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https://www.readbyqxmd.com/read/29917208/type-i-cardiorenal-syndrome-in-patients-with-acutely-decompensated-heart-failure-the-importance-of-new-renal-biomarkers
#1
A Atici, S Emet, R Cakmak, G Yuruyen, A Alibeyoglu, M Akarsu, Y Arman, M Kose, E Ozgun, M Ozcan, O Altun, I Onur, T Tukek
OBJECTIVE: Type 1 cardiorenal syndrome (CRS) is an acute renal failure in patients with acute decompensated heart failure with an incidence of 24% to 45%. The aim of our study was to investigate the significance of new renal biomarkers to predict type 1 CRS. PATIENTS AND METHODS: The study included 111 patients with acute decompensated heart failure diagnosed at the Istanbul Medical Faculty Emergency Department between 2014 and 2016, and 24 healthy volunteers. All urine samples were stored at -80°C after centrifugation...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29916026/acute-kidney-injury-due-to-diarrheal-illness-requiring-hospitalization-data-from-the-national-inpatient-sample
#2
Christina Bradshaw, Yuanchao Zheng, Samuel A Silver, Glenn M Chertow, Jin Long, Shuchi Anand
BACKGROUND: Diarrheal illness is a major reason for hospitalization, but data on consequent acute kidney injury (AKI) are sparse. OBJECTIVE: To determine the incidence of AKI in infectious and non-infectious diarrheal illness requiring hospitalization and to identify correlates and outcomes of diarrhea-associated AKI. DESIGN: Using data from the 2012 National Inpatient Sample (NIS), we created a cohort of patients with a primary diagnosis of diarrheal illness...
June 18, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29915859/neonatal-subcutaneous-fat-necrosis-with-hypercalcemia-treatment-using-calcitonin
#3
Khouloud A Alsofyani
Subcutaneous fat necrosis of newborn is a form of noninfectious panniculitis. It is an uncommon condition and mostly occurs in full-term infants within first weeks of life that have had a significant condition such as hypoxic-ischemic encephalopathy at the time of birth. Subcutaneous fat necrosis of newborn is usually a self-limiting condition but may be associated with hypercalcemia, which may lead to life threatening levels. Hypercalcemia is a significant reason of subcutaneous fat necrosis and needs an intervention involving hyperhydration, calcitonin, diuretics, steroids and sometimes bisphosphonate in resistant cases...
June 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29913138/the-effect-of-thiazide-and-potassium-citrate-use-on-the-health-related-quality-of-life-of-patients-with-urolithiasis
#4
Eric P Raffin, Kristina L Penniston, Jodi A Antonelli, Davis P Viprakasit, Timothy D Averch, Vincent G Bird, Ben H Chew, Sri Sivalingam, Roger L Sur, Stephen Y Nakada, Vernon M Pais
INTRODUCTION: It is unknown whether benefits of medical management of urolithiasis outweigh potential side effects of utilized medications including potassium citrate (Kcit) and thiazide diuretics. Therefore, we sought to evaluate the relationship between Kcit or thiazides and overall stone-related health related quality of life (HRQOL). METHODS: Using cross-sectional data from stone forming enrollees in the North American Stone Quality of Life Consortium, we used the Wisconsin Stone Quality of Life questionnaire (WISQOL) to compare HRQOL between patients treated and not treated with Kcit or thiazide type diuretics...
June 15, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29912952/effects-of-early-diuretic-response-to-carperitide-in-acute-decompensated-heart-failure-treatment-a-single-center-retrospective-study
#5
Yoshitaka Okuhara, Masanori Asakura, Kohei Azuma, Yoshiyuki Orihara, Koichi Nishimura, Tomotaka Ando, Hideyuki Kondo, Yoshiro Naito, Kazunori Kashiwase, Shinichi Hirotani, Masaharu Ishihara, Tohru Masuyama
BACKGROUND: Diuretic response is a strong predictor of outcome for admitted patients of acute decompensated heart failure (ADHF). However, little is known about the effects of early diuretic response to carperitide. METHODS: We retrospectively analyzed records of 85 patients hospitalized for ADHF who received carperitide as initial treatment and <40 mg furosemide during the early period. The eligible patients were divided into good diuretic responder (GR) group and poor diuretic responder (PR) group on the basis of median urinary volume...
2018: PloS One
https://www.readbyqxmd.com/read/29909392/thiazide-diuretics-associated-skin-rash
#6
Filipe Santos Mira, Helena Temido, Elsa Gaspar
No abstract text is available yet for this article.
June 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29907477/successful-treatment-of-normokalemic-periodic-paralysis-with-hydrochlorothiazide
#7
Yuichi Akaba, Satoru Takahashi, Yoshiaki Sasaki, Hiroki Kajino
BACKGROUND: Periodic paralysis (PP) is an autosomal dominant muscle disorder characterized by periodic muscle weakness attacks associated with serum potassium level variations. It is classified into hypokalemic (hypoKPP), hyperkalemic (hyperKPP), and normokalemic (normoKPP) forms based on the ictal serum potassium level. HyperKPP and normoKPP are caused by mutations of the same gene SCN4A, the gene encoding the skeletal muscle voltage-gated sodium channel. Prophylactic treatment with thiazide diuretics is highly effective in preventing attacks in hyperKPP...
June 12, 2018: Brain & Development
https://www.readbyqxmd.com/read/29907406/first-spot-urine-sodium-after-initial-diuretic-identifies-patients-at-high-risk-for-adverse-outcome-after-heart-failure-hospitalization
#8
Adriana Luk, John D Groarke, Akshay S Desai, Syed Saad Mahmood, Deepa M Gopal, Emer Joyce, Sachin P Shah, Joann Lindenfeld, Lynne Stevenson, Neal K Lakdawala
BACKGROUND: Relief of congestion is the primary goal of initial therapy for acute decompensated heart failure (ADHF). Early measurement of urine sodium concentration (UNa) may be useful to identify patients with diminished response to diuretics. The aim of this study was to determine if the first spot UNa after diuretic initiation could select patients likely to require more intensive therapy during hospitalization. METHODS: At the time of admission, 103 patients with ADHF were identified prospectively, and UNa was measured after the first dose of intravenous diuretic...
May 19, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29901287/-characteristic-features-of-urinary-calcium-excretion-and-osteoporosis-risk-factors-in-patients-with-urolithiasis
#9
L S Demidko, V I Rudenko, V A Grigoryan, Yu L Demidko, M E Enikeev, Zh Sh Inoyatov, M V Amosova
RELEVANCE: The prevalence of urolithiasis and osteoporosis (OP) indicates that these diseases may be found concurrently in the same patient. The detection of risk factors for OP and disorders of calcium metabolism in patients with urolithiasis is of interest in the context of primary stone formation and metaphylaxis. AIM: To identify risk factors for osteoporosis and disorders of calcium metabolism in patients with urolithiasis. MATERIALS AND METHODS: Osteoporosis risk factors were studied in 45 urolithiasis patients undergoing surgical treatment...
May 2018: Urologii︠a︡
https://www.readbyqxmd.com/read/29900164/bartter-syndrome-type-3-phenotype-genotype-correlation-and-favorable-response-to-ibuprofen
#10
Xuejun Yang, Gaofu Zhang, Mo Wang, Haiping Yang, Qiu Li
Objective: To investigate the phenotype-genotype correlation in different genetic kinds of Bartter syndrome type 3 in children. Methods: Clinical and genetic data of 2 patients with different mutations in Bartter syndrome type 3 was analyzed while the prognosis was compared after a 6-year follow-up or 2-year follow-up, respectively. Results: Bartter syndrome is a kind of autosomal recessive inherited renal disorder. The manifestation and prognosis of Bartter syndrome change with mutation types, and severe mutation were often accompanied with unfavorable prognosis...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29898484/-drug-prescribing-for-patients-with-chronic-kidney-disease-in-general-practice-a-cross-sectional-study
#11
Maria Mahner, Christina Raus, Fabian Ludwig, Gesine Weckmann, Sylvia Stracke, Jean-François Chenot
BACKGROUND:  Many drugs require dose adjustment or are contraindicated in patients with chronic kidney disease (CKD) to avoid adverse events. The aims of this study were to assess if medication was appropriately dose adjusted in patients with CKD in primary care, to identify medications that were frequently prescribed inappropriately and to identify factors predicting mal-prescription. METHODS:  We conducted a cross-sectional observational study in 34 general practioners' offices, assessing the medication of patients with CKD stage ≥ 3 according to the corresponding pharmaceutical product information...
June 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29897276/focus-on-acute-heart-failure-prehospital-diagnosis-ultrasound-examination-and-monitoring-pathophysiology-diuretic-resistance
#12
Christiaan Jm Vrints
No abstract text is available yet for this article.
June 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29897275/editor-s-choice-diuretic-resistance-in-acute-heart-failure
#13
Frederik H Verbrugge
Diuretic resistance is a powerful predictor of adverse outcome in acute heart failure (AHF), irrespectively of underlying glomerular filtration rate. Metrics of diuretic efficacy such as natriuresis, urine output, weight loss, net fluid balance, or fractional sodium excretion, differ in their risk for measurement error, convenience, and biological plausibility, which should be taken into account when interpreting their results. Loop diuretic resistance in AHF has multiple causes including altered drug pharmacokinetics, impaired renal perfusion and effective circulatory volume, neurohumoral activation, post-diuretic sodium retention, the braking phenomenon and functional as well as structural adaptations in the nephron...
June 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29897099/hypotensive-drugs-and-syncope-due-to-orthostatic-hypotension-in-older-adults-with-dementia-syncope-and-dementia-study
#14
Gianluca Testa, Alice Ceccofiglio, Chiara Mussi, Giuseppe Bellelli, Franco Nicosia, Mario Bo, Daniela Riccio, Francesco Curcio, Anna Maria Martone, Gabriele Noro, Francesco Landi, Andrea Ungar, Pasquale Abete
OBJECTIVES: To determine whether hypotensive drugs may play a pivotal role in inducing orthostatic hypotension (OH)-related syncope. DESIGN: Prospective, observational, multicenter study. SETTING: Acute care wards, syncope units, and centers for the diagnosis of dementia. PARTICIPANTS: Individuals aged 65 and older with a diagnosis of dementia and 1 or more episodes of transient loss of consciousness of a suspected syncopal nature or unexplained falls during the previous 3 months MEASUREMENTS: Blood pressure was measured in the supine position and in the orthostatic position after 1 and 3 minutes...
June 13, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29896315/novel-concept-to-guide-systolic-heart-failure-medication-by-repeated-biomarker-testing-results-from-time-chf-in-context-of-predictive-preventive-and-personalized-medicine
#15
Nasser Davarzani, Sandra Sanders-van Wijk, Micha T Maeder, Peter Rickenbacher, Evgueni Smirnov, Joël Karel, Thomas Suter, Rudolf A de Boer, Dirk Block, Vinzent Rolny, Christian Zaugg, Matthias E Pfisterer, Ralf Peeters, Hans-Peter Brunner-La Rocca
Background: It is uncertain whether repeated measurements of a multi-target biomarker panel may help to personalize medical heart failure (HF) therapy to improve outcome in chronic HF. Methods: This analysis included 499 patients from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF), aged ≥ 60 years, LVEF ≤ 45%, and NYHA ≥ II, who had repeated clinical visits within 19 months follow-up...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29895592/discovery-characterization-and-effects-on-renal-fluid-and-electrolyte-excretion-of-the-kir4-1-potassium-channel-pore-blocker-vu0134992
#16
Sujay V Kharade, Haruto Kurata, Aaron Bender, Anna L Blobaum, Eric E Figueroa, Amanda M Duran, Meghan Kramer, Emily Days, Paige Vinson, Daniel Flores, Lisa M Satlin, Jens Meiler, C David Weaver, Craig W Lindsley, Corey R Hopkins, Jerod S Denton
The inward rectifier potassium (Kir) channel Kir4.1 (KCNJ10) carries out important physiological roles in epithelial cells of the kidney, astrocytes in the central nervous system, and stria vascularis of the inner ear. Loss-of-function mutations in KCNJ10 lead to EAST/SeSAME syndrome, which is characterized by epilepsy, ataxia, renal salt wasting, and sensorineural deafness. While genetic approaches have been indispensable for establishing the importance of Kir4.1 in the normal function of these tissues, the availability of pharmacological tools for acutely manipulating the activity of Kir4...
June 12, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29893446/perturbations-in-serum-chloride-homeostasis-in-heart-failure-with-preserved-ejection-fraction-insights-from-topcat
#17
Justin L Grodin, Jeffrey M Testani, Ambarish Pandey, Kamalanathan Sambandam, Mark H Drazner, James C Fang, W H Wilson Tang
AIMS: Prior cohorts demonstrating the importance of serum chloride levels in heart failure either excluded or had partial representation of patients with heart failure with preserved ejection fraction (HFpEF). We aimed to examine the relationship between serum chloride concentration and outcomes in HFpEF. METHODS AND RESULTS: We included participants from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial (TOPCAT) who met the following criteria: met inclusion by the natriuretic peptide stratum, had recorded serum chloride levels, and were from the Americas (n = 942)...
June 12, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29892833/treatment-of-hypertension-in-chronic-kidney-disease
#18
REVIEW
Rigas G Kalaitzidis, Moses S Elisaf
PURPOSE OF REVIEW: Chronic kidney disease (CKD) is recognized as a worldwide epidemic. Hypertension commonly coexists with CKD and its prevalence is progressively increasing as kidney function declines. RECENT FINDINGS: For patients with established CKD and/or diabetes with albuminuria, the updated hypertension guidelines have recommended a blood pressure (BP) goal < 130/80 mmHg. Blood pressure level above 130/80 mmHg in CKD patients requires lifestyle modifications and multiple antihypertensive medications...
June 11, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29892601/tricuspid-regurgitation-medical-management-and-evolving-interventional-concepts
#19
Frederik Beckhoff, Brunilda Alushi, Christian Jung, Eliano Navarese, Marcus Franz, Daniel Kretzschmar, Bernhard Wernly, Michael Lichtenauer, Alexander Lauten
Severe tricuspid regurgitation (TR) is a complex condition of the right ventricle (RV) and tricuspid valve apparatus and is frequently associated with symptomatic heart failure and a significant morbidity and mortality. In these patients, left heart pathologies lead to chronic pressure overload of the RV, eventually causing progressive RV dilatation and functional TR. Therefore, TR cannot be considered as isolated heart valve disease pathology but has to be understood and treated as one component of a complex structural RV pathology and is frequently also a marker of an advanced stage of cardiac disease...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29889841/fixed-dose-combination-antihypertensive-medications-adherence-and-clinical-outcomes-a-population-based-retrospective-cohort-study
#20
Amol A Verma, Wayne Khuu, Mina Tadrous, Tara Gomes, Muhammad M Mamdani
BACKGROUND: The majority of people with hypertension require more than one medication to achieve blood pressure control. Many patients are prescribed multipill antihypertensive regimens rather than single-pill fixed-dose combination (FDC) treatment. Although FDC use may improve medication adherence, the impact on patient outcomes is unclear. We compared clinical outcomes and medication adherence with FDC therapy versus multipill combination therapy in a real-world setting using linked clinical and administrative databases...
June 2018: PLoS Medicine
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