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https://www.readbyqxmd.com/read/30098577/dnarcdb-a-database-of-cancer-biomarkers-in-dna-repair-genes-that-includes-variants-related-to-multiple-cancer-phenotypes
#1
Pavel Silvestrov, Sarah J Maier, Michelle Fang, G Andrés Cisneros
Functioning DNA repair capabilities are vital for organisms to ensure that the biological information is preserved and correctly propagated. Disruptions in DNA repair pathways can result in the accumulation of DNA mutations, which may lead to onset of complex disease such as cancer. The discovery and characterization of cancer-related biomarkers may allow early diagnosis and targeted treatment, which could significantly contribute to the survival rates of cancer patients. To this end, we have applied a hypothesis driven bioinformatics approach to identify biomarkers related to 25 different DNA repair enzymes, in combination with structural analysis of six selected missense mutations of newly discovered SNPs that are associated with cancer phenotypes...
July 31, 2018: DNA Repair
https://www.readbyqxmd.com/read/30098485/clinical-benefit-of-controversial-first-line-systemic-therapies-for-advanced-stage-ovarian-cancer-esmo-mcbs-scores
#2
REVIEW
K E Broekman, M Jalving, H van Tinteren, C Sessa, A K L Reyners
BACKGROUND: The magnitude of clinical benefit scale (MCBS) was introduced by the European Society of Medical Oncology (ESMO) to quantify the clinical benefit of therapeutic regimens and to prioritise therapies. It distinguishes curative from palliative treatments and ranks their benefit based on overall survival (OS), progression free survival (PFS), quality of life (QoL) and toxicity. Objective of this study on the first line treatment of ovarian cancer was to evaluate the evidence for the current standard of care using the ESMO-MCBSv1...
June 18, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/30098344/clinical-significance-and-functions-of-microrna-93-cdkn1a-axis-in-human-cervical-cancer
#3
Xiaofeng Zhang, Fengshuang Li, Linzhong Zhu
AIM: Accumulating studies have revealed that microRNA (miR)-93 may exert an oncogenic role in various cancers via inhibiting CDKN1A. However, the involvement of miR-93/CDKN1A axis in cervical cancer remains unclear. We aimed to investigate expression pattern, clinical significance and potential functions of miR-93/CDKN1A axis in cervical cancer. METHODS: Expression levels of miR-93 and CDKN1A mRNA in 100 pairs of cervical cancer and matched non-cancerous tissue samples were detected by quantitative-PCR...
August 8, 2018: Life Sciences
https://www.readbyqxmd.com/read/30098234/-unknown-title
#4
K Zaoui, P K Plinkert, P A Federspil
OBJECTIVE: The treatment strategy of squamous cell carcinoma of the nasal vestibule (SCCNV) is controversial. The objective of this study is to investigate the role of surgery, which is the preferred treatment option at our institution. DESIGN: This was a monocentric prospective study of patients that were diagnosed with SCCNV between 2005 and 2013. MATERIAL AND METHODS: Twenty-six patients were included. Tumors were staged using the UICC (7th edition) TNM classification of nasal cavity cancer and the classification proposed by Wang...
August 11, 2018: Rhinology
https://www.readbyqxmd.com/read/30098208/the-association-between-birth-order-and-childhood-leukemia-may-be-modified-by-paternal-age-and-birth-weight-pooled-results-from-the-international-childhood-cancer-cohort-consortium-i4c
#5
Ora Paltiel, Stanley Lemeshow, Gary S Phillips, Gabriella Tikellis, Martha S Linet, Anne-Louise Ponsonby, Per Magnus, Siri E Håberg, Sjurdur F Olsen, Charlotta Granström, Mark Klebanoff, Jean Golding, Zdenko Herceg, Akram Ghantous, Jane Elizabeth Hirst, Arndt Borkhardt, Mary H Ward, Signe Holst Søegaard, Terence Dwyer
The "delayed infection hypothesis" states that a paucity of infections in early childhood may lead to higher risks of childhood leukemia (CL), especially acute lymphoblastic leukemia (ALL). Using prospectively collected data from six population-based birth cohorts we studied the association between birth order (a proxy for pathogen exposure) and CL. We explored whether other birth or parental characteristics modify this association. With 2.2X106 person-years of follow-up, 185 CL and 136 ALL cases were ascertained...
August 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30098163/association-of-muc16-mutation-with-tumor-mutation-load-and-outcomes-in-patients-with-gastric-cancer
#6
Xiangchun Li, Boris Pasche, Wei Zhang, Kexin Chen
Importance: MUC16, which encodes cancer antigen 125 (CA-125), is frequently mutated in gastric cancer (GC); however, its association with tumor mutation load (TML) and outcome in patients with GC has not been established, to date. Objective: To investigate whether MUC16 mutations are associated with TML and prognosis in patients with GC. Design, Setting, and Participants: Statistical analysis of genomic data from 437 GC samples obtained from The Cancer Genome Atlas (TCGA) and 256 samples from an Asian cohort...
August 9, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/30097622/impact-of-cervical-cancer-on-quality-of-life-of-women-in-hubei-china
#7
Niresh Thapa, Muna Maharjan, Yan Xiong, Daqiong Jiang, Thi-Phuong Nguyen, Marcia A Petrini, Hongbing Cai
We aimed to assess the quality of life (QOL) of the patients with cervical cancer after initial treatment, the factors affecting QOL and their clinical relevance. A total of 256 patients with cervical cancer who visited Zhongnan Hospital of Wuhan University from January 2017 to December 2017 were enrolled in this study. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 item (EORTC QLQ-C30) and cervical cancer module (EORTC QLQ-CX24) was used to assess the QOL of patients...
August 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30097503/monosodium-glutamate-reduces-68-ga-psma-11-uptake-in-salivary-glands-and-kidneys-in-preclinical-prostate-cancer-model
#8
Etienne Rousseau, Joseph Lau, Hsiou-Ting Kuo, Zhengxing Zhang, Helen Merkens, Navjit Hundal-Jabal, Nadine Colpo, Kuo-Shyan Lin, François Bénard
We evaluated the ability of monosodium glutamate (MSG) to reduce salivary and kidney uptake of a prostate-specific membrane antigen (PSMA) radioligand without affecting tumor uptake. Methods: LNCaP tumor-bearing mice were intraperitoneally injected with MSG (657, 329, or 164 mg/kg) or phosphate-buffered saline (PBS). Fifteen minutes later, mice were intravenously administered 68 Ga-PSMA-11. PET/CT imaging and biodistribution studies were performed 1 h post-administration. Results: Tumor uptake was not statistically different between groups: 657 mg/kg (8...
August 10, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30097045/impact-of-deformable-image-registration-on-dose-accumulation-applied-electrocardiograph-gated-4dct-in-the-heart-and-left-ventricular-myocardium-during-esophageal-cancer-radiotherapy
#9
Ying Tong, Yong Yin, Pinjing Cheng, Guanzhong Gong
BACKGROUND: The deformable image registration (DIR) technique has the potential to realize the dose accumulation during radiotherapy. This study will analyze the feasibility of evaluating dose-volume parameters for the heart and left ventricular myocardium (LVM) by applying DIR. METHODS: The electrocardiograph-gated four-dimensional CT (ECG-gated 4DCT) data of 21 patients were analyzed retrospectively. The heart and LVM were contoured on 20 phases of 4DCT (0%, 5%,…,95%)...
August 10, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/30097040/the-quality-of-life-of-croatian-women-after-mastectomy-a-cross-sectional-single-center-study
#10
Stana Pačarić, Jozo Kristek, Jure Mirat, Goran Kondža, Tajana Turk, Nikolina Farčić, Želimir Orkić, Ana Nemčić
BACKGROUND: Measuring the quality of life (QoL) of women with breast cancer is an important aspect of measuring treatment success. In Croatia, no QoL studies have been carried out with a focus on patients after mastectomy. The aim of this study was to examine QoL 1 month and 1 year after mastectomy. METHODS: This cross-sectional single-center study of quality of life was conducted in 101 patients, 50 of whom had undergone a mastectomy 1 month prior, and 51 of whom had undergone a mastectomy 1 year prior...
August 10, 2018: BMC Public Health
https://www.readbyqxmd.com/read/30096808/human-papillomavirus-16-dna-quantitation-differentiates-high-grade-anal-neoplasia
#11
Melissa Agsalda-Garcia, Tiffany Shieh, Eleanore Chuang, Nicholas Loi, Cris Milne, Rui Fang, Eunjung Lim, Jeffrey Killeen, Bruce Shiramizu
Background: Due to their higher rates of anal dysplasia/cancer, human immunodeficiency virus (HIV)-positive individuals are recommended to undergo anal dysplasia screening, which consists of anal cytology (AC) and high resolution anoscopy (HRA) with anal biopsy (AB) after abnormal AC result. However, AC variability limits its usefulness. Our objective was to evaluate human papillomavirus (HPV)-16 DNA quantitation as part of the screening algorithm. Methods: HPV-16 was detected in AC specimens from 75 HIV-positive participants using quantitative real-time polymerase chain reaction...
August 8, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30096705/a-pooled-analysis-of-published-basket-trials-in-cancer-medicine
#12
Antonious Hazim, Vinay Prasad
BACKGROUND: There is widespread interest in cancer basket trials. However, to date, there has been no formal analysis of all published basket trials. METHODS: We performed a systematic review to identify all published basket trials in cancer medicine. We included studies that (1) did not place restriction on tumour type and (2) used a biomarker for the basis of enrolment (3) administered at least one anti-cancer agent in prospective fashion and (4) reported responses by each tumour type included...
August 7, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/30096702/a-randomised-phase-ii-trial-of-capecitabine-plus-cisplatin-versus-s-1-plus-cisplatin-as-a-first-line-treatment-for-advanced-gastric-cancer-capecitabine-plus-cisplatin-ascertainment-versus-s-1-plus-cisplatin-randomised-pii-trial-xparts-ii
#13
Kazuhiro Nishikawa, Akira Tsuburaya, Takaki Yoshikawa, Michiya Kobayashi, Junji Kawada, Ryoji Fukushima, Takanori Matsui, Kazuaki Tanabe, Kazuya Yamaguchi, Shigefumi Yoshino, Masazumi Takahashi, Naoki Hirabayashi, Seiji Sato, Hiroshi Nemoto, Yasushi Rino, Junta Nakajima, Toru Aoyama, Yohei Miyagi, Noboru Oriuchi, Kensei Yamaguchi, Yumi Miyashita, Satoshi Morita, Junichi Sakamoto
BACKGROUND: Capecitabine plus cisplatin (XP) is a standard global regimen, while S-1 plus cisplatin (SP) is a Japanese standard for first-line treatment of advanced gastric cancer (AGC). We conducted a phase II trial comparing XP with SP for patients with AGC to confirm whether these regimens can be used as controls in a phase III study and to explore whether histological subtypes favour XP or SP. PATIENTS AND METHODS: Eligible patients were randomised to receive either S-1 40 mg/m2 for 21 days plus cisplatin 60 mg/m2 (q5w) or capecitabine 1000 mg/m2 for 14 days plus cisplatin 80 mg/m2 (q3w)...
August 7, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/30096498/development-of-machine-learning-algorithms-for-prediction-of-five-year-spinal-chordoma-survival
#14
Aditya V Karhade, Quirina Thio, Paul Ogink, Jason Kim, Santiago Lozano-Calderon, Kevin Raskin, Joseph Schwab
INTRODUCTION: Chordomas are locally invasive slow-growing tumors that are difficult to study because of the rarity of the tumors and the lack of significant volumes of patients with longitudinal follow-up. As such, there are currently no machine learning studies in the chordoma literature. The purpose of this study was to develop machine learning models for survival prediction and deploy them as open access web applications as a proof of concept for machine learning in rare nervous system lesions...
August 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30096453/genetic-variants-within-17q12-are-associated-with-the-risk-of-cervical-cancer-in-the-han-chinese-population
#15
Lingmin Hu, Meiqun Jia, Jing Zhou, Hongxia Ma, Guangfu Jin, Ni Li, Dong Hang, Zhibin Hu
Chromosome 4q12 and 17q12 have been identified as two regions associated with susceptibility to cervical cancer in a genome-wide association study. To identify potential causal variants within these two regions, we conducted a case-control study including 1486 patients with cervical cancer and 1536 age-matched (±5 years) healthy controls. Based on RegulomeDB database, 12 potentially functional variants were selected and then genotyped by using Sequenom MassARRAY. Univariate and multivariate logistic regression models were used to evaluate the associations...
August 7, 2018: Gene
https://www.readbyqxmd.com/read/30096292/predictors-of-pathologic-tumor-invasion-and-prognosis-for-ggo-featured-lung-adenocarcinoma
#16
Ting Ye, Lin Deng, Jiaqing Xiang, Yawei Zhang, Hong Hu, Yihua Sun, Yuan Li, Lei Shen, Shengping Wang, Li Xie, Haiquan Chen
BACKGROUND: We make surgical strategies for ground glass opacity (GGO) nodules currently based on thin-section(TS)-CT findings. Whether radiologic measurements could precisely predict tumor invasion and prognosis of GGO-featured lung adenocarcinoma is uncertain. METHODS: We retrospectively evaluated medical records of patients with radiologic GGO nodules receiving surgery at FUSCC. The study endpoints were the predictive value and prognostic significance of radiologic measurements (CTR value, consolidation size and tumor size) for pathologic lung adenocarcinoma...
August 7, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30096150/meta-analysis-of-postoperative-adjuvant-therapy-for-small-bowel-adenocarcinoma
#17
Xiaojian Ye, Guoqiang Zhang, Haibin Chen, Yong Li
OBJECTIVE: The role of adjuvant therapy in small bowel adenocarcinoma (SBA), a rare malignancy with a poor prognosis, is controversial. The purpose of this article is to investigate the impact of adjuvant therapy on the survival of patients with SBA in a meta-analysis. METHODS: We performed a comprehensive search of PubMed, EMBASE and the Cochrane Library database between 2010 and 2017. Hazard ratios (HR) with 95% confidence intervals (95%CI) were used to assess the effect of adjuvant chemotherapy and/or radiation treatment after curative surgery in patients with SBA...
2018: PloS One
https://www.readbyqxmd.com/read/30096142/the-prognostic-significance-of-lymph-node-size-in-node-positive-colon-cancer
#18
Philipp Schrembs, Benedikt Martin, Matthias Anthuber, Gerhard Schenkirsch, Bruno Märkl
OBJECTIVES: To (i) show the outcome benefits of enlarged lymph nodes in node-positive colon cancer cases, as it was shown previously in negative node cases; (ii) disprove the stage migration theory and (iii) list the factors affecting lymph node size and yield. METHODS: A retrospective study including 234 node-positive colon cancer cases was scheduled and performed. All recovered lymph nodes (6969) from 234 cases were microscopically examined in regard to (a) lymph node size (b) presence of metastasis (c) extent of intra-nodal metastasis...
2018: PloS One
https://www.readbyqxmd.com/read/30096003/robotic-right-colectomy-for-colon-cancer-comparison-of-outcomes-from-a-single-institution-with-the-acs-nsqip-database
#19
Tammy Ju, Ivy N Haskins, Xiangyu Kuang, Richard L Amdur, Fred J Brody, Vincent Obias, Samir Agarwal
BACKGROUND: Robotic surgery has increased in recent years for the treatment of colorectal cancer; however, it is not yet the standard of care. This study aims to compare the 30-day outcomes after robotic colectomy for right-sided colon cancer from our institution with those from a national dataset, the targeted colectomy American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. METHODS: Patients undergoing elective, robotic, right colon resection for stage I, II, and III colon cancer were identified within the targeted colectomy ACS-NSQIP database from 2012 to 2014...
August 10, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/30095703/trends-and-complications-of-vulvar-reconstruction-after-vulvectomy-a-study-of-a-nationwide-cohort
#20
Alexandra L Martin, J Ryan Stewart, Harshitha Girithara-Gopalan, Jeremy T Gaskins, Nicole J McConnell, Erin E Medlin
OBJECTIVES: The objective of this study was to determine complications associated with primary closure compared with reconstruction after vulvar excision and predisposing factors to these complications. METHODS: Patients undergoing vulvar excision with or without reconstruction from 2011 to 2015 were abstracted from the National Surgical Quality Improvement Program database. Common Procedural Terminology codes were used to characterize surgical procedures as vulvar excision alone or vulvar excision with reconstruction...
August 7, 2018: International Journal of Gynecological Cancer
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