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https://www.readbyqxmd.com/read/30104999/home-based-orolingual-exercise-improves-the-coordination-of-swallowing-and-respiration-in-early-parkinson-disease-a-quasi-experimental-before-and-after-exercise-program-study
#1
Chin-Man Wang, Wann-Yun Shieh, Chan-Shien Ho, Yu-Wei Hu, Yih-Ru Wu
Introduction: The coordination of swallowing and respiration is important for safety swallowing without aspiration. This coordination was affected in Parkinson disease (PD). A noninvasive assessment tool was used to investigate the effect of an easy-to-perform and device-free home-based orolingual exercise (OLE) program on swallowing and respiration coordination in patients with early-stage PD. Materials and Methods: This study had a quasi-experimental before-and-after exercise program design. Twenty six patients with early-stage PD who were aged 62...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30093319/an-alveolar-recruitment-maneuver-followed-by-positive-end-expiratory-pressure-improves-lung-function-in-healthy-dogs-undergoing-laparoscopy
#2
Caterina Di Bella, Luca Lacitignola, Salvatore Grasso, Paola Centonze, Antonella Greco, Rossella Ostuni, Antonio Crovace, Francesco Staffieri
OBJECTIVE: To evaluate the effects of an alveolar recruitment maneuver (ARM) followed by 5 cmH2 O positive end-expiratory pressure (PEEP) in dogs undergoing laparoscopy. STUDY DESIGN: Prospective, randomized clinical study. ANIMALS: A group of 20 dogs undergoing laparoscopic ovariectomy. METHODS: Dogs were sedated with acepromazine and methadone intramuscularly; anesthesia was induced with propofol intravenously and maintained with inhaled isoflurane...
April 16, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/30010451/the-prognosis-of-infants-with-neonatal-respiratory-inhibition-syndrome
#3
Hideki Minowa, Kumiko Takagi, Ikuyo Arai, Hajime Yasuhara, Reiko Ebisu, Ayako Ohgitani
OBJECTIVE: The goal of this study was to investigate the prognosis of infants with neonatal respiratory inhibition syndrome (NRIS). METHODS: Infants with a gestational age of at least 36 weeks and a birth weight of at least 2000 grams who were born at Nara Prefecture General Medical Center, in Nara, Japan, between March 2013 and June 2016 were screened for NRIS using our established method. NRIS was defined as severe hypoxemia caused by respiratory inhibition immediately after crying (RIAC) or gastroesophageal reflux (RIGER) or as a respiratory pause during feeding (feeding hypoxemia), accompanied clinically by central cyanosis and a decrease in SpO2 to less than 70%...
July 16, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29969653/exploration-of-toxicological-impacts-following-acute-and-sub-chronic-exposure-to-ethyl-anthranilate-loaded-mosquito-repellent-patch
#4
Johirul Islam, Kamaruz Zaman, Srijita Chakrabarti, Pronobesh Chattopadhyay
In the recent years, growing concern about the potential toxicity of synthetic repellents has led to the development of environmentally safe non-toxic insect control methods. Present investigation explores the toxicological impacts of ethyl anthranilate-loaded mosquito repellent patch (EAMRP) on respiratory system following acute and sub-chronic inhalation exposure in Wistar rats. Lungs parameters such as enhanced pause, tidal volume, respiration rate, inspiration time, and expiration time were determined using whole body plethysmograph...
August 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29796202/acute-response-to-7-day-therapy-with-cpap-in-patients-with-moderate-to-severe-obstructive-sleep-apnea-and-cardiac-arrhytmia
#5
Jerónimo Campos, Glenda Ernst, Magali Blanco, Alejandra Cassano, Iván Tello-Santa-Cruz, Cesar Cáceres-Monié, Alexys Muyran, Romina Cansonieri, Alejandro Salvado, Eduardo Borsini
Introduction: Obstructive Sleep Apnea (OSA) has been associated with an elevated risk of cardiac arrhythmia. Continuous positive airway pressure (CPAP) is the selected treatment for moderate to severe OSA and could improve arrhythmias in the long term. However, the acute effect of CPAP has not been studied in detail. Methods: We conducted a prospective study with 25 patients with moderate to severe OSA diagnosed by home respiratory polygraphy (RP) and arrhythmia and/or pauses in 24-hour Holter ECG...
January 2018: Sleep Science
https://www.readbyqxmd.com/read/29515365/persistent-expression-of-serotonin-receptor-5b-alters-breathing-behavior-in-male-mecp2-knockout-mice
#6
Steffen Vogelgesang, Marcus Niebert, Anne M Bischoff, Swen Hülsmann, Till Manzke
Mutations in the transcription factor methyl-CpG-binding protein 2 (MeCP2) cause the neurodevelopmental disorder Rett syndrome (RTT). Besides many other neurological problems, RTT patients show irregular breathing with recurrent apneas or breath-holdings. MeCP2-deficient mice, which recapitulate this breathing phenotype, show a dysregulated, persistent expression of G-protein-coupled serotonin receptor 5-ht5b ( Htr5b ) in the brainstem. To investigate whether the persistence of 5-ht5b expression is contributing to the respiratory phenotype, we crossbred MeCP2-deficient mice with 5-ht5b -deficient mice to generate double knockout mice ( Mecp2-/y ; Htr5b -/- )...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29451946/first-experience-in-switzerland-in-phe508del-homozygous-cystic-fibrosis-patients-with-end-stage-pulmonary-disease-enrolled-in-a-lumacaftor-ivacaftor-therapy-trial-preliminary-results
#7
Christian Murer, Lars Christian Huber, Thomas Kurowski, Astrid Hirt, Cécile A Robinson, Urs Bürgi, Christian Benden
AIMS OF THE STUDY: Cystic fibrosis is the most common genetic disorder in Caucasians. The combination of the cystic fibrosis transmembrane conductance regulator (CFTR) corrector lumacaftor / potentiator ivacaftor (LUM/IVA) has been shown to increase forced expiratory volume in 1 second (FEV1) moderately, but predominantly reduce acute exacerbation rate (AER) in Phe508del homozygous cystic fibrosis patients; however, patients with FEV1 <40% predicted were excluded from studies. We used LUM/IVA on a "compassionate use" basis in cystic fibrosis patients with end-stage pulmonary disease...
2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29396718/chiari-type-i-malformation-of-infants-and-toddlers
#8
Gordan Grahovac, Tatiana Pundy, Tadanori Tomita
OBJECTIVES: Chiari I malformation has been a well-recognized clinical entity; however, its occurrence among infants and toddlers is unusual. Their clinical presentations may be different from other age groups due to their lack of effective verbal communication. The authors analyze their personal series of patients focusing on symptomatology and MRI characteristics. Treatment methods, results, and outcome are analyzed in order to identify appropriate surgical management among infants and toddlers with Chiari I malformation...
June 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29362042/implementing-microstream-end-tidal-co-2-in-the-pacu
#9
Kimberly Latham, Tamera Bird, Joyce Burke
Managing patients with undiagnosed Obstructive Sleep Apnea (OSA) can be a challenge in the postoperative phase. OSA is a chronic disease defined by pauses in breathing that are repetitive during sleep that can last for one minute or longer. This can occur more than five times in an hour. As many as 80-90% of patients undergoing elective surgery have undiagnosed sleep apnea and an increased risk of respiratory complications postoperatively. Capnography is a monitoring tool that can detect increases in end-tidal carbon dioxide levels, which is a sign of respiratory decline...
February 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29335031/respiration-pattern-variability-and-related-default-mode-network-connectivity-are-altered-in-remitted-depression
#10
Vera Eva Zamoscik, Stephanie Nicole Lyn Schmidt, Martin Fungisai Gerchen, Christos Samsouris, Christina Timm, Christine Kuehner, Peter Kirsch
BACKGROUND: Studies with healthy participants and patients with respiratory diseases suggest a relation between respiration and mood. The aim of the present analyses was to investigate whether emotionally challenged remitted depressed participants show higher respiration pattern variability (RPV) and whether this is related to mood, clinical outcome and increased default mode network connectivity. METHODS: To challenge participants, sad mood was induced with keywords of personal negative life events in individuals with remitted depression [recurrent major depressive disorder (rMDD), n = 30] and matched healthy controls (HCs, n = 30) during functional magnetic resonance imaging...
January 16, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29214684/pharmacotherapies-for-apnoea-of-prematurity-time-to-pause-and-consider-targeted-sex-specific-strategies
#11
Ken D O'Halloran, Fiona B McDonald
No abstract text is available yet for this article.
February 1, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29105057/potentially-high-risk-cardiac-arrhythmias-with-focal-to-bilateral-tonic-clonic-seizures-and-generalized-tonic-clonic-seizures-are-associated-with-the-duration-of-periictal-hypoxemia
#12
Katherine J Park, Gaurav Sharma, Jeffrey D Kennedy, Masud Seyal
OBJECTIVE: To investigate potentially high-risk cardiac arrhythmias (PHAs) following focal to bilateral tonic-clonic seizures (FBTCSs) and generalized tonic-clonic seizures (GTCSs) and to study the association of PHAs with seizure characteristics and the severity of associated ictal respiratory dysfunction. METHODS: Electrocardiographic (EKG) and pulse oximetry (SpO2 ) data were recorded concurrently with video-electroencephalographic telemetry in the epilepsy monitoring unit (EMU)...
December 2017: Epilepsia
https://www.readbyqxmd.com/read/29017215/-pulmonary-embolism-despite-rivaroxaban-in-an-obese-patient
#13
Thomas Schuh, Claudia Stöllberger
Introduction  Rivaroxaban, an oral factor Xa inhibitor, is approved for therapy of venous thromboembolism. It is unclear whether the standard dose for patients with a body mass index (BMI) > 40 kg/m2 is sufficient. History  The 45-year-old patient was admitted because of increasing respiratory distress. She had a history of pulmonary embolism 30 months before the admission, a factor V Leiden mutation and several hospitalisations due to dermatomycoses. The patient briefly took phenprocoumon which was changed to 20 mg rivaroxaban due to a lack of adherence...
October 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28970804/inappropriate-timing-of-swallow-in-the-respiratory-cycle-causes-breathing-swallowing-discoordination
#14
Naomi Yagi, Yoshitaka Oku, Shinsuke Nagami, Yoshie Yamagata, Jun Kayashita, Akira Ishikawa, Kazuhisa Domen, Ryosuke Takahashi
Rationale: Swallowing during inspiration and swallowing immediately followed by inspiration increase the chances of aspiration and may cause disease exacerbation. However, the mechanisms by which such breathing-swallowing discoordination occurs are not well-understood. Objectives: We hypothesized that breathing-swallowing discoordination occurs when the timing of the swallow in the respiratory cycle is inappropriate. To test this hypothesis, we monitored respiration and swallowing activity in healthy subjects and in patients with dysphagia using a non-invasive swallowing monitoring system...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28961282/physiologic-effects-of-alveolar-recruitment-and-inspiratory-pauses-during-moderately-high-frequency-ventilation-delivered-by-a-conventional-ventilator-in-a-severe-lung-injury-model
#15
Ricardo Luiz Cordioli, Eduardo Leite Vieira Costa, Luciano Cesar Pontes Azevedo, Susimeire Gomes, Marcelo Britto Passos Amato, Marcelo Park
BACKGROUND AND AIMS: To investigate whether performing alveolar recruitment or adding inspiratory pauses could promote physiologic benefits (VT) during moderately-high-frequency positive pressure ventilation (MHFPPV) delivered by a conventional ventilator in a porcine model of severe acute respiratory distress syndrome (ARDS). METHODS: Prospective experimental laboratory study with eight pigs. Induction of acute lung injury with sequential pulmonary lavages and injurious ventilation was initially performed...
2017: PloS One
https://www.readbyqxmd.com/read/28648837/integrative-characterization-of-chronic-cigarette-smoke-induced-cardiopulmonary-comorbidities-in-a-mouse-model
#16
Ágnes Kemény, Kata Csekő, István Szitter, Zoltán V Varga, Péter Bencsik, Krisztina Kiss, Róbert Halmosi, László Deres, Krisztián Erős, Anikó Perkecz, László Kereskai, Terézia László, Tamás Kiss, Péter Ferdinandy, Zsuzsanna Helyes
Cigarette smoke-triggered inflammatory cascades and consequent tissue damage are the main causes of chronic obstructive pulmonary disease (COPD). There is no effective therapy and the key mediators of COPD are not identified due to the lack of translational animal models with complex characterization. This integrative chronic study investigated cardiopulmonary pathophysiological alterations and mechanisms with functional, morphological and biochemical techniques in a 6-month-long cigarette smoke exposure mouse model...
October 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28648104/a-speculated-cause-of-respiratory-inhibition-in-infants
#17
Hideki Minowa, Ikuyo Arai, Hajime Yasuhara, Reiko Ebisu, Ayako Ohgitani
OBJECTIVE: In our previous studies, we documented that threatened premature labor and asymmetrical intrauterine growth restriction were risk factors for respiratory inhibition. The goal of this study was to determine the cause of respiratory inhibition by considering perinatal risk factors. METHODS: We examined 1497 infants with a gestational age of 36 weeks or greater. All infants were monitored using pulse oximetry and examined via cranial sonography. Respiratory inhibition was defined as severe hypoxemia caused by respiratory inhibition immediately after crying or gastroesophageal reflux or as a respiratory pause during feeding...
October 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28519562/su-d-105-03-developing-qa-procedures-for-gated-vmat-sabr-treatments
#18
F Viel, E Gete, C Duzenli, R Lee
PURPOSE: To develop a QA procedure for gated VMAT SABR liver cancer treatments and investigate the gating parameters for acceptable plan delivery in terms of the dose to a moving volume and treatment delivery time. METHODS: 10 patient plans for VMAT SABR liver were created using the Eclipse™ TPS. The verification plans were then transferred to a CT-scanned Quasar™ phantom and delivered on a TrueBeam™ linac using a 10FFF beam and Varian's RPM system for respiratory gating...
June 2013: Medical Physics
https://www.readbyqxmd.com/read/28389250/significance-and-novelty-effects-in-single-trial-erp-components-and-autonomic-responses
#19
Brett MacDonald, Robert J Barry
The phasic orienting reflex (OR) was investigated in two counterbalanced blocks of an auditory dishabituation paradigm differing in stimulus Significance (operationalised as tone counting). Twelve tones were presented at very long, randomly-varying interstimulus intervals (ISIs). Novelty and Significance were varied within subjects. Stimulus-response patterns were assessed to find ERP matches for autonomic measures. The phasic OR index was represented by the skin conductance response (SCR). SCR decremented over 10 standard trials, showed recovery on trial 11 (change trial), enhancement to re-presentation of the standard tone (trial 12: dishabituation), and a main effect of Significance over the first 10 trials - demonstrating the formal criteria for an OR index...
July 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28327645/a-novel-point-of-care-smartphone-based-system-for-monitoring-the-cardiac-and-respiratory-systems
#20
Kwanghyun Sohn, Faisal M Merchant, Omid Sayadi, Dheeraj Puppala, Rajiv Doddamani, Ashish Sahani, Jagmeet P Singh, E Kevin Heist, Eric M Isselbacher, Antonis A Armoundas
Cardio-respiratory monitoring is one of the most demanding areas in the rapidly growing, mobile-device, based health care delivery. We developed a 12-lead smartphone-based electrocardiogram (ECG) acquisition and monitoring system (called "cvrPhone"), and an application to assess underlying ischemia, and estimate the respiration rate (RR) and tidal volume (TV) from analysis of electrocardiographic (ECG) signals only. During in-vivo swine studies (n = 6), 12-lead ECG signals were recorded at baseline and following coronary artery occlusion...
March 22, 2017: Scientific Reports
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