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C Vallejo, J Fortún
OBJECTIVE: In recent years, the introduction of new antifungals for the prevention of invasive fungal infections (IFIs) in hemato- oncological patients, particularly extended-spectrum azoles, has led to a change in the diagnostic and therapeutic strategies for established or suspected breakthrough IFI. The aim of the study was to identify the diagnostic and therapeutic strategies used in the management of IFIs in hemato-oncological patients in Spain, and to assess compliance with the recommendations of the consensus documents and clinical practice guidelines...
December 13, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Keine Nishiyama, Kanako Sugiura, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba
We have developed a microdevice for therapeutic drug monitoring. In this device, dispensing of sample and reagent was accomplished by simple manual operation of a syringe. Moreover, for a simple and rapid measurement, we used cloned enzyme donor immunoassay as a detection principle. These features and the reagent that is enclosed in microdevice beforehand make it possible to complete the facile analysis. In this paper, our model analyte was 1,3-dimethylxanthine (theophylline), a kind of bronchodilator. The fluorescence measurement of theophylline in whole blood was achieved with the limit of detection of 0...
December 14, 2018: Lab on a Chip
Mingyan Huang, Huamin Wang, Xiang Hu, Xuetao Cao
Hepatocellular carcinoma (HCC) is one type of cancers whose carcinogenesis and progression are closely related to chronic inflammation. Identifying the molecular mechanisms for inflammation-related HCC progression will contribute to improve the efficacy of current therapeutics for HCC patients. Many kinds of epigenetic factors, including long non-coding RNAs (lncRNAs), have been discovered to be important in HCC growth and metastasis. However, how the lncRNAs promote HCC progression and what's the application of lncRNA silencing in vivo in suppressing HCC remain to be further investigated...
2019: Oncoimmunology
Hans A Schlößer, Martin Thelen, Axel Lechner, Kerstin Wennhold, Maria A Garcia-Marquez, Sacha I Rothschild, Elena Staib, Thomas Zander, Dirk Beutner, Birgit Gathof, Ramona Gilles, Engin Cukuroglu, Jonathan Göke, Alexander Shimabukuro-Vornhagen, Uta Drebber, Alexander Quaas, Christiane J Bruns, Arnulf H Hölscher, Michael S Von Bergwelt-Baildon
Tumor-infiltrating lymphocytes (TILs) are correlated to prognosis of several kinds of cancer. Most studies focused on T cells, while the role of tumor-associated B cells (TABs) has only recently gained more attention. TABs contain subpopulations with distinct functions, potentially promoting or inhibiting immune responses. This study provides a detailed analysis of TABs in gastro-esophageal adenocarcinoma (EAC). Flow cytometric analyses of single cell suspensions of tumor samples, mucosa, lymph nodes and peripheral blood mononuclear cells (PBMC) of EAC patients and healthy controls revealed a distinct B cell compartment in cancer patients...
2019: Oncoimmunology
Monica Aniela Zaharie, Marco Seeber
Editors of scientific journals meet increasing challenges to find peer reviewers. Rewarding reviewers has been proposed as a solution to incentives peer review, and journals have already started to offer different kinds of rewards, particularly non-monetary ones. However, research so far has mainly explored the efficacy of monetary rewards, while research on non-monetary rewards is barely absent. The goal of this article is to fill this gap by exploring whether and under what conditions a rather common non-monetary reward employed by journals, i...
2018: Scientometrics
Abi Rimmer, Juliet Dobson
No abstract text is available yet for this article.
December 13, 2018: BMJ: British Medical Journal
Tari Turner, Emily Steele, Chris Mavergames, Julian Elliott
BACKGROUND: The conduct and publication of scientific research are increasingly open and collaborative. There is growing interest in Web-based platforms that can effectively enable global, multidisciplinary scientific teams and foster networks of scientists in areas of shared research interest. Designed to facilitate Web-based collaboration in research evidence synthesis, TaskExchange highlights the potential of these kinds of platforms. OBJECTIVE: This paper describes the development, growth, and future of TaskExchange, a Web-based platform facilitating collaboration in research evidence synthesis...
December 13, 2018: JMIR Research Protocols
Victor Grech
As an experienced writer, one is often asked the question "what can I publish" by younger and inexperienced colleagues who must publish. This paper will briefly review the reasons why academics publish and will then outline what kind of papers one may be able to publish with relative ease, using personal experience and citing first hand material as a practical guide. Potential authors must cultivate "a lean and hungry look" as competition from fellow writers is stiff, and editors are choosy...
December 10, 2018: Early Human Development
Jing Zhan, Yiran Liang, Donghui Liu, Xiaoran Ma, Peize Li, Chang Liu, Xueke Liu, Peng Wang, Zhiqiang Zhou
BACKGROUND: Antibiotics are commonly used worldwide, and pesticide is a kind of xenobiotic to which humans are frequently exposed. The interactive impact of antibiotics on pesticides has rarely been studied. We aim to investigate the effects of antibiotics on the pesticide exposure risk and whether gut microbiota altered by antibiotics has an influence on pesticide bioavailability. Furthermore, we explored the mechanisms of gut microbiota affecting the fate of pesticides in the host. RESULTS: The oral bioavailability of triazine herbicides significantly increased in the rats treated with ampicillin or antibiotic cocktails...
December 13, 2018: Microbiome
Masahiro Sano, Sayaka Sano, Hiromasa Kato, Ken Arakawa, Masaaki Arai
BACKGROUND: When mouth breathing becomes habitual, it can cause sleep disorders and abnormal maxillofacial growth, thus early detection of habitual mouth breathing is important. We created a questionnaire for early detection of habitual mouth breathing using a score based on a spectrum of factors found to be characteristic of mouth breathers. METHODS: First, a draft 50-question questionnaire was given to 101 random dental clinic patients, classified by dental professionals into habitual mouth breathers (n = 28) and nose breathers (n = 73)...
December 13, 2018: BMC Oral Health
Hongchen Wu, Mingyang Li, Huaxiang Zhang
Privacy intrusion has become a major bottleneck for current trust-aware social sensing, since online social media allows anybody to largely disclose their personal information due to the proliferation of the Internet of Things (IoT). State-of-the-art social sensing still suffers from severe privacy threats since it collects users' personal data and disclosure behaviors, which could raise user privacy concerns due to data integration for personalization. In this paper, we propose a trust-aware model, called the User and Item Similarity Model with Trust in Diverse Kinds (UISTD), to enhance the personalization of social sensing while reducing users' privacy concerns...
December 11, 2018: Sensors
Haixing Wang, Yuanyuan Li, Yeqing Huang, Chunyan Zhao, Hon-Yeung Cheung
Lobelia chinensis is a kind of herbal medicine widely distributed and used in Asia. The chemical components of this herb, however, have not been well studied until now. Lobeline, as an essential and famous bioactive compound in Lobelia genus, has been assumed to be present in L. chinensis . In order to ascertain its presence and, more importantly, proper use of this herb, chemical profiling this herb with highly sensitive and high-resolution analytical mass spectrometry was applied. In this study, high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC/Q-TOF MS) method was employed to systematically profile the chemical constituents of L...
December 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yuqi Li, Shengli Pu, Yongliang Zhao, Tianjun Yao
A kind of all-fiber magnetic field sensing structure is proposed and demonstrated here. The sensing element includes a microfiber knot resonator (MKR) cladded with magnetic fluid (MF). The low-index MgF₂ slab is adopted as the substrate. The sensitivity increases with the decrease of the MKR ring diameter. The achieved maximum magnetic field sensitivity is 277 pm/mT. The results of this work have the potential to promote the development of magnetically controllable optical devices and the design of ultra-compact cost-effective magnetic field sensors...
December 10, 2018: Sensors
Baofeng Cai, Yang Zhang, Xianen Wang, Yu Li
Restoring natural wetlands with conservation projects is an urgent task for human well-being. This paper introduces the Interval linear programming (ILP) method in wetland restoration projects for the first time and builds an optimization model. The purpose of the optimization model is to find an optimal restoration measures allocation pattern that can minimize the total investment in wetland restoration projects and obtain additional ecological environment and socio-economic benefits. The optimization model can also decrease the influence of interval uncertainty in the system by expressing the executed solution as interval numbers with an upper bound and a lower bound...
December 10, 2018: International Journal of Environmental Research and Public Health
Hailing Tan, Ziyi Xing, Gong Chen, Xiaofei Tian, Zhenqiang Wu
Yellow Monascus pigments can be of two kinds: Natural and reduced, in which natural yellow Monascus pigments (NYMPs) attract widespread attention for their bioactivities. In this study, the antioxidative and antibreast cancer effects of the water-soluble NYMPs fermented by Monascus ruber CGMCC 10910 were evaluated. Results showed that water-soluble NYMPs had a significantly improved antioxidative activities compared to the reduced yellow Monascus pigments (RYMPs) that were chemically derived from orange or red Monascus pigments...
December 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yazhen Sun, Bincheng Gu, Lin Gao, Linjiang Li, Rui Guo, Qingqing Yue, Jinchang Wang
In order to represent the mechanical response laws of high-modulus asphalt pavement (HMAP) faithfully and objectively, the viscoelasticity of high-modulus asphalt mixture (HMAM) was considered, and the viscoelastic mechanical responses were calculated systematically based on moving load by numerical simulations. The performances of the HMAP in resistance to the deformation and the cracking at the bottom layer were compared with the ordinary asphalt pavement. Firstly, Lubao and Honeywell 7686 (H7686) were selected as the high modulus modifiers...
December 7, 2018: Materials
Gabriela Topa, José F Jurado-Del Pozo
Occupations focused on helping others, guaranteeing people's security, and defending societal values can be stressful and risky for the workers involved. Emotional exhaustion and health complaints usually emerge as indicators of the stress suffered by these workers in undertaking their roles. This research aims to explore the effects of psychological contract breach on both emotional exhaustion and health complaints among three kinds of Spanish workers, namely firefighters ( n = 80), professional soldiers ( n = 77), and prison officers ( n = 107)...
December 7, 2018: Journal of Clinical Medicine
Jian Li, Lu Liu, Hao Hu, Qiuhong Zhao, Libin Guo
Inventory management of deteriorating drugs has attracted considerable attention recently in hospitals. Drugs are a kind of special product. Two characteristics of some drugs are the shorter shelf life and high service level. This causes hospitals a great deal of difficulty in inventory management of perishable drugs. On one hand, hospitals should increase the drug inventory to achieve a higher service level. On the other hand, hospitals should decrease the drug inventory because of the short shelf life of drugs...
December 7, 2018: International Journal of Environmental Research and Public Health
Xianyi Chen, Zeyu Sun, Ligen Shi, Liang Xu, Jun Yu, Bing Fang, Jingwei Zheng, Jing Xu, Jianmin Zhang
Distal posterior inferior cerebellar artery (PICA) aneurysm is a kind of rare intracranial aneurysm with controversial evidence in managements. The main purposes of this research are to study the safety and effectiveness of parent artery occlusion (PAO) compared with selective aneurysm coiling (SAC) as well as figure out factors that affect the outcomes.All characteristics of patients that diagnosed with ruptured distal PICA aneurysm and treated with endovascular management in our hospital from July 2009 to February 2016 were retrospectively collected...
December 2018: Medicine (Baltimore)
(no author information available yet)
On a Sunday morning at 06:22 on October 23, 1983, in Beirut, Lebanon, a semitrailer filled with TNT sped through the guarded barrier into the ground floor of the Civilian Aviation Authority and exploded, killing and wounding US Marines from the 1st Battalion 8th Regiment (2nd Division), as well as the battalion surgeon and deployed corpsmen. The truck bomb explosion, estimated to be the equivalent of 21,000 lbs of TNT, and regarded as the largest nonnuclear explosion since World War II, caused what was then the most lethal single-day death toll for the US Marine Corps since the Battle of Iwo Jima in World War II...
December 1, 2018: Neurosurgical Focus
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