniel E Spratt, Felix Y Feng
Background: Immunotherapy has been less successful in treating prostate cancer than other solid tumors. We sought to better understand the immune landscape in prostate cancer and identify immune-related biomarkers and potential therapeutic targets. Methods: We analyzed gene expression data from 7826 prospectively collected prostatectomy samples (2013-2016), and 1567 retrospective samples with long-term clinical outcomes, for a total of 9393 samples, all profiled on the same commercial clinical platform in a CLIA-certified lab...
October 13, 2018: Journal of the National Cancer Institute
Ki-Hok Liao, Wing-Kai Hon, Chuan-Yi Tang, Wen-Ping Hsieh
Motivation: High-throughput sequencing technology has revolutionized the study of metagenomics and cancer evolution. In a relatively simple environment, a metagenomics sequencing data is dominated by a few species. By analyzing the alignment of reads from microbial species, single nucleotide polymorphisms can be discovered and the evolutionary history of the populations can be reconstructed. The ever-increasing read length will allow more detailed analysis about the evolutionary history of microbial or tumor cell population...
October 13, 2018: Bioinformatics
Marwa M Dawoud, Dalia Abouelfadl, Asmaa G Abdou, Enas A B Elkhouly
Breast cancer (BC) remains the most prevalent female cancer in Egypt and worldwide. Microfibrillar-associated protein 5 (MFAP5) is a multifunctional glycoprotein. Although MFAP5 gene was among the genes that found globally expressed in human cancers, it had been only recently reported in few cancer research studies. This is a retrospective study that has been conducted on 66 Egyptian patients who had invasive carcinoma of no special type. Immunohistochemical staining for MFAP5 was applied on the archival formalin-fixed paraffin-embedded blocks...
October 12, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
Kishor Hadkhale, Jan Ivar Martinsen, Elisabete Weiderpass, Kristina Kjærheim, Pär Sparén, Laufey Tryggvadóttir, Elsebeth Lynge, Eero Pukkala
BACKGROUND: Occupational exposure has been identified as the most important risk factor for bladder cancer second to smoking. The objective of this study was to estimate the occupational variation in risk of bladder cancer that is not attributable to smoking. MATERIAL AND METHODS: In the Nordic Occupational Cancer study (NOCCA), 111,458 cases of bladder cancer and 208,297 cases of lung cancer cases were observed among men in Denmark, Finland, Iceland, Norway and Sweden during 1961-2005...
October 15, 2018: Acta Oncologica
Niranjan J Sathianathen, Yiannis A Philippou, Gretchen M Kuntz, Badrinath R Konety, Shilpa Gupta, Alastair D Lamb, Philipp Dahm
BACKGROUND: There has been considerable development in the treatment of advanced prostate cancer over the last decade. A number of agents, including docetaxel, cabazitaxel, abiraterone acetate, enzalutamide and sipuleucel-T, have been reported to improve outcomes in men with castration-resistant disease and their use is being explored in hormone-sensitive prostate cancer. OBJECTIVES: To assess the effects of early taxane-based chemohormonal therapy for newly diagnosed, metastatic, hormone-sensitive prostate cancer...
October 15, 2018: Cochrane Database of Systematic Reviews
Hui Wei, Ke Pu, Xiao-Guang Liu, Bo-Xuan Li, Heng-Shuo Zhang, Huan Wang, Hao Wang, Wei-Ming Sun, Yu-Ping Wang
Recently, cancer research microRNA studies have drawn great attention. However, the results of these studies have been inconsistent and variable regarding the availability of circulating miRNAs in gastric cancer (GC) diagnosis. Thus, results should be interpreted cautiously. The purpose of the present study was to assess the diagnostic performance of circulating miRNAs in GC diagnosis. We conducted a systematic and comprehensive approach for the inclusion of studies. The sensitivity, specificity, and diagnostic odds ratio were pooled with random effects models, and a summary of receiver operator characteristic (SROC) curves were plotted...
October 11, 2018: Oncology Reports
Vivian J Bea, Joan E Cunningham, Anthony J Alberg, Dana Burshell, Colleen E Bauza, Kendrea D Knight, Tonya R Hazelton, Heidi Varner, Rita Kramer, Susan Bolick, Deborah Hurley, Catishia Mosley, Marvella E Ford
Background/Objective: Data suggest that modifiable risk factors such as alcohol and tobacco use may increase the risk of breast cancer (BC) recurrence and reduce survival. Female BC mortality in South Carolina is 40% higher among African Americans (AAs) than European Americans (EAs). Given this substantial racial disparity, using a cross-sectional survey design we examined alcohol and tobacco use in an ethnically diverse statewide study of women with recently diagnosed invasive breast cancer. This included a unique South Carolina AA subpopulation, the Sea Islanders (SI), culturally isolated and with the lowest European American genetic admixture of any AA group...
2018: Frontiers in Oncology
Eva Lorenz, Maria Blettner, Björn Lange, Marcus Schmidt, Astrid Schneider, Lukas Schwentner, Daniel Wollschläger, Hiltrud Merzenich
Background: Advances in oncological therapy have significantly improved breast cancer survival; therefore comorbid conditions are becoming more relevant. We investigated the prevalence of prior cardiovascular diseases and risk factors in patients with breast cancer compared to those in the general female population in Germany. Methods: The PASSOS heart study is a retrospective multicenter cohort study on cardiac late effects in breast cancer patients treated between 1998 and 2008...
August 2018: Breast Care
Zi Xuan Wang, Lin Li, Feng Ying Tao
Aim: Psychological intervention has been proved a complementary approach to drug analgesia. Another study suggested that health knowledge is associated with psychological symptoms in patients with liver cancer. This study is conducted to assess whether improving the health education (HE) alleviates the postembolization pain during transarterial chemoembolization (TACE). Materials and methods: One hundred and fifteen patients, who required TACE for hepatocellular carcinoma (HCC) and suffered postembolization pain, were randomized into control group (n=63) and HE group (n=52)...
2018: Journal of Pain Research
Roberto Menicagli, O Marotta, Laura Menicagli
Background: Many studies indicate the difficulty on assessing the possible carcinogenic effects of hair dyes, for their high time of the latence. Objectives: Our objective is to determine their prognostic index, by monitoring the oxidative stress, produced exposed to hair dyes, in hairdressers, and in consumers, by measuring the concentration of salivary malondialdehyde. Materials and Methods: Saliva samples are provided by the hairdressers, working in private (NP) or shopping center (CC), by users of hair dyes, for at least 10 years, and by a control group...
May 2018: Indian Journal of Occupational and Environmental Medicine
Magali Laprise-Lachance, Pierre Lemieux, Jean-Pierre Grégoire
Objectives To estimate the relative risk of pulmonary toxicity in patients exposed to a bleomycin-based chemotherapy including filgrastim compared to a similar chemotherapy without filgrastim. Methods We conducted a nested case-control study of patients treated with BEP (bleomycin, etoposide and cisplatin) for germ cell cancer or with ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) for Hodgkin's lymphoma at the Hôtel-Dieu de Lévis Hospital between 31 October 2000 and 30 June 2016. The relative risk was estimated by an adjusted odds ratio (aOR) using a propensity score-adjusted regression analysis...
October 14, 2018: Journal of Oncology Pharmacy Practice
Stefanie K Clark, Lisa M Anselmo
Pemetrexed is a multitargeted antifolate indicated for locally advanced or metastatic non-squamous non-small-cell lung cancer and malignant pleural mesothelioma. Cutaneous reactions are associated with pemetrexed use. Pemetrexed prescribing information recommends oral dexamethasone 4 mg twice daily for three days starting the day before pemetrexed infusion to prevent cutaneous reactions. Patients receive intravenous dexamethasone before pemetrexed infusion at the University of New Mexico Comprehensive Cancer Center, but the oral dexamethasone recommendation is not always followed...
October 14, 2018: Journal of Oncology Pharmacy Practice
Keith S Cover, Katya M Duvivier, Pim de Graaf, Rianne Wittenberg, Ruth Smit, Joost P A Kuijer, Mark B M Hofman, Ben J Slotman, Ruud M Verdaasdonk
BACKGROUND: Each ultrafast dynamic contrast-enhanced (DCE) MRI sequence for breast cancer generates thousands of images in a 4D stack that need to be reviewed by a radiologist. PURPOSE: To assess whether color intensity projections (CIP) effectively summarizes-using only the time of arrival (ToA) and amount of signal enhancement (AoE) of the contrast agent-the thousands of ultrafast images. STUDY TYPE: Retrospective cohort clinical trial. SUBJECTS: The study included 89 patients who had been scanned with an MRI beast protocol, of which 26 had breast cancer and 63 did not...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
W Häuser, E Brähler, G Schmutzer, H Glaesmer
BACKGROUND: Adverse childhood experiences (ACE) might predispose to and resilience might protect against chronic noncancer pain (CNCP). We studied whether ACE are positively associated with CNCP, whether resilience was negatively associated with CNCP and whether resilience buffered a potential association of ACE with CNCP. METHODS: A cross-sectional survey (N=2,425) representative for the adult German general population was conducted in 2013. The following questionnaires were used: Chronic Pain Grade Questionnaire for CNCP stages; Childhood Trauma Screener for ACE; Brief Resilient Coping Scale for resilience; Patient Health Questionnaire for psychological symptom burden; Giessen Subjective Complaints List for somatic symptom burden...
October 14, 2018: European Journal of Pain: EJP
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