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Michael Sieweke

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https://www.readbyqxmd.com/read/29662170/c-maf-controls-immune-responses-by-regulating-disease-specific-gene-networks-and-repressing-il-2-in-cd4-t-cells
#1
Leona Gabryšová, Marisol Alvarez-Martinez, Raphaëlle Luisier, Luke S Cox, Jan Sodenkamp, Caroline Hosking, Damián Pérez-Mazliah, Charlotte Whicher, Yashaswini Kannan, Krzysztof Potempa, Xuemei Wu, Leena Bhaw, Hagen Wende, Michael H Sieweke, Greg Elgar, Mark Wilson, James Briscoe, Vicki Metzis, Jean Langhorne, Nicholas M Luscombe, Anne O'Garra
The transcription factor c-Maf induces the anti-inflammatory cytokine IL-10 in CD4+ T cells in vitro. However, the global effects of c-Maf on diverse immune responses in vivo are unknown. Here we found that c-Maf regulated IL-10 production in CD4+ T cells in disease models involving the TH 1 subset of helper T cells (malaria), TH 2 cells (allergy) and TH 17 cells (autoimmunity) in vivo. Although mice with c-Maf deficiency targeted to T cells showed greater pathology in TH 1 and TH 2 responses, TH 17 cell-mediated pathology was reduced in this context, with an accompanying decrease in TH 17 cells and increase in Foxp3+ regulatory T cells...
May 2018: Nature Immunology
https://www.readbyqxmd.com/read/29650243/testicular-macrophages-guardians-of-fertility
#2
Noushin Mossadegh-Keller, Michael H Sieweke
Macrophages are innate immune cells present in essentially every organ of the body with dedicated tissue specific functions. We will present in this review the unique properties and functions of macrophage populations residing in the testis, an immune-privileged organ. Testicular macrophages (tMΦ) could be seen as guardians of fertility due to their immunosuppressive functions protecting spermatogenesis from auto immune-attack. They exhibit testis specific functions with essential roles in normal testis homeostasis and fetal testicular development...
April 3, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29144502/trained-macrophages-support-hygiene-hypothesis
#3
Bérengère de Laval, Michael H Sieweke
No abstract text is available yet for this article.
November 16, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28784628/developmental-origin-and-maintenance-of-distinct-testicular-macrophage-populations
#4
Noushin Mossadegh-Keller, Rebecca Gentek, Gregory Gimenez, Sylvain Bigot, Sebastien Mailfert, Michael H Sieweke
Testicular macrophages (tMφ) are the principal immune cells of the mammalian testis. Beyond classical immune functions, they have been shown to be important for organogenesis, spermatogenesis, and male hormone production. In the adult testis, two different macrophage populations have been identified based on their distinct tissue localization and morphology, but their developmental origin and mode of homeostatic maintenance are unknown. In this study, we use genetic lineage-tracing models and adoptive transfer protocols to address this question...
October 2, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28701484/sirt1-regulates-macrophage-self-renewal
#5
Francesco Imperatore, Julien Maurizio, Stephanie Vargas Aguilar, Clara J Busch, Jérémy Favret, Elisabeth Kowenz-Leutz, Wilfried Cathou, Rebecca Gentek, Pierre Perrin, Achim Leutz, Carole Berruyer, Michael H Sieweke
Mature differentiated macrophages can self-maintain by local proliferation in tissues and can be extensively expanded in culture under specific conditions, but the mechanisms of this phenomenon remain only partially defined. Here, we show that SIRT1, an evolutionary conserved regulator of life span, positively affects macrophage self-renewal ability in vitro and in vivo Overexpression of SIRT1 during bone marrow-derived macrophage differentiation increased their proliferative capacity. Conversely, decrease of SIRT1 expression by shRNA inactivation, CRISPR/Cas9 mediated deletion and pharmacological inhibition restricted macrophage self-renewal in culture...
August 15, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28084216/dna-damage-signaling-instructs-polyploid-macrophage-fate-in-granulomas
#6
Laura Herrtwich, Indrajit Nanda, Konstantinos Evangelou, Teodora Nikolova, Veronika Horn, Sagar, Daniel Erny, Jonathan Stefanowski, Leif Rogell, Claudius Klein, Kourosh Gharun, Marie Follo, Maximilian Seidl, Bernhard Kremer, Nikolas Münke, Julia Senges, Manfred Fliegauf, Tom Aschman, Dietmar Pfeifer, Sandrine Sarrazin, Michael H Sieweke, Dirk Wagner, Christine Dierks, Thomas Haaf, Thomas Ness, Mario M Zaiss, Reinhard E Voll, Sachin D Deshmukh, Marco Prinz, Torsten Goldmann, Christoph Hölscher, Anja E Hauser, Andres J Lopez-Contreras, Dominic Grün, Vassilis Gorgoulis, Andreas Diefenbach, Philipp Henneke, Antigoni Triantafyllopoulou
Granulomas are immune cell aggregates formed in response to persistent inflammatory stimuli. Granuloma macrophage subsets are diverse and carry varying copy numbers of their genomic information. The molecular programs that control the differentiation of such macrophage populations in response to a chronic stimulus, though critical for disease outcome, have not been defined. Here, we delineate a macrophage differentiation pathway by which a persistent Toll-like receptor (TLR) 2 signal instructs polyploid macrophage fate by inducing replication stress and activating the DNA damage response...
November 17, 2016: Cell
https://www.readbyqxmd.com/read/27811055/m-csf-improves-protection-against-bacterial-and-fungal-infections-after-hematopoietic-stem-progenitor-cell-transplantation
#7
Prashanth K Kandalla, Sandrine Sarrazin, Kaaweh Molawi, Carole Berruyer, David Redelberger, Anne Favel, Christophe Bordi, Sophie de Bentzmann, Michael H Sieweke
Myeloablative treatment preceding hematopoietic stem cell (HSC) and progenitor cell (HS/PC) transplantation results in severe myeloid cytopenia and susceptibility to infections in the lag period before hematopoietic recovery. We have previously shown that macrophage colony-stimulating factor (CSF-1; M-CSF) directly instructed myeloid commitment in HSCs. In this study, we tested whether this effect had therapeutic benefit in improving protection against pathogens after HS/PC transplantation. M-CSF treatment resulted in an increased production of mature myeloid donor cells and an increased survival of recipient mice infected with lethal doses of clinically relevant opportunistic pathogens, namely the bacteria Pseudomonas aeruginosa and the fungus Aspergillus fumigatus M-CSF treatment during engraftment or after infection efficiently protected from these pathogens as early as 3 days after transplantation and was effective as a single dose...
October 17, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27729526/efficient-crispr-mediated-mutagenesis-in-primary-immune-cells-using-crisprgold-and-a-c57bl-6-cas9-transgenic-mouse-line
#8
Van Trung Chu, Robin Graf, Tristan Wirtz, Timm Weber, Jeremy Favret, Xun Li, Kerstin Petsch, Ngoc Tung Tran, Michael H Sieweke, Claudia Berek, Ralf Kühn, Klaus Rajewsky
Applying clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9)-mediated mutagenesis to primary mouse immune cells, we used high-fidelity single guide RNAs (sgRNAs) designed with an sgRNA design tool (CrispRGold) to target genes in primary B cells, T cells, and macrophages isolated from a Cas9 transgenic mouse line. Using this system, we achieved an average knockout efficiency of 80% in B cells. On this basis, we established a robust small-scale CRISPR-mediated screen in these cells and identified genes essential for B-cell activation and plasma cell differentiation...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27456703/the-feasibility-and-safety-of-extracorporeal-carbon-dioxide-removal-to-avoid-intubation-in-patients-with-copd-unresponsive-to-noninvasive-ventilation-for-acute-hypercapnic-respiratory-failure-eclair-study-multicentre-case-control-study
#9
MULTICENTER STUDY
Stephan Braune, Annekatrin Sieweke, Franz Brettner, Thomas Staudinger, Michael Joannidis, Serge Verbrugge, Daniel Frings, Axel Nierhaus, Karl Wegscheider, Stefan Kluge
INTRODUCTION: The aim of the study was to evaluate the feasibility and safety of avoiding invasive mechanical ventilation (IMV) by using extracorporeal CO2 removal (ECCO2R) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and acute hypercapnic respiratory failure refractory to noninvasive ventilation (NIV). METHODS: Case-control study. Patients with acute hypercapnic respiratory failure refractory to NIV being treated with a pump-driven veno-venous ECCO2R system (iLA-Activve(®); Novalung, Heilbronn, Germany) were prospectively observed in five European intensive care units (ICU)...
September 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27338705/microglia-development-follows-a-stepwise-program-to-regulate-brain-homeostasis
#10
Orit Matcovitch-Natan, Deborah R Winter, Amir Giladi, Stephanie Vargas Aguilar, Amit Spinrad, Sandrine Sarrazin, Hila Ben-Yehuda, Eyal David, Fabiola Zelada González, Pierre Perrin, Hadas Keren-Shaul, Meital Gury, David Lara-Astaiso, Christoph A Thaiss, Merav Cohen, Keren Bahar Halpern, Kuti Baruch, Aleksandra Deczkowska, Erika Lorenzo-Vivas, Shalev Itzkovitz, Eran Elinav, Michael H Sieweke, Michal Schwartz, Ido Amit
Microglia, the resident myeloid cells of the central nervous system, play important roles in life-long brain maintenance and in pathology. Despite their importance, their regulatory dynamics during brain development have not been fully elucidated. Using genome-wide chromatin and expression profiling coupled with single-cell transcriptomic analysis throughout development, we found that microglia undergo three temporal stages of development in synchrony with the brain--early, pre-, and adult microglia--which are under distinct regulatory circuits...
August 19, 2016: Science
https://www.readbyqxmd.com/read/27196510/eosinophils-and-mast-cells-a-lineage-apart
#11
COMMENT
Sandrine Sarrazin, Michael H Sieweke
No abstract text is available yet for this article.
May 19, 2016: Nature Immunology
https://www.readbyqxmd.com/read/26797145/lineage-specific-enhancers-activate-self-renewal-genes-in-macrophages-and-embryonic-stem-cells
#12
Erinn L Soucie, Ziming Weng, Laufey Geirsdóttir, Kaaweh Molawi, Julien Maurizio, Romain Fenouil, Noushine Mossadegh-Keller, Gregory Gimenez, Laurent VanHille, Meryam Beniazza, Jeremy Favret, Carole Berruyer, Pierre Perrin, Nir Hacohen, J-C Andrau, Pierre Ferrier, Patrice Dubreuil, Arend Sidow, Michael H Sieweke
Differentiated macrophages can self-renew in tissues and expand long term in culture, but the gene regulatory mechanisms that accomplish self-renewal in the differentiated state have remained unknown. Here we show that in mice, the transcription factors MafB and c-Maf repress a macrophage-specific enhancer repertoire associated with a gene network that controls self-renewal. Single-cell analysis revealed that, in vivo, proliferating resident macrophages can access this network by transient down-regulation of Maf transcription factors...
February 12, 2016: Science
https://www.readbyqxmd.com/read/26139534/molecular-profiling-of-cd8-t-cells-in-autochthonous-melanoma-identifies-maf-as-driver-of-exhaustion
#13
Marilyn Giordano, Coralie Henin, Julien Maurizio, Claire Imbratta, Pierre Bourdely, Michel Buferne, Lukas Baitsch, Laurent Vanhille, Michael H Sieweke, Daniel E Speiser, Nathalie Auphan-Anezin, Anne-Marie Schmitt-Verhulst, Grégory Verdeil
T cells infiltrating neoplasms express surface molecules typical of chronically virus-stimulated T cells, often termed "exhausted" T cells. We compared the transcriptome of "exhausted" CD8 T cells infiltrating autochthonous melanomas to those of naïve and acutely stimulated CD8 T cells. Despite strong similarities between transcriptional signatures of tumor- and virus-induced exhausted CD8 T cells, notable differences appeared. Among transcriptional regulators, Nr4a2 and Maf were highly overexpressed in tumor-exhausted T cells and significantly upregulated in CD8 T cells from human melanoma metastases...
August 4, 2015: EMBO Journal
https://www.readbyqxmd.com/read/25607453/monocytes-compensate-kupffer-cell-loss-during-bacterial-infection
#14
COMMENT
Kaaweh Molawi, Michael H Sieweke
Liver Kupffer cells (KCs) are self-maintained tissue-resident macrophages. In this issue of Immunity, Blériot et al. demonstrate that bacterial infection leads to KC necroptosis and quantitative replacement by monocyte-derived macrophages that contribute to antibacterial immunity and restoration of tissue integrity.
January 20, 2015: Immunity
https://www.readbyqxmd.com/read/25575076/waddington-s-valleys-and-captain-cook-s-islands
#15
Michael H Sieweke
Somatic reprogramming has relied heavily on theoretical models that view differentiation in terms of developmental branch point decisions. Recent studies in Cell now reveal a dominant role of the microenvironment in shaping epigenetic identity of macrophages, thus providing support for alternative models of cell fate acquisition.
January 8, 2015: Cell Stem Cell
https://www.readbyqxmd.com/read/25534619/epigenetic-control-of-myeloid-cell-differentiation-identity-and-function
#16
REVIEW
Damiana Álvarez-Errico, Roser Vento-Tormo, Michael Sieweke, Esteban Ballestar
Myeloid cells are crucial effectors of the innate immune response and important regulators of adaptive immunity. The differentiation and activation of myeloid cells requires the timely regulation of gene expression; this depends on the interplay of a variety of elements, including transcription factors and epigenetic mechanisms. Epigenetic control involves histone modifications and DNA methylation, and is coupled to lineage-specifying transcription factors, upstream signalling pathways and external factors released in the bone marrow, blood and tissue environments...
January 2015: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/25319327/tissue-macrophage-identity-and-self-renewal
#17
REVIEW
Rebecca Gentek, Kaaweh Molawi, Michael H Sieweke
Macrophages are cellular components of the innate immune system that reside in virtually all tissues and contribute to immunity, repair, and homeostasis. The traditional view that all tissue-resident macrophages derive from the bone marrow through circulating monocyte intermediates has dramatically shifted recently with the observation that macrophages from embryonic progenitors can persist into adulthood and self-maintain by local proliferation. In several tissues, however, monocytes also contribute to the resident macrophage population, on which the local environment can impose tissue-specific macrophage functions...
November 2014: Immunological Reviews
https://www.readbyqxmd.com/read/25245760/progressive-replacement-of-embryo-derived-cardiac-macrophages-with-age
#18
Kaaweh Molawi, Yochai Wolf, Prashanth K Kandalla, Jeremy Favret, Nora Hagemeyer, Kathrin Frenzel, Alexander R Pinto, Kay Klapproth, Sandrine Henri, Bernard Malissen, Hans-Reimer Rodewald, Nadia A Rosenthal, Marc Bajenoff, Marco Prinz, Steffen Jung, Michael H Sieweke
Cardiac macrophages (cMΦ) are critical for early postnatal heart regeneration and fibrotic repair in the adult heart, but their origins and cellular dynamics during postnatal development have not been well characterized. Tissue macrophages can be derived from embryonic progenitors or from monocytes during inflammation. We report that within the first weeks after birth, the embryo-derived population of resident CX3CR1(+) cMΦ diversifies into MHCII(+) and MHCII(-) cells. Genetic fate mapping demonstrated that cMΦ derived from CX3CR1(+) embryonic progenitors persisted into adulthood but the initially high contribution to resident cMΦ declined after birth...
October 20, 2014: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/24530283/design-of-a-bzip-transcription-factor-with-homo-heterodimer-induced-dna-binding-preference
#19
Vivian Pogenberg, Larissa Consani Textor, Laurent Vanhille, Simon J Holton, Michael H Sieweke, Matthias Wilmanns
The ability of basic leucine zipper transcription factors for homo- or heterodimerization provides a paradigm for combinatorial control of eukaryotic gene expression. It has been unclear, however, how facultative dimerization results in alternative DNA-binding repertoires on distinct regulatory elements. To unravel the molecular basis of such coupled preferences, we determined two high-resolution structures of the transcription factor MafB as a homodimer and as a heterodimer with c-Fos bound to variants of the Maf-recognition element...
March 4, 2014: Structure
https://www.readbyqxmd.com/read/24499617/effects-of-therapeutic-goal-management-tgm-on-treatment-attendance-and-drug-abstinence-among-men-with-co-occurring-substance-use-and-axis-i-mental-disorders-who-are-homeless-results-of-the-birmingham-earth-program
#20
Anna Davidson, Michael Jensen, Emilee Burgess, Angee Stevens, Lauren Hayes, Susan Sieweke, Karen Stough, Anne Wright, Robin McCarty, Lillian Eddleman, Young-Il Kim, Jesse B Milby, Joseph E Schumacher
PURPOSE: This study describes the implementation and impact of Therapeutic Goal Management (TGM) in a Substance Abuse and Mental Health Services Administration (SAMHSA)-sponsored demonstration project entitled Enhanced Addiction Recovery through Housing (EARTH). PARTICIPANTS: The sample included 28 male participants followed at six months who completed some treatment. Forty-three percent were Caucasian, and 57% were African American. The average age of participants was 42 years...
2013: Addiction Science & Clinical Practice
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