Robyn Laura Kosinsky, Maria Zerche, Ana Patricia Kutschat, Asha Nair, Zhenqing Ye, Dominik Saul, Maximilian von Heesen, Jessica J Friton, Ana Carolina Schwarzer, Nadia Paglilla, Shehzad Z Sheikh, Florian Wegwitz, Zhifu Sun, Michael Ghadimi, Rodney D Newberry, R Balfour Sartor, William A Faubion, Steven A Johnsen
Despite the identification of several genetic factors linked to increased susceptibility to inflammatory bowel disease (IBD), underlying molecular mechanisms remain to be elucidated in detail. The ubiquitin ligases RNF20 and RNF40 mediate the monoubiquitination of histone H2B at lysine 120 (H2Bub1) and were shown to play context-dependent roles in the development of inflammation. Here, we aimed to examine the function of the RNF20/RNF40/H2Bub1 axis in intestinal inflammation in IBD patients and mouse models...
November 2021: Cell Death and Differentiation